DE19581854T1 - Asiatsäure-Derivate, Verfahren zu ihrer Herstellung und sie enthaltendes dermatologisches Agens - Google Patents

Asiatsäure-Derivate, Verfahren zu ihrer Herstellung und sie enthaltendes dermatologisches Agens

Info

Publication number
DE19581854T1
DE19581854T1 DE19581854T DE19581854T DE19581854T1 DE 19581854 T1 DE19581854 T1 DE 19581854T1 DE 19581854 T DE19581854 T DE 19581854T DE 19581854 T DE19581854 T DE 19581854T DE 19581854 T1 DE19581854 T1 DE 19581854T1
Authority
DE
Germany
Prior art keywords
preparation
acid derivatives
agent containing
dermatological agent
asian acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19581854T
Other languages
English (en)
Inventor
Sang Sup Jew
Hee Doo Kim
Young Hoon Jung
Eun Hee Park
Sung Ki Seo
Tae Gyu Nam
Duc Ky Hahn
Jae Ho Park
Pil Jong Sim
Min Jung Lim
Kyung Haw Lim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dong Kook Pharmaceutical Co Ltd
Original Assignee
Dong Kook Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong Kook Pharmaceutical Co Ltd filed Critical Dong Kook Pharmaceutical Co Ltd
Publication of DE19581854T1 publication Critical patent/DE19581854T1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C07C61/29—Unsaturated compounds polycyclic having a carboxyl group bound to a condensed ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/61—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/05—Alcohols containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/05—Alcohols containing rings other than six-membered aromatic rings
    • C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19581854T 1994-12-03 1995-11-30 Asiatsäure-Derivate, Verfahren zu ihrer Herstellung und sie enthaltendes dermatologisches Agens Withdrawn DE19581854T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR19940032697 1994-12-03
PCT/KR1995/000158 WO1996017819A1 (en) 1994-12-03 1995-11-30 Asiatic acid derivatives, its manufacturing method and dermatological agent containing it

Publications (1)

Publication Number Publication Date
DE19581854T1 true DE19581854T1 (de) 1997-12-04

Family

ID=19400256

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19581854T Withdrawn DE19581854T1 (de) 1994-12-03 1995-11-30 Asiatsäure-Derivate, Verfahren zu ihrer Herstellung und sie enthaltendes dermatologisches Agens

Country Status (9)

Country Link
US (1) US5834437A (de)
JP (1) JPH10509959A (de)
KR (1) KR0169547B1 (de)
CN (1) CN1067976C (de)
AU (1) AU3995595A (de)
DE (1) DE19581854T1 (de)
FR (1) FR2727678B1 (de)
GB (1) GB2309695B (de)
WO (1) WO1996017819A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998023574A1 (en) * 1996-11-27 1998-06-04 Dong Kook Pharmaceutical Co., Ltd. Asiatic acid derivatives and medicines for treating wounds, which contains the same
US6071898A (en) * 1996-11-27 2000-06-06 Dong Kook Pharmaceutical Co., Ltd. Asiatic acid derivatives having modified A-ring
US6169112B1 (en) 1996-11-27 2001-01-02 Dong Kook Pharmaceutical Co., Ltd. Medicines for treating dementia or cognitive disorder, which comprises asiatic acid derivatives
KR100530278B1 (ko) * 1997-02-28 2006-04-06 동국제약 주식회사 아시아트산 유도체를 유효성분으로 하는 간 보호 및치료제
KR100228873B1 (ko) * 1997-03-24 1999-11-01 강재헌 센텔라아시아티카에서 분리한 아시아티코사이드와 마테카소 사이드의 수용성 추출물을 함유한 간세포 및 항간섬유화 치료제
KR100379067B1 (ko) * 2000-04-19 2003-04-08 동국제약 주식회사 병풀 정량 추출물을 함유한 외용제
DE20109044U1 (de) * 2001-05-30 2001-08-09 Weber & Weber GmbH & Co. KG, 82266 Inning Pharmazeutische Zubereitung
CN1228042C (zh) * 2003-01-30 2005-11-23 上海家化联合股份有限公司 积雪草甙脂质体及其用途
US20060014285A1 (en) * 2004-07-14 2006-01-19 Eldridge Gary R Methods and compositions for inhibiting biofilms
US7604978B2 (en) * 2004-07-14 2009-10-20 Sequoia Sciences, Inc. Inhibition of biofilm formation
US20060264411A1 (en) * 2005-05-20 2006-11-23 Eldridge Gary R Control of biofilm formation
CA2580078A1 (en) 2004-09-14 2006-03-23 Gary R. Eldridge Compounds, compositions and methods for controlling biofilms and bacterial infections
US20070010459A1 (en) * 2005-01-14 2007-01-11 Ying Liu Application of asiatic acid and its derivatives to treat pulmonary fibrosis
US20060228384A1 (en) * 2005-04-06 2006-10-12 Sequoia Sciences, Inc. Control of biofilm with a biofilm inhibitor
US20070014739A1 (en) * 2005-07-14 2007-01-18 Eldridge Gary R Compositions and methods for controlling biofilms and bacterial infections
TWI361074B (en) 2005-12-22 2012-04-01 Dev Center Biotechnology Plant extracts for enhancing healing of wounds,and the preparation process and use thereof
EP1925310B1 (de) 2006-11-24 2015-03-25 Development Center For Biotechnology Pflanzenextrakte aus Plectranthus und Centella zur Behandlung von Hautkrankeiten und zur Beschleunigung der Wundheilung bei Diabetikern
US8449924B2 (en) * 2007-08-29 2013-05-28 Development Center For Biotechnology Process for the preparation of plant extracts for treating skin disorders and enhancing healing of wounds
CN101969942A (zh) * 2008-01-11 2011-02-09 上海医药工业研究院 基于积雪草酸及其特定盐的治疗剂
US8324264B1 (en) 2011-07-22 2012-12-04 Sequoia Sciences, Inc. Inhibitors of bacterial biofilms and related methods
CN102391351B (zh) * 2011-11-03 2013-06-19 沈阳化工大学 一种具有抗肿瘤活性的积雪草酸修饰物及其制备方法
CN104311622B (zh) * 2014-10-08 2016-11-16 四川大学 一种积雪草酸酰胺类衍生物
CN104274504B (zh) * 2014-10-21 2018-01-30 上海交通大学 一种积雪草提取物及其制备与应用
TWI746597B (zh) 2016-07-17 2021-11-21 合一生技股份有限公司 促進傷口癒合的局部配方
CN106349319B (zh) * 2016-08-25 2018-03-16 桂林益天成生物科技有限公司 水解积雪草苷制备积雪草酸的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1530410A (fr) * 1963-08-28 1968-06-28 Nouveaux dérivés de l'acide asiatique et leur procédé de préparation
EP0383171A3 (de) * 1989-02-11 1991-07-24 Hoechst Aktiengesellschaft 2,3,23-Trihydroxy-urs-12-en Derivate zur Behandlung von Kognitiven Störungen
JPH06329537A (ja) * 1993-05-24 1994-11-29 Kobe Steel Ltd 肺癌抑制剤

Also Published As

Publication number Publication date
GB2309695A (en) 1997-08-06
GB9710644D0 (en) 1997-07-16
AU3995595A (en) 1996-06-26
CN1067976C (zh) 2001-07-04
CN1168662A (zh) 1997-12-24
WO1996017819A1 (en) 1996-06-13
US5834437A (en) 1998-11-10
GB2309695B (en) 1998-12-02
FR2727678B1 (fr) 1998-06-19
KR0169547B1 (ko) 1999-03-20
JPH10509959A (ja) 1998-09-29
FR2727678A1 (fr) 1996-06-07
KR960022435A (ko) 1996-07-18

Similar Documents

Publication Publication Date Title
DE19581854T1 (de) Asiatsäure-Derivate, Verfahren zu ihrer Herstellung und sie enthaltendes dermatologisches Agens
DE69210067D1 (de) Hydraxamsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung
DE58909834D1 (de) Phthalimidoperoxihexansäure, Verfahren zu deren Herstellung und deren Verwendung
ATE236161T1 (de) Purinderivate und verfahren zu ihrer herstellung
DE69518031D1 (de) Feste fettlösliche Zusammensetzung und Verfahren zu ihrer Herstellung
DE69637298D1 (de) Celluloseacetatlösung und Verfahren zu ihrer Herstellung
DE69506807D1 (de) Kühlmittel enthaltend Polyetherderivate und Verfahren zu ihrer Herstellung
DE69411604D1 (de) Wirkstoffzusammensetzung und Verfahren zu ihrer Herstellung
DE69021444D1 (de) Pteridin-4 (3H)-onen, Verfahren zu ihrer Herstellung und sie enthaltende Medikamente.
DE59007528D1 (de) Biskationische säureamid- und -imidderivate und verfahren zu ihrer herstellung.
DE69326569D1 (de) Sterinderivate, Verfahren zu ihrer Herstellung und dermatologische Präparate
DE69522372D1 (de) Polyasparaginsäurederivate und Verfahren zu ihrer Herstellung
DE69933222D1 (de) Benzoesäurederivate und verfahren zu ihrer herstellung
ATE143010T1 (de) Pyridazin-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE59603659D1 (de) Substituierte Zimtsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Herz-Kreislauf-Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ATA260590A (de) Glyzerinderivate, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen
DE69225625D1 (de) Carbaminsäurederivate und Verfahren zu ihrer Herstellung
DE69201964D1 (de) Phenoxyalkylcarbonsäurederivate, Verfahren zu ihrer Herstellung und anti-allergische Mittel.
DE69520118D1 (de) Cyclopropanderivate und Verfahren zu ihrer Herstellung
DE69502772D1 (de) Baccatinderivate und Verfahren zu ihrer Herstellung
DE69306279D1 (de) 3-Aryl-Glycidsäureester und Verfahren zu ihrer Herstellung
DE3888529D1 (de) Tylosinderivate und Verfahren zu ihrer Herstellung.
ATE217008T1 (de) Erythromycinderivate, verfahren zu ihrer herstellung, und ihrer verwendung als arzneimitteln
DE59608533D1 (de) 4-Fluoralkyl-substituierte Benzoylguandine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament
DE69732570D1 (de) Sulfonsäureester-derivate, verfahren zu ihrer herstellung und ihre verwendung

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8139 Disposal/non-payment of the annual fee