ES2566797T3 - Compuestos de polímero de polialquileno y usos de éstos - Google Patents
Compuestos de polímero de polialquileno y usos de éstos Download PDFInfo
- Publication number
- ES2566797T3 ES2566797T3 ES03731987.8T ES03731987T ES2566797T3 ES 2566797 T3 ES2566797 T3 ES 2566797T3 ES 03731987 T ES03731987 T ES 03731987T ES 2566797 T3 ES2566797 T3 ES 2566797T3
- Authority
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- Spain
- Prior art keywords
- ifn
- alkyl
- biologically active
- group
- kda
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 229920001281 polyalkylene Polymers 0.000 title description 2
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- 125000000217 alkyl group Chemical group 0.000 abstract description 29
- 125000003118 aryl group Chemical group 0.000 abstract description 24
- 238000006243 chemical reaction Methods 0.000 abstract description 20
- 125000000623 heterocyclic group Chemical group 0.000 abstract description 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract description 18
- 125000001424 substituent group Chemical group 0.000 abstract description 18
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract description 16
- 125000001072 heteroaryl group Chemical group 0.000 abstract description 14
- 108090000467 Interferon-beta Proteins 0.000 abstract description 13
- 150000002148 esters Chemical group 0.000 abstract description 13
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- 150000002367 halogens Chemical group 0.000 abstract description 12
- 229910052736 halogen Inorganic materials 0.000 abstract description 11
- 125000003710 aryl alkyl group Chemical group 0.000 abstract description 10
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract description 9
- 125000004404 heteroalkyl group Chemical group 0.000 abstract description 9
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical group [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 abstract description 8
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- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract description 7
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- 125000000304 alkynyl group Chemical group 0.000 description 6
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 6
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 6
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
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