ES2554228T3 - Ciclopenta[d]pirimidinas hidroxiladas como inhibidores de la proteína quinasa AKT - Google Patents

Ciclopenta[d]pirimidinas hidroxiladas como inhibidores de la proteína quinasa AKT Download PDF

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Publication number
ES2554228T3
ES2554228T3 ES11166123.7T ES11166123T ES2554228T3 ES 2554228 T3 ES2554228 T3 ES 2554228T3 ES 11166123 T ES11166123 T ES 11166123T ES 2554228 T3 ES2554228 T3 ES 2554228T3
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Spain
Prior art keywords
piperazin
pyrimidin
dihydro
cyclopenta
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11166123.7T
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English (en)
Spanish (es)
Inventor
Ian S. Mitchell
James F. Blake
Rui Xu
Nicholas C. Kallan
Dengming Xiao
Keith Lee Spencer
Josef R. Bencsik
Jun Liang
Brian Safina
Birong Zhang
Christine Chabot
Steven Do
Eli W. Wallace
Anna L. Banka
Stephen T. Schlachter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Array Biopharma Inc
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Genentech Inc
Array Biopharma Inc
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Application filed by Genentech Inc, Array Biopharma Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ES2554228T3 publication Critical patent/ES2554228T3/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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  • Diabetes (AREA)
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  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
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  • Hospice & Palliative Care (AREA)
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ES11166123.7T 2006-07-06 2007-07-05 Ciclopenta[d]pirimidinas hidroxiladas como inhibidores de la proteína quinasa AKT Active ES2554228T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81871806P 2006-07-06 2006-07-06
US818718P 2006-07-06

Publications (1)

Publication Number Publication Date
ES2554228T3 true ES2554228T3 (es) 2015-12-17

Family

ID=38686743

Family Applications (3)

Application Number Title Priority Date Filing Date
ES11166123.7T Active ES2554228T3 (es) 2006-07-06 2007-07-05 Ciclopenta[d]pirimidinas hidroxiladas como inhibidores de la proteína quinasa AKT
ES07799337T Active ES2372774T3 (es) 2006-07-06 2007-07-05 Ciclopenta[d]pirimidinas hidroxiladas y metoxiladas como inhibidores de la proteína quinasa akt.
ES11166125.2T Active ES2554252T3 (es) 2006-07-06 2007-07-05 Ciclopenta[d]pirimidinas hidroxiladas como inhibidores de la proteína quinasa AKT

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES07799337T Active ES2372774T3 (es) 2006-07-06 2007-07-05 Ciclopenta[d]pirimidinas hidroxiladas y metoxiladas como inhibidores de la proteína quinasa akt.
ES11166125.2T Active ES2554252T3 (es) 2006-07-06 2007-07-05 Ciclopenta[d]pirimidinas hidroxiladas como inhibidores de la proteína quinasa AKT

Country Status (34)

Country Link
EP (4) EP2402325B1 (online.php)
JP (4) JP5266216B2 (online.php)
KR (5) KR101495408B1 (online.php)
CN (2) CN101578273B (online.php)
AR (3) AR061842A1 (online.php)
AT (1) ATE524447T1 (online.php)
AU (1) AU2007269060B2 (online.php)
BR (3) BR122013028005B8 (online.php)
CA (2) CA2656622C (online.php)
CL (1) CL2007001993A1 (online.php)
CO (1) CO6150161A2 (online.php)
CR (1) CR10600A (online.php)
CY (1) CY1112117T1 (online.php)
DK (2) DK2049501T3 (online.php)
ES (3) ES2554228T3 (online.php)
HR (1) HRP20110908T1 (online.php)
HU (1) HUE026237T2 (online.php)
IL (2) IL196028A (online.php)
IN (1) IN2014KN02886A (online.php)
MA (1) MA31655B1 (online.php)
MX (4) MX377920B (online.php)
MY (1) MY147364A (online.php)
NO (1) NO342346B1 (online.php)
NZ (3) NZ597647A (online.php)
PL (2) PL2049501T3 (online.php)
PT (1) PT2049501E (online.php)
RS (1) RS52212B (online.php)
RU (2) RU2478632C2 (online.php)
SG (4) SG188905A1 (online.php)
SI (2) SI2049501T1 (online.php)
TW (2) TW201332994A (online.php)
UA (1) UA95641C2 (online.php)
WO (1) WO2008006040A1 (online.php)
ZA (1) ZA200900070B (online.php)

Families Citing this family (52)

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WO2008006032A1 (en) 2006-07-06 2008-01-10 Array Biopharma Inc. Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CN101511842B (zh) * 2006-07-06 2012-10-31 阵列生物制药公司 作为akt蛋白激酶抑制剂的二氢呋喃并嘧啶
ATE532789T1 (de) 2006-07-06 2011-11-15 Array Biopharma Inc Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren
UA95641C2 (xx) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы
US20110135569A1 (en) 2007-03-20 2011-06-09 Peak Biosciences Inc. Method for therapeutic administration of radionucleosides
US8618097B2 (en) 2007-07-05 2013-12-31 Array Biopharma, Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
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