ES2489516T3 - Derivados bacterioclorofílicos aniónicos solubles en agua y sus utilizaciones - Google Patents

Derivados bacterioclorofílicos aniónicos solubles en agua y sus utilizaciones Download PDF

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Publication number
ES2489516T3
ES2489516T3 ES03773967.9T ES03773967T ES2489516T3 ES 2489516 T3 ES2489516 T3 ES 2489516T3 ES 03773967 T ES03773967 T ES 03773967T ES 2489516 T3 ES2489516 T3 ES 2489516T3
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ES
Spain
Prior art keywords
compound
composition according
photodynamic therapy
pdt
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03773967.9T
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English (en)
Spanish (es)
Inventor
Avigdor Scherz
Alexander Brandis
Ohad Mazor
Yoram Salomon
Hugo Scheer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
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Yeda Research and Development Co Ltd
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Publication date
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Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
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Publication of ES2489516T3 publication Critical patent/ES2489516T3/es
Anticipated expiration legal-status Critical
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/062Photodynamic therapy, i.e. excitation of an agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0076PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036Porphyrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/0624Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00Compounds containing elements of Groups 1 or 11 of the Periodic System
    • C07F1/08Copper compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005Compounds without a metal-carbon linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/006Palladium compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/006Palladium compounds
    • C07F15/0066Palladium compounds without a metal-carbon linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/04Nickel compounds
    • C07F15/045Nickel compounds without a metal-carbon linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00Compounds containing elements of Groups 2 or 12 of the Periodic System
    • C07F3/02Magnesium compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00Compounds containing elements of Groups 2 or 12 of the Periodic System
    • C07F3/06Zinc compounds
ES03773967.9T 2002-11-17 2003-11-17 Derivados bacterioclorofílicos aniónicos solubles en agua y sus utilizaciones Expired - Lifetime ES2489516T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL15290002 2002-11-17
IL15290002A IL152900A0 (en) 2002-11-17 2002-11-17 Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses
PCT/IL2003/000973 WO2004045492A2 (fr) 2002-11-17 2003-11-17 Derives bacteriochlorophylles anioniques solubles dans l'eau et leurs utilisations

Publications (1)

Publication Number Publication Date
ES2489516T3 true ES2489516T3 (es) 2014-09-02

Family

ID=30011928

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03773967.9T Expired - Lifetime ES2489516T3 (es) 2002-11-17 2003-11-17 Derivados bacterioclorofílicos aniónicos solubles en agua y sus utilizaciones

Country Status (24)

Country Link
US (6) US7947672B2 (fr)
EP (2) EP2522349A1 (fr)
JP (3) JP4922559B2 (fr)
CN (2) CN102002048B (fr)
AU (1) AU2003282354C1 (fr)
BE (1) BE2018C018I2 (fr)
BR (1) BRPI0316319B8 (fr)
CA (1) CA2506296C (fr)
CY (2) CY1115458T1 (fr)
DK (1) DK1567147T3 (fr)
ES (1) ES2489516T3 (fr)
FR (1) FR18C0002I2 (fr)
HK (1) HK1081858A1 (fr)
HU (1) HUS1800020I1 (fr)
IL (2) IL152900A0 (fr)
LU (1) LUC00073I2 (fr)
MX (1) MXPA05005262A (fr)
NL (1) NL300934I2 (fr)
NO (2) NO334978B1 (fr)
NZ (1) NZ540790A (fr)
PL (1) PL216661B1 (fr)
PT (1) PT1567147E (fr)
RU (1) RU2353624C2 (fr)
WO (1) WO2004045492A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152900A0 (en) * 2002-11-17 2003-06-24 Yeda Res & Dev Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses
PT1753457T (pt) * 2004-06-07 2016-11-10 Yeda Res & Dev Derivados catiónicos de bacterioclorofilas e utilizações dos mesmos
US9957293B2 (en) * 2006-08-23 2018-05-01 Yeda Research And Development Company Ltd. Conjugates of RGD peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses
WO2009107139A1 (fr) 2008-02-27 2009-09-03 Yeda Research And Development Co. Ltd Conjugués rgd-(bactério)chlorophylle utilisés dans le traitement photodynamique et l’imagerie de tumeurs nécrosantes
EP2425873A1 (fr) 2010-09-07 2012-03-07 Steba Maor SA Modélisation de l'action d'une fibre optique dans un traitement par therapie photodynamique, et assistance à la planification d'un tel traitement
WO2012123343A1 (fr) 2011-03-11 2012-09-20 Steba Maor Sa Procédés de thérapie photodynamique focalisée
CA2846011C (fr) 2011-08-23 2019-10-15 Yeda Research And Development Co.Ltd. Photosensibilisateurs (bacterio)chlorophylliens destines au traitement de troubles et de maladies oculaires
PL2971026T3 (pl) 2013-03-11 2021-06-14 Tookad Ip Sarl Sposób wytwarzania bakteriochlorofilu a
RU2682674C2 (ru) 2013-03-15 2019-03-20 Шерри Энн МАКФАРЛЭНД Координационные комплексы на основе металлов в качестве фотодинамических соединений и их применение
JP2019510807A (ja) * 2016-04-10 2019-04-18 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド バクテリオクロロフィル誘導体を含む、がんの治療のための併用療法
CN107987081B (zh) * 2016-10-26 2019-12-06 刘辉 一种二氢卟吩e6衍生物及其药学上可接受的盐、其制备方法和应用
KR102591737B1 (ko) * 2016-12-22 2023-10-20 다이이찌 산쿄 가부시키가이샤 가령 황반 변성증 치료용 펩티드
US10933134B2 (en) 2017-03-16 2021-03-02 Memorial Sloan Kettering Cancer Center Combination therapies for treatment of cancer
WO2019116376A1 (fr) * 2017-12-17 2019-06-20 Yeda Research And Development Co. Ltd. Modulateurs du complexe signalosome cop9 (csn) et leurs utilisations
CN111848656B (zh) * 2020-06-24 2023-03-14 天津大学 离子修饰的原卟啉镓化合物及其制备方法和应用
US20230277604A1 (en) * 2020-07-29 2023-09-07 Japan Advanced Institute Of Science And Technology Therapeutic agent or diagnostic agent for cancer
CN115843960A (zh) * 2022-11-03 2023-03-28 中国农业科学院农产品加工研究所 一种提高叶绿素稳定性的方法

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US4656186A (en) * 1985-04-30 1987-04-07 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
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DE3853995T2 (de) * 1987-04-17 1995-11-23 David H Dolphin Porphyrine, verfahren zu deren herstellung und verwendungen.
US5004811A (en) * 1987-12-24 1991-04-02 Nippon Petrochemicals Company, Ltd. Tetrapyrrole aminocarboxylic acids
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JP3191223B2 (ja) * 1991-10-04 2001-07-23 株式会社光ケミカル研究所 ポルフィリン誘導体とその用途
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IL102645A (en) * 1992-07-26 1998-02-22 Yeda Res & Dev Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
US6147195A (en) * 1993-07-26 2000-11-14 Yeda Research And Development Co., Ltd. Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
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EP0945454B1 (fr) * 1996-10-01 2003-07-02 Wyeth Lederle Japan LTD. Derives d'acide iminochlorinaspartique
IL129929A0 (en) * 1996-12-17 2000-02-29 Du Pont Polymerization of ethylene with specific iron or cobalt complexes novel pyridinebis (imines) and novel complexes of pyridinebis(imines) with iron and cobalt
HU228208B1 (en) * 1998-12-09 2013-01-28 Yeda Res & Dev Palladium-substituted bacteriochlorophyll derivatives and use thereof
IL133253A0 (en) * 1999-12-01 2001-04-30 Yeda Res & Dev Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them
JP4277159B2 (ja) 2000-06-02 2009-06-10 独立行政法人科学技術振興機構 新規なテトラピロリル置換ポルフィリン及びその製法
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AU2002312154B2 (en) 2001-06-01 2008-05-15 Biolitec Pharma Marketing Ltd Water-soluble porphyrin derivatives for photodynamic therapy, their use and manufacture
IL152900A0 (en) * 2002-11-17 2003-06-24 Yeda Res & Dev Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses

Also Published As

Publication number Publication date
JP5555659B2 (ja) 2014-07-23
CY1115458T1 (el) 2017-01-04
JP4922559B2 (ja) 2012-04-25
CN1741801B (zh) 2010-12-22
NZ540790A (en) 2009-12-24
US20150238773A1 (en) 2015-08-27
NO334978B1 (no) 2014-08-11
HUS1800020I1 (hu) 2018-05-28
WO2004045492A2 (fr) 2004-06-03
CN102002048B (zh) 2012-11-28
DK1567147T3 (da) 2014-08-11
JP5566945B2 (ja) 2014-08-06
WO2004045492A3 (fr) 2004-07-08
FR18C0002I2 (fr) 2020-03-13
CN102002048A (zh) 2011-04-06
LUC00073I2 (en) 2018-06-20
EP1567147A4 (fr) 2008-07-09
BR0316319A (pt) 2005-09-27
IL152900A0 (en) 2003-06-24
FR18C0002I1 (fr) 2018-06-15
US20170143988A1 (en) 2017-05-25
JP2006515836A (ja) 2006-06-08
BRPI0316319B1 (pt) 2017-06-27
PT1567147E (pt) 2014-08-25
NL300934I2 (nl) 2018-05-22
AU2003282354B8 (en) 2009-05-14
NO2018012I2 (no) 2018-04-10
IL168480A (en) 2015-01-29
US20060142260A1 (en) 2006-06-29
PL376734A1 (pl) 2006-01-09
NO20052925L (no) 2005-06-15
NO2018012I1 (no) 2018-04-10
EP1567147A2 (fr) 2005-08-31
PL216661B1 (pl) 2014-04-30
US7947672B2 (en) 2011-05-24
CY2018012I1 (el) 2018-09-05
US20130345417A1 (en) 2013-12-26
NO20052925D0 (no) 2005-06-15
JP2011162551A (ja) 2011-08-25
AU2003282354C1 (en) 2009-10-29
BRPI0316319B8 (pt) 2021-05-25
EP1567147B1 (fr) 2014-05-07
CN1741801A (zh) 2006-03-01
RU2005118771A (ru) 2006-01-20
CY2018012I2 (el) 2018-09-05
MXPA05005262A (es) 2005-07-25
RU2353624C2 (ru) 2009-04-27
CA2506296C (fr) 2012-09-11
JP2011148822A (ja) 2011-08-04
CA2506296A1 (fr) 2004-06-03
HK1081858A1 (en) 2006-05-26
AU2003282354A1 (en) 2004-06-15
US8461142B2 (en) 2013-06-11
AU2003282354B2 (en) 2009-04-23
EP2522349A1 (fr) 2012-11-14
US20110117029A1 (en) 2011-05-19
US20200094069A1 (en) 2020-03-26
BE2018C018I2 (fr) 2023-03-07

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