ES2535088T3 - Formulaciones terapéuticas basadas en ácido asiático y sales seleccionadas del mismo - Google Patents

Formulaciones terapéuticas basadas en ácido asiático y sales seleccionadas del mismo Download PDF

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Publication number
ES2535088T3
ES2535088T3 ES09700319.8T ES09700319T ES2535088T3 ES 2535088 T3 ES2535088 T3 ES 2535088T3 ES 09700319 T ES09700319 T ES 09700319T ES 2535088 T3 ES2535088 T3 ES 2535088T3
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ES
Spain
Prior art keywords
asian
acid
asian acid
group
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09700319.8T
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English (en)
Spanish (es)
Inventor
Ying Liu
Quanhai Liu
Yan Qin
Tong Wu
Zhiru Xu
Min-yu LIU
Fei Li
Yan Li
Michael J. Newman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Institute of Pharmaceutical Industry
Original Assignee
Shanghai Institute of Pharmaceutical Industry
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
ES09700319.8T 2008-01-11 2009-01-08 Formulaciones terapéuticas basadas en ácido asiático y sales seleccionadas del mismo Active ES2535088T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US643208P 2008-01-11 2008-01-11
US6432P 2008-01-11
PCT/US2009/030458 WO2009089365A2 (en) 2008-01-11 2009-01-08 Therapeutic formulations based on asiatic acid and selected salts thereof

Publications (1)

Publication Number Publication Date
ES2535088T3 true ES2535088T3 (es) 2015-05-05

Family

ID=40853764

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09700319.8T Active ES2535088T3 (es) 2008-01-11 2009-01-08 Formulaciones terapéuticas basadas en ácido asiático y sales seleccionadas del mismo

Country Status (6)

Country Link
US (1) US8742167B2 (enExample)
EP (1) EP2231139B1 (enExample)
JP (1) JP5539224B2 (enExample)
CN (1) CN101969942A (enExample)
ES (1) ES2535088T3 (enExample)
WO (1) WO2009089365A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5913297B2 (ja) * 2010-06-10 2016-04-27 インダス バイオテック プライベート リミティド センテラ・アジアティカからの高純度アジアチコサイドの製造法及びその使用法
CN102641273A (zh) * 2011-02-17 2012-08-22 苏州迪星生物医药科技有限公司 积雪草酸及其衍生物的新用途
CN102690314B (zh) 2011-03-22 2015-06-10 上海医药工业研究院 一种无定型积雪草酸氨丁三醇盐及其制备方法
CN102755332A (zh) * 2011-04-29 2012-10-31 上海医药工业研究院 积雪草酸盐片剂及其制备方法
CN102755329B (zh) * 2011-04-29 2016-03-09 上海医药工业研究院 积雪草酸盐气雾剂及其制备方法
CN102755333B (zh) * 2011-04-29 2015-07-29 上海医药工业研究院 积雪草酸盐微乳制剂及其制备方法
CN102755327B (zh) * 2011-04-29 2015-03-11 上海医药工业研究院 积雪草酸或其盐的应用及其注射混悬剂和其制备方法
CN102755330B (zh) * 2011-04-29 2015-06-24 上海医药工业研究院 积雪草酸盐颗粒剂及其制备方法
CN102755328B (zh) * 2011-04-29 2015-05-06 上海医药工业研究院 积雪草酸盐微乳软胶囊及其制备方法
CN102755331A (zh) * 2011-04-29 2012-10-31 上海医药工业研究院 积雪草酸盐硬胶囊及其制备方法
CN105237611B (zh) * 2011-06-17 2018-11-13 上海医药工业研究院 积雪草酸氨丁三醇盐晶型及其制备方法
CN104211951A (zh) * 2013-06-05 2014-12-17 韩文毅 含有金属离子的聚合物及其制备和用途
CN104829678B (zh) * 2014-02-10 2017-01-11 上海医药工业研究院 积雪草酸盐及其制备方法和用途
CN104829677B (zh) * 2014-02-10 2017-06-06 上海医药工业研究院 一种羟基积雪草酸盐及其制备方法和用途
KR101802212B1 (ko) * 2015-12-04 2017-11-28 원광대학교산학협력단 아시아틱산 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 골 재생 촉진용 약학적 조성물
CN106349320B (zh) * 2016-08-25 2018-01-19 桂林益天成生物科技有限公司 从积雪草中提取积雪草酸的方法
CN106860494A (zh) * 2017-02-28 2017-06-20 宁波绿之健药业有限公司 一种积雪草提取物的制备工艺
CN108125812B (zh) * 2018-01-10 2019-01-08 壹田（广州）生活健康用品有限公司 一种氨基酸型抑菌泡沫洗手液及其制备方法
CN112773807B (zh) * 2019-11-06 2024-03-19 鲁南制药集团股份有限公司 一种由淫羊藿苷元和积雪草酸组成的组合物的医药用途
CN112773806B (zh) * 2019-11-06 2024-03-19 鲁南制药集团股份有限公司 包含淫羊藿苷元和羟基积雪草酸的药物组合物的医药用途
CN111297877A (zh) * 2019-12-31 2020-06-19 中国药科大学 积雪草苷或其类似物的制药用途
CN113087758B (zh) * 2021-04-07 2022-05-24 西藏甘露藏药股份有限公司 源自蔓菁的碳环化合物的衍生物及其应用
CN116440144A (zh) * 2023-03-03 2023-07-18 杭州市中医院 积雪草苷在制备治疗糖尿病肾脏疾病中拮抗肾脏纤维化药物中的应用

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FR1530410A (fr) * 1963-08-28 1968-06-28 Nouveaux dérivés de l'acide asiatique et leur procédé de préparation
ATE1855T1 (de) * 1978-09-08 1982-12-15 Imperial Chemical Industries Plc Antiarthritische hydroxyessigsaeurederivate, pharmazeutische zusammensetzungen daraus und verfahren zu ihrer herstellung.
AU3995595A (en) * 1994-12-03 1996-06-26 Dong Kook Pharmaceutical Co., Ltd. Asiatic acid derivatives, its manufacturing method and dermatological agent containing it
KR100530278B1 (ko) 1997-02-28 2006-04-06 동국제약 주식회사 아시아트산 유도체를 유효성분으로 하는 간 보호 및치료제
KR100228873B1 (ko) 1997-03-24 1999-11-01 강재헌 센텔라아시아티카에서 분리한 아시아티코사이드와 마테카소 사이드의 수용성 추출물을 함유한 간세포 및 항간섬유화 치료제
IT1312089B1 (it) * 1999-04-21 2002-04-04 Euphar Group Srl Sali dell'acido asiatico e medacassico atti alla preparazione dicomposizioni farmaceutiche e cosmetiche.
MY138883A (en) * 2000-08-29 2009-08-28 Government Of Malaysia As Represented By The Ministry Of Science Tehnology And Innovation Malaysia Use of asiatic acid for treatment of cencer
ITMI20021280A1 (it) * 2002-06-11 2003-12-11 Carlo Ghisalberti Metodo di trattamento anticellulite
FR2848117B1 (fr) * 2002-12-10 2006-08-04 Roche Consumer Health Ltd Procede de preparation d'un extrait de centella asiatica riche en madecassoside et en terminoloside
CN1256090C (zh) * 2003-11-25 2006-05-17 中国人民解放军第二军医大学 积雪草酸及其衍生物在制备抗抑郁药物中的应用
CN1582946B (zh) * 2004-06-09 2010-04-28 北京苏里曼医药科技有限公司 积雪草酸衍生物在制备防治心、脑血管疾病的药物中的用途
US20070010459A1 (en) * 2005-01-14 2007-01-11 Ying Liu Application of asiatic acid and its derivatives to treat pulmonary fibrosis
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Also Published As

Publication number Publication date
JP5539224B2 (ja) 2014-07-02
EP2231139B1 (en) 2015-02-25
CN101969942A (zh) 2011-02-09
EP2231139A2 (en) 2010-09-29
EP2231139A4 (en) 2012-08-01
CN105017373A (zh) 2015-11-04
US20100331413A1 (en) 2010-12-30
WO2009089365A2 (en) 2009-07-16
US8742167B2 (en) 2014-06-03
JP2011509303A (ja) 2011-03-24
WO2009089365A3 (en) 2009-09-03

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