ATE236161T1 - Purinderivate und verfahren zu ihrer herstellung - Google Patents

Purinderivate und verfahren zu ihrer herstellung

Info

Publication number
ATE236161T1
ATE236161T1 AT96934774T AT96934774T ATE236161T1 AT E236161 T1 ATE236161 T1 AT E236161T1 AT 96934774 T AT96934774 T AT 96934774T AT 96934774 T AT96934774 T AT 96934774T AT E236161 T1 ATE236161 T1 AT E236161T1
Authority
AT
Austria
Prior art keywords
production
purine derivatives
purine
derivatives
Prior art date
Application number
AT96934774T
Other languages
English (en)
Inventor
Juerg Zimmermann
Hans-Georg Capraro
Patricia Imbach
Pascal Furet
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE236161T1 publication Critical patent/ATE236161T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT96934774T 1995-11-01 1996-10-22 Purinderivate und verfahren zu ihrer herstellung ATE236161T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH309495 1995-11-01
CH221396 1996-09-10
PCT/EP1996/004573 WO1997016452A1 (en) 1995-11-01 1996-10-22 Purine derivatives and processes for their preparation

Publications (1)

Publication Number Publication Date
ATE236161T1 true ATE236161T1 (de) 2003-04-15

Family

ID=25689809

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96934774T ATE236161T1 (de) 1995-11-01 1996-10-22 Purinderivate und verfahren zu ihrer herstellung

Country Status (14)

Country Link
US (1) US7091346B1 (de)
EP (1) EP0874846B1 (de)
JP (2) JP4004066B2 (de)
CN (1) CN1066147C (de)
AR (1) AR004134A1 (de)
AT (1) ATE236161T1 (de)
AU (1) AU7296896A (de)
BR (1) BR9611157A (de)
CA (1) CA2234609C (de)
DE (1) DE69627195T2 (de)
ES (1) ES2196181T3 (de)
HK (1) HK1016580A1 (de)
PT (1) PT874846E (de)
WO (1) WO1997016452A1 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
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FR2741881B1 (fr) 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
US6790958B2 (en) * 1996-08-02 2004-09-14 Robert T. Lum Purine inhibitors of cyclin dependent kinase 2 & IKBA
US6794390B2 (en) * 1996-08-02 2004-09-21 Cv Therapeutics, Inc. Purine inhibitors of cyclin dependent kinase 2 & ikappabalpha
US5866702A (en) * 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
AU4920397A (en) * 1996-10-11 1998-05-11 Chiron Corporation Purine inhibitors of glycogen synthase kinase 3 (gsk3)
US6432947B1 (en) * 1997-02-19 2002-08-13 Berlex Laboratories, Inc. N-heterocyclic derivatives as NOS inhibitors
US6573044B1 (en) 1997-08-07 2003-06-03 The Regents Of The University Of California Methods of using chemical libraries to search for new kinase inhibitors
JP2001516694A (ja) 1997-08-07 2001-10-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア プロテインキナーゼ、ｇプロテイン及びポリメラーゼのプリン阻害剤
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AU1631699A (en) * 1997-12-18 1999-07-05 E.I. Du Pont De Nemours And Company Cyclohexylamine arthropodicides and fungicides
DK1056745T3 (da) * 1998-02-26 2004-10-25 Aventis Pharma Inc 6,9-Disubstituerede 2-[trans-(4-aminocyklohexyl)amino]puriner
RU2200162C2 (ru) * 1998-02-26 2003-03-10 Авентис Фармасьютикалз Инк. 6,9-дизамещенные 2-[транс(4-аминоциклогексил)амино] пурины
US6642231B2 (en) * 1998-02-26 2003-11-04 Aventis Pharmaceuticals Inc. 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
US6413974B1 (en) * 1998-02-26 2002-07-02 Aventis Pharmaceuticals Inc. 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
US6479487B1 (en) 1998-02-26 2002-11-12 Aventis Pharmaceuticals Inc. 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
CZ27399A3 (cs) * 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
GB9903762D0 (en) 1999-02-18 1999-04-14 Novartis Ag Organic compounds
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
FR2793794B1 (fr) * 1999-05-21 2001-07-27 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
GB9918035D0 (en) * 1999-07-30 1999-09-29 Novartis Ag Organic compounds
AU3540101A (en) * 2000-01-07 2001-07-16 Universitaire Instelling Antwerpen Purine derivatives, process for their preparation and use thereof
WO2001082967A1 (en) * 2000-04-28 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. MEDICINAL COMPOSITIONS FOR SUPPRESSING β-AMYLOID PRODUCTION
US6861524B2 (en) 2000-10-31 2005-03-01 Aventis Pharmaceuticals Inc. Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
FR2818642B1 (fr) * 2000-12-26 2005-07-15 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion
PE20030008A1 (es) 2001-06-19 2003-01-22 Bristol Myers Squibb Co Inhibidores duales de pde 7 y pde 4
JP4381804B2 (ja) 2001-06-27 2009-12-09 サイクラセル リミテッド ２，６，９−置換プリン誘導体及び増殖性疾患の治療におけるその使用
CN1523991A (zh) 2001-08-10 2004-08-25 ��˹��ŵ�� 单独的c-Src抑制剂或其与STI571的组合用于治疗白血病的用途
AU2002342051B2 (en) * 2001-10-12 2009-06-11 Irm Llc Kinase inhibitor scaffolds and methods for their preparation
GB0219052D0 (en) 2002-08-15 2002-09-25 Cyclacel Ltd New puring derivatives
GB0219054D0 (en) 2002-08-15 2002-09-25 Cyclacel Ltd New purine derivatives
ATE382048T1 (de) 2002-09-19 2008-01-15 Schering Corp Pyrazolopyrimdine als hemmstoffe cyclin abhängiger kinasen
US7273864B2 (en) * 2002-10-15 2007-09-25 The Scripps Research Institute Compositions and methods for inducing osteogenesis
JP2006521398A (ja) * 2003-03-28 2006-09-21 サイオス・インコーポレーテツド ＴＧＦβの二−環式ピリミジン阻害剤
US20050288290A1 (en) * 2004-06-28 2005-12-29 Borzilleri Robert M Fused heterocyclic kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
ES2562428T3 (es) 2005-12-15 2016-03-04 Rigel Pharmaceuticals, Inc. Inhibidores de cinasa y sus usos
AU2007333394C1 (en) * 2006-12-08 2011-08-18 Novartis Ag Compounds and compositions as protein kinase inhibitors
EP3012249A1 (de) 2006-12-08 2016-04-27 Novartis AG Verbindungen und zusammensetzungen als proteinkinase-hemmer
EP2142546B1 (de) * 2007-03-28 2017-06-07 Saniona A/S Purinylderivate und ihre verwendung als kaliumkanalmodulatoren
US20100105705A1 (en) * 2007-03-28 2010-04-29 Neurosearch A/S Purinyl derivatives and their use as potassium channel modulators
CZ302225B6 (cs) * 2007-07-04 2010-12-29 Univerzita Palackého v Olomouci Substituované 6-anilinopurinové deriváty jako inhibitory cytokinin oxidasy a prípravky obsahující tyto slouceniny
MX2010010968A (es) * 2008-04-07 2010-10-26 Irm Llc Compuestos y composiciones como inhibidores de cinasa de proteina.
WO2010034706A1 (en) * 2008-09-26 2010-04-01 Neurosearch A/S Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators
US8268838B2 (en) 2008-09-26 2012-09-18 Neurosearch A/S Substituted purinyl-pyrazole derivatives and their use as potassium channel modulators
BR112013023050A8 (pt) 2011-03-09 2018-09-25 G Pestell Richard antagonista de ccr5, método para determinar se um indivíduo humano tendo câncer de próstata está sofrendo de ou sob o risco de desenvolver metástase, para identificar um antagonista de ccr5, método para determinar se um indivíduo humano tendo câncer de próstata está sofrendo de ou sob o risco de desenvolver metástase, para identificar um composto candidato, para produzir in vitro células epiteliais primárias, para diagnosticar câncer de próstata, para selecionar um tratamento para um indivíduo tendo um câncer/tumor de próstata, linhagem de célula, e, modelo animal
WO2013074986A1 (en) 2011-11-17 2013-05-23 Dana-Farber Cancer Institute, Inc. Inhibitors of c-jun-n-terminal kinase (jnk)
CA2873743C (en) 2012-05-14 2022-12-06 Prostagene, Llc Using modulators of ccr5 for treating cancer
US9475797B2 (en) 2012-06-26 2016-10-25 Saniona A/S Phenyl triazole derivative and its use for modulating the GABAA receptor complex
CN105283206B (zh) * 2013-03-27 2019-11-08 财团法人峨山社会福祉财团 包含p34的表达抑制剂或活性抑制剂作为有效成分的用于治疗或转移抑制癌的组合物
JP6491202B2 (ja) 2013-10-18 2019-03-27 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド サイクリン依存性キナーゼ７（ｃｄｋ７）の多環阻害剤
EP3194572B1 (de) 2014-07-30 2023-10-25 Yeda Research and Development Co. Ltd. Medien zur kultivierung pluripotenter stammzellen
WO2016105528A2 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
CA2978518C (en) * 2015-03-27 2023-11-21 Nathanael S. Gray Inhibitors of cyclin-dependent kinases
EP4019515A1 (de) 2015-09-09 2022-06-29 Dana-Farber Cancer Institute, Inc. Hemmer von cyclinabhängigen kinasen
EP4086257A1 (de) * 2016-09-30 2022-11-09 SRI International Duale clk/cdk1-inhibitoren zur krebsbehandlung
WO2020152686A1 (en) 2019-01-23 2020-07-30 Yeda Research And Development Co. Ltd. Culture media for pluripotent stem cells

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DE3529497A1 (de) 1985-08-17 1987-02-26 Boehringer Mannheim Gmbh N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
EP0457773A4 (en) 1989-01-31 1993-03-10 Whitby Research Incorporated N?6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
DE69324244T2 (de) * 1992-01-06 1999-09-30 Wellcome Found Therapeutische nukleoside der 2',3'-dideoxy-3'-fluor -purin reihe
US6403599B1 (en) 1995-11-08 2002-06-11 Pfizer Inc Corticotropin releasing factor antagonists
FR2741881B1 (fr) 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
US6107300A (en) 1996-03-27 2000-08-22 Dupont Pharmaceuticals Arylamino fused pyrimidines
US5866702A (en) 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
US5753635A (en) 1996-08-16 1998-05-19 Berlex Laboratories, Inc. Purine derivatives and their use as anti-coagulants
AU4920397A (en) 1996-10-11 1998-05-11 Chiron Corporation Purine inhibitors of glycogen synthase kinase 3 (gsk3)
GB9903762D0 (en) * 1999-02-18 1999-04-14 Novartis Ag Organic compounds
AU2002342051B2 (en) * 2001-10-12 2009-06-11 Irm Llc Kinase inhibitor scaffolds and methods for their preparation
US7273864B2 (en) * 2002-10-15 2007-09-25 The Scripps Research Institute Compositions and methods for inducing osteogenesis

Also Published As

Publication number Publication date
EP0874846B1 (de) 2003-04-02
CN1066147C (zh) 2001-05-23
CA2234609C (en) 2006-11-28
CA2234609A1 (en) 1997-05-09
BR9611157A (pt) 1999-03-30
EP0874846A1 (de) 1998-11-04
JP2007231023A (ja) 2007-09-13
CN1202896A (zh) 1998-12-23
US7091346B1 (en) 2006-08-15
WO1997016452A1 (en) 1997-05-09
DE69627195T2 (de) 2004-01-29
JP4004066B2 (ja) 2007-11-07
ES2196181T3 (es) 2003-12-16
AR004134A1 (es) 1998-09-30
PT874846E (pt) 2003-08-29
HK1016580A1 (en) 1999-11-05
DE69627195D1 (de) 2003-05-08
JPH11514336A (ja) 1999-12-07
AU7296896A (en) 1997-05-22

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