DK411882A - 3beta,7beta,15alfa-trihydroxy-5-androsten-17-on og dens 3,15-dipivalat samt fremgangsmaade til deres fremstilling - Google Patents

3beta,7beta,15alfa-trihydroxy-5-androsten-17-on og dens 3,15-dipivalat samt fremgangsmaade til deres fremstilling Download PDF

Info

Publication number
DK411882A
DK411882A DK411882A DK411882A DK411882A DK 411882 A DK411882 A DK 411882A DK 411882 A DK411882 A DK 411882A DK 411882 A DK411882 A DK 411882A DK 411882 A DK411882 A DK 411882A
Authority
DK
Denmark
Prior art keywords
beta
androsten
trihydroxy
alpha
dipivalate
Prior art date
Application number
DK411882A
Other languages
Danish (da)
English (en)
Inventor
Karl Petzoldt
Henry Laurent
Rudolf Wiechert
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK411882A publication Critical patent/DK411882A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK411882A 1981-09-21 1982-09-15 3beta,7beta,15alfa-trihydroxy-5-androsten-17-on og dens 3,15-dipivalat samt fremgangsmaade til deres fremstilling DK411882A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3137919 1981-09-21

Publications (1)

Publication Number Publication Date
DK411882A true DK411882A (da) 1983-03-22

Family

ID=6142442

Family Applications (1)

Application Number Title Priority Date Filing Date
DK411882A DK411882A (da) 1981-09-21 1982-09-15 3beta,7beta,15alfa-trihydroxy-5-androsten-17-on og dens 3,15-dipivalat samt fremgangsmaade til deres fremstilling

Country Status (11)

Country Link
US (1) US4435327A (de)
EP (1) EP0075189B1 (de)
JP (1) JPS5865299A (de)
AT (1) ATE15206T1 (de)
AU (1) AU555388B2 (de)
CA (1) CA1203796A (de)
DE (1) DE3265852D1 (de)
DK (1) DK411882A (de)
HU (1) HU185184B (de)
IE (1) IE53956B1 (de)
IL (1) IL66820A (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3042136A1 (de) * 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
US5461042A (en) * 1988-12-30 1995-10-24 Loria; Roger M. Regulation of the immune system
DE19633685C1 (de) * 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
US20050101581A1 (en) * 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
WO2004070048A1 (en) * 2003-02-07 2004-08-19 Pharmacia & Upjohn Company Llc A microbial process to prepare 5-androsten-3beta, 7alpha, 15alpha-triol-17-one and related analogues
ITMI20040367A1 (it) * 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
HUP0402465A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
DE102004058300B4 (de) 2004-12-02 2016-09-15 Austriamicrosystems Ag Schaltungsanordnung zur Erzeugung eines komplexen Signals und Verwendung in einem Hochfrequenz-Sender oder -Empfänger
ITMI20042338A1 (it) 2004-12-06 2005-03-06 Ind Chimica Srl Processo per la preparazione di drospirenone
US7319154B2 (en) 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
ES2311927T5 (es) 2005-07-21 2014-09-08 Bayer Pharma Aktiengesellschaft Proceso para la producción de 3-oxo-pregn-4-en-21,17-carbolactonas por la oxidación sin metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos
MX2008000936A (es) 2005-07-21 2008-03-27 Bayer Schering Pharma Ag Proceso para producir 3-oxo-pregn-4-eno-21,17-carbolactonas por oxidacion libre de metales de 17-(3-hidroxipropil)-3,17-dihidroxia ndrostanos.
MX2008016571A (es) * 2007-05-01 2009-03-09 Sicor Inc Proceso para preparar drospirenona y su intermediarios.
DE102007030596B3 (de) * 2007-06-28 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
CN101343306B (zh) * 2007-07-12 2011-06-08 江苏希迪制药有限公司 合成6,7-亚甲基甾体化合物的方法
WO2009111574A2 (en) * 2008-03-05 2009-09-11 Evestra, Inc. BISMETHYLENE-17α CARBOLACTONES AND RELATED USES
CN101570775B (zh) * 2008-05-04 2012-03-21 上海医药工业研究院 微生物转化法制备3β,7β-二羟基-15β,16β-亚甲基-5-雄烯-17-酮的方法
US8222237B2 (en) * 2008-11-25 2012-07-17 Evestra, Inc. Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones
ES2432063T3 (es) 2009-06-16 2013-11-29 Crystal Pharma, S.A.U. Procedimiento para la obtención de 17-espirolactonas en esteroides
EP2548881B1 (de) 2010-03-16 2014-12-17 Taizhou Taifa Pharmaceuticals Co., Ltd Verfahren zur herstellung von drospirenon
EP2415778B1 (de) 2010-08-03 2013-05-15 Newchem S.p.A. Herstellungsverfahren für Drospirenon und Zwischenprodukte davon
ITMI20111383A1 (it) 2011-07-25 2013-01-26 Ind Chimica Srl Processo per la preparazione di drospirenone
CA2856324C (en) 2011-11-22 2019-08-13 Industriale Chimica S.R.L. Process for the preparation of drospirenone
EP2597101A1 (de) 2011-11-22 2013-05-29 Industriale Chimica S.R.L. Verfahren zur Herstellung von Drospirenon
CN102617685B (zh) * 2012-03-08 2014-01-22 广州市赛普特医药科技有限公司 雄甾-3β,5α,6β-三醇的晶型化合物及其制备方法
CN102887934B (zh) * 2012-09-20 2015-05-27 杭州福斯特药业有限公司 一种屈螺酮的制备方法
EP2958929B1 (de) 2013-02-20 2017-09-13 Industriale Chimica S.R.L. Verfahren zur herstellung von drospirenon
DK2984100T3 (en) 2013-04-12 2017-07-10 Ind Chimica Srl Process for the preparation of drospirenone
CN104163846A (zh) * 2013-05-17 2014-11-26 上海创诺制药有限公司 一种制备曲螺酮的方法
CN103408628B (zh) * 2013-08-19 2015-12-02 江苏佳尔科药业集团有限公司 3β,5-二羟基-6β,7β；15β,16β-二亚甲基-5β-雄甾-17-酮的制备方法
CN110407905B (zh) * 2019-08-22 2021-09-28 武汉九珑人福药业有限责任公司 一种屈螺酮及其中间体的制备方法
CN114478672B (zh) * 2022-01-27 2024-06-14 浙江仙居君业药业有限公司 一种he3286的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2746298A1 (de) * 1977-10-13 1979-04-19 Schering Ag 4-androsten-3,17-dion-derivate, ihre herstellung und verwendung
US4303754A (en) * 1980-03-17 1981-12-01 Macdonald Ian Method for obtaining 7β hydroxy steroids
DE3042136A1 (de) * 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden

Also Published As

Publication number Publication date
IE53956B1 (en) 1989-04-26
US4435327A (en) 1984-03-06
AU555388B2 (en) 1986-09-25
IL66820A (en) 1985-12-31
DE3265852D1 (en) 1985-10-03
JPS5865299A (ja) 1983-04-18
IL66820A0 (en) 1982-12-31
HU185184B (en) 1984-12-28
EP0075189A1 (de) 1983-03-30
CA1203796A (en) 1986-04-29
AU8845882A (en) 1983-03-31
ATE15206T1 (de) 1985-09-15
JPH0357917B2 (de) 1991-09-03
IE822284L (en) 1983-03-21
EP0075189B1 (de) 1985-08-28

Similar Documents

Publication Publication Date Title
DK411882A (da) 3beta,7beta,15alfa-trihydroxy-5-androsten-17-on og dens 3,15-dipivalat samt fremgangsmaade til deres fremstilling
NO883540D0 (no) Fremgangsmaate og anlegg for behandling av slam.
DK572788A (da) Polysvovlsyreestere af bis-aldonamider og derivater deraf samt fremgangsmaade til fremstilling af samme
NL188266C (nl) Werkwijze ter bereiding van een oogheelkundig inplantaat.
IS3412A7 (is) Hliðstæðuaðferð til framleiðslu á cytidine-afleiðum
NL191308C (nl) Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside.
GB2100601B (en) An aromatase-inhibitor for use in a method of prophylaxis and/or of treatment by therapy of prostatic hyperplasia, and pharmaceutical preparations suitable for such a use.
IS1571B (is) Aðferð til framleiðslu á afleiðum tetralíns, cromans og skyldra efnasambanda til meðferðar á asma, liðagigt og skyldum sjúkdómum
BR8108413A (pt) Processo organico,de uma fase,para a preparacao de um composto halocarbonilbis(triorganofosforo)rodio;processo para preparar um composto hidretocarboniltris(triorganofosforo)rodio;processo para preparar hidretocarboniltris(trifenilfosfica)rodio
FI890257A (fi) Menetelmä terapeuttisesti käyttökelpoisten pyridiinijohdannaisten valmistamiseksi
DK188286A (da) Phenylalkyl-2,3-dihydrobenzofuraner og analoge heraf samt praeparater indeholdende disse forbindelser
NL190485B (nl) Alfa-fluormethyl-alfa-aminoalkaanzuurderivaat, farmaceutisch preparaat dat een of meer zodanige verbindingen bevat, alsmede werkwijze voor het bereiden van de verbindingen.
NL7904231A (nl) Werkwijze ter bereiding van anti-wormpreparaten.
DK162880C (da) Fremgangsmaade til behandling af acycli hos faar og kvaeg, og anvendelse af gestagener og lh-rh eller dettes analoge ved behandling af acycli hos faar og kvaeg
IT1216724B (it) Dispositivo di accoppiamento per organi di impostazione da accoppiare reciprocamente specialmente aste cavetti bowdeno similari.
DK585984D0 (da) 1,7-diphenyl-3-methylaza-7-cyan-8-methyl-nonan og salte deraf til anvendelse ved bekaempelse af sygdomme samt fremgangsmaade til fremstilling af saadanne nonanderivater
DE2964324D1 (en) Process for the preparation of compounds containing hydantoin groups
DK428184A (da) 2-oxocarbonsyrereduktase, fremgangsmaade til fremstilling heraf samt anvendelse heraf til reduktion af 2-oxocarbonsyrer og disses estere
FI890864A (fi) Anvaendning av 1,4-dihydropyridinderivat.
FR2623503B1 (de)
NO880592D0 (no) Herdbare harpikser, fremgangsmaate for fremstilling av disse og anvendelse av disse.
IT8183384A0 (it) Procedimento per la maturazione forzata della sostanza organica in compost.
DE2964718D1 (en) Process for the preparation of 7-oxabicyclo(4.1.0)heptane-3,4-dicarboxylic acid diglycidyl ester
FR2630104B1 (fr) Procede de preparation de disulfures organiques
JPS5245991A (en) Method and device for drying and incinerating organic samples

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment