ES2317999T3 - Terapia de inmunizacion para el tratamiento de la ateroesclerosis. - Google Patents

Terapia de inmunizacion para el tratamiento de la ateroesclerosis. Download PDF

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Publication number
ES2317999T3
ES2317999T3 ES02714667T ES02714667T ES2317999T3 ES 2317999 T3 ES2317999 T3 ES 2317999T3 ES 02714667 T ES02714667 T ES 02714667T ES 02714667 T ES02714667 T ES 02714667T ES 2317999 T3 ES2317999 T3 ES 2317999T3
Authority
ES
Spain
Prior art keywords
peptide
peptides
antibodies
mda
ldl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02714667T
Other languages
English (en)
Spanish (es)
Inventor
Jan Nilsson
Prediman K. Shah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forskarpatent I SYD AB
Cedars Sinai Medical Center
Original Assignee
Forskarpatent I SYD AB
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0101232A external-priority patent/SE0101232D0/xx
Application filed by Forskarpatent I SYD AB, Cedars Sinai Medical Center filed Critical Forskarpatent I SYD AB
Application granted granted Critical
Publication of ES2317999T3 publication Critical patent/ES2317999T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
ES02714667T 2001-04-05 2002-04-05 Terapia de inmunizacion para el tratamiento de la ateroesclerosis. Expired - Lifetime ES2317999T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE2001101232 2001-04-05
SE0101232A SE0101232D0 (sv) 2001-04-05 2001-04-05 Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based elisa for determination of immune responses against oxidized low density liprotein
SE2001103754 2001-11-09
SE0103754A SE0103754L (sv) 2001-04-05 2001-11-09 Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid

Publications (1)

Publication Number Publication Date
ES2317999T3 true ES2317999T3 (es) 2009-05-01

Family

ID=26655437

Family Applications (2)

Application Number Title Priority Date Filing Date
ES02714667T Expired - Lifetime ES2317999T3 (es) 2001-04-05 2002-04-05 Terapia de inmunizacion para el tratamiento de la ateroesclerosis.
ES10181267.5T Expired - Lifetime ES2546293T3 (es) 2001-04-05 2002-04-05 Terapia de inmunización basada en péptidos para el tratamiento de aterosclerosis que fija ApoB como objetivo

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES10181267.5T Expired - Lifetime ES2546293T3 (es) 2001-04-05 2002-04-05 Terapia de inmunización basada en péptidos para el tratamiento de aterosclerosis que fija ApoB como objetivo

Country Status (18)

Country Link
EP (42) EP2305708A1 (https=)
JP (6) JP2004529143A (https=)
CN (4) CN101284874B (https=)
AT (2) ATE415423T1 (https=)
AU (1) AU2002246484B8 (https=)
BR (1) BR0208685A (https=)
CA (3) CA2443223C (https=)
CY (1) CY1108817T1 (https=)
DE (1) DE60230029D1 (https=)
DK (3) DK1383526T3 (https=)
EE (2) EE200300487A (https=)
ES (2) ES2317999T3 (https=)
IL (4) IL158285A0 (https=)
PL (4) PL217858B1 (https=)
PT (1) PT1383526E (https=)
RU (1) RU2296582C2 (https=)
SE (1) SE0103754L (https=)
WO (1) WO2002080954A1 (https=)

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SE0103754L (sv) * 2001-04-05 2002-10-06 Forskarpatent I Syd Ab Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
US20030105003A1 (en) 2001-04-05 2003-06-05 Jan Nilsson Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein
PL372925A1 (en) 2001-09-28 2005-08-08 Esperion Therapeutics Inc. Prevention and treatment of restenosis by local administration of drug
AU2003267905B2 (en) * 2002-10-04 2009-02-05 Biolnvent International Ab Peptide-based passive immunization therapy for treatment of atherosclerosis
SE0302312D0 (sv) * 2002-10-04 2003-08-27 Forskarpatent I Syd Ab Peptide-based passive immunization therapy for treatment of atherosclerosis
SE0302422D0 (sv) * 2003-09-11 2003-09-11 Forskarpatent I Syd Ab Peptide-based immunization therapy for treatment of atherosclerosis
SE0400683D0 (sv) 2004-03-19 2004-03-19 Forskarpatent I Syd Ab Use of modified extracellular matrix proteins in diagnosis and treatment of a atherosclerosis
JP2007531537A (ja) 2004-04-06 2007-11-08 セダーズ−シナイ　メディカル　センター アポリポタンパク質ａ−ｉおよびアポリポタンパク質ａ−ｉｍｉｌａｎｏをコードする組換えアデノ随伴ウイルスベクターによる血管疾患の予防および処置
ATE463254T1 (de) * 2004-04-15 2010-04-15 Athera Biotechnologies Ab Antikörper gegen phosphorylcholinkonjugate
EP1676602A1 (en) * 2005-01-04 2006-07-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Continuous administration of epitopes derived from protein present in atherosclerotic plaque for the treatment of atherosclerosis
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CA2669863A1 (en) * 2006-12-22 2008-07-03 Abbott Laboratories Cardiovascular autoimmune disease panel and methods of using same
WO2008104194A1 (en) * 2007-02-28 2008-09-04 Bioinvent International Ab Oxidized ldl and antibodies thereto for the treatment of atheroscleroti c plaques
CA2681162C (en) 2007-03-15 2015-11-24 Novartis Ag Benzyl and pyridine derivatives as modulators of hedgehog pathway
ES2897492T3 (es) * 2007-11-05 2022-03-01 Nordic Bioscience Imaging As Marcadores bioquímicos para la evaluación de riesgos de CVD
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
JP5742002B2 (ja) * 2008-08-15 2015-07-01 藤倉化成株式会社 動脈硬化診断用ポリペプチドマーカー、及び該マーカー等を用いる動脈硬化の検出を補助する方法、並びに動脈硬化診断用キット
WO2011060329A1 (en) 2009-11-14 2011-05-19 Kuang-Yuh Chyu Immunomodulatory methods and systems for treatment and/or prevention of atherosclerosis
US8506964B2 (en) 2010-02-05 2013-08-13 Cardiovax, Llc Fusion proteins and related compositions, methods and systems for treatment and/or prevention of atherosclerosis
US20130142760A1 (en) 2010-08-18 2013-06-06 Cedars-Sinai Medical Center Atherosclerosis inhibition via modulation of monocyte-macrophage phenotype using apo a-i milano gene transfer
RU2013126626A (ru) * 2010-11-12 2014-12-20 Седарс-Синаи Медикал Сентер Иммуномодулирующие способы и системы для лечения и/или предотвращения гипертензий
CN103501806A (zh) * 2010-11-12 2014-01-08 赛达斯西奈医疗中心 用于治疗和/或预防动脉瘤的免疫调节方法和系统
EP2637686A2 (en) 2010-11-12 2013-09-18 Cedars-Sinai Medical Center Immunomodulatory compositions, methods and systems comprising immunogenic fragments of apob100
HUE045163T2 (hu) 2011-08-09 2019-12-30 Athera Biotechnologies Ab Új ellenanyagok foszforilkolin ellen
CN103906532B (zh) 2011-08-09 2018-01-26 阿瑟拉生物技术公司 结合磷酰胆碱（pc）和/或pc结合物的抗体
RU2495048C1 (ru) * 2012-04-18 2013-10-10 Андрей Валентинович Исаев Пептид, обладающий антиатеросклеротическим действием и композиция для профилактики и лечения атеросклероза сосудов
ES2859559T3 (es) * 2012-11-06 2021-10-04 Les Hopitaux Univ De Geneve Péptidos miméticos
CN103520713B (zh) * 2013-10-16 2015-10-28 西北农林科技大学 一种ApoB100酵母重组疫苗及其制备方法和应用
CN103860470A (zh) * 2014-03-05 2014-06-18 贵州中泰生物科技有限公司 一种口服高密度脂蛋白脂质体的制备方法
CN105315364B (zh) * 2014-06-17 2018-09-18 广州文瑞生物科技有限公司 胶原蛋白vi疫苗预防动脉粥样硬化
CN114085283A (zh) 2015-05-19 2022-02-25 拉·约拉过敏反应及免疫医学研究所 调节炎症应答及治疗不良心血管事件、病和粥样硬化的人apob100表位、方法和用途
US10858422B2 (en) 2016-05-31 2020-12-08 Abcentra, Llc Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody
CN108478817B (zh) * 2018-03-16 2020-10-27 北京大学 一种动脉粥样硬化检测试剂及其制备方法
JP7357646B2 (ja) 2018-05-29 2023-10-06 アブセントラ，エルエルシー 乾癬の治療のための組成物及び方法
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CN115025210B (zh) * 2021-03-05 2025-09-05 香港中文大学 减少动脉粥样硬化进展的肽疫苗组合物和药物制剂
CN115025211A (zh) * 2021-11-02 2022-09-09 南京理工大学 用于动脉粥样硬化治疗的纳米疫苗及其制备方法

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SE0103754L (sv) * 2001-04-05 2002-10-06 Forskarpatent I Syd Ab Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
KR20030097854A (ko) * 2001-05-15 2003-12-31 저팬 이뮤너리서치 래버래터리스 컴퍼니 리미티드 고밀도 리포단백질 반응성 펩티드
JP2005504025A (ja) * 2001-07-20 2005-02-10 アイトゲネシシェ テクニシェ ホッヒシュル チューリッヒ（エーテーハーツェット） スルフォネート化またはスルフェート化アミノ酸から誘導された生物学的薬剤の使用法と組成物

Also Published As

Publication number Publication date
JP2011068654A (ja) 2011-04-07
EP1383526B1 (en) 2008-11-26
ATE415423T1 (de) 2008-12-15
JP5300819B2 (ja) 2013-09-25
EP2289924A1 (en) 2011-03-02
PL367301A1 (en) 2005-02-21
EP1383526A1 (en) 2004-01-28
JP5270456B2 (ja) 2013-08-21
DE60230029D1 (de) 2009-01-08
EP2289931A1 (en) 2011-03-02
CN1505525B (zh) 2012-11-07
EP2295461A1 (en) 2011-03-16
RU2296582C2 (ru) 2007-04-10
EP2147930A2 (en) 2010-01-27
CN103122031B (zh) 2015-07-22
EP2289913A1 (en) 2011-03-02
AU2002246484B2 (en) 2007-04-19
EP2289920A1 (en) 2011-03-02
DK2006301T3 (da) 2011-09-12
JP2013144687A (ja) 2013-07-25
CN101486766A (zh) 2009-07-22
EP2289934A1 (en) 2011-03-02
EP2289928A1 (en) 2011-03-02
SE0103754L (sv) 2002-10-06
EP2289912A1 (en) 2011-03-02
EP2289929A1 (en) 2011-03-02
EP2289933A1 (en) 2011-03-02
EP2295464A1 (en) 2011-03-16
EP2289923A1 (en) 2011-03-02
EP2289930A1 (en) 2011-03-02
DK1383526T3 (da) 2009-03-30
EP2295464B1 (en) 2015-06-03
JP2011063598A (ja) 2011-03-31
IL158285A0 (en) 2004-05-12
DK2295464T3 (en) 2015-08-17
PL400308A1 (pl) 2012-12-17
AU2002246484B8 (en) 2007-06-14
EP2295457A1 (en) 2011-03-16
EP2305706A1 (en) 2011-04-06
EP2289914A1 (en) 2011-03-02
CA2606839A1 (en) 2002-10-17
EP2006301B1 (en) 2011-05-25
EP2305707A1 (en) 2011-04-06
JP5300820B2 (ja) 2013-09-25
EP2289927A1 (en) 2011-03-02
IL158285A (en) 2009-12-24
EP2295463A1 (en) 2011-03-16
CA2443223A1 (en) 2002-10-17
CY1108817T1 (el) 2014-04-09
RU2003132443A (ru) 2005-02-27
EE200300487A (et) 2004-02-16
EP2289919A1 (en) 2011-03-02
EP2289932A1 (en) 2011-03-02
BR0208685A (pt) 2004-03-30
EP2289915A1 (en) 2011-03-02
EP2147929A3 (en) 2010-04-14
EP2147928A3 (en) 2010-04-14
CN101284874B (zh) 2012-10-03
JP2009191078A (ja) 2009-08-27
CN101284874A (zh) 2008-10-15
JP5613890B2 (ja) 2014-10-29
EP2289922A1 (en) 2011-03-02
EP2295459A1 (en) 2011-03-16
JP2004529143A (ja) 2004-09-24
EP2289926A1 (en) 2011-03-02
EP2295458A1 (en) 2011-03-16
EP2289921A1 (en) 2011-03-02
EP2289918A1 (en) 2011-03-02
EP2295460A1 (en) 2011-03-16
EP2289925A1 (en) 2011-03-02
IL195356A0 (en) 2009-08-03
PL215401B1 (pl) 2013-12-31
ES2546293T3 (es) 2015-09-22
EP1918300A2 (en) 2008-05-07
PL217858B1 (pl) 2014-08-29
EP2147680A2 (en) 2010-01-27
CN103122031A (zh) 2013-05-29
JP2008169215A (ja) 2008-07-24
EP2147930A3 (en) 2010-04-14
ATE510851T1 (de) 2011-06-15
EP2289917A1 (en) 2011-03-02
CA2443223C (en) 2013-11-26
EP2147680A3 (en) 2010-04-14
PT1383526E (pt) 2009-02-27
AU2002246484A1 (en) 2002-10-21
EP2305708A1 (en) 2011-04-06
EP2295460B1 (en) 2015-06-03
CA2606839C (en) 2015-06-09
EE200700052A (et) 2008-08-15
CN1505525A (zh) 2004-06-16
EP2147928A2 (en) 2010-01-27
EP2289935A1 (en) 2011-03-02
WO2002080954A1 (en) 2002-10-17
EP1918300A3 (en) 2009-06-17
EP2006301A1 (en) 2008-12-24
IL188286A0 (en) 2008-03-20
EP2295462A1 (en) 2011-03-16
CA2827167A1 (en) 2002-10-17
SE0103754D0 (sv) 2001-11-09
EP2147929A2 (en) 2010-01-27
EP2289916A1 (en) 2011-03-02
EP2289934B1 (en) 2013-11-13

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