ATE15206T1 - 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-1 - one, ihre 3,15-trimethylessigsaeure-ester und ihre herstellung. - Google Patents

3-beta,7-beta,15-alpha-trihydroxy-5-androsten-1 - one, ihre 3,15-trimethylessigsaeure-ester und ihre herstellung.

Info

Publication number
ATE15206T1
ATE15206T1 AT82108252T AT82108252T ATE15206T1 AT E15206 T1 ATE15206 T1 AT E15206T1 AT 82108252 T AT82108252 T AT 82108252T AT 82108252 T AT82108252 T AT 82108252T AT E15206 T1 ATE15206 T1 AT E15206T1
Authority
AT
Austria
Prior art keywords
beta
alpha
trihydroxy
androstene
production
Prior art date
Application number
AT82108252T
Other languages
English (en)
Inventor
Karl Dr Petzoldt
Henry Dr Laurent
Rudolf Prof Dr Wiechert
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of ATE15206T1 publication Critical patent/ATE15206T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT82108252T 1981-09-21 1982-09-08 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-1 - one, ihre 3,15-trimethylessigsaeure-ester und ihre herstellung. ATE15206T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3137919 1981-09-21
EP82108252A EP0075189B1 (de) 1981-09-21 1982-09-08 3-Beta,7-beta,15-alpha-Trihydroxy-5-androsten-17-one, ihre 3,15-Trimethylessigsäure-Ester und ihre Herstellung

Publications (1)

Publication Number Publication Date
ATE15206T1 true ATE15206T1 (de) 1985-09-15

Family

ID=6142442

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82108252T ATE15206T1 (de) 1981-09-21 1982-09-08 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-1 - one, ihre 3,15-trimethylessigsaeure-ester und ihre herstellung.

Country Status (11)

Country Link
US (1) US4435327A (de)
EP (1) EP0075189B1 (de)
JP (1) JPS5865299A (de)
AT (1) ATE15206T1 (de)
AU (1) AU555388B2 (de)
CA (1) CA1203796A (de)
DE (1) DE3265852D1 (de)
DK (1) DK411882A (de)
HU (1) HU185184B (de)
IE (1) IE53956B1 (de)
IL (1) IL66820A (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3042136A1 (de) * 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
US5461042A (en) * 1988-12-30 1995-10-24 Loria; Roger M. Regulation of the immune system
DE19633685C1 (de) 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
US20050101581A1 (en) * 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
WO2004070048A1 (en) * 2003-02-07 2004-08-19 Pharmacia & Upjohn Company Llc A microbial process to prepare 5-androsten-3beta, 7alpha, 15alpha-triol-17-one and related analogues
ITMI20040367A1 (it) 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
HUP0402465A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
DE102004058300B4 (de) 2004-12-02 2016-09-15 Austriamicrosystems Ag Schaltungsanordnung zur Erzeugung eines komplexen Signals und Verwendung in einem Hochfrequenz-Sender oder -Empfänger
ITMI20042338A1 (it) * 2004-12-06 2005-03-06 Ind Chimica Srl Processo per la preparazione di drospirenone
US7319154B2 (en) 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
PL1746101T5 (pl) 2005-07-21 2014-11-28 Bayer Pharma AG Sposób wytwarzania 3-oksopreg-4-eno-21,17-karbolaktonów drogą bezmetalowego utleniania 17-(3-hydroksypropylo-3,17-dihydroksyandrostanu
PT1910403T (pt) 2005-07-21 2016-07-14 Bayer Pharma AG Processo para a produção de 3-oxo-pregn-4-eno-21,17- carbolactonas através da oxidação isenta de metais de 17- (3-hidroxipropil)-3,17-diidroxiandrostanos
EP2057182A2 (de) * 2007-05-01 2009-05-13 Sicor, Inc. Verfahren zur herstellung von drospirenon und zwischenprodukten davon
DE102007030596B3 (de) * 2007-06-28 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
CN101343306B (zh) * 2007-07-12 2011-06-08 江苏希迪制药有限公司 合成6,7-亚甲基甾体化合物的方法
EP2265629B1 (de) * 2008-03-05 2015-06-24 Evestra, Inc. Bismethylen-17-carbolactone und damit in zusammenhang stehende anwendungen
CN101570775B (zh) * 2008-05-04 2012-03-21 上海医药工业研究院 微生物转化法制备3β,7β-二羟基-15β,16β-亚甲基-5-雄烯-17-酮的方法
WO2010068500A2 (en) * 2008-11-25 2010-06-17 Evestra, Inc. PROGESTATIONAL 3-(6,6-ETHYLENE-17b-HYDROXY-3-OXO-17a-PREGNA-4-ENE-17a -YL) PROPIONIC ACID g-LACTONES
ES2432063T3 (es) 2009-06-16 2013-11-29 Crystal Pharma, S.A.U. Procedimiento para la obtención de 17-espirolactonas en esteroides
EP2548881B1 (de) 2010-03-16 2014-12-17 Taizhou Taifa Pharmaceuticals Co., Ltd Verfahren zur herstellung von drospirenon
ES2419663T3 (es) 2010-08-03 2013-08-21 Newchem S.P.A. Métodos para la preparación de Drospirenona y productos intermedios de la misma
ITMI20111383A1 (it) 2011-07-25 2013-01-26 Ind Chimica Srl Processo per la preparazione di drospirenone
ES2607778T3 (es) 2011-11-22 2017-04-04 Industriale Chimica S.R.L. Proceso para la preparación de drospirenona
EP2597101A1 (de) 2011-11-22 2013-05-29 Industriale Chimica S.R.L. Verfahren zur Herstellung von Drospirenon
CN103626817B (zh) * 2012-03-08 2016-01-20 广州市赛普特医药科技有限公司 雄甾-3β,5α,6β-三醇的晶型化合物及其制备方法
CN102887934B (zh) * 2012-09-20 2015-05-27 杭州福斯特药业有限公司 一种屈螺酮的制备方法
ES2651145T3 (es) 2013-02-20 2018-01-24 Industriale Chimica S.R.L. Proceso para la preparación de drospirenona
PL2984100T3 (pl) 2013-04-12 2017-10-31 Ind Chimica Srl Sposób otrzymywania drospirenonu
CN104163846A (zh) * 2013-05-17 2014-11-26 上海创诺制药有限公司 一种制备曲螺酮的方法
CN103408628B (zh) * 2013-08-19 2015-12-02 江苏佳尔科药业集团有限公司 3β,5-二羟基-6β,7β；15β,16β-二亚甲基-5β-雄甾-17-酮的制备方法
CN110407905B (zh) * 2019-08-22 2021-09-28 武汉九珑人福药业有限责任公司 一种屈螺酮及其中间体的制备方法
CN114478672B (zh) * 2022-01-27 2024-06-14 浙江仙居君业药业有限公司 一种he3286的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2746298A1 (de) * 1977-10-13 1979-04-19 Schering Ag 4-androsten-3,17-dion-derivate, ihre herstellung und verwendung
US4303754A (en) * 1980-03-17 1981-12-01 Macdonald Ian Method for obtaining 7β hydroxy steroids
DE3042136A1 (de) * 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden

Also Published As

Publication number Publication date
DE3265852D1 (en) 1985-10-03
IL66820A (en) 1985-12-31
US4435327A (en) 1984-03-06
IE822284L (en) 1983-03-21
EP0075189A1 (de) 1983-03-30
HU185184B (en) 1984-12-28
IL66820A0 (en) 1982-12-31
AU8845882A (en) 1983-03-31
CA1203796A (en) 1986-04-29
AU555388B2 (en) 1986-09-25
JPS5865299A (ja) 1983-04-18
IE53956B1 (en) 1989-04-26
EP0075189B1 (de) 1985-08-28
DK411882A (da) 1983-03-22
JPH0357917B2 (de) 1991-09-03

Similar Documents

Publication Publication Date Title
ATE15206T1 (de) 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-1 - one, ihre 3,15-trimethylessigsaeure-ester und ihre herstellung.
DE68920234D1 (de) Verfahren zur Herstellung eines oxidischen Supraleiters.
SE8604059D0 (sv) A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
BE860052A (fr) Procede de preparation de derives organiques d'etain d'esters mercaptoalcooliques
IS1697B (is) Hliðstæð aðferð til framleiðslu á 3,3'-dithiobis (própíónsýrum) og esterum þeirra
FR2317540A1 (fr) Rondelle d'arret axial et ses applications, ainsi que procede et dispositif pour sa fabrication
NO891265L (no) Fremgangsmaate for fremstilling av 4-halogen-3-okso-alkoksyiminosmoersyreestere.
NL182565C (nl) 1-oxo-1h-thiazolo(3,2-a)pyrimidine-2-carbonzuurderivaat met antiallergische en/of antimaagzuurwerking en farmaceutisch voorwerp, dat een dergelijke verbinding bevat.
DE69020627D1 (de) Supraleitende Einrichtung mit drei Anschlüssen und Prozess für deren Herstellung.
FI890864A (fi) Anvaendning av 1,4-dihydropyridinderivat.
DE2964718D1 (en) Process for the preparation of 7-oxabicyclo(4.1.0)heptane-3,4-dicarboxylic acid diglycidyl ester
DD138981A5 (de) Verfahren zur herstellung von 17 alpha-(3-jodbenzoyloxy)-9 alpha-chlor-4-pregnen-3.20-dionen und deren d-homo-analoga
ATA437279A (de) Phenanthrenderivate, verfahren zu deren herstellung sowie die phenanthren- derivate enthaltenden pharmazeutischen zusammensetzungen
SU672036A2 (ru) Устройство дл изготовлени железобетонных изделий
DE3854134D1 (de) Supraleitendes Oxyd und Verfahren zur seiner Herstellung.
AU2484488A (en) Method for the production of antigenic protein-hapten conjugates, and antibodies corresponding thereto
ES481296A1 (es) Un procedimiento para la preparacion de esteres de deriva- dos del acido aminolo-piran-4-ona-2-carboxilico.
ZA792412B (en) Penicillanic acid derivative and process for preparing the same
DE2964538D1 (en) Process for the preparation of 7-oxabicyclo(4.1.0)heptane-3,4-dicarboxylic acid diglycidyl ester
IL65853A0 (en) Process for the preparation of 3,3-dimethylglutaric acid and its esters
FR1274420A (fr) Procédé de préparation de la delta-16alpha-méthyl-prégnadiène-11alpha, 17alpha-21-triol-3, 20 dione et de ses esters, ainsi que de la 16alpha-méthyl-2, 4-dibromo-prégnadiène-11alpha, 17alpha, 21-triol-3, 20-dione et de ses esters
CA597947A (en) Process for the production of naphthalene-2,6-dicarboxylic acid and its derivatives
KR790000589B1 (en) Method for producing 6l-fluoro-17,21-dehydroxy-16b-methylpregna-4,9(11)diene-3,20-dione17,21-diacetate
IL57838A (en) Process for the preparation of o-methyl-n-cyclohexyl-2,5-dimethyl-furan-3-hydroxamic acid,n-cyclohexyl-n-methoxyacetoacetamide employed as intermediate therein and its preparation
CA920597A (en) Process for the production of o,o-dimethyl-thionophosphoric acid (o-quinoxalyl-(2)) ester

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee