DK1735349T3 - Fremgangsmåde til fastlæggelse af risikoen for iskæmisk cardiovaskulær sygdom under anvendelse af phosphorylcholinkonjugater - Google Patents

Fremgangsmåde til fastlæggelse af risikoen for iskæmisk cardiovaskulær sygdom under anvendelse af phosphorylcholinkonjugater

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Publication number
DK1735349T3
DK1735349T3 DK05735991.1T DK05735991T DK1735349T3 DK 1735349 T3 DK1735349 T3 DK 1735349T3 DK 05735991 T DK05735991 T DK 05735991T DK 1735349 T3 DK1735349 T3 DK 1735349T3
Authority
DK
Denmark
Prior art keywords
risk
determining
cardiovascular disease
ischemic cardiovascular
phosphorylcholine conjugates
Prior art date
Application number
DK05735991.1T
Other languages
English (en)
Inventor
Faire Ulf De
Johan Frostegaard
Original Assignee
Athera Biotechnologies Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Athera Biotechnologies Ab filed Critical Athera Biotechnologies Ab
Application granted granted Critical
Publication of DK1735349T3 publication Critical patent/DK1735349T3/da

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39583—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/323—Arteriosclerosis, Stenosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
DK05735991.1T 2004-04-15 2005-04-15 Fremgangsmåde til fastlæggelse af risikoen for iskæmisk cardiovaskulær sygdom under anvendelse af phosphorylcholinkonjugater DK1735349T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52138404P 2004-04-15 2004-04-15
PCT/GB2005/001463 WO2005100405A2 (en) 2004-04-15 2005-04-15 Phosphorylcholine conjugates and corresponding antibodies

Publications (1)

Publication Number Publication Date
DK1735349T3 true DK1735349T3 (da) 2010-12-06

Family

ID=34981497

Family Applications (2)

Application Number Title Priority Date Filing Date
DK05735991.1T DK1735349T3 (da) 2004-04-15 2005-04-15 Fremgangsmåde til fastlæggelse af risikoen for iskæmisk cardiovaskulær sygdom under anvendelse af phosphorylcholinkonjugater
DK06077208.4T DK1797893T3 (da) 2004-04-15 2005-04-15 Antistoffer mod phosphorylcholinkonjugater

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK06077208.4T DK1797893T3 (da) 2004-04-15 2005-04-15 Antistoffer mod phosphorylcholinkonjugater

Country Status (15)

Country Link
US (4) US8012483B2 (da)
EP (3) EP2258728A1 (da)
JP (2) JP4891228B2 (da)
CN (4) CN105699669A (da)
AT (2) ATE480778T1 (da)
AU (2) AU2005233361B2 (da)
CA (2) CA2776927C (da)
CY (2) CY1110188T1 (da)
DE (2) DE602005020474D1 (da)
DK (2) DK1735349T3 (da)
ES (2) ES2357606T3 (da)
PL (2) PL1735349T3 (da)
PT (2) PT1797893E (da)
SI (2) SI1797893T1 (da)
WO (1) WO2005100405A2 (da)

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WO2006086288A2 (en) * 2005-02-07 2006-08-17 The Regents Of The University Of California Methods for reducing the symptoms of autoimmunity and inflammation using binding proteins against antigens exposed on dead or dying cells
EP2047263A4 (en) * 2006-07-26 2009-11-18 Inova Diagnostics Inc COMPOSITIONS AND METHODS OF DIAGNOSIS IN PATIENTS WITH ACUTE ATHEROSCLEROTIC SYNDROME
EP2115466A4 (en) * 2006-12-22 2010-07-28 Abbott Lab HEART CIRCUIT AUTOIMMUNE DISEASE TEST GROUP AND METHOD FOR USE THEREOF
JP2011500868A (ja) * 2007-10-30 2011-01-06 アセラ・バイオテクノロジーズ・アーベー 心血管疾患用の診断及び治療法並びに組成物
WO2010003602A1 (en) 2008-07-07 2010-01-14 Athera Biotechnologies Ab New therapeutic and diagnostic methods for alzheimer's disease
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WO2011107291A1 (en) * 2010-03-04 2011-09-09 Medirista Biotechnologies Ab Antibodies against phosphorylcholine in combination therapy with biologic agents
WO2012010291A1 (en) 2010-07-21 2012-01-26 Athera Biotechnologies Ab Diagnostic and therapeutic methods and compositions for metabolic disease
WO2012067165A1 (ja) * 2010-11-17 2012-05-24 国立大学法人愛媛大学 自己免疫疾患に関与するタンパク質の解析方法及び該疾患の検査方法
JP6277126B2 (ja) * 2011-08-09 2018-02-07 アセラ・バイオテクノロジーズ・アーベー ホスホリルコリン（ｐｃ）および／またはｐｃコンジュゲートに結合する抗体
SG2014009344A (en) * 2011-08-09 2014-07-30 Athera Biotechnologies Ab New antibodies against phosphorylcholine
US10046021B2 (en) 2013-02-05 2018-08-14 Tpcera Ltd. Phosphorylcholine conjugates and uses thereof
WO2014122646A1 (en) 2013-02-05 2014-08-14 Tel Hashomer Medical Research Infrastructure And Services Ltd. Phosphorylcholine conjugates and uses thereof
US11065319B2 (en) * 2014-02-04 2021-07-20 3Dt Holdings, Llc Methods for diagnosing and reducing incidences of cardiac allograft rejection
US10500260B2 (en) * 2014-02-04 2019-12-10 3Dt Holdings, Llc Substances, vaccines and methods for diagnosing and reducing incidences of transplant rejection
US9850266B2 (en) 2014-10-15 2017-12-26 Nof Corporation Phosphorylcholine group-containing compound and phosphorylcholine complex
CN105175504A (zh) * 2015-09-08 2015-12-23 苏州普罗达生物科技有限公司 血管性血友病因子抑制多肽及其应用
WO2018220224A1 (en) * 2017-06-02 2018-12-06 Medirista Biotechnologies Ab Lipid-related antigens and antibodies directed against them
GB2622559A (en) 2022-05-10 2024-03-27 Johan Frostegaard Compositions, methods and uses
WO2024028192A1 (de) 2022-08-04 2024-02-08 Pentracor Gmbh Verwendung von phosphocholin-humanserumalbumin-konjugaten zur blockade von c-reaktivem protein

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Also Published As

Publication number Publication date
ES2362222T3 (es) 2011-06-29
DK1797893T3 (da) 2010-08-02
PT1735349E (pt) 2010-12-14
AU2011202334B2 (en) 2012-12-06
CN103908669A (zh) 2014-07-09
CN103743898B (zh) 2019-02-05
AU2011202334A1 (en) 2011-06-09
AU2005233361A1 (en) 2005-10-27
CY1111659T1 (el) 2015-10-07
EP2258728A1 (en) 2010-12-08
US20160131661A1 (en) 2016-05-12
SI1735349T1 (sl) 2010-12-31
CA2776927C (en) 2014-08-12
EP1797893A2 (en) 2007-06-20
CN103743898A (zh) 2014-04-23
WO2005100405A2 (en) 2005-10-27
PT1797893E (pt) 2010-07-14
EP1735349B1 (en) 2010-09-08
ATE480778T1 (de) 2010-09-15
CA2562550C (en) 2013-09-24
JP4891228B2 (ja) 2012-03-07
ES2357606T3 (es) 2011-04-28
CA2562550A1 (en) 2005-10-27
US8012483B2 (en) 2011-09-06
CA2776927A1 (en) 2005-10-27
EP1735349A2 (en) 2006-12-27
AU2005233361B2 (en) 2011-02-24
JP2011099871A (ja) 2011-05-19
WO2005100405A3 (en) 2006-04-13
CY1110188T1 (el) 2015-01-14
US20120039895A1 (en) 2012-02-16
PL1797893T3 (pl) 2010-09-30
US20140186360A1 (en) 2014-07-03
DE602005023428D1 (de) 2010-10-21
SI1797893T1 (sl) 2010-08-31
JP2008501636A (ja) 2008-01-24
US10222382B2 (en) 2019-03-05
EP1797893A3 (en) 2007-06-27
DE602005020474D1 (de) 2010-05-20
PL1735349T3 (pl) 2011-03-31
EP1797893B1 (en) 2010-04-07
US20070286868A1 (en) 2007-12-13
ATE463254T1 (de) 2010-04-15
CN1968965A (zh) 2007-05-23
CN105699669A (zh) 2016-06-22
JP5366987B2 (ja) 2013-12-11
CN1968965B (zh) 2015-12-16
CN103908669B (zh) 2017-07-04

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