KR100530278B1 - 아시아트산 유도체를 유효성분으로 하는 간 보호 및치료제 - Google Patents
아시아트산 유도체를 유효성분으로 하는 간 보호 및치료제 Download PDFInfo
- Publication number
- KR100530278B1 KR100530278B1 KR1019980006424A KR19980006424A KR100530278B1 KR 100530278 B1 KR100530278 B1 KR 100530278B1 KR 1019980006424 A KR1019980006424 A KR 1019980006424A KR 19980006424 A KR19980006424 A KR 19980006424A KR 100530278 B1 KR100530278 B1 KR 100530278B1
- Authority
- KR
- South Korea
- Prior art keywords
- group
- hydrogen
- methyl
- compound
- hydroxy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (2)
- 하기 화학식 1로 표시되는 아시아트산 유도체 및 그의 약제학적으로 허용되는 염 및 에스테르를 유효성분으로 포함하는 간 보호 및 치료제.{식중 R1은 수소, 아세틸기로 보호되어도 좋은 히드록시기, 메틸 또는 에틸기를 나타내고; R2는 수소, 아세틸기로 보호되어도 좋은 히드록시기를 나타내며; R1 및 R2는 함께 옥소기를 형성할 수 있고; R3는 수소 또는 아세틸기로 보호되어도 좋은 히드록시기를 나타내며; R4는 수소 또는 아세틸기로 보호되어도 좋은 히드록시기를 나타내고; R2 및 R4는 함께 에폭시기를 형성할 수 있으며; R3 및 R4는 함께 옥소기를 형성할 수 있고; R5는 히드록시기가 아세틸기로 보호되어도 좋은 히드록시메틸기, 카르복실에스테르 잔기, 카르복실아미드 잔기 또는 알데히드기를 나타내며; R4는 R5와 함께 -OC(R6)(R7)OCH2-를 형성할 수 있고 [여기에서 R6는 수소 또는 탄소수 1~4의 저급알킬기이고, R7은 수소 또는 탄소수 1~4의 저급알킬기이다.]; R8는 수소 또는 메틸기를 나타내며; R9은 -COOR [여기에서, R은 수소, 탄소수 1~4의 저급알킬, 2-테트라히드로피라닐, CH(OR11)R10, (R10은 수소, 메틸 또는 에틸기이고, R11은 탄소수 1~4의 저급알킬기이다.) 또는 히드록시기가 아세틸 또는 벤조일로 보호되어도 좋은 클루코실기이다]이며; R14,R15은 각각 수소를 나타낸다. [단, R1이 히드록시, R2가 수소, R3이 수소, R4가 히드록시, R5가 히드록시메틸, R8이 메틸인 경우에 R은 수소나 메틸이 아니고, R10은 수소가 아니며; R1이 히드록시, R2가 수소, R3나 R4가 R5와 함께 -OC(R6)(R7)OCH2-를 형성할 수 있고 R6가 메틸인 경우에 R은 메틸이 아니다].}
- 제1항에 있어서, 유효성분이 2-옥소아시아트산, 2-메틸아시아트산, 메틸 2α-아세톡시우르스-12-엔-23-알-3-온-28-오에이트, 테트라히드로피라닐3β,23-디아세톡시우르스-12-엔-28-오에이트, 에톡시메틸2α-히드록시-3β,23-이소프로필리덴디옥시우르스-12-엔-28-오에이트, 메틸 2,3-β-에폭시-12-엔-23-카보메톡시우르스-28-오에이트, 메틸 2,3-β-에폭시-12-엔-23-벤즈아미도우르스-28-오에이트, 1-에톡시에틸 아시아테이트 및 2',3',4',6'-테트라-O-아세틸글루코실 2,3,23-트리-O-아세틸우르스-28-오에이트 중에서 선택됨을 특징으로 하는 간 보호 및 치료제.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR19970006655 | 1997-02-28 | ||
KR1019970006655 | 1997-02-28 | ||
KR101997006655 | 1997-02-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR19980071806A KR19980071806A (ko) | 1998-10-26 |
KR100530278B1 true KR100530278B1 (ko) | 2006-04-06 |
Family
ID=19498412
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019980006424A KR100530278B1 (ko) | 1997-02-28 | 1998-02-27 | 아시아트산 유도체를 유효성분으로 하는 간 보호 및치료제 |
Country Status (6)
Country | Link |
---|---|
US (1) | US6274559B1 (ko) |
EP (1) | EP1001787A1 (ko) |
JP (1) | JP2001513769A (ko) |
KR (1) | KR100530278B1 (ko) |
CN (1) | CN1248918A (ko) |
WO (1) | WO1998037899A1 (ko) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1582946B (zh) * | 2004-06-09 | 2010-04-28 | 北京苏里曼医药科技有限公司 | 积雪草酸衍生物在制备防治心、脑血管疾病的药物中的用途 |
US20070010459A1 (en) * | 2005-01-14 | 2007-01-11 | Ying Liu | Application of asiatic acid and its derivatives to treat pulmonary fibrosis |
JP5539224B2 (ja) * | 2008-01-11 | 2014-07-02 | シャンハイ・インスティチュート・オブ・ファーマシューティカル・インダストリー(エスアイピーアイ) | アジアティック酸(asiaticacid)及びその選択される塩に基づく治療用製剤 |
CN107056874A (zh) * | 2016-12-28 | 2017-08-18 | 福建广生堂药业股份有限公司 | 一种积雪草酸替诺福韦二吡呋酯的化合物及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR19980042830A (ko) * | 1996-11-27 | 1998-08-17 | 강재헌 | A환이 변형된 아시아트산 유도체 |
KR19980074333A (ko) * | 1997-03-24 | 1998-11-05 | 강재헌 | 센텔라아시아티카에서 분리한 아시아티코사이드와 마테카소 사이드의 수용성 추출물 및 그 분리방법 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB923414A (en) * | 1960-04-13 | 1963-04-10 | Laroche Navarron Lab | Therapeutic compositions comprising asiatic and arjunolic acids |
FR1433383A (fr) * | 1965-01-08 | 1966-04-01 | Laroche Navarron Lab | Composition cosmétique pour léntretien et la régénération du derme |
BE707409A (ko) * | 1967-12-01 | 1968-04-16 | ||
DE3650445T2 (de) | 1985-04-06 | 1996-05-09 | Nippon Paint Co Ltd | Verfahren um 1-sesamin zu produzieren mittels Pflanenzellkulturen. |
CH662505A5 (it) | 1985-04-30 | 1987-10-15 | Seuref Ag | Composizioni farmaceutiche ad azione protettiva vascolare. |
JPS6439973A (en) | 1987-08-06 | 1989-02-10 | Taiyo Kagaku Kk | Drink composition |
EP0383171A3 (en) | 1989-02-11 | 1991-07-24 | Hoechst Aktiengesellschaft | 2,3,23-trihydroxy-urs-12-ene derivatives for treating cognitive disorders |
JPH03287530A (ja) | 1990-03-31 | 1991-12-18 | Snow Brand Milk Prod Co Ltd | 免疫抑制剤 |
DE19581854T1 (de) * | 1994-12-03 | 1997-12-04 | Dong Kook Pharmaceutical Co | Asiatsäure-Derivate, Verfahren zu ihrer Herstellung und sie enthaltendes dermatologisches Agens |
DK0879824T3 (da) * | 1995-07-07 | 2004-08-30 | Meiji Seika Kaisha | Triterpenderivater og middel mod leversygdom |
CZ154898A3 (cs) * | 1995-11-21 | 1998-09-16 | Icn Pharmaceuticals, Inc. | Oligonukleotidy pro inhibici růstu nádorů zprostředkovaných IL-8 a receptorem IL-8 |
TW505653B (en) * | 1996-02-26 | 2002-10-11 | Meiji Seika Co | Triterpene derivatives possessing an effect of treating liver diseases and pharmacentical compositions containing the same |
KR19980042832A (ko) * | 1996-11-27 | 1998-08-17 | 강재헌 | 아시아트산 유도체를 유효성분으로 하는 치매 및 인식장애치료제 |
WO1998023574A1 (en) * | 1996-11-27 | 1998-06-04 | Dong Kook Pharmaceutical Co., Ltd. | Asiatic acid derivatives and medicines for treating wounds, which contains the same |
-
1998
- 1998-02-27 KR KR1019980006424A patent/KR100530278B1/ko not_active IP Right Cessation
- 1998-02-28 US US09/380,100 patent/US6274559B1/en not_active Expired - Fee Related
- 1998-02-28 WO PCT/KR1998/000038 patent/WO1998037899A1/en not_active Application Discontinuation
- 1998-02-28 EP EP98905855A patent/EP1001787A1/en not_active Withdrawn
- 1998-02-28 CN CN98802898A patent/CN1248918A/zh active Pending
- 1998-02-28 JP JP53753198A patent/JP2001513769A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR19980042830A (ko) * | 1996-11-27 | 1998-08-17 | 강재헌 | A환이 변형된 아시아트산 유도체 |
KR19980074333A (ko) * | 1997-03-24 | 1998-11-05 | 강재헌 | 센텔라아시아티카에서 분리한 아시아티코사이드와 마테카소 사이드의 수용성 추출물 및 그 분리방법 |
KR100228873B1 (ko) * | 1997-03-24 | 1999-11-01 | 강재헌 | 센텔라아시아티카에서 분리한 아시아티코사이드와 마테카소 사이드의 수용성 추출물을 함유한 간세포 및 항간섬유화 치료제 |
Non-Patent Citations (3)
Title |
---|
Arch. Pham. Res. Vol.21, No.5, pp. 508-513, 1998 * |
Fundam Appl Toxicol. 1994 Jan;22(1):34-40 * |
Indian J. Pharmacol. Vol.28(4), pp.232-239 (1996 * |
Also Published As
Publication number | Publication date |
---|---|
CN1248918A (zh) | 2000-03-29 |
US6274559B1 (en) | 2001-08-14 |
JP2001513769A (ja) | 2001-09-04 |
WO1998037899A1 (en) | 1998-09-03 |
EP1001787A1 (en) | 2000-05-24 |
KR19980071806A (ko) | 1998-10-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4654370A (en) | Glyceryl valproates | |
JPH04297439A (ja) | HMG−CoA還元酵素阻害代謝物 | |
JPH06504529A (ja) | 架橋環状ケタール誘導体 | |
US6030993A (en) | 2-hydroxypropionic acid derivative and its manufacturing method | |
GB1599863A (en) | Pharmaceutical compositions for use in the inhibition of the biosynthesis of mevalonic acid | |
KR100530278B1 (ko) | 아시아트산 유도체를 유효성분으로 하는 간 보호 및치료제 | |
US6169112B1 (en) | Medicines for treating dementia or cognitive disorder, which comprises asiatic acid derivatives | |
US6013666A (en) | Oxirane carboxylic acid derivative and its manufacturing method | |
CN1034574C (zh) | 5-氧取代的(rs)-2-(2,3-二氢-4,6,7-三甲基苯并呋喃基)乙酸衍生物的制备方法 | |
CH663413A5 (de) | Furylderivate von in 16-stellung substituierten prostaglandinen und verfahren zu deren herstellung. | |
US5698585A (en) | Pharmaceutical preparation for prevention and/or treatment for cataract | |
EP0130142B1 (de) | Neue Prostacyclinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel | |
KR19980042831A (ko) | 아시아트산 유도체 및 이를 함유하는 창상치료제 | |
US6071898A (en) | Asiatic acid derivatives having modified A-ring | |
US4312882A (en) | Thienyoxy and furyl containing analogs of prostacyclin and their use as medicaments | |
DE3853126T2 (de) | Derivate der fluorierten Arachidonsäure. | |
DE3632893A1 (de) | 4-(r)-hydroxy-6(s)-arylthiomethyl-tetrahydropyran-2-one, deren entsprechende sulfoxide und sulfone, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte | |
US4055593A (en) | Alkyl diethers of prostaglandins | |
US4107188A (en) | Pregnanes | |
JPH05221901A (ja) | セコステロール誘導体 | |
JP3108474B2 (ja) | 活性型ビタミンd誘導体 | |
US5786385A (en) | Polyacetylenes | |
DE2542686A1 (de) | 2a,2b-dihomo-15-methyl- und -15- aethyl-pgf-und pge-verbindungen und verfahren zu deren herstellung | |
EP0094443A1 (en) | 6(R)-(2-(8(S) (2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S))ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one, process for preparing and pharmaceutical composition containing the same | |
US4115545A (en) | Pharmaceutical composition containing prostadienoic acid for regulating gastric secretion |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20120809 Year of fee payment: 8 |
|
FPAY | Annual fee payment |
Payment date: 20130820 Year of fee payment: 9 |
|
FPAY | Annual fee payment |
Payment date: 20140930 Year of fee payment: 10 |
|
FPAY | Annual fee payment |
Payment date: 20150818 Year of fee payment: 11 |
|
FPAY | Annual fee payment |
Payment date: 20161110 Year of fee payment: 12 |
|
FPAY | Annual fee payment |
Payment date: 20171107 Year of fee payment: 13 |
|
EXPY | Expiration of term |