ES2338459T5 - Exploración de alto rendimiento de poblaciones mutagenizadas - Google Patents

Exploración de alto rendimiento de poblaciones mutagenizadas

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Publication number
ES2338459T5
ES2338459T5 ES06783930.8T ES06783930T ES2338459T5 ES 2338459 T5 ES2338459 T5 ES 2338459T5 ES 06783930 T ES06783930 T ES 06783930T ES 2338459 T5 ES2338459 T5 ES 2338459T5
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Spain
Prior art keywords
dna
sequence
mutation
primers
sequencing
Prior art date
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ES06783930.8T
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English (en)
Spanish (es)
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ES2338459T3 (es
Inventor
Michael Josephus Theresia Van Eijk
Adrianus Johannes Van Tunen
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Keygene NV
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Keygene NV
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37709618&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2338459(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Keygene NV filed Critical Keygene NV
Publication of ES2338459T3 publication Critical patent/ES2338459T3/es
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Publication of ES2338459T5 publication Critical patent/ES2338459T5/es
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6846—Common amplification features
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855—Ligating adaptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/13—Plant traits

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nanotechnology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ES06783930.8T 2005-09-29 2006-09-21 Exploración de alto rendimiento de poblaciones mutagenizadas Active ES2338459T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72152805P 2005-09-29 2005-09-29
US721528P 2005-09-29

Publications (2)

Publication Number Publication Date
ES2338459T3 ES2338459T3 (es) 2010-05-07
ES2338459T5 true ES2338459T5 (es) 2014-02-24

Family

ID=37709618

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06783930.8T Active ES2338459T5 (es) 2005-09-29 2006-09-21 Exploración de alto rendimiento de poblaciones mutagenizadas

Country Status (11)

Country Link
US (12) US20090170713A1 (https=)
EP (1) EP1929039B2 (https=)
JP (1) JP5237099B2 (https=)
CN (1) CN101313078B (https=)
AT (1) ATE453728T1 (https=)
AU (1) AU2006295556B2 (https=)
CA (2) CA2910861C (https=)
DE (1) DE602006011486D1 (https=)
DK (1) DK1929039T4 (https=)
ES (1) ES2338459T5 (https=)
WO (1) WO2007037678A2 (https=)

Families Citing this family (163)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3257949A1 (en) 2005-06-15 2017-12-20 Complete Genomics Inc. Nucleic acid analysis by random mixtures of non-overlapping fragments
DK2302070T3 (da) 2005-06-23 2012-11-26 Keygene Nv Strategier til identifikation og detektion af polymorfismer med højt gennemløb
WO2007037678A2 (en) 2005-09-29 2007-04-05 Keygene N.V. High throughput screening of mutagenized populations
US10316364B2 (en) 2005-09-29 2019-06-11 Keygene N.V. Method for identifying the source of an amplicon
CN103937899B (zh) 2005-12-22 2017-09-08 凯津公司 用于基于aflp的高通量多态性检测的方法
EP3239304B1 (en) 2006-04-04 2020-08-19 Keygene N.V. High throughput detection of molecular markers based on aflp and high troughput sequencing
CA2669728C (en) * 2006-11-15 2017-04-11 Biospherex Llc Multitag sequencing and ecogenomics analysis
CA2700563C (en) * 2007-09-24 2017-03-14 Jeroen Stuurman Method for the selection of plants with specific mutations
WO2009068604A1 (en) * 2007-11-27 2009-06-04 Vib Vzw Marker assisted directed evolution
US8592150B2 (en) 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
EP2326732A4 (en) * 2008-08-26 2012-11-14 Fluidigm Corp TEST METHODS FOR INCREASED SURPLUS OF SAMPLES AND / OR TARGETS
US20110275076A1 (en) * 2008-11-17 2011-11-10 Keygene N.V. Bulked mutant analysis (bma)
WO2010057525A1 (en) * 2008-11-19 2010-05-27 Fondazione Parco Tecnologico Padano Oligonucleotide primers for nucleotide indexing of polymorphic pcr products and methods for their use
EP2373790B1 (en) 2008-12-05 2015-02-11 Keygene N.V. Farnesene synthase
SG174617A1 (en) 2009-04-02 2011-10-28 Fluidigm Corp Multi-primer amplification method for barcoding of target nucleic acids
EP2425011A1 (en) * 2009-04-29 2012-03-07 Hendrix Genetics Research, Technology & Services B.V. Method of pooling samples for performing a biological assay
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
EP2977455B1 (en) * 2009-06-15 2020-04-15 Complete Genomics, Inc. Method for long fragment read sequencing
KR101183199B1 (ko) 2009-11-16 2012-09-14 (주)지노믹트리 지노타이핑 방법
AU2010330940A1 (en) * 2009-12-18 2012-08-02 Keygene N.V. Improved bulked mutant analysis
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
WO2011127099A1 (en) 2010-04-05 2011-10-13 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US9080210B2 (en) 2010-06-09 2015-07-14 Keygene N.V. High throughput screening using combinatorial sequence barcodes
CA2803940C (en) * 2010-06-30 2019-07-02 Bgi Genomics Co., Ltd. Application of a pcr sequencing method, based on dna barcoding technique and dna incomplete shearing strategy, in hla genotyping
CN101921842B (zh) * 2010-06-30 2013-08-07 深圳华大基因科技有限公司 Hla-a,b基因分型用pcr引物及其使用方法
CN101921840B (zh) * 2010-06-30 2014-06-25 深圳华大基因科技有限公司 一种基于dna分子标签技术和dna不完全打断策略的pcr测序方法
CN101921841B (zh) * 2010-06-30 2014-03-12 深圳华大基因科技有限公司 基于Illumina GA测序技术的HLA基因高分辨率分型方法
WO2012008831A1 (en) * 2010-07-13 2012-01-19 Keygene N.V. Simplified de novo physical map generation from clone libraries
CN102409047B (zh) * 2010-09-21 2014-07-23 深圳华大基因科技服务有限公司 一种构建杂交测序文库的方法
AU2012214312A1 (en) 2011-02-09 2013-08-22 Bio-Rad Laboratories, Inc. Analysis of nucleic acids
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US9487825B2 (en) * 2011-05-13 2016-11-08 Mount Sinai School Of Medicine Pooled adapter strategy for reducing bias in small RNA characterization
SG10201605049QA (en) 2011-05-20 2016-07-28 Fluidigm Corp Nucleic acid encoding reactions
JP6164657B2 (ja) 2011-06-10 2017-07-19 シュティッヒティング・テクノロジッシュ・トップインスティテュート・グレーネ・ジェネティカ・（ファウンデーション・テクノロジカル・トップ・インスティテュート・グリーン・ジェネティクス） テルペン生合成を調節する転写因子
US20150045258A1 (en) * 2012-02-14 2015-02-12 Gnubio, Inc. Cascaded addition of target specific universal adapters to nucleic acids
WO2013123442A1 (en) 2012-02-17 2013-08-22 Fred Hutchinson Cancer Research Center Compositions and methods for accurately identifying mutations
PT2828218T (pt) 2012-03-20 2020-11-11 Univ Washington Through Its Center For Commercialization Métodos para baixar a taxa de erro da sequenciação paralela massiva de adn utilizando sequenciação duplex de consensus
WO2013177206A2 (en) 2012-05-21 2013-11-28 Fluidigm Corporation Single-particle analysis of particle populations
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
JP2014023434A (ja) * 2012-07-24 2014-02-06 Lotte Co Ltd デンタルプラークの細菌叢の解析方法
CN104781421B (zh) 2012-09-04 2020-06-05 夸登特健康公司 检测稀有突变和拷贝数变异的系统和方法
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP4592400A3 (en) 2012-10-17 2025-10-29 10x Genomics Sweden AB Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
WO2014092458A1 (ko) * 2012-12-11 2014-06-19 연세대학교 산학협력단 코돈 조합화 및 변이유발을 이용한 유전자 라이브러리의 합성 방법
WO2014134729A1 (en) 2013-03-08 2014-09-12 Vineland Research And Innovation Centre High throughput method of screening a population for members comprising mutation(s) in a target sequence
US9822408B2 (en) 2013-03-15 2017-11-21 Nugen Technologies, Inc. Sequential sequencing
EP3597772A1 (en) 2013-04-17 2020-01-22 Agency For Science, Technology And Research Method for generating extended sequence reads
CA2916662C (en) 2013-06-25 2022-03-08 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
CN105555972B (zh) 2013-07-25 2020-07-31 伯乐生命医学产品有限公司 遗传测定
JP2015035212A (ja) * 2013-07-29 2015-02-19 アジレント・テクノロジーズ・インクＡｇｉｌｅｎｔ Ｔｅｃｈｎｏｌｏｇｉｅｓ， Ｉｎｃ． ターゲットシークエンシングパネルから変異を見つける方法
WO2015073711A1 (en) 2013-11-13 2015-05-21 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
EP3074528A1 (en) * 2013-11-26 2016-10-05 Qiagen GmbH Generation of ligation-ready dna amplicons
ES2693217T3 (es) * 2013-12-02 2018-12-10 Personal Genome Diagnostics Inc. Método para evaluar variantes minoritarias en una muestra
CN103617375B (zh) * 2013-12-02 2017-08-25 深圳华大基因健康科技有限公司 聚合酶链式反应产物测序分型的方法及系统
ES2660989T3 (es) 2013-12-28 2018-03-27 Guardant Health, Inc. Métodos y sistemas para detectar variantes genéticas
MA40435A (fr) 2014-07-25 2016-01-28 Enza Zaden Beheer Bv Plant de concombre stay green
US10233490B2 (en) 2014-11-21 2019-03-19 Metabiotech Corporation Methods for assembling and reading nucleic acid sequences from mixed populations
EP3901282B1 (en) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
EP3307908B1 (en) 2015-06-09 2019-09-11 Life Technologies Corporation Methods for molecular tagging
EP3356392A1 (en) 2015-10-02 2018-08-08 Keygene N.V. Method for the production of haploid and subsequent doubled haploid plants
BR112018006573A2 (pt) 2015-10-02 2018-10-09 método para a produção de plantas haploides e subsequentes haploides duplicadas
WO2017062970A1 (en) 2015-10-10 2017-04-13 Guardant Health, Inc. Methods and applications of gene fusion detection in cell-free dna analysis
CA2911002C (en) 2015-11-04 2016-11-29 Travis Wilfred BANKS High throughput method of screening a population for members comprising mutations(s) in a target sequence using alignment-free sequence analysis
CA3006792A1 (en) 2015-12-08 2017-06-15 Twinstrand Biosciences, Inc. Improved adapters, methods, and compositions for duplex sequencing
CN108603224B (zh) 2015-12-16 2022-06-28 富鲁达公司 高水平多路复用扩增
SG11201805119QA (en) 2015-12-17 2018-07-30 Guardant Health Inc Methods to determine tumor gene copy number by analysis of cell-free dna
EP3199642A1 (en) 2016-02-01 2017-08-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Plant breeding using high throughput sequencing
CN105734130B (zh) * 2016-03-11 2019-10-25 中国农业科学院生物技术研究所 全基因组范围的植物基因功能鉴定的方法
ES3002715T3 (en) 2016-04-14 2025-03-07 Guardant Health Inc Methods for early detection of cancer
US11384382B2 (en) 2016-04-14 2022-07-12 Guardant Health, Inc. Methods of attaching adapters to sample nucleic acids
WO2017200386A1 (en) 2016-05-20 2017-11-23 Keygene N.V. Method for the production of haploid and subsequent doubled haploid plants
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
EP3461274B1 (en) 2016-09-30 2020-11-04 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
WO2018183942A1 (en) 2017-03-31 2018-10-04 Grail, Inc. Improved library preparation and use thereof for sequencing-based error correction and/or variant identification
US12492430B2 (en) 2017-04-11 2025-12-09 Tecan Genomics, Inc. Library quantitation and qualification
US10633651B2 (en) * 2017-07-10 2020-04-28 Agilent Technologies, Inc. Assay methods and compositions for detecting contamination of nucleic acid identifiers
US11505826B2 (en) 2017-07-12 2022-11-22 Agilent Technologies, Inc. Sequencing method for genomic rearrangement detection
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
AU2018366213B2 (en) 2017-11-08 2025-05-15 Twinstrand Biosciences, Inc. Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
WO2019121603A1 (en) 2017-12-18 2019-06-27 Keygene N.V. Chemical mutagenesis of cassava
CN108315396B (zh) * 2018-03-28 2021-07-16 潍坊兴旺生物种业有限公司 一种简单便捷检测snp的新方法
DE202019005627U1 (de) 2018-04-02 2021-05-31 Grail, Inc. Methylierungsmarker und gezielte Methylierungssondenpanels
WO2019236726A1 (en) 2018-06-06 2019-12-12 The Regents Of The University Of California Methods of producing nucleic acid libraries and compositions and kits for practicing same
BR112021000409A2 (pt) 2018-07-12 2021-04-06 Twinstrand Biosciences, Inc. Métodos e reagentes para caracterizar edição genômica, expansão clonal e aplicações associadas
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
JP7535998B2 (ja) 2018-08-31 2024-08-19 ガーダント ヘルス， インコーポレイテッド マージされたリードおよびマージされないリードに基づいた遺伝的変異体の検出
WO2020069350A1 (en) 2018-09-27 2020-04-02 Grail, Inc. Methylation markers and targeted methylation probe panel
US10945844B2 (en) 2018-10-10 2021-03-16 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
WO2020109412A1 (en) 2018-11-28 2020-06-04 Keygene N.V. Targeted enrichment by endonuclease protection
JP2020080761A (ja) * 2018-11-28 2020-06-04 大成建設株式会社 植物種の地域性変異特定方法
WO2020123316A2 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Methods for determining a location of a biological analyte in a biological sample
US12529094B2 (en) 2018-12-10 2026-01-20 10X Genomics, Inc. Imaging system hardware
TWI725686B (zh) 2018-12-26 2021-04-21 財團法人工業技術研究院 用於產生液珠的管狀結構及液珠產生方法
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
WO2020160414A1 (en) 2019-01-31 2020-08-06 Guardant Health, Inc. Compositions and methods for isolating cell-free dna
CA3127572A1 (en) 2019-02-21 2020-08-27 Keygene N.V. Genotyping of polyploids
MX2021014131A (es) 2019-05-24 2021-12-15 Enza Zaden Beheer Bv Plantas de melon resistentes al mildiu.
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
WO2021109344A1 (zh) * 2019-12-03 2021-06-10 湖南杂交水稻研究中心 鉴定理化诱变植物m1代突变及获取突变体的方法及鉴定水稻突变用分型引物、突变型基因及应用
CN110904258B (zh) * 2019-12-03 2021-08-17 湖南杂交水稻研究中心 一种高通量靶向鉴定理化诱变植株m1代突变及获取突变体的方法
WO2021116371A1 (en) 2019-12-12 2021-06-17 Keygene N.V. Semi-solid state nucleic acid manipulation
EP4077661A1 (en) 2019-12-20 2022-10-26 Keygene N.V. Ngs library preparation using covalently closed nucleic acid molecule ends
EP4081656A1 (en) 2019-12-23 2022-11-02 10X Genomics, Inc. Compositions and methods for using fixed biological samples in partition-based assays
CN115135984B (zh) 2019-12-23 2025-12-23 10X基因组学有限公司 可逆固定试剂及其使用方法
ES2982420T3 (es) 2019-12-23 2024-10-16 10X Genomics Inc Métodos para el análisis espacial mediante el uso de la ligazón con plantilla de ARN
US12365942B2 (en) 2020-01-13 2025-07-22 10X Genomics, Inc. Methods of decreasing background on a spatial array
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
EP3851542A1 (en) 2020-01-20 2021-07-21 Tecan Genomics, Inc. Depletion of abundant uninformative sequences
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US12059674B2 (en) 2020-02-03 2024-08-13 Tecan Genomics, Inc. Reagent storage system
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
WO2021158925A1 (en) 2020-02-07 2021-08-12 10X Genomics, Inc. Quantitative and automated permeabilization performance evaluation for spatial transcriptomics
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
EP4139485B1 (en) 2020-04-22 2023-09-06 10X Genomics, Inc. Methods for spatial analysis using targeted rna depletion
WO2021226581A1 (en) * 2020-05-08 2021-11-11 Baebies, Inc. Multidimensional barcode pooling
EP4414459B1 (en) 2020-05-22 2025-09-03 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
EP4153776B1 (en) 2020-05-22 2025-03-05 10X Genomics, Inc. Spatial analysis to detect sequence variants
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
EP4421186B1 (en) 2020-06-08 2025-08-13 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
EP4165207B1 (en) 2020-06-10 2024-09-25 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
ES2994976T3 (en) 2020-06-25 2025-02-05 10X Genomics Inc Spatial analysis of dna methylation
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US12209280B1 (en) 2020-07-06 2025-01-28 10X Genomics, Inc. Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
MX2023002239A (es) 2020-09-01 2023-03-15 Enza Zaden Beheer Bv Plantas de calabaza resistentes a enfermedades.
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
WO2022074058A1 (en) 2020-10-06 2022-04-14 Keygene N.V. Targeted sequence addition
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
WO2022112316A1 (en) 2020-11-24 2022-06-02 Keygene N.V. Targeted enrichment using nanopore selective sequencing
US20240093288A1 (en) 2020-11-25 2024-03-21 Koninklijke Nederlandse Akademie Van Wetenschappen Ribosomal profiling in single cells
EP4729631A2 (en) 2020-12-21 2026-04-22 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
MX2023011486A (es) 2021-04-01 2023-10-05 Enza Zaden Beheer Bv Planta cucurbitacea de color verde permanente.
CN113130005B (zh) * 2021-04-12 2022-11-22 中国科学院东北地理与农业生态研究所 一种基于m2群体的候选因果突变位点基因定位的方法
EP4305196B1 (en) 2021-04-14 2025-04-02 10X Genomics, Inc. Methods of measuring mislocalization of an analyte
AU2022256793A1 (en) 2021-04-15 2023-09-28 Keygene N.V. Co-regeneration recalcitrant plants
EP4320271B1 (en) 2021-05-06 2025-03-19 10X Genomics, Inc. Methods for increasing resolution of spatial analysis
WO2022256503A1 (en) 2021-06-03 2022-12-08 10X Genomics, Inc. Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
WO2023086880A1 (en) 2021-11-10 2023-05-19 10X Genomics, Inc. Methods, compositions, and kits for determining the location of an analyte in a biological sample
WO2023102118A2 (en) 2021-12-01 2023-06-08 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
EP4482979B1 (en) 2022-11-09 2025-10-01 10X Genomics, Inc. Methods, compositions, and kits for determining the location of multiple analytes in a biological sample
WO2024121354A1 (en) 2022-12-08 2024-06-13 Keygene N.V. Duplex sequencing with covalently closed dna ends
CA3275398A1 (en) 2022-12-22 2024-06-27 Keygene N.V. REGENERATION BY PROTOPLASTIC CALL GRAFTING
EP4689157A1 (en) 2023-04-04 2026-02-11 Keygene N.V. Linkers for duplex sequencing
IL325766A (en) 2023-07-14 2026-03-01 Enza Zaden Beheer Bv Evergreen cucumber plant
WO2025257212A1 (en) 2024-06-11 2025-12-18 Keygene N.V. Screening and regeneration of protoplast callus

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US24939A (en) 1859-08-02 Improvement in sewing-machines
DE3465508D1 (en) 1983-04-28 1987-09-24 Flexible Steel Lacing Co Method and apparatus for riveting fasteners to a belt
EP0456721A4 (en) 1989-01-31 1992-06-03 University Of Miami Microdissection and amplification of chromosomal dna
AU672760B2 (en) 1991-09-24 1996-10-17 Keygene N.V. Selective restriction fragment amplification: a general method for DNA fingerprinting
US20100267023A1 (en) 1992-09-24 2010-10-21 Keygene N.V. Selective restriction fragment amplification: fingerprinting
WO1995019697A1 (en) 1994-01-21 1995-07-27 North Carolina State University Methods for within family selection in woody perennials using genetic markers
EG23907A (en) 1994-08-01 2007-12-30 Delta & Pine Land Co Control of plant gene expression
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
WO1996017082A2 (en) 1994-11-28 1996-06-06 E.I. Du Pont De Nemours And Company Compound microsatellite primers for the detection of genetic polymorphisms
US5565340A (en) 1995-01-27 1996-10-15 Clontech Laboratories, Inc. Method for suppressing DNA fragment amplification during PCR
US5935793A (en) * 1996-09-27 1999-08-10 The Chinese University Of Hong Kong Parallel polynucleotide sequencing method using tagged primers
AU6024598A (en) 1997-01-10 1998-08-03 Pioneer Hi-Bred International, Inc. Hybridization-based genetic amplification and analysis
US6090556A (en) 1997-04-07 2000-07-18 Japan Science & Technology Corporation Method for quantitatively determining the expression of a gene
JP2001515362A (ja) 1997-05-13 2001-09-18 ディスプレイ・システムズ・バイオテック・アクティーゼルスカブ ｍＲＮＡをクローニングする方法および差次的に発現された転写物のディスプレイ（ＤＯＤＥＴ）
EP0930370B1 (en) * 1997-12-15 2007-08-08 CSL Behring GmbH Labeled primer for use in detection of target nucleic acids
CA2273616A1 (en) 1998-06-08 1999-12-08 The Board Of Trustees Of The Leland Stanford Junior University Method for parallel screening of allelic variation
US6124201A (en) 1998-06-12 2000-09-26 Advanced Micro Devices, Inc. Method for manufacturing semiconductors with self-aligning vias
EP0976835B1 (en) 1998-07-29 2003-07-09 Keygene N.V. Method for detecting nucleic acid methylation using AFLPTM
US6232067B1 (en) 1998-08-17 2001-05-15 The Perkin-Elmer Corporation Adapter directed expression analysis
US6703228B1 (en) 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1001037A3 (en) 1998-09-28 2003-10-01 Whitehead Institute For Biomedical Research Pre-selection and isolation of single nucleotide polymorphisms
CA2345441A1 (en) 1998-10-27 2000-05-04 Affymetrix, Inc. Complexity management and analysis of genomic dna
US6480791B1 (en) 1998-10-28 2002-11-12 Michael P. Strathmann Parallel methods for genomic analysis
US6534293B1 (en) 1999-01-06 2003-03-18 Cornell Research Foundation, Inc. Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing
US20040029155A1 (en) 1999-01-08 2004-02-12 Curagen Corporation Method for identifying a biomolecule
JP2002534461A (ja) 1999-01-12 2002-10-15 クアナム メディカル コーポレイション 水不溶性のパクリタキセル誘導体の投与のための組成物および方法
DE19911130A1 (de) 1999-03-12 2000-09-21 Hager Joerg Verfahren zur Identifikation chromosomaler Regionen und Gene
JP2002540802A (ja) 1999-04-06 2002-12-03 イェール ユニバーシティ 配列標識の固定されたアドレス分析
EP1173612B1 (en) 1999-04-09 2004-09-29 Keygene N.V. METHOD FOR THE DETECTION AND/OR ANALYSIS, BY MEANS OF PRIMER EXTENSION TECHNIQUES, OF SINGLE NUCLEOTIDE POLYMORPHISMS IN RESTRICTION FRAGMENTS, IN PARTICULAR IN AMPLIFIED RESTRICTION FRAGMENTS GENERATED USING AFLP$m(3)
US20040031072A1 (en) 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
US20020119448A1 (en) 1999-06-23 2002-08-29 Joseph A. Sorge Methods of enriching for and identifying polymorphisms
US20030204075A9 (en) 1999-08-09 2003-10-30 The Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
WO2001021840A2 (en) 1999-09-23 2001-03-29 Gene Logic, Inc. Indexing populations
US6287778B1 (en) * 1999-10-19 2001-09-11 Affymetrix, Inc. Allele detection using primer extension with sequence-coded identity tags
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
AU1413601A (en) 1999-11-19 2001-06-04 Takara Bio Inc. Method of amplifying nucleic acids
WO2001075167A1 (en) 2000-03-31 2001-10-11 Fred Hutchinson Cancer Research Center Reverse genetic strategy for identifying functional mutations in genes of known sequence
US20110131679A2 (en) 2000-04-19 2011-06-02 Thomas La Rosa Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
EP1282729A2 (en) 2000-05-15 2003-02-12 Keygene N.V. Microsatellite-aflp
US7300751B2 (en) 2000-06-30 2007-11-27 Syngenta Participations Ag Method for identification of genetic markers
GB0016742D0 (en) * 2000-07-10 2000-08-30 Simeg Limited Diagnostic method
DE60131903T2 (de) * 2000-10-24 2008-11-27 The Board of Trustees of the Leland S. Stanford Junior University, Palo Alto Direkte multiplex charakterisierung von genomischer dna
US6958217B2 (en) * 2001-01-24 2005-10-25 Genomic Expression Aps Single-stranded polynucleotide tags
US7141364B1 (en) 2001-03-29 2006-11-28 Council Of Scientific And Industrial Research Universal primers for wildlife identification
US20040053236A1 (en) * 2001-03-30 2004-03-18 Mccallum Claire M. Reverse genetic strategy for identifying functional mutations in genes of known sequences
WO2002083911A1 (en) 2001-04-12 2002-10-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Production of plants with increased tolerance to drought stress or with increased transpiration
US20050064406A1 (en) 2001-04-20 2005-03-24 Eugene Zabarovsky Methods for high throughput genome analysis using restriction site tagged microarrays
WO2003020015A2 (en) 2001-08-30 2003-03-13 Purdue Research Foundation Methods to produce transgenic plants resistant to osmotic stress
EP1288301A1 (en) 2001-08-31 2003-03-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin Plant-derived resistance gene
US7504222B2 (en) 2001-10-31 2009-03-17 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
AU2003224789B2 (en) 2002-03-27 2007-03-15 Agrinomics, Llc Generation of plants with improved drought tolerance
US6815167B2 (en) 2002-04-25 2004-11-09 Geneohm Sciences Amplification of DNA to produce single-stranded product of defined sequence and length
US20070065816A1 (en) 2002-05-17 2007-03-22 Affymetrix, Inc. Methods for genotyping
US7108976B2 (en) 2002-06-17 2006-09-19 Affymetrix, Inc. Complexity management of genomic DNA by locus specific amplification
WO2004001074A1 (en) 2002-06-21 2003-12-31 Lynx Therapeutics, Inc. Method for detecting foreign dna in a host genome
CA2496517A1 (en) 2002-09-05 2004-03-18 Plant Bioscience Limited Genome partitioning
US20040157238A1 (en) 2002-09-20 2004-08-12 Quinn John J. Method for detection of multiple nucleic acid sequence variations
AU2003298095A1 (en) 2002-10-18 2004-05-04 Cropdesign N.V. Identification of e2f target genes and uses thereof
JP4230457B2 (ja) 2002-12-18 2009-02-25 サード・ウェーブ・テクノロジーズ・インク 低分子核酸の検出方法
JP2004208586A (ja) * 2002-12-27 2004-07-29 Wakunaga Pharmaceut Co Ltd Ｈｌａの検出
JP4690307B2 (ja) 2003-01-10 2011-06-01 ケイヘーネ・エヌ・ブイ 物理的および遺伝的地図を統合するためのａｆｌｐに基づいた方法
CA2513899C (en) * 2003-01-29 2013-03-26 454 Corporation Methods of amplifying and sequencing nucleic acids
CN103396933B (zh) 2003-02-26 2016-04-20 凯利达基因组股份有限公司 通过杂交进行的随机阵列dna分析
JP4888876B2 (ja) 2003-06-13 2012-02-29 田平 武 アルツハイマー病の治療のための組換えアデノ随伴ウィルスベクター
DE602004032374D1 (de) 2003-06-24 2011-06-01 Agrigenetics Inc Erzeugung von pflanzen mit verbesserter toleranz gegenüber trockenheit
US7754945B2 (en) 2003-06-24 2010-07-13 Agrigenetics Inc. Generation of plants with improved drought tolerance
US7051935B2 (en) 2003-07-28 2006-05-30 Imageid Ltd. Color calibration for color bar codes
WO2005026686A2 (en) 2003-09-09 2005-03-24 Compass Genetics, Llc Multiplexed analytical platform
CN101415826A (zh) * 2003-10-21 2009-04-22 沃尔坎尼中心-以色列农业部农业研究组织 导致番茄高色素-1突变表型(hp-1和hp-1w)的分离的核苷酸序列及其应用
US20050153317A1 (en) 2003-10-24 2005-07-14 Metamorphix, Inc. Methods and systems for inferring traits to breed and manage non-beef livestock
EP1701785A1 (en) 2004-01-07 2006-09-20 Solexa Ltd. Modified molecular arrays
US20050233354A1 (en) 2004-01-22 2005-10-20 Affymetrix, Inc. Genotyping degraded or mitochandrial DNA samples
WO2005080604A2 (en) 2004-02-12 2005-09-01 Compass Genetics, Llc Genetic analysis by sequence-specific sorting
US7709262B2 (en) * 2004-02-18 2010-05-04 Trustees Of Boston University Method for detecting and quantifying rare mutations/polymorphisms
EP1574585A1 (en) 2004-03-12 2005-09-14 Plant Research International B.V. Method for selective amplification of DNA fragments for genetic fingerprinting
JP4809594B2 (ja) 2004-08-02 2011-11-09 東京エレクトロン株式会社 検査装置
FR2876479B1 (fr) 2004-10-11 2006-12-15 Parkeon Machine a pieces a receptacle de pieces de monnaie amovible
US7220549B2 (en) * 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US7407757B2 (en) 2005-02-10 2008-08-05 Population Genetics Technologies Genetic analysis by sequence-specific sorting
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US20070009925A1 (en) * 2005-05-05 2007-01-11 Applera Corporation Genomic dna sequencing methods and kits
WO2006122215A2 (en) 2005-05-10 2006-11-16 State Of Oregon Acting By & Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods of mapping polymorphisms and polymorphism microarrays
EP3257949A1 (en) 2005-06-15 2017-12-20 Complete Genomics Inc. Nucleic acid analysis by random mixtures of non-overlapping fragments
DK2302070T3 (da) 2005-06-23 2012-11-26 Keygene Nv Strategier til identifikation og detektion af polymorfismer med højt gennemløb
DE602006013831D1 (de) 2005-06-23 2010-06-02 Keygene Nv Verbesserte strategien zur sequenzierung komplexer genome unter verwendung von sequenziertechniken mit hohem durchsatz
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
US10316364B2 (en) 2005-09-29 2019-06-11 Keygene N.V. Method for identifying the source of an amplicon
WO2007037678A2 (en) * 2005-09-29 2007-04-05 Keygene N.V. High throughput screening of mutagenized populations
JP5166276B2 (ja) 2005-11-14 2013-03-21 ケイヘーネ・エヌ・ブイ トランスポゾンタギング集団のハイスループットスクリーニングおよび挿入部位の大規模並行配列特定のための方法
CN103937899B (zh) 2005-12-22 2017-09-08 凯津公司 用于基于aflp的高通量多态性检测的方法
WO2007087312A2 (en) 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Molecular counting
EP3239304B1 (en) 2006-04-04 2020-08-19 Keygene N.V. High throughput detection of molecular markers based on aflp and high troughput sequencing
US8362325B2 (en) 2007-10-03 2013-01-29 Ceres, Inc. Nucleotide sequences and corresponding polypeptides conferring modulated plant characteristics
US20090124758A1 (en) 2007-11-09 2009-05-14 Bridgestone Sports Co., Ltd. Golf ball
US20140051585A1 (en) 2012-08-15 2014-02-20 Natera, Inc. Methods and compositions for reducing genetic library contamination
WO2014196863A1 (en) 2013-06-07 2014-12-11 Keygene N.V. Method for targeted sequencing

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