IT1242002B - Composti con attivita' farmacologica antiipertensiva, analgesica, immunomodulante e antiinfiammatoria, che presentano nella molecola una sequenza di tre radicali, essendo alfa-amminoacido quello centrale - Google Patents
Composti con attivita' farmacologica antiipertensiva, analgesica, immunomodulante e antiinfiammatoria, che presentano nella molecola una sequenza di tre radicali, essendo alfa-amminoacido quello centraleInfo
- Publication number
- IT1242002B IT1242002B IT48335A IT4833590A IT1242002B IT 1242002 B IT1242002 B IT 1242002B IT 48335 A IT48335 A IT 48335A IT 4833590 A IT4833590 A IT 4833590A IT 1242002 B IT1242002 B IT 1242002B
- Authority
- IT
- Italy
- Prior art keywords
- immunomodulating
- hypertensive
- analgesic
- radicals
- molecule
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT48335A IT1242002B (it) | 1990-10-03 | 1990-10-03 | Composti con attivita' farmacologica antiipertensiva, analgesica, immunomodulante e antiinfiammatoria, che presentano nella molecola una sequenza di tre radicali, essendo alfa-amminoacido quello centrale |
EP91917743A EP0503044B1 (en) | 1990-10-03 | 1991-10-03 | Peptide compounds of laevorotatory amino acids and ring molecules, and therapeutical applications thereof |
ES91917743T ES2089234T3 (es) | 1990-10-03 | 1991-10-03 | Compuestos peptidos de aminoacidos y moleculas ciclicas levogiras y aplicaciones terapeuticas de los mismos. |
DE69120247T DE69120247T2 (de) | 1990-10-03 | 1991-10-03 | Peptidverbindungen von linksdrehenden aminosäuren und ringmolekülen, und therapeutische anwendung davon |
JP3516511A JP2502868B2 (ja) | 1990-10-03 | 1991-10-03 | 連続した3個の基を有し、中央のものがα―アミノ酸性である化合物、およびその治療薬への適用 |
CA002070169A CA2070169C (en) | 1990-10-03 | 1991-10-03 | Compounds with a sequence of three radicals, the central one being -aminoacidic and therapeutical applications thereof |
PCT/IT1991/000080 WO1992006108A1 (en) | 1990-10-03 | 1991-10-03 | Peptide compounds of laevorotatory amino acids and ring molecules, and therapeutical applications thereof |
AU87150/91A AU640534B2 (en) | 1990-10-03 | 1991-10-03 | Peptide compounds of laevorotatory amino acids and ring molecules, and therapeutical applications thereof |
US08/311,449 US5504071A (en) | 1990-10-03 | 1994-09-26 | Compounds with a sequence of three radicals, the central one being α-a |
US08/573,399 US5736518A (en) | 1990-10-03 | 1995-12-15 | Peptide compounds of (L) amino acids and ring molecules, and therapeutical applications thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT48335A IT1242002B (it) | 1990-10-03 | 1990-10-03 | Composti con attivita' farmacologica antiipertensiva, analgesica, immunomodulante e antiinfiammatoria, che presentano nella molecola una sequenza di tre radicali, essendo alfa-amminoacido quello centrale |
Publications (3)
Publication Number | Publication Date |
---|---|
IT9048335A0 IT9048335A0 (it) | 1990-10-03 |
IT9048335A1 IT9048335A1 (it) | 1992-04-03 |
IT1242002B true IT1242002B (it) | 1994-02-02 |
Family
ID=11265965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT48335A IT1242002B (it) | 1990-10-03 | 1990-10-03 | Composti con attivita' farmacologica antiipertensiva, analgesica, immunomodulante e antiinfiammatoria, che presentano nella molecola una sequenza di tre radicali, essendo alfa-amminoacido quello centrale |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0503044B1 (it) |
JP (1) | JP2502868B2 (it) |
AU (1) | AU640534B2 (it) |
CA (1) | CA2070169C (it) |
DE (1) | DE69120247T2 (it) |
ES (1) | ES2089234T3 (it) |
IT (1) | IT1242002B (it) |
WO (1) | WO1992006108A1 (it) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1277904B1 (it) * | 1995-08-07 | 1997-11-12 | Polifarma Spa | Metodo per determinare l'attivita' terapeutica di composti inibitori di metalloproteinasi, nuovi composti inibitori, e loro impiego |
US6057297A (en) * | 1996-08-06 | 2000-05-02 | Polifarma S.P.A. | Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof |
IT1296305B1 (it) * | 1997-07-17 | 1999-06-25 | Polifarma Spa | Inibitori di metalloproteinasi loro uso terapeutico e procedimento per la produzione del composto di partenza nella loro |
IL137820A (en) * | 2000-08-10 | 2009-06-15 | S I S Shulov Inst For Science | Pharmaceutical composition for topical administration comprising an analgesic peptide |
GB0107924D0 (en) * | 2001-03-29 | 2001-05-23 | Angeletti P Ist Richerche Bio | Inhibitor of hepatitis C virus NS3 protease |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU518836B2 (en) * | 1978-04-13 | 1981-10-22 | Merck & Co., Inc | Treating hypertension with tripeptides |
IT1172391B (it) * | 1983-12-23 | 1987-06-18 | Polifarma Spa | Composti tirpeptidici contenenti acido piroglutaminico e triptofano,procedimentio di produzione ed applicazioni terapeutiche |
IT1186733B (it) * | 1985-06-05 | 1987-12-16 | Eniricerche Spa | Composti tripeptidici ad azione ipotensiva |
FR2585709B1 (fr) * | 1985-08-05 | 1987-10-02 | Adir | Nouveaux derives peptidiques a structure lactonique ou cycloamidique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
1990
- 1990-10-03 IT IT48335A patent/IT1242002B/it active IP Right Grant
-
1991
- 1991-10-03 EP EP91917743A patent/EP0503044B1/en not_active Expired - Lifetime
- 1991-10-03 JP JP3516511A patent/JP2502868B2/ja not_active Expired - Fee Related
- 1991-10-03 CA CA002070169A patent/CA2070169C/en not_active Expired - Fee Related
- 1991-10-03 DE DE69120247T patent/DE69120247T2/de not_active Expired - Fee Related
- 1991-10-03 AU AU87150/91A patent/AU640534B2/en not_active Ceased
- 1991-10-03 WO PCT/IT1991/000080 patent/WO1992006108A1/en active IP Right Grant
- 1991-10-03 ES ES91917743T patent/ES2089234T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0503044B1 (en) | 1996-06-12 |
EP0503044A1 (en) | 1992-09-16 |
AU8715091A (en) | 1992-04-28 |
DE69120247D1 (de) | 1996-07-18 |
CA2070169A1 (en) | 1992-04-04 |
IT9048335A0 (it) | 1990-10-03 |
JPH04506083A (ja) | 1992-10-22 |
JP2502868B2 (ja) | 1996-05-29 |
DE69120247T2 (de) | 1997-01-23 |
AU640534B2 (en) | 1993-08-26 |
WO1992006108A1 (en) | 1992-04-16 |
CA2070169C (en) | 2001-03-20 |
IT9048335A1 (it) | 1992-04-03 |
ES2089234T3 (es) | 1996-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971021 |