ES2311927T5 - Proceso para la producción de 3-oxo-pregn-4-en-21,17-carbolactonas por la oxidación sin metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos - Google Patents

Proceso para la producción de 3-oxo-pregn-4-en-21,17-carbolactonas por la oxidación sin metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos Download PDF

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Publication number
ES2311927T5
ES2311927T5 ES05090214.7T ES05090214T ES2311927T5 ES 2311927 T5 ES2311927 T5 ES 2311927T5 ES 05090214 T ES05090214 T ES 05090214T ES 2311927 T5 ES2311927 T5 ES 2311927T5
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Spain
Prior art keywords
hydrogen
group
process according
double bond
formula
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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ES05090214.7T
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English (en)
Spanish (es)
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ES2311927T3 (es
Inventor
Carsten Seilz
Hartmut Seba
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Bayer Pharma AG
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Bayer Pharma AG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35744678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2311927(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of ES2311927T3 publication Critical patent/ES2311927T3/es
Application granted granted Critical
Publication of ES2311927T5 publication Critical patent/ES2311927T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES05090214.7T 2005-07-21 2005-07-21 Proceso para la producción de 3-oxo-pregn-4-en-21,17-carbolactonas por la oxidación sin metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos Expired - Lifetime ES2311927T5 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05090214.7A EP1746101B2 (de) 2005-07-21 2005-07-21 Verfahren zur Herstellung von 3-Oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie Oxidation von 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanen

Publications (2)

Publication Number Publication Date
ES2311927T3 ES2311927T3 (es) 2009-02-16
ES2311927T5 true ES2311927T5 (es) 2014-09-08

Family

ID=35744678

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05090214.7T Expired - Lifetime ES2311927T5 (es) 2005-07-21 2005-07-21 Proceso para la producción de 3-oxo-pregn-4-en-21,17-carbolactonas por la oxidación sin metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos

Country Status (22)

Country Link
US (2) US20070049747A1 (OSRAM)
EP (1) EP1746101B2 (OSRAM)
JP (2) JP5345843B2 (OSRAM)
CN (1) CN101223186B (OSRAM)
AR (1) AR055993A1 (OSRAM)
AT (1) ATE403668T1 (OSRAM)
CY (1) CY1110411T1 (OSRAM)
DE (1) DE502005004948D1 (OSRAM)
DK (1) DK1746101T4 (OSRAM)
DO (1) DOP2006000172A (OSRAM)
ES (1) ES2311927T5 (OSRAM)
GT (1) GT200600321A (OSRAM)
MY (1) MY147795A (OSRAM)
PE (2) PE20131303A1 (OSRAM)
PL (1) PL1746101T5 (OSRAM)
PT (1) PT1746101E (OSRAM)
SI (1) SI1746101T2 (OSRAM)
SV (1) SV2007002621A (OSRAM)
TW (1) TWI392683B (OSRAM)
UA (1) UA100092C2 (OSRAM)
UY (1) UY29686A1 (OSRAM)
ZA (1) ZA200801674B (OSRAM)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE502005004948D1 (de) * 2005-07-21 2008-09-18 Bayer Schering Pharma Ag Verfahren zur Herstellung von 3-Oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie Oxidation von 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanen
WO2009111574A2 (en) * 2008-03-05 2009-09-11 Evestra, Inc. BISMETHYLENE-17α CARBOLACTONES AND RELATED USES
DE102008026793A1 (de) * 2008-06-02 2009-12-03 Bayer Schering Pharma Aktiengesellschaft C-Ring-substituierte Pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate
WO2010068500A2 (en) * 2008-11-25 2010-06-17 Evestra, Inc. PROGESTATIONAL 3-(6,6-ETHYLENE-17b-HYDROXY-3-OXO-17a-PREGNA-4-ENE-17a -YL) PROPIONIC ACID g-LACTONES
US8334375B2 (en) * 2009-04-10 2012-12-18 Evestra, Inc. Methods for the preparation of drospirenone
ES2432063T3 (es) 2009-06-16 2013-11-29 Crystal Pharma, S.A.U. Procedimiento para la obtención de 17-espirolactonas en esteroides
CN101775057B (zh) * 2010-02-09 2014-07-16 浙江仙琚制药股份有限公司 屈螺酮及其中间体的制备方法
CN101830959B (zh) * 2010-05-27 2012-07-18 杭州龙山化工有限公司 一种曲螺酮的合成方法
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
WO2012107513A1 (en) 2011-02-10 2012-08-16 Crystal Pharma, S.A.U. Process for obtaining drospirenone
CN102746370A (zh) * 2011-04-22 2012-10-24 天津金耀集团有限公司 一种氧化合成孕甾11位酮基的新工艺
DE202012013491U1 (de) * 2012-01-13 2017-02-24 Saint-Gobain Glass France Abstandshalter für Isolierverglasungen
CN102887934B (zh) * 2012-09-20 2015-05-27 杭州福斯特药业有限公司 一种屈螺酮的制备方法
CN105164144B (zh) * 2013-04-12 2017-03-08 工业化学有限公司 用于制备屈螺酮的工艺
CN104163846A (zh) * 2013-05-17 2014-11-26 上海创诺制药有限公司 一种制备曲螺酮的方法
WO2015086457A2 (de) 2013-12-12 2015-06-18 Saint-Gobain Glass France Isolierverglasung mit verbesserter abdichtung
KR20160095129A (ko) 2013-12-12 2016-08-10 쌩-고벵 글래스 프랑스 압출된 프로파일링된 밀봉체를 포함하는, 절연 글레이징 유닛용 스페이서
CN104788524B (zh) * 2014-01-16 2016-07-06 浙江仙居君业药业有限公司 一种19-去甲-4-雄甾烯-3,17-二酮的制备方法
WO2015197491A1 (de) 2014-06-27 2015-12-30 Saint-Gobain Glass France Isolierverglasung mit abstandhalter und verfahren zur herstellung
PL3161237T3 (pl) 2014-06-27 2018-12-31 Saint-Gobain Glass France Oszklenie zespolone z elementem dystansowym i sposób wytwarzania takiego oszklenia oraz jego zastosowanie jako oszklenia budynku
MX374373B (es) 2014-09-25 2025-03-06 Saint Gobain Separador para unidades de acristalamiento aislantes.
US10508486B2 (en) 2015-03-02 2019-12-17 Saint Gobain Glass France Glass-fiber-reinforced spacer for insulating glazing unit
CA2989975C (en) 2015-06-23 2021-10-12 Laboratorios Leon Farma Sa Drospirenone-based contraceptive for a female patient affected with excess weight
EP3108889A1 (en) 2015-06-23 2016-12-28 Philippe Perrin Drospirenone-based contraceptive for a female patient affected with excess weight

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069219A (en) 1976-12-27 1978-01-17 G. D. Searle & Co. 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters
DE3026783C2 (de) 1980-07-11 1982-07-29 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 5β-Hydroxy-δ↑6↑-steroiden
DE3042136A1 (de) 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
ATE15206T1 (de) 1981-09-21 1985-09-15 Schering Ag 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-1 - one, ihre 3,15-trimethylessigsaeure-ester und ihre herstellung.
US5106995A (en) 1989-05-05 1992-04-21 Isp Investments Inc. Production of lactones from diols
DE3916112A1 (de) * 1989-05-16 1990-11-22 Schering Ag Dihydrospirorenon als antiandrogen
DE19633685C1 (de) * 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
CA2495412A1 (en) * 2002-08-16 2004-02-26 Pharmacia & Upjohn Company 5 androsten-3.beta.-ol steroid intermediates and processes for their preparation
JP2005027184A (ja) * 2003-07-04 2005-01-27 Seiko Epson Corp 高周波複合部品
ITMI20040367A1 (it) * 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
ITMI20042338A1 (it) * 2004-12-06 2005-03-06 Ind Chimica Srl Processo per la preparazione di drospirenone
DE502005004948D1 (de) * 2005-07-21 2008-09-18 Bayer Schering Pharma Ag Verfahren zur Herstellung von 3-Oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie Oxidation von 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanen
US7319154B2 (en) * 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
US20080032147A1 (en) * 2005-08-26 2008-02-07 Thomas Neel Medium density fibreboard

Also Published As

Publication number Publication date
PE20131303A1 (es) 2013-11-27
ATE403668T1 (de) 2008-08-15
SI1746101T1 (sl) 2009-02-28
SI1746101T2 (sl) 2014-09-30
DK1746101T4 (da) 2014-08-11
US20070049747A1 (en) 2007-03-01
AR055993A1 (es) 2007-09-12
EP1746101A1 (de) 2007-01-24
DE502005004948D1 (de) 2008-09-18
EP1746101B1 (de) 2008-08-06
TW200716660A (en) 2007-05-01
PL1746101T3 (pl) 2009-01-30
EP1746101B2 (de) 2014-05-14
CN101223186B (zh) 2012-09-05
TWI392683B (zh) 2013-04-11
PT1746101E (pt) 2008-10-27
ES2311927T3 (es) 2009-02-16
GT200600321A (es) 2007-02-23
JP2009501753A (ja) 2009-01-22
UY29686A1 (es) 2007-02-28
CY1110411T1 (el) 2015-04-29
PE20070215A1 (es) 2007-04-11
US20110275796A1 (en) 2011-11-10
JP2013177450A (ja) 2013-09-09
PL1746101T5 (pl) 2014-11-28
DOP2006000172A (es) 2007-02-15
SV2007002621A (es) 2007-12-12
MY147795A (en) 2013-01-31
UA100092C2 (en) 2012-11-12
US8658788B2 (en) 2014-02-25
JP5345843B2 (ja) 2013-11-20
CN101223186A (zh) 2008-07-16
ZA200801674B (en) 2009-08-26
DK1746101T3 (da) 2008-11-24

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