ES2437108T3 - Tetrahidroazolopirazinas sulfoniladas y su utilización como productos médicos - Google Patents

Tetrahidroazolopirazinas sulfoniladas y su utilización como productos médicos Download PDF

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ES2437108T3
ES2437108T3 ES10708496.4T ES10708496T ES2437108T3 ES 2437108 T3 ES2437108 T3 ES 2437108T3 ES 10708496 T ES10708496 T ES 10708496T ES 2437108 T3 ES2437108 T3 ES 2437108T3
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aryl
heteroaryl
cycloalkyl
alkyl
alkylene group
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Beatrix Merla
Stefan OBERBÖRSCH
Melanie Reich
Stefan Schunk
Ruth Jostock
Sabine Hees
Michael Engels
Tieno Germann
Edward Bijsterveld
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Gruenenthal GmbH
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
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Abstract

Compuesto de fórmula general I donde a representa 1 o 2; b representa 0, 1 o 2; B representa C(R6a)(R6b), NR7, O o un enlace simple, con la condición de que si b es igual a 0,B no es NR7; W1, W2 y W3 representan, independientemente entre sí, CR5 o N, con la condición de que al menosuno de W1, W2 y W3 represente CR5; R1 representa arilo, heteroarilo, CH(arilo)2 o un arilo o heteroarilo unido a través de un grupoalquileno(C1-3); R2a, R2b, R3a, R3b, R6a y R6b representan, independientemente entre sí, H, F, Cl, Br, I, -CF3, OH, SH,O-alquilo(C1-6), alquilo(C1-6), cicloalquilo(C3-8), arilo o heteroarilo; o un cicloalquilo(C3-8), arilo oheteroarilo unido a través de un grupo alquileno(C1-6) o alquenileno(C2-6); y/o R2a y R2b y/o R3a y R3bpueden representar juntos >=O; R4 representa de 0 a 4 sustituyentes seleccionados, independientemente entre sí, entre F; Cl; OH; >=O; alquilo(C1-6); O-alquilo(C1-6); cicloalquilo(C3-8); arilo o heteroarilo; cicloalquilo(C3-8), arilo oheteroarilo unidos a través de un grupo alquileno(C1-6); y/o dos sustituyentes adyacentes de estos 0a 4 sustituyentes R4 forman un arilo o hereroarilo condensado; R5 representa H, alquilo(C1-6), halógeno, -CN o CF3; R7 representa H, alquilo(C1-6), cicloalquilo(C3-8), arilo, heteroarilo o cicloalquilo(C3-8), arilo oheteroarilo unido a través de un grupo alquileno(C1-6), alquenileno(C2-6) o alquinileno(C2-6);s >= 0 o 1, t >= 0, 1, 2 o 3, R8 representa H; alquilo(C1-6); cicloalquilo(C3-8); arilo o heteroarilo; cicloalquilo(C3-8), arilo oheteroarilo unidos a través de un grupo alquileno(C1-6); R9a y R9b representan, independientemente entre sí, H; F; Cl; OH; alquilo(C1-6); O- alquilo(C1-6); cicloalquilo(C3-8); arilo o heteroarilo; cicloalquilo(C3-8), arilo o heteroarilo unidos a través de un grupoalquileno(C1-6).
ES10708496.4T 2009-03-04 2010-03-03 Tetrahidroazolopirazinas sulfoniladas y su utilización como productos médicos Active ES2437108T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09003075 2009-03-04
EP09003075 2009-03-04
PCT/EP2010/001299 WO2010099938A1 (en) 2009-03-04 2010-03-03 Sulfonylated tetrahydroazolopyrazines and their use as medicinal products

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ES2437108T3 true ES2437108T3 (es) 2014-01-08

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US (1) US8158628B2 (es)
EP (1) EP2403854B1 (es)
JP (1) JP2012519196A (es)
CN (1) CN102341398A (es)
AR (1) AR075539A1 (es)
AU (1) AU2010220561A1 (es)
BR (1) BRPI1010533A2 (es)
CA (1) CA2754330A1 (es)
ES (1) ES2437108T3 (es)
HK (1) HK1160450A1 (es)
IL (1) IL214911A0 (es)
MX (1) MX305105B (es)
PL (1) PL2403854T3 (es)
RU (1) RU2011140061A (es)
TW (1) TW201035102A (es)
WO (1) WO2010099938A1 (es)

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MA37756B1 (fr) 2012-06-13 2018-09-28 Hoffmann La Roche Nouveaux composés diazaspirocycloalcane et azaspirocycloalcane
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HK1160450A1 (en) 2012-08-17
WO2010099938A1 (en) 2010-09-10
US8158628B2 (en) 2012-04-17
IL214911A0 (en) 2011-11-30
MX2011008864A (es) 2011-09-15
PL2403854T3 (pl) 2014-02-28
CN102341398A (zh) 2012-02-01
BRPI1010533A2 (pt) 2016-03-15
RU2011140061A (ru) 2013-04-10
TW201035102A (en) 2010-10-01
JP2012519196A (ja) 2012-08-23
EP2403854A1 (en) 2012-01-11
AR075539A1 (es) 2011-04-20
US20100234387A1 (en) 2010-09-16
AU2010220561A1 (en) 2011-10-27
CA2754330A1 (en) 2010-09-10
MX305105B (es) 2012-11-12
EP2403854B1 (en) 2013-09-11

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