ATE463254T1 - Antikörper gegen phosphorylcholinkonjugate - Google Patents

Antikörper gegen phosphorylcholinkonjugate

Info

Publication number
ATE463254T1
ATE463254T1 AT06077208T AT06077208T ATE463254T1 AT E463254 T1 ATE463254 T1 AT E463254T1 AT 06077208 T AT06077208 T AT 06077208T AT 06077208 T AT06077208 T AT 06077208T AT E463254 T1 ATE463254 T1 AT E463254T1
Authority
AT
Austria
Prior art keywords
antibodies against
phosphorylcholine conjugates
against phosphorylcholine
conjugates
immunization
Prior art date
Application number
AT06077208T
Other languages
English (en)
Inventor
Faire Ulf De
Johan Frostegard
Original Assignee
Athera Biotechnologies Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Athera Biotechnologies Ab filed Critical Athera Biotechnologies Ab
Application granted granted Critical
Publication of ATE463254T1 publication Critical patent/ATE463254T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39583—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/323—Arteriosclerosis, Stenosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
AT06077208T 2004-04-15 2005-04-15 Antikörper gegen phosphorylcholinkonjugate ATE463254T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52138404P 2004-04-15 2004-04-15

Publications (1)

Publication Number Publication Date
ATE463254T1 true ATE463254T1 (de) 2010-04-15

Family

ID=34981497

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06077208T ATE463254T1 (de) 2004-04-15 2005-04-15 Antikörper gegen phosphorylcholinkonjugate
AT05735991T ATE480778T1 (de) 2004-04-15 2005-04-15 Verfahren zur feststellung der gefahren von ischemischen herzgefässerkrankungen mit phosphorylcholinkonjugaten

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT05735991T ATE480778T1 (de) 2004-04-15 2005-04-15 Verfahren zur feststellung der gefahren von ischemischen herzgefässerkrankungen mit phosphorylcholinkonjugaten

Country Status (15)

Country Link
US (4) US8012483B2 (de)
EP (3) EP1797893B1 (de)
JP (2) JP4891228B2 (de)
CN (4) CN1968965B (de)
AT (2) ATE463254T1 (de)
AU (2) AU2005233361B2 (de)
CA (2) CA2776927C (de)
CY (2) CY1110188T1 (de)
DE (2) DE602005023428D1 (de)
DK (2) DK1735349T3 (de)
ES (2) ES2357606T3 (de)
PL (2) PL1735349T3 (de)
PT (2) PT1797893E (de)
SI (2) SI1797893T1 (de)
WO (1) WO2005100405A2 (de)

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* Cited by examiner, † Cited by third party
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CN101076254B (zh) 2004-12-22 2012-10-31 雅芳产品公司 减轻皱纹外观的方法和组合物
AU2006212889A1 (en) * 2005-02-07 2006-08-17 The Regents Of The University Of California Methods for reducing the symptoms of autoimmunity and inflammation using binding proteins against antigens exposed on dead or dying cells
AU2007277146B2 (en) * 2006-07-26 2011-10-20 Inova Diagnostics, Inc. Compositions and methods for diagnosing patients with acute atherosclerotic syndromes
JP2010515023A (ja) * 2006-12-22 2010-05-06 アボット・ラボラトリーズ 心血管系自己免疫疾患パネルおよびその使用方法
CN101842119A (zh) * 2007-10-30 2010-09-22 阿瑟拉生物技术公司 心血管疾病的诊断和治疗方法及组合物
WO2010003602A1 (en) 2008-07-07 2010-01-14 Athera Biotechnologies Ab New therapeutic and diagnostic methods for alzheimer's disease
CU23736A1 (es) 2009-05-04 2011-11-15 Centro Inmunologia Molecular Anticuerpos que reconocen sulfatidos y proteoglicanos sulfatados y su uso
AU2011223222B2 (en) * 2010-03-04 2016-11-17 Athera Biotechnologies Ab Antibodies against phosphorylcholine in combination therapy with biologic agents
WO2012010291A1 (en) 2010-07-21 2012-01-26 Athera Biotechnologies Ab Diagnostic and therapeutic methods and compositions for metabolic disease
WO2012067165A1 (ja) * 2010-11-17 2012-05-24 国立大学法人愛媛大学 自己免疫疾患に関与するタンパク質の解析方法及び該疾患の検査方法
US9796786B2 (en) 2011-08-09 2017-10-24 Athera Biotechnologies Ab Antibodies binding to phosphorylcholine (PC) and/or PC conjugates
PL2742068T3 (pl) * 2011-08-09 2020-01-31 Athera Biotechnologies Ab Nowe przeciwciała przeciwko fosforylcholinie
US9987372B2 (en) 2013-02-05 2018-06-05 Tpcera Ltd. Phosphorylcholine conjugates and uses thereof
US10046021B2 (en) 2013-02-05 2018-08-14 Tpcera Ltd. Phosphorylcholine conjugates and uses thereof
US10500260B2 (en) * 2014-02-04 2019-12-10 3Dt Holdings, Llc Substances, vaccines and methods for diagnosing and reducing incidences of transplant rejection
US11065319B2 (en) * 2014-02-04 2021-07-20 3Dt Holdings, Llc Methods for diagnosing and reducing incidences of cardiac allograft rejection
JP6547755B2 (ja) 2014-10-15 2019-07-24 日油株式会社 ホスホリルコリン基含有化合物およびホスホリルコリン複合体
CN105175504A (zh) * 2015-09-08 2015-12-23 苏州普罗达生物科技有限公司 血管性血友病因子抑制多肽及其应用
WO2018220224A1 (en) * 2017-06-02 2018-12-06 Medirista Biotechnologies Ab Lipid-related antigens and antibodies directed against them
GB2622559A (en) * 2022-05-10 2024-03-27 Johan Frostegaard Compositions, methods and uses
WO2024028192A1 (de) 2022-08-04 2024-02-08 Pentracor Gmbh Verwendung von phosphocholin-humanserumalbumin-konjugaten zur blockade von c-reaktivem protein

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JPS6251699A (ja) * 1985-08-30 1987-03-06 Nichirei:Kk 単クロ−ン性抗体およびそれを用いる測定法
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Also Published As

Publication number Publication date
DK1735349T3 (da) 2010-12-06
CN103908669A (zh) 2014-07-09
EP1735349B1 (de) 2010-09-08
US8012483B2 (en) 2011-09-06
CN103743898B (zh) 2019-02-05
CN1968965A (zh) 2007-05-23
SI1797893T1 (sl) 2010-08-31
AU2005233361A1 (en) 2005-10-27
PT1735349E (pt) 2010-12-14
CY1111659T1 (el) 2015-10-07
US10222382B2 (en) 2019-03-05
DE602005020474D1 (de) 2010-05-20
DE602005023428D1 (de) 2010-10-21
AU2011202334B2 (en) 2012-12-06
CA2776927A1 (en) 2005-10-27
DK1797893T3 (da) 2010-08-02
PL1797893T3 (pl) 2010-09-30
US20140186360A1 (en) 2014-07-03
ES2357606T3 (es) 2011-04-28
PL1735349T3 (pl) 2011-03-31
EP1797893B1 (de) 2010-04-07
PT1797893E (pt) 2010-07-14
JP5366987B2 (ja) 2013-12-11
ATE480778T1 (de) 2010-09-15
JP4891228B2 (ja) 2012-03-07
EP2258728A1 (de) 2010-12-08
CN103743898A (zh) 2014-04-23
ES2362222T3 (es) 2011-06-29
CA2776927C (en) 2014-08-12
CN1968965B (zh) 2015-12-16
US20160131661A1 (en) 2016-05-12
US20120039895A1 (en) 2012-02-16
US20070286868A1 (en) 2007-12-13
CY1110188T1 (el) 2015-01-14
EP1735349A2 (de) 2006-12-27
SI1735349T1 (sl) 2010-12-31
JP2011099871A (ja) 2011-05-19
AU2005233361B2 (en) 2011-02-24
JP2008501636A (ja) 2008-01-24
CA2562550A1 (en) 2005-10-27
CA2562550C (en) 2013-09-24
WO2005100405A3 (en) 2006-04-13
WO2005100405A2 (en) 2005-10-27
EP1797893A2 (de) 2007-06-20
EP1797893A3 (de) 2007-06-27
CN105699669A (zh) 2016-06-22
AU2011202334A1 (en) 2011-06-09
CN103908669B (zh) 2017-07-04

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