ES2305096T3 - Composicion farmaceutico que comprende un peptido analgesico. - Google Patents
Composicion farmaceutico que comprende un peptido analgesico. Download PDFInfo
- Publication number
- ES2305096T3 ES2305096T3 ES01958334T ES01958334T ES2305096T3 ES 2305096 T3 ES2305096 T3 ES 2305096T3 ES 01958334 T ES01958334 T ES 01958334T ES 01958334 T ES01958334 T ES 01958334T ES 2305096 T3 ES2305096 T3 ES 2305096T3
- Authority
- ES
- Spain
- Prior art keywords
- peptide
- trp
- amino acid
- asn
- pglu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 64
- 150000001413 amino acids Chemical group 0.000 claims abstract description 48
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 25
- 230000000202 analgesic effect Effects 0.000 claims abstract description 25
- 208000002193 Pain Diseases 0.000 claims abstract description 23
- 230000036407 pain Effects 0.000 claims abstract description 22
- 230000000699 topical effect Effects 0.000 claims abstract description 9
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 238000011200 topical administration Methods 0.000 claims abstract description 6
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- 239000000203 mixture Substances 0.000 claims description 15
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- 125000005907 alkyl ester group Chemical group 0.000 claims description 4
- 150000001408 amides Chemical class 0.000 claims description 3
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 abstract description 9
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- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 5
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- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 4
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- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 4
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- 239000002435 venom Substances 0.000 description 4
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- ADFXKUOMJKEIND-UHFFFAOYSA-N 1,3-dicyclohexylurea Chemical compound C1CCCCC1NC(=O)NC1CCCCC1 ADFXKUOMJKEIND-UHFFFAOYSA-N 0.000 description 3
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- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 208000000094 Chronic Pain Diseases 0.000 description 1
- 241000272060 Elapidae Species 0.000 description 1
- 206010061459 Gastrointestinal ulcer Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
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- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical group C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241000272139 Naja melanoleuca Species 0.000 description 1
- 102400001103 Neurotensin Human genes 0.000 description 1
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- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
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- CLZISMQKJZCZDN-UHFFFAOYSA-N [benzotriazol-1-yloxy(dimethylamino)methylidene]-dimethylazanium Chemical compound C1=CC=C2N(OC(N(C)C)=[N+](C)C)N=NC2=C1 CLZISMQKJZCZDN-UHFFFAOYSA-N 0.000 description 1
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- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
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- PCJGZPGTCUMMOT-ISULXFBGSA-N neurotensin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 PCJGZPGTCUMMOT-ISULXFBGSA-N 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
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- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL137820A IL137820A (en) | 2000-08-10 | 2000-08-10 | Pharmaceutical composition for topical administration comprising an analgesic peptide |
| IL137820 | 2000-08-10 | ||
| PCT/IL2001/000724 WO2002012269A2 (en) | 2000-08-10 | 2001-08-06 | Pharmaceutical composition comprising an analgesic peptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2305096T3 true ES2305096T3 (es) | 2008-11-01 |
Family
ID=11074512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01958334T Expired - Lifetime ES2305096T3 (es) | 2000-08-10 | 2001-08-06 | Composicion farmaceutico que comprende un peptido analgesico. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7220725B2 (enExample) |
| EP (1) | EP1309613B1 (enExample) |
| JP (1) | JP4860096B2 (enExample) |
| CN (2) | CN1462277A (enExample) |
| AT (1) | ATE392428T1 (enExample) |
| AU (2) | AU8005201A (enExample) |
| CA (1) | CA2418793C (enExample) |
| DE (1) | DE60133654T2 (enExample) |
| DK (1) | DK1309613T3 (enExample) |
| ES (1) | ES2305096T3 (enExample) |
| IL (1) | IL137820A (enExample) |
| WO (1) | WO2002012269A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL137820A (en) * | 2000-08-10 | 2009-06-15 | S I S Shulov Inst For Science | Pharmaceutical composition for topical administration comprising an analgesic peptide |
| JP2008537739A (ja) * | 2005-03-21 | 2008-09-25 | ザ トラスティース オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | 新規神経疼痛経路 |
| CA2681593A1 (en) * | 2007-03-23 | 2008-10-02 | Nisshin Pharma Inc. | Preventive or therapeutic composition for liver disease |
| KR20110060940A (ko) * | 2008-09-22 | 2011-06-08 | 닛신 파마 가부시키가이샤 | 항염증성 펩티드 |
| DK2459183T3 (en) | 2009-07-27 | 2016-01-18 | Nocicepta Llc | Methods for the treatment of pain |
| FR2948809B1 (fr) * | 2009-07-31 | 2012-08-17 | St Microelectronics Rousset | Amplificateur de lecture faible puissance auto-minute |
| MX2013011219A (es) | 2011-03-28 | 2013-10-17 | S I S Shulov Innovative Science Ltd | Metodo para el tratamiento de trastornos de la piel. |
| HRP20231438T1 (hr) | 2015-01-07 | 2024-06-07 | Tonix Pharma Limited | Formulacije oksitocina koje sadrže magnezij i načini uporabe |
| CN115814055A (zh) | 2016-04-12 | 2023-03-21 | 三叉神经股份公司 | 含镁催产素制剂和应用方法 |
| RU2669386C1 (ru) * | 2017-08-11 | 2018-10-11 | Закрытое акционерное общество "Институт экспериментальной фармакологии" | Состав и способ получения анальгетического средства пептидной структуры |
| AU2019245521B2 (en) * | 2018-03-29 | 2024-10-31 | S.I.S Shulov Innovative Science Ltd. | Pharmaceutical compositions for inhibiting inflammatory cytokines |
| US11644463B2 (en) * | 2019-08-30 | 2023-05-09 | Euroimmun Medizinische Labordiagnostika Ag | Detection of an autoantibody |
| CA3155594C (en) | 2019-09-26 | 2025-06-17 | S.I.S. Shulov Innovative Science Ltd. | Topical anti-aging compositions containing a tetrapeptide |
| WO2021059267A1 (en) * | 2019-09-26 | 2021-04-01 | S.I.S. Shulov Innovative Science Ltd. | Compositions and methods for treating degenerative, age-related and trauma-induced disorders |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4491541A (en) * | 1982-11-10 | 1985-01-01 | Farmitalia Carlo Erba | Peptides |
| IT1172391B (it) * | 1983-12-23 | 1987-06-18 | Polifarma Spa | Composti tirpeptidici contenenti acido piroglutaminico e triptofano,procedimentio di produzione ed applicazioni terapeutiche |
| JPH0680079B2 (ja) * | 1984-11-09 | 1994-10-12 | エーザイ株式会社 | ポリペプチド |
| IT1242002B (it) * | 1990-10-03 | 1994-02-02 | Polifarma Spa | Composti con attivita' farmacologica antiipertensiva, analgesica, immunomodulante e antiinfiammatoria, che presentano nella molecola una sequenza di tre radicali, essendo alfa-amminoacido quello centrale |
| AU1907292A (en) | 1991-04-24 | 1992-12-21 | Warner-Lambert Company | Alpha-substituted polypeptides having therapeutic activity |
| AUPM489194A0 (en) * | 1994-04-07 | 1994-04-28 | Luminis Pty Limited | Peptides |
| RU2107691C1 (ru) * | 1995-03-02 | 1998-03-27 | Дейгин Владислав Исакович | Пептид и способ его получения |
| US5776896A (en) * | 1996-01-03 | 1998-07-07 | Zeneca Limited | Analgesic peptides from venom of grammostola spatulata and use thereof |
| CA2256365A1 (en) * | 1996-05-22 | 1997-11-27 | Diversified Pharmaceuticals, Inc. | Compositions, methods and devices for the transdermal delivery of drugs |
| US6126939A (en) * | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| IL123001A (en) * | 1998-01-20 | 1998-12-06 | Shulov Inst For Venom Research | Analgesic fraction from snake March and pharmacy preparations containing it |
| CA2341810A1 (en) * | 1998-08-28 | 2000-03-09 | Myelos Corporation | Cyclic prosaposin-derived peptides and uses thereof |
| IL137820A (en) * | 2000-08-10 | 2009-06-15 | S I S Shulov Inst For Science | Pharmaceutical composition for topical administration comprising an analgesic peptide |
-
2000
- 2000-08-10 IL IL137820A patent/IL137820A/en active IP Right Grant
-
2001
- 2001-08-06 US US10/344,129 patent/US7220725B2/en not_active Expired - Lifetime
- 2001-08-06 WO PCT/IL2001/000724 patent/WO2002012269A2/en not_active Ceased
- 2001-08-06 DK DK01958334T patent/DK1309613T3/da active
- 2001-08-06 CN CN01816060A patent/CN1462277A/zh active Pending
- 2001-08-06 CN CN2011100520229A patent/CN102160890B/zh not_active Expired - Lifetime
- 2001-08-06 ES ES01958334T patent/ES2305096T3/es not_active Expired - Lifetime
- 2001-08-06 AU AU8005201A patent/AU8005201A/xx active Pending
- 2001-08-06 EP EP01958334A patent/EP1309613B1/en not_active Expired - Lifetime
- 2001-08-06 DE DE60133654T patent/DE60133654T2/de not_active Expired - Lifetime
- 2001-08-06 AT AT01958334T patent/ATE392428T1/de not_active IP Right Cessation
- 2001-08-06 AU AU2001280052A patent/AU2001280052B2/en not_active Expired
- 2001-08-06 JP JP2002518242A patent/JP4860096B2/ja not_active Expired - Lifetime
- 2001-08-06 CA CA2418793A patent/CA2418793C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002012269A2 (en) | 2002-02-14 |
| CN102160890A (zh) | 2011-08-24 |
| CA2418793A1 (en) | 2002-02-14 |
| WO2002012269A3 (en) | 2002-12-19 |
| HK1160778A1 (en) | 2012-08-17 |
| AU8005201A (en) | 2002-02-18 |
| US20040014673A1 (en) | 2004-01-22 |
| DK1309613T3 (da) | 2008-08-11 |
| DE60133654D1 (de) | 2008-05-29 |
| ATE392428T1 (de) | 2008-05-15 |
| CN102160890B (zh) | 2013-02-06 |
| JP4860096B2 (ja) | 2012-01-25 |
| AU2001280052B2 (en) | 2007-11-29 |
| CA2418793C (en) | 2011-11-15 |
| IL137820A0 (en) | 2001-10-31 |
| EP1309613B1 (en) | 2008-04-16 |
| CN1462277A (zh) | 2003-12-17 |
| JP2004513079A (ja) | 2004-04-30 |
| US7220725B2 (en) | 2007-05-22 |
| DE60133654T2 (de) | 2009-06-04 |
| IL137820A (en) | 2009-06-15 |
| EP1309613A2 (en) | 2003-05-14 |
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