ES2570600T3 - Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso - Google Patents
Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y usoInfo
- Publication number
- ES2570600T3 ES2570600T3 ES07867341T ES07867341T ES2570600T3 ES 2570600 T3 ES2570600 T3 ES 2570600T3 ES 07867341 T ES07867341 T ES 07867341T ES 07867341 T ES07867341 T ES 07867341T ES 2570600 T3 ES2570600 T3 ES 2570600T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- reactive
- combinations
- compound
- hapten
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- C07D277/76—Sulfur atoms attached to a second hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/12—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 3 and unsubstituted in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6841—In situ hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/583—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with non-fluorescent dye label
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/807—Hapten conjugated with peptide or protein
Abstract
Un conjugado que tiene una fórmula (hapteno)m-(conector)''-(grupo reactivo)0-(vehículo)p donde: el hapteno es un oxazol; el conector, para unir un hapteno a un grupo reactivo, es un polímero que contiene entre 1 y 15 unidades de glicol de etileno; el grupo reactivo, para unir un conector a un vehículo, se selecciona del grupo compuesto por un grupo reactivo a amina seleccionado del grupo compuesto por un isotiocianato, un isocianato, una acil azida, un éster NHS, un cloruro ácido, un aldehído, un gioxal, un epósido, un oxirano, un carbonato, un agente arilante, un imidoéster, una carbodiimida, un anhídrico y combinaciones de estos; un grupo funcional reactivo a tiol se selecciona del grupo compuesto por un haloacetilo, un alquil haluro, una maleimida, una aziridina, un derivado de acriloil, un agente arilante; un reactivo de intercambio de 1-disulfuro seleccionado del grupo compuesto por piridi-disulfuro, un tiol TNB, un reductor de disulfuro y combinaciones de estos; grupos funcionales reactivos a carboxilato seleccionados del grupo compuesto por diazoalcano, un compuesto de diazoacetilo, un compuesto de carbonildiimidazol y una carbodiimida; los grupos funcionales reactivos a hidroxilo seleccionados del grupo compuesto por un epósito, un orixano, un carbonildiimidazol, un N,N'-disuccinimidil carbonato, un N-hidroxisuccinimidil cloroformato, un compuesto oxidante de periodato, un halógeno de alquilo y un isocianato; grupos funcionales reactivos a aldehído y cetona seleccionados del grupo compuesto por una hidracina, una base de Schiff, un producto de ion amina reductor, un producto de condensación de Marmich, y combinaciones de estos; un compuesto activo reactivo a hidrógeno seleccionado del grupo compuesto por un derivado de diazonio, un producto de condensación de Mannich, un producto de reacción a la yodación, y combinaciones de estos; un grupo funcional químico fotorreactivo seleccionado del grupo compuesto por una aril azida, una aril azida halogenada, una benzofonona, un compuesto diazo, un derivado de diazirina y combinaciones de estos; el vehículo se selecciona del grupo compuesto por un aminoácido, un polipéptido, una proteína, un nucleósido, un nucleótido, una cadena de nucleótidos, un ácido nucleico, ADN, ARN, ARNm, un polímero, aminoalquil-agarosa, cristal de aminopropilo y dextrano reticulado; m, n, o y p son 1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85613306P | 2006-11-01 | 2006-11-01 | |
PCT/US2007/023140 WO2008063378A2 (en) | 2006-11-01 | 2007-11-01 | Haptens, hapten conjugates, compositions thereof and method for their preparation and use |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2570600T3 true ES2570600T3 (es) | 2016-05-19 |
Family
ID=39430271
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES07867341T Active ES2570600T3 (es) | 2006-11-01 | 2007-11-01 | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso |
ES12151520.9T Active ES2491743T3 (es) | 2006-11-01 | 2007-11-01 | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso |
ES12150646.3T Active ES2465465T3 (es) | 2006-11-01 | 2007-11-01 | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso |
ES12151524.1T Active ES2493166T3 (es) | 2006-11-01 | 2007-11-01 | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso |
ES17192133T Active ES2761949T3 (es) | 2006-11-01 | 2007-11-01 | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso |
ES19178774T Active ES2905054T3 (es) | 2006-11-01 | 2007-11-01 | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso |
ES16151995.4T Active ES2663080T3 (es) | 2006-11-01 | 2007-11-01 | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso |
Family Applications After (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES12151520.9T Active ES2491743T3 (es) | 2006-11-01 | 2007-11-01 | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso |
ES12150646.3T Active ES2465465T3 (es) | 2006-11-01 | 2007-11-01 | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso |
ES12151524.1T Active ES2493166T3 (es) | 2006-11-01 | 2007-11-01 | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso |
ES17192133T Active ES2761949T3 (es) | 2006-11-01 | 2007-11-01 | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso |
ES19178774T Active ES2905054T3 (es) | 2006-11-01 | 2007-11-01 | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso |
ES16151995.4T Active ES2663080T3 (es) | 2006-11-01 | 2007-11-01 | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso |
Country Status (8)
Country | Link |
---|---|
US (5) | US7695929B2 (es) |
EP (7) | EP2444807B1 (es) |
JP (6) | JP5576120B2 (es) |
AU (1) | AU2007322261B2 (es) |
CA (5) | CA2858359C (es) |
DK (7) | DK3564674T3 (es) |
ES (7) | ES2570600T3 (es) |
WO (1) | WO2008063378A2 (es) |
Families Citing this family (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4868698B2 (ja) | 2001-05-02 | 2012-02-01 | パーデュー・リサーチ・ファウンデーション | マクロファージが仲介する疾患の治療および診断 |
US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
US8043603B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
WO2007006041A2 (en) | 2005-07-05 | 2007-01-11 | Purdue Research Foundation | Imaging and therapeutic method using monocytes |
EP1940473A2 (en) | 2005-09-23 | 2008-07-09 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
EP3591069A3 (en) * | 2005-10-27 | 2020-03-04 | The President and Fellows of Harvard College | Methods and compositions for labeling nucleic acids |
CA2858359C (en) * | 2006-11-01 | 2018-04-03 | Ventana Medical Systems, Inc. | Haptens, hapten conjugates, compositions thereof and method for their preparation and use |
WO2008057437A2 (en) | 2006-11-03 | 2008-05-15 | Purdue Research Foundation | Ex vivo flow cytometry method and device |
CA2677792C (en) | 2007-02-07 | 2015-04-14 | Purdue Research Foundation | Positron emission tomography imaging method |
US7682789B2 (en) * | 2007-05-04 | 2010-03-23 | Ventana Medical Systems, Inc. | Method for quantifying biomolecules conjugated to a nanoparticle |
WO2008153744A2 (en) | 2007-05-23 | 2008-12-18 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
EP2164525A2 (en) | 2007-05-25 | 2010-03-24 | Purdue Research Foundation | Method of imaging localized infections |
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
CA2720728C (en) | 2008-06-05 | 2018-04-03 | Ventana Medical Systems, Inc. | Compositions comprising nanomaterials and method for using such compositions for histochemical processes |
ES2538123T3 (es) * | 2008-08-22 | 2015-06-17 | Ventana Medical Systems, Inc. | Método para la detección cromogénica de dos o más moléculas diana en una sola muestra |
US8734796B2 (en) * | 2009-03-20 | 2014-05-27 | Amgen Inc. | Carrier immunoglobulins |
CN106519588B (zh) | 2009-11-09 | 2019-08-20 | 华盛顿大学商业化中心 | 官能化发色聚合物点及其生物共轭体 |
USPP22463P3 (en) * | 2010-02-16 | 2012-01-17 | Menachem Bornstein | Gypsophila plant named ‘Pearl Blossom’ |
US20120301886A1 (en) * | 2010-02-26 | 2012-11-29 | Michael Farrell | Polytag probes |
US10126216B2 (en) | 2011-02-17 | 2018-11-13 | Ventana Medical Systems, Inc. | Method for tissue sample fixation |
US10539487B2 (en) | 2010-03-04 | 2020-01-21 | Ventana Medical Systems, Inc. | Systems and methods for monitoring tissue sample processing |
ES2759007T3 (es) | 2010-03-04 | 2020-05-07 | Ventana Med Syst Inc | Sistema de procesamiento para procesar muestras usando energía acústica |
AU2011242766B2 (en) * | 2010-04-20 | 2015-01-15 | Ventana Medical Systems, Inc. | Two-color chromogenic in situ hybridization |
PL2560645T3 (pl) | 2010-04-21 | 2017-01-31 | Syntarga B.V. | Koniugaty analogów CC-1065 i łączników dwufunkcyjnych |
DK2564203T3 (en) | 2010-04-27 | 2017-08-21 | Ventana Med Syst Inc | Antibody-nanoparticle conjugates and methods for preparing and using such conjugates |
WO2012003478A2 (en) | 2010-07-02 | 2012-01-05 | Ventana Medical Systems, Inc. | Detecting targets using mass tags and mass spectrometry |
AU2011274369A1 (en) * | 2010-07-02 | 2012-12-06 | Ventana Medical Systems, Inc. | Hapten conjugates for target detection |
US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
WO2012024185A1 (en) | 2010-08-16 | 2012-02-23 | Ventana Medical Systems, Inc. | Substrates for chromogenic detection and methods of use in detection assays and kits |
WO2012040518A2 (en) | 2010-09-22 | 2012-03-29 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
EP3434642A1 (en) | 2010-10-18 | 2019-01-30 | University of Washington through its Center for Commercialization | Chromophoric polymer dots |
MX350974B (es) | 2010-11-18 | 2017-09-27 | Univ Yale | Moleculas bifuncionales con actividad reclutadora de anticuerpos e inhibidora de la entrada frente al virus de inmunodeficiencia humana. |
JP5840708B2 (ja) | 2011-03-14 | 2016-01-06 | ヴェンタナ メディカル システムズ, インク. | 染色体転座を解析する方法及びそのシステム |
US9797840B2 (en) | 2011-11-28 | 2017-10-24 | University Of Washington Through Its Center For Commercialization | Highly fluorescent polymer nanoparticle |
WO2013079606A1 (en) | 2011-12-01 | 2013-06-06 | Ventana Medical Systems, Inc. | Automated dual stain of mirna and protein targets |
WO2013101902A2 (en) | 2011-12-30 | 2013-07-04 | University Of Washington, Through Its Center For Commercialization | Chromophoric polymer dots with narrow-band emission |
WO2013108126A2 (en) | 2012-01-16 | 2013-07-25 | University Of Oslo | Methyltransferases and uses thereof |
EP2807269B1 (en) | 2012-01-23 | 2018-05-02 | Ventana Medical Systems, Inc. | Polymer stabilization of chromogen solutions |
WO2013116614A1 (en) | 2012-02-03 | 2013-08-08 | University Of Washington Through Its Center For Commercialization | Polyelectrolyte-coated polymer dots and related methods |
ES2678211T3 (es) * | 2012-03-27 | 2018-08-09 | Ventana Medical Systems, Inc. | Conjugados de señalización y procedimientos de uso |
US9123538B2 (en) * | 2012-04-26 | 2015-09-01 | Regents Of The University Of Minnesota | Silicon nanocrystal inks, films, and methods |
CN102654500A (zh) * | 2012-05-17 | 2012-09-05 | 重庆市科学技术研究院 | 一种检测喹噁啉-2-羧酸的检测试剂盒及其方法 |
PT3663317T (pt) * | 2012-08-21 | 2023-01-23 | Janssen Pharmaceutica Nv | Anticorpos para haptenos de quetiapina e sua utilização |
CA2900842C (en) | 2013-03-12 | 2020-01-21 | Ventana Medical Systems, Inc. | Digitally enhanced microscopy for multiplexed histology |
WO2014139979A1 (en) | 2013-03-12 | 2014-09-18 | Ventana Medical Systems, Inc. | Quantum dot in situ hybridization |
EP2971064B1 (en) | 2013-03-12 | 2019-10-16 | Ventana Medical Systems, Inc. | Proximity assay for in situ detection of targets |
WO2014153051A1 (en) | 2013-03-14 | 2014-09-25 | University Of Washington Through Its Center For Commercialization | Polymer dot compositions and related methods |
AU2014333815B2 (en) * | 2013-10-11 | 2020-07-09 | Nihon University School Of Medicine | Multiplex HER2 and estrogen receptor co-staining assays for detecting tumor heterogeneity |
EP3060917B1 (en) | 2013-10-24 | 2019-05-15 | Siemens Healthcare Diagnostics Inc. | Assays for macromolecular analytes |
MX368234B (es) | 2014-01-10 | 2019-09-25 | Synthon Biopharmaceuticals Bv | Conjugados de anticuerpo-fármaco (adcs) que contienen duocarmicina para usarse en el tratamiento de cáncer endometrial. |
SG10201911860VA (en) | 2014-01-10 | 2020-02-27 | Synthon Biopharmaceuticals Bv | Duocarmycin adcs showing improved in vivo antitumor activity |
JP6644713B2 (ja) | 2014-02-24 | 2020-02-12 | ヴェンタナ メディカル システムズ, インク. | キノンメチドアナログシグナル増幅 |
EP3110966A1 (en) | 2014-02-24 | 2017-01-04 | Ventana Medical Systems, Inc. | Automated rna detection using labeled 2'-o-methyl rna oligonucleotide probes and signal amplification systems |
DK3152577T3 (en) | 2014-06-06 | 2018-10-01 | Ventana Med Syst Inc | SIGNIFICANCE OF INTRATUMORAL HER2 HETEROGENITY IN BREAST CANCER AND APPLICATIONS HEFAR |
WO2016046173A1 (en) * | 2014-09-22 | 2016-03-31 | Synthon Biopharmaceuticals B.V. | Pan-reactive antibodies to duocarmycins |
WO2016050913A2 (en) | 2014-10-02 | 2016-04-07 | Ventana Medical Systems, Inc. | Polymers and conjugates comprising the same |
EP3224621B1 (en) | 2014-11-25 | 2019-06-12 | Ventana Medical Systems, Inc. | Proximity assays using chemical ligation and hapten transfer |
JP6654634B2 (ja) | 2014-12-03 | 2020-02-26 | ベンタナ メディカル システムズ, インコーポレイテッド | 不均一なバイオマーカー分布を定量的に分析するための方法、システム及び装置 |
IL282614B2 (en) | 2015-02-06 | 2024-02-01 | Cell Idx Inc | Antigen-conjugated immune reagents |
EP3283881B1 (en) | 2015-04-13 | 2022-12-14 | Ventana Medical Systems, Inc. | Thermochemical-based antibody inactivation methods and systems |
JP6720208B2 (ja) | 2015-04-17 | 2020-07-08 | スプリング バイオサイエンス コーポレーション | C4.4aを検出するための抗体、組成物、及び免疫組織化学法 |
JP6711352B2 (ja) * | 2015-05-28 | 2020-06-17 | コニカミノルタ株式会社 | インサイチュハイブリダイゼイション用のプローブ試薬 |
CN105018072B (zh) * | 2015-07-08 | 2017-02-01 | 山东理工大学 | 检测人血清白蛋白的荧光探针及其制备方法 |
CN107923915B (zh) * | 2015-08-28 | 2021-05-04 | 文塔纳医疗系统公司 | 使用经掩蔽的半抗原在福尔马林固定石蜡包埋的组织中的蛋白质邻近测定 |
CN108449995B (zh) | 2015-11-06 | 2022-02-01 | 文塔纳医疗系统公司 | 代表性诊断 |
CA3016555A1 (en) | 2016-03-08 | 2017-09-14 | Ventana Medical Systems, Inc. | Multiplexed immunohistochemistry using recombinant antibodies with epitope tags |
CN109642898B (zh) | 2016-06-28 | 2023-07-07 | 文塔纳医疗系统公司 | 用多染料醌甲基化物和酪酰胺缀合物的显色ihc和ish染色的新颜色 |
EP3475291A1 (en) | 2016-06-28 | 2019-05-01 | Ventana Medical Systems, Inc. | Application of click chemistry for signal amplification in ihc and ish assays |
CN116515950A (zh) * | 2016-07-18 | 2023-08-01 | 赛尔伊迪克斯公司 | 抗原偶联的杂交试剂 |
EP3515449B1 (en) | 2016-09-26 | 2023-07-12 | Dana-Farber Cancer Institute, Inc. | Quinoline derivatives as chromobox (cbx) protein inhibitors for treating cancer |
CN110300806B (zh) * | 2016-12-16 | 2024-03-19 | 艾瑞特姆有限责任公司 | 使用连接扩增的分子检测 |
WO2018118759A1 (en) | 2016-12-19 | 2018-06-28 | Ventana Medical Systems, Inc. | Peptide nucleic acid conjugates |
CN110337588B (zh) | 2016-12-19 | 2023-02-17 | 文塔纳医疗系统公司 | 用于定量免疫组织化学的方法和系统 |
EP3568157A4 (en) * | 2017-01-13 | 2021-01-06 | National Research Council of Canada | METHOD FOR OPTIMIZING THE PEPTIDE IMMUNO-EPITOP BY GLYCOSYLATION, OPTIMIZED PEPTIDE THEREOF AND ITS USE FOR CONJUGATE VACCINES |
US10246738B2 (en) | 2017-03-31 | 2019-04-02 | Ultivue, Inc. | DNA-antigen exchange and amplification |
US10768185B2 (en) * | 2017-07-20 | 2020-09-08 | Trustees Of Boston University | Tenofovir detection assay |
JP2021507695A (ja) | 2017-12-18 | 2021-02-25 | ヴェンタナ メディカル システムズ, インク. | ペプチド核酸コンジュゲート |
WO2019194994A1 (en) * | 2018-04-05 | 2019-10-10 | Rarecyte, Inc. | Analyte detection |
US10330684B1 (en) | 2018-04-05 | 2019-06-25 | Rarecyte, Inc. | Analyte detection |
WO2019224153A1 (en) | 2018-05-21 | 2019-11-28 | Genentech, Inc. | Her2 heterogeneity as a biomarker in cancer |
JP7455816B2 (ja) | 2018-09-20 | 2024-03-26 | ヴェンタナ メディカル システムズ, インク. | クマリン系架橋試薬 |
JP2022533577A (ja) | 2019-05-14 | 2022-07-25 | ヴェンタナ メディカル システムズ, インク. | 生物学的試料処理チャンバを含むシステム |
CN110330488A (zh) * | 2019-06-20 | 2019-10-15 | 深圳市易瑞生物技术股份有限公司 | 一种吡罗昔康半抗原及其制备方法和应用 |
WO2021123074A1 (en) | 2019-12-18 | 2021-06-24 | F. Hoffmann-La Roche Ag | Methods of sequencing by synthesis using a consecutive labeling scheme |
US11814677B2 (en) * | 2019-12-30 | 2023-11-14 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods and systems for sensitive and multiplexed analysis of biological samples using cleavable fluorescent streptavidin and anti-hapten antibodies |
EP4110823A1 (en) | 2020-02-26 | 2023-01-04 | A2 Biotherapeutics, Inc. | Polypeptides targeting mage-a3 peptide-mhc complexes and methods of use thereof |
EP4147054A1 (en) | 2020-05-07 | 2023-03-15 | Ventana Medical Systems, Inc. | Histochemical systems and methods for evaluating egfr and egfr ligand expression in tumor samples |
KR102506288B1 (ko) * | 2020-09-07 | 2023-03-06 | 국립암센터 | 디그옥시제닌에 대한 항체를 포함하는 복합체, 및 이들의 용도 |
CN112362863B (zh) * | 2020-11-02 | 2024-02-13 | 上海市农业科学院 | 一种巯基功能化脂质体纳米材料及其制备方法和应用 |
JP2024504944A (ja) | 2021-01-15 | 2024-02-02 | ヴェンタナ メディカル システムズ, インク. | 保存安定なケージドハプテン |
WO2022156920A1 (en) | 2021-01-25 | 2022-07-28 | Ventana Medical Systems, Inc. | Stained biological specimens including one or more biomarkers labeled with one or more detectable moieties |
JP2024516380A (ja) | 2021-04-18 | 2024-04-15 | ヴェンタナ メディカル システムズ, インク. | 形態学的マーカー染色 |
WO2022240641A1 (en) * | 2021-05-12 | 2022-11-17 | The Scripps Research Institute | High-throughput assay for identification of myc inhibitors |
WO2023205669A2 (en) * | 2022-04-19 | 2023-10-26 | Purdue Research Foundation | Dual and triple hapten conjugates, compositions, processes for making, and methods of treatment therewith |
US20230383342A1 (en) * | 2022-05-31 | 2023-11-30 | Illumina Cambridge Limited | Compositions and methods for nucleic acid sequencing |
WO2024002924A2 (en) | 2022-06-28 | 2024-01-04 | F. Hoffmann-La Roche Ag | Fluorescent dyes with large stokes shift |
Family Cites Families (170)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3892530A (en) * | 1974-09-23 | 1975-07-01 | Hoffmann La Roche | Colorimetric and fluorometric method |
US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
US4230683A (en) * | 1978-08-09 | 1980-10-28 | Abbott Laboratories | Hapten conjugated antibody for antibody or antigen detection |
US4223013A (en) * | 1978-12-29 | 1980-09-16 | Syva Company | Amitriptyline conjugates to antigenic proteins and enzymes |
US4495296A (en) * | 1979-05-21 | 1985-01-22 | New York Blood Center, Inc. | Labeled anti-hapten antibodies and their use as a universal reagent for solid phase radio- and/or enzyme-immunoassays |
US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
US4425427A (en) * | 1980-03-13 | 1984-01-10 | Vitafin N.V. | Simultaneous, kinetic, spectrophotometric analysis of blood serum for multiple components |
US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
US4469797A (en) | 1982-09-23 | 1984-09-04 | Miles Laboratories, Inc. | Digoxigenin immunogens, antibodies, labeled conjugates, and related derivatives |
US4490473A (en) * | 1983-03-28 | 1984-12-25 | Panab | Labeled antibodies and methods |
JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
CA1256638A (en) | 1984-07-06 | 1989-06-27 | Motoaki Tanaka | Polymer and its production |
US4879224A (en) | 1985-01-10 | 1989-11-07 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing human phospholipase inhibitor polypeptides |
JP2551756B2 (ja) | 1985-05-07 | 1996-11-06 | 武田薬品工業株式会社 | ポリオキシカルボン酸エステルおよびその製造法 |
US5447841A (en) | 1986-01-16 | 1995-09-05 | The Regents Of The Univ. Of California | Methods for chromosome-specific staining |
US6280929B1 (en) | 1986-01-16 | 2001-08-28 | The Regents Of The University Of California | Method of detecting genetic translocations identified with chromosomal abnormalities |
US5756696A (en) | 1986-01-16 | 1998-05-26 | Regents Of The University Of California | Compositions for chromosome-specific staining |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
EP0317001B1 (en) | 1987-11-16 | 1993-02-03 | Janssen Pharmaceutica N.V. | A new universally applicable detection system based 0n ultra small colloidal metal particles |
DE3811692A1 (de) * | 1988-04-07 | 1989-10-19 | Idt Ag Fuer In Vivo Diagnostik | Diagnostikverfahren und mittel zur diagnose und behandlung immunologischer erkrankungen |
CA1308022C (en) * | 1988-08-11 | 1992-09-29 | Eleftherios P. Diamandis | Multiple fluorescence labelling with europium chelators |
DE3836656A1 (de) | 1988-10-27 | 1990-05-03 | Boehringer Mannheim Gmbh | Neue digoxigenin-derivate und ihre verwendung |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5225325A (en) | 1990-03-02 | 1993-07-06 | Ventana Medical Systems, Inc. | Immunohistochemical staining method and reagents therefor |
US5595707A (en) | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
WO1992016838A1 (en) * | 1991-03-20 | 1992-10-01 | Gec-Marconi Limited | Separation method |
WO1993020094A1 (en) * | 1992-03-27 | 1993-10-14 | Abbott Laboratories | Haptens, tracers, immunogens and antibodies for quinoline |
US6100099A (en) * | 1994-09-06 | 2000-08-08 | Abbott Laboratories | Test strip having a diagonal array of capture spots |
US5403747A (en) * | 1992-04-01 | 1995-04-04 | Thomas Jefferson University | Protein assay using microwave energy |
US5350686A (en) | 1992-04-16 | 1994-09-27 | Pioneer Hi-Bred International, Inc. | Microwave acceleration of enzyme-catalyzed modification of macromolecules |
US5834202A (en) * | 1992-08-04 | 1998-11-10 | Replicon, Inc. | Methods for the isothermal amplification of nucleic acid molecules |
US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
DK1087013T3 (da) | 1992-08-21 | 2009-05-11 | Univ Bruxelles | Immunoglobuliner uden lette kæder |
US5393891A (en) * | 1993-06-08 | 1995-02-28 | The Du Pont Merck Pharmaceutical Company | Immunoassay reagents and methods for detecting brequinar and analogs |
US5679582A (en) | 1993-06-21 | 1997-10-21 | Scriptgen Pharmaceuticals, Inc. | Screening method for identifying ligands for target proteins |
US5661040A (en) * | 1993-07-13 | 1997-08-26 | Abbott Laboratories | Fluorescent polymer labeled conjugates and intermediates |
CA2166782A1 (en) * | 1993-07-20 | 1995-02-02 | James R. Fino | Haptens, tracers, immunogens and antibodies for carbazole and dibenzofuran derivatives |
US5731171A (en) * | 1993-07-23 | 1998-03-24 | Arch Development Corp. | Sequence independent amplification of DNA |
US5643761A (en) | 1993-10-27 | 1997-07-01 | The Trustees Of Columbia University In The City Of New York | Method for generating a subtracted cDNA library and uses of the generated library |
US5487975A (en) | 1993-11-15 | 1996-01-30 | Ventana Medical Systems, Inc. | Biotin/avidin formulation |
DE4407538C1 (de) * | 1994-03-07 | 1995-02-23 | Deutsches Krebsforsch | Bindungsreagens für Zell-Oberflächenprotein und Effektorzelle |
US5648211A (en) * | 1994-04-18 | 1997-07-15 | Becton, Dickinson And Company | Strand displacement amplification using thermophilic enzymes |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
EP0772619B2 (en) | 1994-07-15 | 2010-12-08 | The University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
GB9420355D0 (en) * | 1994-10-10 | 1994-11-23 | Univ Nottingham | Preparation of protein microspheres, films and coatings |
US6057099A (en) * | 1994-12-02 | 2000-05-02 | Intelligene Ltd. | Detection of nucleic acid sequences |
US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
US5648245A (en) * | 1995-05-09 | 1997-07-15 | Carnegie Institution Of Washington | Method for constructing an oligonucleotide concatamer library by rolling circle replication |
US5684142A (en) | 1995-06-07 | 1997-11-04 | Oncor, Inc. | Modified nucleotides for nucleic acid labeling |
US5883081A (en) * | 1995-07-26 | 1999-03-16 | The Regents Of The University Of California | Isolation of novel HIV-2 proviruses |
US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
US6361944B1 (en) | 1996-07-29 | 2002-03-26 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6506564B1 (en) * | 1996-07-29 | 2003-01-14 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6582921B2 (en) * | 1996-07-29 | 2003-06-24 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses thereof |
US6750016B2 (en) * | 1996-07-29 | 2004-06-15 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
JPH10104230A (ja) * | 1996-09-30 | 1998-04-24 | Aisin Seiki Co Ltd | 核酸等の検出方法,並びに標識物質及び検出物質 |
AU4116397A (en) * | 1996-10-04 | 1998-05-05 | Universitat Heidelberg | A method of purifying dna |
US5952890A (en) | 1997-02-05 | 1999-09-14 | Fox Enterprises, Inc. | Crystal oscillator programmable with frequency-defining parameters |
JP2001513776A (ja) | 1997-02-28 | 2001-09-04 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | LPS関連障害の処置における非メチル化CpGジヌクレオチドを含む核酸の使用 |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
US5994071A (en) | 1997-04-04 | 1999-11-30 | Albany Medical College | Assessment of prostate cancer |
AU7690898A (en) | 1997-05-20 | 1998-12-11 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
JPH1151935A (ja) * | 1997-08-06 | 1999-02-26 | Aisin Seiki Co Ltd | 複数種類のターゲット分子の同時検出方法 |
US6124120A (en) * | 1997-10-08 | 2000-09-26 | Yale University | Multiple displacement amplification |
US6322901B1 (en) | 1997-11-13 | 2001-11-27 | Massachusetts Institute Of Technology | Highly luminescent color-selective nano-crystalline materials |
JPH11240879A (ja) * | 1997-12-22 | 1999-09-07 | Nissan Chem Ind Ltd | ピラゾールスルホニルウレアのポリクローナル抗体及び検出方法 |
US6358682B1 (en) | 1998-01-26 | 2002-03-19 | Ventana Medical Systems, Inc. | Method and kit for the prognostication of breast cancer |
JP3847559B2 (ja) | 1998-02-27 | 2006-11-22 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 独立スライド加熱器を有する自動化分子病理学装置 |
US6582962B1 (en) | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
US6855559B1 (en) | 1998-09-03 | 2005-02-15 | Ventana Medical Systems, Inc. | Removal of embedding media from biological samples and cell conditioning on automated staining instruments |
US20030211630A1 (en) | 1998-02-27 | 2003-11-13 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
US6235480B1 (en) * | 1998-03-13 | 2001-05-22 | Promega Corporation | Detection of nucleic acid hybrids |
JP2002510644A (ja) | 1998-04-03 | 2002-04-09 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | 免疫治療用オリゴヌクレオチドおよびサイトカインを用いる免疫系刺激のための方法および産物 |
US6855552B2 (en) | 1998-09-03 | 2005-02-15 | Ventana Medical Systems | Automated immunohistochemical and in situ hybridization assay formulations |
US7550298B2 (en) | 1998-09-03 | 2009-06-23 | Ventana Medical Systems, Inc. | Automated immunohistochemical and in situ hybridization assay formulations |
JP2000095769A (ja) * | 1998-09-22 | 2000-04-04 | Kankyo Meneki Gijutsu Kenkyusho:Kk | プロベナゾールのハプテン化合物、抗体及び測定方法 |
JP4630459B2 (ja) * | 1998-09-24 | 2011-02-09 | インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション | 水溶性発光量子ドットおよびその生体分子コンジュゲート |
US6414133B1 (en) | 1998-10-13 | 2002-07-02 | Ventana Medical Systems, Inc. | Multiple fusion probes |
US7569344B2 (en) | 1998-10-26 | 2009-08-04 | Ventana Medical Systems, Inc. | Detection of human papilloma virus in papanicolaou (Pap) smears |
US6432320B1 (en) | 1998-11-02 | 2002-08-13 | Patrick Bonsignore | Refrigerant and heat transfer fluid additive |
US6699973B1 (en) * | 1998-11-19 | 2004-03-02 | Elan Corporation, Plc | Antibodies to peptides that target GIT receptors and related methods |
AU2410500A (en) | 1999-01-11 | 2000-08-01 | President And Fellows Of Harvard College | Isothermal amplification of dna |
AU3498200A (en) * | 1999-02-19 | 2000-09-04 | Michigan State University | An antigen test to detect equine protozoal myeloencephalitis in horse serum and cerebrospinal fluid |
US6696304B1 (en) * | 1999-02-24 | 2004-02-24 | Luminex Corporation | Particulate solid phase immobilized protein quantitation |
US6544798B1 (en) | 1999-02-26 | 2003-04-08 | Ventana Medical Systems, Inc. | Removal of embedding media from biological samples and cell conditioning on automated staining instruments |
US6673214B1 (en) * | 1999-04-09 | 2004-01-06 | Rocky Mountain Biosystems, Inc. | Energy enhanced reaction catalysis and uses thereof |
DE50015293D1 (de) | 1999-04-13 | 2008-09-11 | Wilex Ag | Diagnostischer und therapeutischer Einsatz von Antikörpern gegen den Urokinase-Rezeptor |
AU4701200A (en) * | 1999-05-07 | 2000-11-21 | Quantum Dot Corporation | A method of detecting an analyte using semiconductor nanocrystals |
US6180349B1 (en) * | 1999-05-18 | 2001-01-30 | The Regents Of The University Of California | Quantitative PCR method to enumerate DNA copy number |
US6326148B1 (en) | 1999-07-12 | 2001-12-04 | The Regents Of The University Of California | Detection of copy number changes in colon cancer |
DE19933701A1 (de) * | 1999-07-19 | 2001-01-25 | Wilex Biotechnology Gmbh | Zyklische peptidomimetische Urokinaserezeptorantagonisten |
JP2001089484A (ja) * | 1999-09-22 | 2001-04-03 | Kankyo Meneki Gijutsu Kenkyusho:Kk | トリシクラゾールのハプテン化合物、抗体及び測定方法 |
EP1218547A4 (en) * | 1999-10-15 | 2005-04-20 | Ventana Med Syst Inc | METHOD FOR DETECTING UNIQUE GENE IN SITU COPIES |
US20060275784A1 (en) | 1999-10-26 | 2006-12-07 | Ventana Medical Systems, Inc. | Detection of Human Papilloma Virus in Papanicolaou (Pap) Smears |
WO2001051928A1 (en) | 2000-01-12 | 2001-07-19 | Ventana Medical Systems, Inc. | Method for quantitating a protein by image analysis |
WO2001051665A2 (en) * | 2000-01-13 | 2001-07-19 | Nanosphere Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
AU2001250882A1 (en) * | 2000-03-20 | 2001-10-03 | Massachusetts Institute Of Technology | Inorganic particle conjugates |
WO2001079855A2 (en) | 2000-04-14 | 2001-10-25 | Ventana Medical Systems, Inc. | Method for quantification of akt protein expression |
US6291187B1 (en) | 2000-05-12 | 2001-09-18 | Molecular Staging, Inc. | Poly-primed amplification of nucleic acid sequences |
US6828097B1 (en) * | 2000-05-16 | 2004-12-07 | The Childrens Mercy Hospital | Single copy genomic hybridization probes and method of generating same |
AU6461001A (en) | 2000-05-16 | 2001-11-26 | Childrens Mercy Hospital | Single copy genomic hybridization probes and method of generating same |
US6794362B1 (en) * | 2000-05-30 | 2004-09-21 | Connective Tissue Imagineering Llc | Asparagine containing elastin peptide analogs |
US7763421B2 (en) | 2000-06-05 | 2010-07-27 | Ventana Medical Systems, Inc. | Methods for producing nucleic acid hybridization probes that amplify hybridization signal by promoting network formation |
US6323009B1 (en) | 2000-06-28 | 2001-11-27 | Molecular Staging, Inc. | Multiply-primed amplification of nucleic acid sequences |
US6447692B1 (en) | 2000-08-04 | 2002-09-10 | Hrl Laboratories, Llc | Nanometer sized phase change materials for enhanced heat transfer fluid performance |
US6942970B2 (en) | 2000-09-14 | 2005-09-13 | Zymed Laboratories, Inc. | Identifying subjects suitable for topoisomerase II inhibitor treatment |
US20040209303A1 (en) | 2000-10-03 | 2004-10-21 | Martin Mark T. | Methods and compositions for directed microwave chemistry |
US6649138B2 (en) | 2000-10-13 | 2003-11-18 | Quantum Dot Corporation | Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media |
US6576291B2 (en) * | 2000-12-08 | 2003-06-10 | Massachusetts Institute Of Technology | Preparation of nanocrystallites |
KR20030055346A (ko) * | 2000-12-11 | 2003-07-02 | 프레지던트 앤드 펠로우즈 오브 하버드 칼리지 | 나노센서 |
US20020083888A1 (en) | 2000-12-28 | 2002-07-04 | Zehnder Donald A. | Flow synthesis of quantum dot nanocrystals |
US20030022166A1 (en) * | 2001-01-19 | 2003-01-30 | Colin Collins | Repeat-free probes for molecular cytogenetics |
US6656685B2 (en) | 2001-01-29 | 2003-12-02 | Ventana Medical Systems, Inc. | Hybridization buffers using low molecular weight dextran sulfate and methods for their use |
EP1373430A4 (en) * | 2001-01-30 | 2007-04-25 | Mat & Electrochem Res Corp | CARBON MATERIALS, OF A NANOMETRIC SIZE, FOR IMPROVING THERMAL TRANSFER IN FLUIDS |
DE10105912A1 (de) * | 2001-02-09 | 2002-08-14 | Roche Diagnostics Gmbh | Rekombinante Proteinase K |
WO2002088670A1 (en) | 2001-04-30 | 2002-11-07 | Ventana Medical Systems, Inc. | Method and composition for staining microorganisms |
ES2400448T3 (es) | 2001-04-30 | 2013-04-10 | Ventana Medical Systems, Inc. | Reactivos y métodos para la hibridación automatizada in situ o para microarray |
NZ511705A (en) * | 2001-05-14 | 2004-03-26 | Horticulture & Food Res Inst | Methods and rapid immunoassay device for detecting progesterone and other steroids |
US20030022243A1 (en) * | 2001-06-20 | 2003-01-30 | Les Kondejewski | Protein aggregation assays and uses thereof |
ATE447178T1 (de) * | 2001-07-02 | 2009-11-15 | Arctic Diagnostics Oy | Zwei photonen absorbierende bordipyrromethen- difluorid-farbstoffe und ihre anwendungen |
ATE556845T1 (de) | 2001-07-20 | 2012-05-15 | Life Technologies Corp | Lumineszierende nanopartikel und ihre herstellung |
US20030066998A1 (en) * | 2001-08-02 | 2003-04-10 | Lee Howard Wing Hoon | Quantum dots of Group IV semiconductor materials |
MXPA04003451A (es) * | 2001-10-09 | 2005-02-17 | Dimensional Pharm Inc | Difeniloxazoles substituidos, la sintesis de los mismos y el uso de los mismo como detectores fluorescencia. |
US6977148B2 (en) | 2001-10-15 | 2005-12-20 | Qiagen Gmbh | Multiple displacement amplification |
US6617137B2 (en) | 2001-10-15 | 2003-09-09 | Molecular Staging Inc. | Method of amplifying whole genomes without subjecting the genome to denaturing conditions |
US20030165485A1 (en) | 2001-11-09 | 2003-09-04 | Goran Bertilsson | Functional role and potential therapeutic use of Reelin, Gas6 and Protein S in relation to adult neural stem or progenitor cells |
US7358041B2 (en) * | 2001-11-30 | 2008-04-15 | Short Mary K | Antibodies to magmas and uses thereof |
US20050019901A1 (en) * | 2002-01-31 | 2005-01-27 | Evgenia Matveeva | Methods for synthesis of bio-active nanoparticles and nanocapsules for use in optical bio-disc assays and disc assembly including same |
US20040248151A1 (en) | 2002-04-05 | 2004-12-09 | Ventana Medical Systems, Inc. | Method for predicting the response to HER2-directed therapy |
US7285289B2 (en) | 2002-04-12 | 2007-10-23 | Nagy Jon O | Nanoparticle vaccines |
US20040057958A1 (en) | 2002-05-17 | 2004-03-25 | Waggoner David W. | Immunogenicity-enhancing carriers and compositions thereof and methods of using the same |
US7476442B2 (en) | 2002-07-17 | 2009-01-13 | Massachusetts Institute Of Technology | Nanoparticle chains and preparation thereof |
EP1565754B1 (en) * | 2002-10-25 | 2007-08-01 | Sense Proteomic Limited | New uses of proteins encoded by ble genes and antibiotics from the bleomycin family |
US7200252B2 (en) | 2002-10-28 | 2007-04-03 | Ventana Medical Systems, Inc. | Color space transformations for use in identifying objects of interest in biological specimens |
US7233817B2 (en) | 2002-11-01 | 2007-06-19 | Brian Yen | Apparatus and method for pattern delivery of radiation and biological characteristic analysis |
US20040101822A1 (en) * | 2002-11-26 | 2004-05-27 | Ulrich Wiesner | Fluorescent silica-based nanoparticles |
GB0227738D0 (en) * | 2002-11-28 | 2003-01-08 | Univ Liverpool | Nanoparticle conjugates and method of production thereof |
US20040115727A1 (en) * | 2002-12-11 | 2004-06-17 | Allergan, Inc., A Corporation | Evolved clostridial toxins with altered protease specificity |
US7056471B1 (en) * | 2002-12-16 | 2006-06-06 | Agency For Science Technology & Research | Ternary and quarternary nanocrystals, processes for their production and uses thereof |
US20040229300A1 (en) | 2003-04-22 | 2004-11-18 | Frederickson Christopher J. | Zinc-based screening test and kit for early diagnosis of prostate cancer |
US6944333B2 (en) | 2003-04-30 | 2005-09-13 | Ventana Medical Systems, Inc. | Color image compression via spectral decorrelation and elimination of spatial redundancy |
WO2005001889A2 (en) * | 2003-05-07 | 2005-01-06 | Indiana University Research & Technology Corporation | Alloyed semiconductor quantum dots and concentration-gradient alloyed quantum dots, series comprising the same and methods related thereto |
EP1625382A2 (en) | 2003-05-19 | 2006-02-15 | Ventana Medical Systems, Inc. | Electrophoretic in situ tissue staining |
US20050181394A1 (en) | 2003-06-20 | 2005-08-18 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
ES2330441T3 (es) | 2003-06-24 | 2009-12-10 | Ventana Medical Systems, Inc. | Deposito de metal catalizado por una enzima para la deteccion in situ mejorada de epitopos inmunohistoquimicos y secuencias de acido nucleico. |
KR100657891B1 (ko) | 2003-07-19 | 2006-12-14 | 삼성전자주식회사 | 반도체 나노결정 및 그 제조방법 |
US20050048498A1 (en) * | 2003-08-29 | 2005-03-03 | Applera Corporation | Compositions, methods, and kits for assembling probes |
KR100571817B1 (ko) * | 2003-09-19 | 2006-04-17 | 삼성전자주식회사 | 태그 서열에 혼성화하는 검출 프로브를 이용하는 표적핵산의 검출방법 |
US20050112636A1 (en) * | 2003-09-23 | 2005-05-26 | Atom Sciences | Polymeric nucleic acid hybridization probes |
TWI356064B (en) | 2003-11-07 | 2012-01-11 | Immunex Corp | Antibodies that bind interleukin-4 receptor |
TW200526224A (en) * | 2003-12-22 | 2005-08-16 | Alcon Inc | Short form c-Maf transcription factor antagonists for treatment of glaucoma |
US7541455B2 (en) | 2003-12-22 | 2009-06-02 | Ventana Medical Systems, Inc. | Microwave mediated synthesis of nucleic acid probes |
US7104313B2 (en) | 2003-12-31 | 2006-09-12 | Intel Corporation | Apparatus for using fluid laden with nanoparticles for application in electronic cooling |
US7244665B2 (en) | 2004-04-29 | 2007-07-17 | Micron Technology, Inc. | Wafer edge ring structures and methods of formation |
AU2005240215A1 (en) * | 2004-05-04 | 2005-11-17 | Ventana Medical Systems, Inc. | Internal control in situ hybridization |
US20060110744A1 (en) * | 2004-11-23 | 2006-05-25 | Sampas Nicolas M | Probe design methods and microarrays for comparative genomic hybridization and location analysis |
US7947839B2 (en) * | 2004-12-01 | 2011-05-24 | Genentech, Inc. | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use |
US20060160116A1 (en) * | 2004-12-16 | 2006-07-20 | The Regents Of The University Of California | Repetitive sequence-free DNA libraries |
EP1893241A2 (en) | 2005-04-28 | 2008-03-05 | Ventana Medical Systems, Inc. | Fluorescent nanoparticles conjugated to antibodies via a peg linker |
US7615800B2 (en) | 2005-09-14 | 2009-11-10 | Eastman Kodak Company | Quantum dot light emitting layer |
CN101535244B (zh) * | 2005-11-23 | 2014-07-23 | 文塔納医疗系统公司 | 分子缀合物 |
ATE456053T1 (de) | 2005-12-30 | 2010-02-15 | Ventana Med Syst Inc | Na+, k+-atpase-expression bei zervixdysplasie und krebs |
ATE522627T1 (de) | 2006-09-01 | 2011-09-15 | Ventana Med Syst Inc | Verfahren zur herstellung von nukleinsäuresonden |
CA2858359C (en) * | 2006-11-01 | 2018-04-03 | Ventana Medical Systems, Inc. | Haptens, hapten conjugates, compositions thereof and method for their preparation and use |
US7682789B2 (en) * | 2007-05-04 | 2010-03-23 | Ventana Medical Systems, Inc. | Method for quantifying biomolecules conjugated to a nanoparticle |
WO2008153744A2 (en) * | 2007-05-23 | 2008-12-18 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
WO2010104899A1 (en) * | 2009-03-12 | 2010-09-16 | Glaxosmithkline Llc | Thiazole sulfonamide and oxazole sulfonamide kinase inhibitors |
-
2007
- 2007-11-01 CA CA2858359A patent/CA2858359C/en active Active
- 2007-11-01 ES ES07867341T patent/ES2570600T3/es active Active
- 2007-11-01 AU AU2007322261A patent/AU2007322261B2/en active Active
- 2007-11-01 ES ES12151520.9T patent/ES2491743T3/es active Active
- 2007-11-01 DK DK19178774.6T patent/DK3564674T3/da active
- 2007-11-01 CA CA3069091A patent/CA3069091C/en active Active
- 2007-11-01 CA CA3125026A patent/CA3125026C/en active Active
- 2007-11-01 DK DK07867341.5T patent/DK2078197T3/en active
- 2007-11-01 DK DK12150646.3T patent/DK2442107T3/da active
- 2007-11-01 DK DK12151520.9T patent/DK2444806T3/da active
- 2007-11-01 EP EP12151524.1A patent/EP2444807B1/en active Active
- 2007-11-01 ES ES12150646.3T patent/ES2465465T3/es active Active
- 2007-11-01 EP EP12151520.9A patent/EP2444806B1/en active Active
- 2007-11-01 EP EP12150646.3A patent/EP2442107B1/en active Active
- 2007-11-01 DK DK16151995.4T patent/DK3029461T3/en active
- 2007-11-01 DK DK12151524.1T patent/DK2444807T3/da active
- 2007-11-01 EP EP16151995.4A patent/EP3029461B1/en active Active
- 2007-11-01 US US11/982,627 patent/US7695929B2/en active Active
- 2007-11-01 EP EP07867341.5A patent/EP2078197B1/en active Active
- 2007-11-01 ES ES12151524.1T patent/ES2493166T3/es active Active
- 2007-11-01 ES ES17192133T patent/ES2761949T3/es active Active
- 2007-11-01 CA CA2666234A patent/CA2666234C/en active Active
- 2007-11-01 DK DK17192133T patent/DK3276349T3/da active
- 2007-11-01 ES ES19178774T patent/ES2905054T3/es active Active
- 2007-11-01 ES ES16151995.4T patent/ES2663080T3/es active Active
- 2007-11-01 JP JP2009535326A patent/JP5576120B2/ja active Active
- 2007-11-01 CA CA2995467A patent/CA2995467C/en active Active
- 2007-11-01 WO PCT/US2007/023140 patent/WO2008063378A2/en active Application Filing
- 2007-11-01 EP EP19178774.6A patent/EP3564674B1/en active Active
- 2007-11-01 EP EP17192133.1A patent/EP3276349B1/en active Active
-
2010
- 2010-02-17 US US12/660,017 patent/US8846320B2/en active Active
- 2010-03-02 US US12/660,744 patent/US8618265B2/en active Active
-
2013
- 2013-06-17 JP JP2013126544A patent/JP5722952B2/ja active Active
-
2014
- 2014-06-23 US US14/312,341 patent/US9719986B2/en active Active
- 2014-10-23 JP JP2014216691A patent/JP5973524B2/ja active Active
-
2016
- 2016-02-19 JP JP2016029756A patent/JP6259477B2/ja active Active
-
2017
- 2017-07-31 US US15/665,291 patent/US11092594B2/en active Active
- 2017-12-05 JP JP2017233050A patent/JP6691092B2/ja active Active
-
2020
- 2020-04-06 JP JP2020068075A patent/JP7000489B2/ja active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2570600T3 (es) | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso | |
ES2660594T3 (es) | Métodos y composiciones relacionados con oligosacáridos sintéticos de beta-1,6 glucosamina | |
Leriche et al. | Optimization of the azobenzene scaffold for reductive cleavage by dithionite; development of an azobenzene cleavable linker for proteomic applications | |
Kushwaha et al. | Click reaction in carbohydrate chemistry: recent developments and future perspective | |
Dalhoff et al. | Synthesis of S‐Adenosyl‐L‐homocysteine Capture Compounds for Selective Photoinduced Isolation of Methyltransferases | |
JP2021119345A5 (es) | ||
CN109661232A (zh) | 核苷酸衍生物及其使用方法 | |
JP2011510120A5 (es) | ||
RU2013134746A (ru) | Низкомолекулярные конъюгаты для внутриклеточной доставки биологически активных соединений | |
CZ401697A3 (cs) | Modifikovaná molekula typu avidin vázající biotin, její použití, nitro-tyrosinový přírodní avidin a způsob jeho výroby, bakteriální streptavidin, kolona pro imobolizaci biotinylovaného ligandu a způsob získání avidinové kolony nebo biotinylovaného ligandu | |
NO333251B1 (no) | Fremgangsmate for fremstilling av N-substituerte 2-cyanopyrrolidoner | |
BR0116698A (pt) | Composto de modafinila e misturas de ciclodextrina, uso e método de obtenção dos mesmos | |
KAKEMI et al. | Absorption and excretion of drugs. XXXIV. An aspect of the mechanism of drug absorption from the intestinal tract in rats | |
Liu et al. | Construction of an IMiD-based azide library as a kit for PROTAC research | |
CN108866065A (zh) | 特异性识别庆大霉素的ssDNA适配体及其应用 | |
US8043666B2 (en) | Photoreactive compound, photoreactive polyamine and method for producing polyamine sheet | |
ES2272099T3 (es) | Composicion estable en el almacenamiento que comprende un soporte activado por acido escuarico utilizable para la inmovilizacion de compuestos que contienen grupos de amina. | |
BR0213774A (pt) | Molécula de ácido nucleio isolada, vetor, célula hospedeira, e, método para a preparação de um composto de quìmica fina | |
Guillaumie et al. | Immobilization of pectin fragments on solid supports: novel coupling by thiazolidine formation | |
Baigude et al. | Synthesis of spherical and hemispherical sugar‐containing poly (ornithine) dendrimers | |
BR0213771A (pt) | Molécula de ácido nucleico isolada, vetor, célula hospedeira, e, método para a preparação de um composto de quìmica fina | |
JP2010101661A (ja) | 物質固定化法 | |
Millon et al. | Synthesis of a new reagent, ethyl 4‐azidobenzoylaminoacetimidate, and its use for RNA‐protein cross‐linking within Escherichia coli ribosomal 30‐S subunits | |
Yura et al. | Structural effect of galactose residue in synthetic glycoconjugates on interaction with rat hepatocytes | |
CN104931687A (zh) | 一种三维生物表面及其制备方法和一种三维生物芯片及其用途 |