MX368234B - Conjugados de anticuerpo-fármaco (adcs) que contienen duocarmicina para usarse en el tratamiento de cáncer endometrial. - Google Patents
Conjugados de anticuerpo-fármaco (adcs) que contienen duocarmicina para usarse en el tratamiento de cáncer endometrial.Info
- Publication number
- MX368234B MX368234B MX2016009069A MX2016009069A MX368234B MX 368234 B MX368234 B MX 368234B MX 2016009069 A MX2016009069 A MX 2016009069A MX 2016009069 A MX2016009069 A MX 2016009069A MX 368234 B MX368234 B MX 368234B
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- endometrial cancer
- duocarmycin
- adcs
- her2
- Prior art date
Links
- 206010014733 Endometrial cancer Diseases 0.000 title abstract 3
- 206010014759 Endometrial neoplasm Diseases 0.000 title abstract 3
- VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 title abstract 3
- 229960005501 duocarmycin Drugs 0.000 title abstract 3
- 229930184221 duocarmycin Natural products 0.000 title abstract 3
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 4
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 239000000611 antibody drug conjugate Substances 0.000 abstract 3
- 229940049595 antibody-drug conjugate Drugs 0.000 abstract 3
- 208000018463 endometrial serous adenocarcinoma Diseases 0.000 abstract 3
Classifications
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
La presente invención se refiere a conjugados de anticuerpo-fármaco (ADCs) que contienen duocarmicina para su uso en el tratamiento de tumores sólidos humanos que expresan a HER2, en donde el tumor sólido humano que expresa a HER2 es cáncer endometrial, en particular carcinoma seroso uterino (USC); en particular la presente invención se refiere a ADCs que contienen duocarmicina para su uso en el tratamiento de cáncer endometrial, notablemente USC, con estado del tejido tumoral HER2 IHC 2+ o 1+ y HER2 negativo para FISH.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14150791 | 2014-01-10 | ||
PCT/EP2015/050332 WO2015104373A2 (en) | 2014-01-10 | 2015-01-09 | Duocarmycin adcs for use in treatment of endometrial cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016009069A MX2016009069A (es) | 2017-02-06 |
MX368234B true MX368234B (es) | 2019-09-25 |
Family
ID=49917013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016009069A MX368234B (es) | 2014-01-10 | 2015-01-09 | Conjugados de anticuerpo-fármaco (adcs) que contienen duocarmicina para usarse en el tratamiento de cáncer endometrial. |
Country Status (20)
Country | Link |
---|---|
US (2) | US9427480B2 (es) |
EP (1) | EP2948183B1 (es) |
JP (1) | JP6224268B2 (es) |
KR (2) | KR20160099725A (es) |
CN (1) | CN105899237B (es) |
AU (1) | AU2015205588B2 (es) |
CA (1) | CA2935430C (es) |
CL (1) | CL2016001743A1 (es) |
CY (1) | CY1117712T1 (es) |
DK (1) | DK2948183T3 (es) |
ES (1) | ES2578831T3 (es) |
HR (1) | HRP20160797T1 (es) |
HU (1) | HUE029672T2 (es) |
MX (1) | MX368234B (es) |
MY (1) | MY189713A (es) |
PL (1) | PL2948183T3 (es) |
PT (1) | PT2948183T (es) |
RU (1) | RU2686085C2 (es) |
SG (1) | SG11201605597VA (es) |
WO (1) | WO2015104373A2 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20220045075A (ko) | 2022-04-12 |
RU2686085C2 (ru) | 2019-04-24 |
CY1117712T1 (el) | 2017-05-17 |
HUE029672T2 (en) | 2017-03-28 |
US9427480B2 (en) | 2016-08-30 |
HRP20160797T1 (hr) | 2016-08-12 |
RU2016132635A (ru) | 2018-02-16 |
WO2015104373A3 (en) | 2015-09-03 |
ES2578831T3 (es) | 2016-08-01 |
EP2948183B1 (en) | 2016-04-06 |
CA2935430C (en) | 2018-09-18 |
JP6224268B2 (ja) | 2017-11-01 |
PL2948183T3 (pl) | 2017-03-31 |
CN105899237B (zh) | 2019-09-03 |
AU2015205588B2 (en) | 2019-08-08 |
EP2948183A2 (en) | 2015-12-02 |
DK2948183T3 (en) | 2016-06-27 |
CL2016001743A1 (es) | 2017-01-06 |
AU2015205588A1 (en) | 2016-07-28 |
US20160008487A1 (en) | 2016-01-14 |
MY189713A (en) | 2022-02-28 |
SG11201605597VA (en) | 2016-08-30 |
JP2017502086A (ja) | 2017-01-19 |
MX2016009069A (es) | 2017-02-06 |
US20170007717A1 (en) | 2017-01-12 |
RU2016132635A3 (es) | 2018-08-13 |
CA2935430A1 (en) | 2015-07-16 |
CN105899237A (zh) | 2016-08-24 |
PT2948183T (pt) | 2016-07-13 |
WO2015104373A2 (en) | 2015-07-16 |
KR20160099725A (ko) | 2016-08-22 |
US10092659B2 (en) | 2018-10-09 |
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