ES2624131T3 - Moduladores heterocíclicos de la síntesis de lípidos - Google Patents

Moduladores heterocíclicos de la síntesis de lípidos Download PDF

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ES2624131T3
ES2624131T3 ES12754969.9T ES12754969T ES2624131T3 ES 2624131 T3 ES2624131 T3 ES 2624131T3 ES 12754969 T ES12754969 T ES 12754969T ES 2624131 T3 ES2624131 T3 ES 2624131T3
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alkyl
cycloalkyl
compound according
cancer
branched
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Spanish (es)
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Johan D. Oslob
Robert S. Mcdowell
Russell Johnson
Hanbiao Yang
Marc EVANCHIK
Cristiana A. Zaharia
Haiying CAI
Lily W. HU
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Sagimet Biosciences Inc
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3V Biosciences Inc
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Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170119786A1 (en) 2011-03-08 2017-05-04 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
TWI522348B (zh) 2011-03-08 2016-02-21 3 V生物科技公司 脂質合成之雜環調節劑
US9624173B2 (en) 2011-03-08 2017-04-18 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
NZ703162A (en) 2012-07-03 2017-05-26 3-V Biosciences Inc Heterocyclic modulators of lipid synthesis
AR092211A1 (es) * 2012-09-24 2015-04-08 Merck Patent Ges Mit Beschränkter Haftung Derivados de hidropirrolopirrol
JP6409001B2 (ja) * 2012-12-27 2018-10-17 ドレクセル ユニバーシティ Hbv感染に対する新規抗ウイルス剤
CN104995170A (zh) * 2013-02-14 2015-10-21 盖尔德马研究及发展公司 合成4-哌啶-4-基-苯-1,3-二醇及其盐以及新型化合物4-(2,4-二羟基-苯基)-4-羟基-哌啶-1-甲酸叔丁酯的方法
CN105102449B (zh) * 2013-03-06 2017-06-13 豪夫迈·罗氏有限公司 抗病毒化合物
WO2014164767A1 (en) 2013-03-13 2014-10-09 Forma Therapeutics, Inc. Novel compounds and compositions for inhibition of fasn
ES2841137T3 (es) * 2013-12-20 2021-07-07 Sagimet Biosciences Inc Moduladores heterocíclicos de la síntesis de lípidos y combinaciones de los mismos
MX2016008841A (es) * 2014-01-07 2016-10-13 3-V Biosciences Inc Moduladores heterociclicos de la sintesis de lipidos para su uso contra el cancer e infecciones virales.
CN104774204A (zh) * 2014-01-15 2015-07-15 鲁南贝特制药有限公司 一种制备奈韦拉平及其中间体的方法
WO2015199206A1 (ja) * 2014-06-27 2015-12-30 塩野義製薬株式会社 Trpv4阻害活性を有する6員環誘導体
ES2833454T3 (es) * 2014-08-15 2021-06-15 Sagimet Biosciences Inc Inhibidor de la ácido graso sintasa para su uso en el tratamiento de un cáncer farmacorresistente
JP6758314B2 (ja) * 2015-03-19 2020-09-23 サギメット バイオサイエンシーズ インコーポレイテッド 脂質合成の複素環式調節因子
CN105175277B (zh) * 2015-05-18 2018-04-03 中山大学肿瘤防治中心 一种3‑磷酸甘油醛脱氢酶的抑制剂及其制备方法和应用
ES2821049T3 (es) 2015-06-18 2021-04-23 89Bio Ltd Derivados de piperidina 1,4 sustituidos
JP6986972B2 (ja) 2015-06-18 2021-12-22 エイティナイン バイオ リミテッド 置換4−ベンジル及び4−ベンゾイルピペリジン誘導体
KR102591220B1 (ko) * 2015-09-04 2023-10-18 폴리 엠디 에스.알.엘. 인유두종 바이러스 피부 감염의 치료를 위한 아세틸살리실산을 포함하는 조성물 및 의료 장치
CN116139138A (zh) * 2016-11-11 2023-05-23 3-V生物科学股份有限公司 脂质合成的杂环调节剂
CN107043347B (zh) * 2016-11-18 2019-07-02 泰州禾益新材料科技有限公司 一种阿加曲班中间体(2r,4r)-4-甲基哌啶-2-甲酸乙酯的合成方法
CN108456005B (zh) * 2018-04-20 2021-04-27 郑州大学 石墨抗氧化涂层
CN109212056B (zh) * 2018-08-19 2021-05-07 丁立平 一种测定水源水中三种痕量单卤代甲基苯甲酸的气相色谱-质谱联用法
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
US10793554B2 (en) 2018-10-29 2020-10-06 Forma Therapeutics, Inc. Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone
US20230218557A1 (en) * 2020-05-14 2023-07-13 Palani Llc A fatty acid based composition for treatment and/or prevention of enveloped-virus related infections
CN114469945A (zh) * 2020-10-28 2022-05-13 歌礼生物科技(杭州)有限公司 脂肪酸合酶抑制剂的用途和药物组合物
CN113584044A (zh) * 2021-08-28 2021-11-02 青岛农业大学 一种牙鲆socs3基因及其真核表达载体、表达系统和异源表达方法
WO2024069574A1 (en) * 2022-10-01 2024-04-04 Assia Chemical Industries Ltd. Solid state forms of denifanstat

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3625214A (en) 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US4906474A (en) 1983-03-22 1990-03-06 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4789734A (en) 1985-08-06 1988-12-06 La Jolla Cancer Research Foundation Vitronectin specific cell receptor derived from mammalian mesenchymal tissue
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
NL8720442A (nl) 1986-08-18 1989-04-03 Clinical Technologies Ass Afgeefsystemen voor farmacologische agentia.
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US6024983A (en) 1986-10-24 2000-02-15 Southern Research Institute Composition for delivering bioactive agents for immune response and its preparation
US4992445A (en) 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
US5001139A (en) 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
US5766573A (en) 1988-12-06 1998-06-16 Riker Laboratories, Inc. Medicinal aerosol formulations
US5190029A (en) 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
US5376359A (en) 1992-07-07 1994-12-27 Glaxo, Inc. Method of stabilizing aerosol formulations
DK0678034T3 (da) 1993-01-11 1999-11-08 Dana Farber Cancer Inst Inc Induktion af cytotoksiske T-lymfocytreaktioner
AU2006261845C1 (en) * 2005-06-27 2013-05-16 Exelixis Patent Company Llc Imidazole based LXR modulators
ES2335698T3 (es) * 2005-12-01 2010-03-31 F. Hoffmann-La Roche Ag Derivados de piperidina sustituida por heteroarilo como inhibidores de l-cpt1.
AU2007292306A1 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof
WO2008059214A1 (en) * 2006-11-13 2008-05-22 Astrazeneca Ab Bisamlde derivatives and use thereof as fatty acid synthase inhibitors
WO2008075077A1 (en) * 2006-12-21 2008-06-26 Astrazeneca Ab Piperidine derivatives for the treatment of obesity
TW200833663A (en) * 2006-12-21 2008-08-16 Astrazeneca Ab Therapeutic agents
TW200831092A (en) * 2006-12-21 2008-08-01 Astrazeneca Ab Therapeutic agents

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