HRP20161006T1 - Postupak liječenja kožnih poremećaja - Google Patents
Postupak liječenja kožnih poremećaja Download PDFInfo
- Publication number
- HRP20161006T1 HRP20161006T1 HRP20161006TT HRP20161006T HRP20161006T1 HR P20161006 T1 HRP20161006 T1 HR P20161006T1 HR P20161006T T HRP20161006T T HR P20161006TT HR P20161006 T HRP20161006 T HR P20161006T HR P20161006 T1 HRP20161006 T1 HR P20161006T1
- Authority
- HR
- Croatia
- Prior art keywords
- use according
- pharmaceutical form
- topical pharmaceutical
- trp
- peptide
- Prior art date
Links
- 230000000699 topical effect Effects 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000008575 L-amino acids Chemical class 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 2
- 208000010201 Exanthema Diseases 0.000 claims 1
- 206010019972 Herpes viral infections Diseases 0.000 claims 1
- 208000006877 Insect Bites and Stings Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010063562 Radiation skin injury Diseases 0.000 claims 1
- 206010053615 Thermal burn Diseases 0.000 claims 1
- 206010053510 Venomous sting Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000036575 thermal burns Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Birds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
Claims (13)
1. Farmaceutski oblik za primjenu na kožu (topikalni oblik) za uporabu u liječenju kožnog poremećaja odabranog iz grupe koju čine virusna Herpes infekcija, virusna Varicella infekcija, osip, ubodi insekata, opekline meduze, toplinske opekline ili opekline od zračenja, psorijaza i alergijski kožni odogovor;
gdje taj oblik sadrži peptid s L-aminokiselinama formule (I):
pGLU-X-Y-Z (I)
gdje je X aminokiselina odabrana iz grupe koju čine GLY, VAL, GLU, ASP, SER, ALA, ASN, GLN, ILE, LEU, PRO, LYS i ARG,
Y je TRP ili THR,
i Z je bilo koja L-aminokiselina, ili Z nema,
i gdje ako je Z bilo koja L-aminokiselina, jedan, ali ne i oba od Y i Z je TRP, i ako Z nema, tada je Y=TRP,
ili gdje taj oblik sadrži derivat peptida formule (I) gdje je alkilna skupina spojena na amonikiselinu tog peptida,
pri čemu je liječenje boli samo po sebi (per se) isključeno.
2. Topikalni farmaceutski oblik za uporabu prema zahtjevu 1 gdje je alkilna skupina vezana amidnom vezom.
3. Topikalni farmaceutski oblik za uporabu prema zahtjevu 1 gdje je alkilna skupina vezana esterskom vezom.
4. Topikalni farmaceutski oblik za uporabu prema zahtjevu 1 gdje se alkil odabire iz grupe koju čine C4-C30.
5. Topikalni farmaceutski oblik za uporabu prema zahtjevu 1 gdje je peptid tetrapeptid.
6. Topikalni farmaceutski oblik za uporabu prema zahtjevu 5, gdje X = ASN.
7. Topikalni farmaceutski oblik za uporabu prema zahtjevu 6, gdje Y = TRP.
8. Topikalni farmaceutski oblik za uporabu prema zahtjevu 7, gdje Z = THR ili LYS.
9. Topikalni farmaceutski oblik za uporabu prema zahtjevu 8, gdje je peptid pGLU-ASN-TRP-THR.
10. Topikalni farmaceutski oblik za uporabu prema zahtjevu 8, gdje je alkilna skupina C8.
11. Topikalni farmaceutski oblik za uporabu prema zahtjevu 10, gdje je peptid pGLU-ASN-TRP-LYS-C8.
12. Topikalni farmaceutski oblik za uporabu prema bilo kojem od zahtjeva 1-11 gdje se početni terapijski učinak postiže unutar 24 sata od primjene.
13. Topikalni farmaceutski oblik za uporabu prema bilo kojem od zahtjeva 1-11 gdje taj oblik dalje sadrži farmaceutski prikladne pomoćne tvari.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161468212P | 2011-03-28 | 2011-03-28 | |
| EP12720285.1A EP2691103B1 (en) | 2011-03-28 | 2012-03-25 | Method for treating disorders of the skin |
| PCT/IL2012/050105 WO2012131676A1 (en) | 2011-03-28 | 2012-03-25 | Method for treating disorders of the skin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20161006T1 true HRP20161006T1 (hr) | 2016-10-21 |
Family
ID=46052836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161006TT HRP20161006T1 (hr) | 2011-03-28 | 2016-08-10 | Postupak liječenja kožnih poremećaja |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9012397B2 (hr) |
| EP (1) | EP2691103B1 (hr) |
| JP (1) | JP5872673B2 (hr) |
| KR (1) | KR101782671B1 (hr) |
| CN (1) | CN103458912B (hr) |
| AU (1) | AU2012235632B2 (hr) |
| BR (1) | BR112013023537B1 (hr) |
| CA (1) | CA2830135C (hr) |
| DK (1) | DK2691103T3 (hr) |
| ES (1) | ES2598829T3 (hr) |
| HK (1) | HK1186986A1 (hr) |
| HR (1) | HRP20161006T1 (hr) |
| HU (1) | HUE030152T2 (hr) |
| IL (1) | IL228292A (hr) |
| MX (1) | MX2013011219A (hr) |
| PL (1) | PL2691103T3 (hr) |
| PT (1) | PT2691103T (hr) |
| RU (1) | RU2583137C2 (hr) |
| WO (1) | WO2012131676A1 (hr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10538561B2 (en) | 2015-01-22 | 2020-01-21 | Isanaka Ram | Peptide for treating inflammatory diseases |
| BR102017010169A2 (pt) * | 2017-05-15 | 2019-02-26 | Remer Consultores Assessoria Empresarial Ltda. | composto, intermediário de síntese, uso na preparação de anticonvulsivante, composição farmacêutica anticonvulsivante |
| MX2020009999A (es) * | 2018-03-29 | 2020-11-06 | S I S Shulov Innovative Science Ltd | Composiciones farmacéuticas para inhibir citocinas inflamatorias. |
| EP4034078A4 (en) * | 2019-09-26 | 2023-09-20 | S.I.S. Shulov Innovative Science Ltd. | ANTI-AGING COMPOSITIONS AND METHODS OF USE |
| WO2021059267A1 (en) * | 2019-09-26 | 2021-04-01 | S.I.S. Shulov Innovative Science Ltd. | Compositions and methods for treating degenerative, age-related and trauma-induced disorders |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1172391B (it) | 1983-12-23 | 1987-06-18 | Polifarma Spa | Composti tirpeptidici contenenti acido piroglutaminico e triptofano,procedimentio di produzione ed applicazioni terapeutiche |
| IT1237474B (it) * | 1989-10-05 | 1993-06-07 | Polifarma Spa | Composti tripeptidici e loro uso farmaceutico come immuno-modulatori |
| AU1907292A (en) | 1991-04-24 | 1992-12-21 | Warner-Lambert Company | Alpha-substituted polypeptides having therapeutic activity |
| IL123001A (en) | 1998-01-20 | 1998-12-06 | Shulov Inst For Venom Research | Analgesic fraction from snake March and pharmacy preparations containing it |
| WO2001001748A2 (en) * | 1999-07-02 | 2001-01-11 | Genentech, Inc. | Peptide compounds that bind her2 |
| CA2377914A1 (en) * | 1999-07-14 | 2001-01-18 | S.I.S. Shulov Institute For Science Ltd. | Analgesic from snake venom |
| IL137820A (en) * | 2000-08-10 | 2009-06-15 | S I S Shulov Inst For Science | Pharmaceutical composition for topical administration comprising an analgesic peptide |
| AU2002307369A1 (en) * | 2001-04-13 | 2002-10-28 | Genome Therapeutics Corporation | Novel human gene relating to respiratory diseases, obesity, and inflammatory bowel disease |
| WO2005107357A2 (en) * | 2004-05-06 | 2005-11-17 | Laboratório Biosintética Ltda. | Analgesic peptides derived from the venom of crotalus durissus terrificuss snakes |
| CN101058572A (zh) * | 2007-03-13 | 2007-10-24 | 中国药科大学 | 一种新的具有抗肿瘤活性的肽类化合物 |
| CN101239178A (zh) * | 2008-03-13 | 2008-08-13 | 中国药科大学 | 一种肽类化合物的抗血栓用途 |
| US8518399B2 (en) * | 2010-11-17 | 2013-08-27 | Tamir Biotechnology, Inc. | Methods of treating infections originating from viruses in the herpesviridae family |
-
2012
- 2012-03-25 ES ES12720285.1T patent/ES2598829T3/es active Active
- 2012-03-25 WO PCT/IL2012/050105 patent/WO2012131676A1/en active Application Filing
- 2012-03-25 DK DK12720285.1T patent/DK2691103T3/en active
- 2012-03-25 CN CN201280015711.5A patent/CN103458912B/zh active Active
- 2012-03-25 EP EP12720285.1A patent/EP2691103B1/en active Active
- 2012-03-25 BR BR112013023537-3A patent/BR112013023537B1/pt active IP Right Grant
- 2012-03-25 US US13/982,708 patent/US9012397B2/en active Active
- 2012-03-25 AU AU2012235632A patent/AU2012235632B2/en active Active
- 2012-03-25 PT PT127202851T patent/PT2691103T/pt unknown
- 2012-03-25 CA CA2830135A patent/CA2830135C/en active Active
- 2012-03-25 MX MX2013011219A patent/MX2013011219A/es active IP Right Grant
- 2012-03-25 KR KR1020137025194A patent/KR101782671B1/ko active IP Right Grant
- 2012-03-25 HU HUE12720285A patent/HUE030152T2/en unknown
- 2012-03-25 JP JP2014501811A patent/JP5872673B2/ja active Active
- 2012-03-25 RU RU2013143041/15A patent/RU2583137C2/ru active
- 2012-03-25 PL PL12720285.1T patent/PL2691103T3/pl unknown
-
2013
- 2013-09-08 IL IL228292A patent/IL228292A/en active IP Right Grant
-
2014
- 2014-01-07 HK HK14100155.5A patent/HK1186986A1/zh unknown
-
2016
- 2016-08-10 HR HRP20161006TT patent/HRP20161006T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US9012397B2 (en) | 2015-04-21 |
| PL2691103T3 (pl) | 2016-12-30 |
| CA2830135C (en) | 2019-12-17 |
| AU2012235632B2 (en) | 2015-12-03 |
| KR101782671B1 (ko) | 2017-09-27 |
| RU2013143041A (ru) | 2015-03-27 |
| HUE030152T2 (en) | 2017-04-28 |
| ES2598829T3 (es) | 2017-01-30 |
| MX2013011219A (es) | 2013-10-17 |
| AU2012235632A1 (en) | 2013-09-26 |
| HK1186986A1 (zh) | 2014-03-28 |
| JP2014510748A (ja) | 2014-05-01 |
| CN103458912B (zh) | 2016-01-20 |
| IL228292A (en) | 2017-05-29 |
| EP2691103B1 (en) | 2016-07-20 |
| KR20140027122A (ko) | 2014-03-06 |
| CN103458912A (zh) | 2013-12-18 |
| CA2830135A1 (en) | 2012-10-04 |
| RU2583137C2 (ru) | 2016-05-10 |
| EP2691103A1 (en) | 2014-02-05 |
| US20130310309A1 (en) | 2013-11-21 |
| WO2012131676A1 (en) | 2012-10-04 |
| BR112013023537A2 (pt) | 2016-12-06 |
| BR112013023537B1 (pt) | 2022-05-31 |
| PT2691103T (pt) | 2016-10-25 |
| JP5872673B2 (ja) | 2016-03-01 |
| DK2691103T3 (en) | 2016-11-21 |
| WO2012131676A4 (en) | 2012-11-22 |
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