CN102160890B - 包含止痛肽的药物组合物 - Google Patents
包含止痛肽的药物组合物 Download PDFInfo
- Publication number
- CN102160890B CN102160890B CN2011100520229A CN201110052022A CN102160890B CN 102160890 B CN102160890 B CN 102160890B CN 2011100520229 A CN2011100520229 A CN 2011100520229A CN 201110052022 A CN201110052022 A CN 201110052022A CN 102160890 B CN102160890 B CN 102160890B
- Authority
- CN
- China
- Prior art keywords
- trp
- peptide
- pglu
- asn
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
活性成分 | 动物数 | 平均“舔”次数 | 标准差 | SEM | P* |
对照 | 25 | 113.9 | 69.1 | 13.8 | - |
pENW | 27 | 59.7 | 58.9 | 11.3 | 0.0017 |
pENWK-C8 | 28 | 37.9 | 34.8 | 6.6 | <0.0001 |
pENWGAT | 32 | 117.0 | 81.2 | 14.4 | 0.9872 |
活性成分 | 动物数 | 平均“舔”次数 | SEM | p* |
对照 | 24 | 117 | 6 | - |
pENW | 25 | 44 | 31 | <0.05 |
pEEW | 26 | 35 | 30 | <0.05 |
pENTW或pENWT | 25 | 39 | 26 | <0.05 |
涂药后天数 | 动物数 | 平均“舔”次数 | SEM | p* |
对照 | 26 | 106 | 11.2 | - |
11 | 28 | 66 | 10 | <0.05 |
23 | 27 | 35.7 | 6.5 | <0.05 |
48 | 21 | 62.4 | 11 | <0.05 |
Claims (7)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL137820A IL137820A (en) | 2000-08-10 | 2000-08-10 | Pharmaceutical composition for topical administration comprising an analgesic peptide |
IL137820 | 2000-08-10 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN01816060A Division CN1462277A (zh) | 2000-08-10 | 2001-08-06 | 包含止痛肽的药物组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102160890A CN102160890A (zh) | 2011-08-24 |
CN102160890B true CN102160890B (zh) | 2013-02-06 |
Family
ID=11074512
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN01816060A Pending CN1462277A (zh) | 2000-08-10 | 2001-08-06 | 包含止痛肽的药物组合物 |
CN2011100520229A Expired - Lifetime CN102160890B (zh) | 2000-08-10 | 2001-08-06 | 包含止痛肽的药物组合物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN01816060A Pending CN1462277A (zh) | 2000-08-10 | 2001-08-06 | 包含止痛肽的药物组合物 |
Country Status (13)
Country | Link |
---|---|
US (1) | US7220725B2 (zh) |
EP (1) | EP1309613B1 (zh) |
JP (1) | JP4860096B2 (zh) |
CN (2) | CN1462277A (zh) |
AT (1) | ATE392428T1 (zh) |
AU (2) | AU8005201A (zh) |
CA (1) | CA2418793C (zh) |
DE (1) | DE60133654T2 (zh) |
DK (1) | DK1309613T3 (zh) |
ES (1) | ES2305096T3 (zh) |
HK (1) | HK1160778A1 (zh) |
IL (1) | IL137820A (zh) |
WO (1) | WO2002012269A2 (zh) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL137820A (en) * | 2000-08-10 | 2009-06-15 | S I S Shulov Inst For Science | Pharmaceutical composition for topical administration comprising an analgesic peptide |
JP2008537739A (ja) * | 2005-03-21 | 2008-09-25 | ザ トラスティース オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | 新規神経疼痛経路 |
KR101566036B1 (ko) * | 2007-03-23 | 2015-11-04 | 닛신 파마 가부시키가이샤 | 간질환의 예방 또는 치료용 조성물 |
US20110183925A1 (en) * | 2008-09-22 | 2011-07-28 | Nisshin Pharma Inc. | Anti-inflammatory peptide |
JP5863650B2 (ja) | 2009-07-27 | 2016-02-16 | ノシセプタ エルエルシー | 疼痛を処置するための方法 |
FR2948809B1 (fr) * | 2009-07-31 | 2012-08-17 | St Microelectronics Rousset | Amplificateur de lecture faible puissance auto-minute |
HUE030152T2 (en) * | 2011-03-28 | 2017-04-28 | S I S Shulov Innovative Science Ltd | A method for treating skin diseases |
CA2972975A1 (en) | 2015-01-07 | 2016-07-14 | Trigemina, Inc. | Magnesium-containing oxytocin formulations and methods of use |
RU2669386C1 (ru) * | 2017-08-11 | 2018-10-11 | Закрытое акционерное общество "Институт экспериментальной фармакологии" | Состав и способ получения анальгетического средства пептидной структуры |
CN112203674A (zh) | 2018-03-29 | 2021-01-08 | S.I.S舒洛夫创新科学有限公司 | 用于抑制炎性细胞因子的药物组合物 |
US11644463B2 (en) | 2019-08-30 | 2023-05-09 | Euroimmun Medizinische Labordiagnostika Ag | Detection of an autoantibody |
US20220362325A1 (en) * | 2019-09-26 | 2022-11-17 | S.I.S Shulov Innovative Science Ltd. | Compositions and methods for treating degenerative, age-related and trauma-induced disorders |
WO2021059266A1 (en) * | 2019-09-26 | 2021-04-01 | S.I.S. Shulov Innovative Science Ltd. | Anti-aging compositions and methods of use thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0148133A2 (en) * | 1983-12-23 | 1985-07-10 | POLIFARMA S.p.A. | Tripeptide compounds containing pyroglutamic acid and tryptophan, process for their production and therapeutic applications |
CN85109722A (zh) * | 1984-11-09 | 1986-10-08 | 伊萨株式会社 | 制造敌诺芬(dynophine)衍生物的方法 |
WO1995027728A1 (en) * | 1994-04-07 | 1995-10-19 | Luminis Pty. Limited | Peptides |
WO2000012553A1 (en) * | 1998-08-28 | 2000-03-09 | Myelos Corporation | Cyclic prosaposin-derived peptides and uses thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4491541A (en) * | 1982-11-10 | 1985-01-01 | Farmitalia Carlo Erba | Peptides |
IT1242002B (it) * | 1990-10-03 | 1994-02-02 | Polifarma Spa | Composti con attivita' farmacologica antiipertensiva, analgesica, immunomodulante e antiinfiammatoria, che presentano nella molecola una sequenza di tre radicali, essendo alfa-amminoacido quello centrale |
EP0668770A1 (en) | 1991-04-24 | 1995-08-30 | Warner-Lambert Company | $g(a)-SUBSTITUTED POLYPEPTIDES HAVING THERAPEUTIC ACTIVITY |
RU2107691C1 (ru) * | 1995-03-02 | 1998-03-27 | Дейгин Владислав Исакович | Пептид и способ его получения |
US5776896A (en) * | 1996-01-03 | 1998-07-07 | Zeneca Limited | Analgesic peptides from venom of grammostola spatulata and use thereof |
JP2000513336A (ja) * | 1996-05-22 | 2000-10-10 | ディバーシファイド ファーマシューティカルズ,インコーポレーテッド | 薬物の経皮送達のための組成物、方法及びデバイス |
US6126939A (en) * | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
IL123001A (en) * | 1998-01-20 | 1998-12-06 | Shulov Inst For Venom Research | Analgesic fraction from snake March and pharmacy preparations containing it |
IL137820A (en) * | 2000-08-10 | 2009-06-15 | S I S Shulov Inst For Science | Pharmaceutical composition for topical administration comprising an analgesic peptide |
-
2000
- 2000-08-10 IL IL137820A patent/IL137820A/en active IP Right Grant
-
2001
- 2001-08-06 DK DK01958334T patent/DK1309613T3/da active
- 2001-08-06 CN CN01816060A patent/CN1462277A/zh active Pending
- 2001-08-06 JP JP2002518242A patent/JP4860096B2/ja not_active Expired - Lifetime
- 2001-08-06 CA CA2418793A patent/CA2418793C/en not_active Expired - Lifetime
- 2001-08-06 WO PCT/IL2001/000724 patent/WO2002012269A2/en active IP Right Grant
- 2001-08-06 ES ES01958334T patent/ES2305096T3/es not_active Expired - Lifetime
- 2001-08-06 AU AU8005201A patent/AU8005201A/xx active Pending
- 2001-08-06 AU AU2001280052A patent/AU2001280052B2/en not_active Expired
- 2001-08-06 US US10/344,129 patent/US7220725B2/en not_active Expired - Lifetime
- 2001-08-06 CN CN2011100520229A patent/CN102160890B/zh not_active Expired - Lifetime
- 2001-08-06 AT AT01958334T patent/ATE392428T1/de not_active IP Right Cessation
- 2001-08-06 EP EP01958334A patent/EP1309613B1/en not_active Expired - Lifetime
- 2001-08-06 DE DE60133654T patent/DE60133654T2/de not_active Expired - Lifetime
-
2012
- 2012-02-08 HK HK12101216.2A patent/HK1160778A1/xx not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0148133A2 (en) * | 1983-12-23 | 1985-07-10 | POLIFARMA S.p.A. | Tripeptide compounds containing pyroglutamic acid and tryptophan, process for their production and therapeutic applications |
CN85109722A (zh) * | 1984-11-09 | 1986-10-08 | 伊萨株式会社 | 制造敌诺芬(dynophine)衍生物的方法 |
WO1995027728A1 (en) * | 1994-04-07 | 1995-10-19 | Luminis Pty. Limited | Peptides |
WO2000012553A1 (en) * | 1998-08-28 | 2000-03-09 | Myelos Corporation | Cyclic prosaposin-derived peptides and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
DE60133654T2 (de) | 2009-06-04 |
CA2418793A1 (en) | 2002-02-14 |
HK1160778A1 (en) | 2012-08-17 |
EP1309613B1 (en) | 2008-04-16 |
CN102160890A (zh) | 2011-08-24 |
ES2305096T3 (es) | 2008-11-01 |
US7220725B2 (en) | 2007-05-22 |
CN1462277A (zh) | 2003-12-17 |
IL137820A (en) | 2009-06-15 |
CA2418793C (en) | 2011-11-15 |
EP1309613A2 (en) | 2003-05-14 |
DK1309613T3 (da) | 2008-08-11 |
US20040014673A1 (en) | 2004-01-22 |
IL137820A0 (en) | 2001-10-31 |
DE60133654D1 (de) | 2008-05-29 |
AU8005201A (en) | 2002-02-18 |
AU2001280052B2 (en) | 2007-11-29 |
WO2002012269A3 (en) | 2002-12-19 |
JP4860096B2 (ja) | 2012-01-25 |
JP2004513079A (ja) | 2004-04-30 |
ATE392428T1 (de) | 2008-05-15 |
WO2002012269A2 (en) | 2002-02-14 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1160778 Country of ref document: HK |
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C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Address after: Rehovot Applicant after: S.I.S. Shulov Innovative Science Ltd. Address before: Rehovot Applicant before: S. I. S. Shulov Inst For Science |
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COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: S. I. S. SHULOV INSTITUTE FOR SCIENCE LTD. TO: S. I. S. SHULOV INSTITUTE FOR SCIENTIFIC INNOVATION LTD. |
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