ES2635386T3 - Inhibidores de indazol de las vías de señalización WNT y usos terapéuticos de los mismos - Google Patents

Inhibidores de indazol de las vías de señalización WNT y usos terapéuticos de los mismos Download PDF

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Publication number
ES2635386T3
ES2635386T3 ES13772420.9T ES13772420T ES2635386T3 ES 2635386 T3 ES2635386 T3 ES 2635386T3 ES 13772420 T ES13772420 T ES 13772420T ES 2635386 T3 ES2635386 T3 ES 2635386T3
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smdrome
disease
cancer
compound
pharmaceutically acceptable
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Spanish (es)
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John Hood
David Mark WALLACE
Sunil Kumar Kc
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Biosplice Therapeutics Inc
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Samumed LLC
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
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ES13772420.9T 2012-04-04 2013-03-13 Inhibidores de indazol de las vías de señalización WNT y usos terapéuticos de los mismos Active ES2635386T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261620107P 2012-04-04 2012-04-04
US201261620107P 2012-04-04
PCT/US2013/031055 WO2013151708A1 (en) 2012-04-04 2013-03-13 Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
ES2635386T3 true ES2635386T3 (es) 2017-10-03

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ES13772420.9T Active ES2635386T3 (es) 2012-04-04 2013-03-13 Inhibidores de indazol de las vías de señalización WNT y usos terapéuticos de los mismos

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US (9) US8673936B2 (OSRAM)
EP (3) EP3284744B1 (OSRAM)
JP (3) JP6167169B2 (OSRAM)
KR (1) KR102048107B1 (OSRAM)
CN (2) CN104202984B (OSRAM)
AU (2) AU2013243899B2 (OSRAM)
BR (1) BR112014023639B1 (OSRAM)
CA (1) CA2853703C (OSRAM)
CL (1) CL2014002511A1 (OSRAM)
CO (1) CO7230336A2 (OSRAM)
CY (1) CY1119485T1 (OSRAM)
DK (1) DK2760285T3 (OSRAM)
ES (1) ES2635386T3 (OSRAM)
HR (1) HRP20171322T1 (OSRAM)
HU (1) HUE033829T2 (OSRAM)
IL (2) IL234743A (OSRAM)
LT (1) LT2760285T (OSRAM)
MA (1) MA37450B1 (OSRAM)
ME (1) ME02832B (OSRAM)
MX (1) MX355435B (OSRAM)
MY (1) MY174896A (OSRAM)
NZ (3) NZ629323A (OSRAM)
PE (1) PE20142216A1 (OSRAM)
PH (3) PH12017500997A1 (OSRAM)
PL (1) PL2760285T3 (OSRAM)
PT (1) PT2760285T (OSRAM)
RS (1) RS56292B1 (OSRAM)
RU (2) RU2638932C2 (OSRAM)
SG (2) SG11201406310RA (OSRAM)
SI (1) SI2760285T1 (OSRAM)
SM (1) SMT201700414T1 (OSRAM)
WO (1) WO2013151708A1 (OSRAM)
ZA (3) ZA201406273B (OSRAM)

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GB201322334D0 (en) * 2013-12-17 2014-01-29 Agency Science Tech & Res Maleimide derivatives as modulators of WNT pathway
MA39763A (fr) 2014-03-20 2017-01-25 Samumed Llc Indazole-3-carboxamides 5-substitués, et préparation et utilisation de ceux-ci
WO2015144290A1 (en) * 2014-03-27 2015-10-01 Merck Patent Gmbh Pyridyl piperidines
CN106488775A (zh) 2014-07-11 2017-03-08 基因泰克公司 Notch途径抑制
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WO2016040182A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
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US10383861B2 (en) 2015-08-03 2019-08-20 Sammumed, LLC 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
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