ES2602743T3 - Receptores de antígenos quiméricos con una región bisagra optimizada - Google Patents

Receptores de antígenos quiméricos con una región bisagra optimizada Download PDF

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Publication number
ES2602743T3
ES2602743T3 ES11755014.5T ES11755014T ES2602743T3 ES 2602743 T3 ES2602743 T3 ES 2602743T3 ES 11755014 T ES11755014 T ES 11755014T ES 2602743 T3 ES2602743 T3 ES 2602743T3
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cells
amino acid
domain
human
car
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Spanish (es)
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Kurt SCHÖNFELD
Christiane Knopp
Winfried Wels
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Chemotherapeutisches Forschungsinstitut Georg Speyer Haus
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Chemotherapeutisches Forschungsinstitut Georg Speyer Haus
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES11755014.5T 2010-09-08 2011-09-06 Receptores de antígenos quiméricos con una región bisagra optimizada Active ES2602743T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10009345 2010-09-08
EP10009345 2010-09-08
PCT/EP2011/004490 WO2012031744A1 (en) 2010-09-08 2011-09-06 Chimeric antigen receptors with an optimized hinge region

Publications (1)

Publication Number Publication Date
ES2602743T3 true ES2602743T3 (es) 2017-02-22

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ES11755014.5T Active ES2602743T3 (es) 2010-09-08 2011-09-06 Receptores de antígenos quiméricos con una región bisagra optimizada
ES16182059T Active ES2754394T3 (es) 2010-09-08 2011-09-06 Receptores de antígenos quiméricos con una región bisagra optimizada
ES15199344.1T Active ES2656414T3 (es) 2010-09-08 2011-09-06 Receptores de antígenos quiméricos con una región bisagra optimizada

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ES16182059T Active ES2754394T3 (es) 2010-09-08 2011-09-06 Receptores de antígenos quiméricos con una región bisagra optimizada
ES15199344.1T Active ES2656414T3 (es) 2010-09-08 2011-09-06 Receptores de antígenos quiméricos con una región bisagra optimizada

Country Status (7)

Country Link
US (3) US9212229B2 (cg-RX-API-DMAC7.html)
EP (3) EP3012268B1 (cg-RX-API-DMAC7.html)
DK (2) DK2614077T3 (cg-RX-API-DMAC7.html)
ES (3) ES2602743T3 (cg-RX-API-DMAC7.html)
NO (1) NO3012268T3 (cg-RX-API-DMAC7.html)
PT (2) PT3012268T (cg-RX-API-DMAC7.html)
WO (1) WO2012031744A1 (cg-RX-API-DMAC7.html)

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