ES2274810T3 - Agonistas retinoides selectivos rar-gamma para el tratamiento de enfisema. - Google Patents

Agonistas retinoides selectivos rar-gamma para el tratamiento de enfisema. Download PDF

Info

Publication number
ES2274810T3
ES2274810T3 ES00972754T ES00972754T ES2274810T3 ES 2274810 T3 ES2274810 T3 ES 2274810T3 ES 00972754 T ES00972754 T ES 00972754T ES 00972754 T ES00972754 T ES 00972754T ES 2274810 T3 ES2274810 T3 ES 2274810T3
Authority
ES
Spain
Prior art keywords
alkyl
rar
carbons
hydrogen
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00972754T
Other languages
English (en)
Spanish (es)
Inventor
Paula Nanette Belloni
Michael Klaus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2274810T3 publication Critical patent/ES2274810T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355Tocopherols, e.g. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES00972754T 1999-10-19 2000-10-13 Agonistas retinoides selectivos rar-gamma para el tratamiento de enfisema. Expired - Lifetime ES2274810T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16041599P 1999-10-19 1999-10-19
US160415P 1999-10-19

Publications (1)

Publication Number Publication Date
ES2274810T3 true ES2274810T3 (es) 2007-06-01

Family

ID=22576814

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00972754T Expired - Lifetime ES2274810T3 (es) 1999-10-19 2000-10-13 Agonistas retinoides selectivos rar-gamma para el tratamiento de enfisema.

Country Status (33)

Country Link
US (1) US6300350B1 (enExample)
EP (1) EP1225878B1 (enExample)
JP (2) JP4074458B2 (enExample)
KR (1) KR100485581B1 (enExample)
CN (1) CN1201730C (enExample)
AR (1) AR029648A1 (enExample)
AT (1) ATE344661T1 (enExample)
AU (1) AU777325B2 (enExample)
BR (1) BR0015225A (enExample)
CA (1) CA2387844C (enExample)
CY (1) CY1105941T1 (enExample)
CZ (1) CZ20021657A3 (enExample)
DE (1) DE60031790T2 (enExample)
DK (1) DK1225878T3 (enExample)
ES (1) ES2274810T3 (enExample)
HR (1) HRP20020329A2 (enExample)
HU (1) HUP0203295A3 (enExample)
IL (1) IL149151A0 (enExample)
JO (1) JO2178B1 (enExample)
MA (1) MA26835A1 (enExample)
MX (1) MXPA02003843A (enExample)
MY (1) MY129001A (enExample)
NO (1) NO328738B1 (enExample)
NZ (1) NZ518118A (enExample)
PE (1) PE20010678A1 (enExample)
PL (1) PL357499A1 (enExample)
PT (1) PT1225878E (enExample)
RS (1) RS50165B (enExample)
RU (1) RU2257383C2 (enExample)
TR (1) TR200201071T2 (enExample)
TW (1) TWI288639B (enExample)
WO (1) WO2001030326A1 (enExample)
ZA (1) ZA200202576B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061233A2 (en) * 1999-04-14 2000-10-19 Allergan Sales, Inc. Methods and compositions for the treatment and prevention of lung disease involving a specific rar-gamma agonist
CA2460693C (en) * 2001-09-18 2010-12-07 F. Hoffmann-La Roche Ag Alkyl urea retinoid agonists i
RU2303027C2 (ru) 2001-09-18 2007-07-20 Ф.Хоффманн-Ля Рош Аг Производные замещенной мочевины, фармацевтическая композиция и лекарственное средство на их основе, обладающие ретиноидной активностью
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
ES2481167T3 (es) 2003-08-22 2014-07-29 Dupont Nutrition Biosciences Aps Composición que comprende una bacteriocina y un extracto de una planta de la familia Labiatae
GB2388581A (en) 2003-08-22 2003-11-19 Danisco Coated aqueous beads
EP2089017A2 (en) * 2006-11-02 2009-08-19 Aestus Therapeutics, Inc. Methods of treating neuropathic pain by modulation of glycogenolysis or glycolysis pathways
US9789074B2 (en) 2010-09-01 2017-10-17 Thomas Jefferson University Composition and method for muscle repair and regeneration
CN103732231B (zh) 2011-06-24 2020-04-10 格里生物公司 炎性病症的预防和治疗
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
EP2736332A4 (en) * 2011-07-29 2015-03-18 Tempero Pharmaceuticals Inc CONNECTIONS AND METHODS
NZ709197A (en) 2012-12-17 2020-06-26 Parion Sciences Inc 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds
HUE032891T2 (hu) 2012-12-17 2017-11-28 Parion Sciences Inc Klórpirazin-karboxamid-származékok nem kielégítõ nyálkahártya-hidratáció által elõsegített megbetegedések kezelésére
WO2015026990A2 (en) 2013-08-20 2015-02-26 University Of Washington Through Its Center For Commercialization Novel and specific inhibitors of cytochrome p450 26 retinoic acid hydrolase
US10500232B2 (en) 2013-08-26 2019-12-10 The J. David Gladstone Ins., a testamentary trust established under the Will of J. David Gladstone Small molecule cellular reprogramming to generate neuronal cells
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU618590B2 (en) * 1988-04-11 1992-01-02 Allergan, Inc. Tetralin esters of phenols or benzoic acids having retinoid like activity
AU677428B2 (en) * 1993-08-19 1997-04-24 Janssen Pharmaceutica N.V. Vasoconstrictive dihydrobenzopyran derivatives
CA2129773C (en) * 1993-09-02 2007-05-01 Michael Klaus Aromatic carboxylic acid derivatives
US5498795A (en) * 1994-12-29 1996-03-12 Allergan, Inc. Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity
DE69604713T2 (de) * 1995-02-24 2000-06-21 F. Hoffmann-La Roche Ag, Basel Retinoide
US5807900A (en) * 1995-03-31 1998-09-15 Hoffmann-La Roche, Inc. Method for identifying compounds having increased activity for the repair of skin photodamage
TW418186B (en) * 1995-06-05 2001-01-11 Bristol Myers Squibb Co Retinoid-like compounds
US5624957A (en) * 1995-06-06 1997-04-29 Bristol-Myers Squibb Company Rary-specific retinobenzoic acid derivatives
FR2739557B1 (fr) * 1995-10-09 1997-11-14 Cird Galderma Utilisation d'un ligand agoniste specifique rar-gamma
US5726191A (en) 1995-11-16 1998-03-10 Hoffmann-La Roche Inc. Aromatic carboxylic acid esters
FR2747041B1 (fr) 1996-04-05 1998-05-22 Cird Galderma Utilisation de derives benzonaphtaleniques pour la fabrication de medicaments destines au traitement des neuropathies
WO1999024024A2 (en) * 1997-11-12 1999-05-20 F. Hoffmann-La Roche Ag Treatment of t-helper cell type 2 mediated immune diseases with retinoid antagonists
US6083973A (en) * 1998-03-09 2000-07-04 Syntex (U.S.A.) Inc. Methods for inhibiting mucin secretion using RAR α selective antagonists
WO2000061233A2 (en) * 1999-04-14 2000-10-19 Allergan Sales, Inc. Methods and compositions for the treatment and prevention of lung disease involving a specific rar-gamma agonist
WO2000061182A2 (en) 1999-04-14 2000-10-19 Allergan Sales, Inc. Methods and compositions for the treatment and prevention of lung disease involving a selective rar-alpha agonist
AU4225500A (en) * 1999-04-14 2000-11-14 Allergan Sales, Inc. Methods and compositions for the treatment and prevention of lung disease
EP1206436B1 (en) * 1999-08-02 2004-10-13 F. Hoffmann-La Roche Ag Retinoids for the treatment of emphysema
US6479670B1 (en) * 1999-08-25 2002-11-12 Hoffmann-La Roche Inc. Selective retinoid acid receptor agonists

Also Published As

Publication number Publication date
TR200201071T2 (tr) 2002-08-21
DE60031790T2 (de) 2007-09-20
US6300350B1 (en) 2001-10-09
HRP20020329A2 (en) 2004-04-30
CZ20021657A3 (cs) 2002-10-16
JP4850791B2 (ja) 2012-01-11
BR0015225A (pt) 2002-07-16
CN1382042A (zh) 2002-11-27
KR100485581B1 (ko) 2005-04-27
WO2001030326A1 (en) 2001-05-03
PT1225878E (pt) 2007-01-31
PE20010678A1 (es) 2001-07-04
NO20021823L (no) 2002-04-18
IL149151A0 (en) 2002-11-10
CA2387844C (en) 2009-04-14
AR029648A1 (es) 2003-07-10
TWI288639B (en) 2007-10-21
RS50165B (sr) 2009-05-06
JO2178B1 (en) 2003-04-23
NO20021823D0 (no) 2002-04-18
PL357499A1 (pl) 2004-07-26
JP2003512418A (ja) 2003-04-02
JP4074458B2 (ja) 2008-04-09
HUP0203295A2 (hu) 2003-01-28
MA26835A1 (fr) 2004-12-20
NO328738B1 (no) 2010-05-03
NZ518118A (en) 2004-02-27
MY129001A (en) 2007-03-30
CA2387844A1 (en) 2001-05-03
AU777325B2 (en) 2004-10-14
MXPA02003843A (es) 2002-09-30
JP2007302689A (ja) 2007-11-22
ATE344661T1 (de) 2006-11-15
ZA200202576B (en) 2003-09-23
HK1051002A1 (zh) 2003-07-18
AU1137401A (en) 2001-05-08
RU2257383C2 (ru) 2005-07-27
DK1225878T3 (da) 2007-03-05
HUP0203295A3 (en) 2003-04-28
EP1225878B1 (en) 2006-11-08
EP1225878A1 (en) 2002-07-31
CN1201730C (zh) 2005-05-18
KR20020043640A (ko) 2002-06-10
DE60031790D1 (de) 2006-12-21
YU29002A (sh) 2005-06-10
CY1105941T1 (el) 2011-04-06

Similar Documents

Publication Publication Date Title
JP4850791B2 (ja) Rar選択的レチノイド拮抗薬を用いた気腫の治療
ES2753639T3 (es) Acidos tetrahidrocannabinol-11-oicos para su uso en el tratamiento de enfermedades fibróticas
JP2015025024A (ja) アンドログラフィス・パニキュラータ抽出物及び同抽出物を含む製薬組成物並びに同抽出物の製薬組成物の製造における使用
JPH04364124A (ja) 灌注によるショック状態の処置用医薬組成物
ES2292620T3 (es) Empleo de acido 13-cis retionico para el tratamiento de enfisema.
MXPA03005672A (es) Metodo y composicion para el tratamiento de la neuropatia diabetica.
AU2015287947B2 (en) Compositions for anti-inflammatory, antioxidant effects and improved respiratory function by specific histone deacetylase inhibition
AU735382B2 (en) Use of alpha-rar antagonists for inhibition of mucin secretion
US20090203776A1 (en) Methods of using menthol propyleneglycol-carbonate and analogs thereof for producing anti-inflammatory and anti-angiogenic effects
CN110384694A (zh) 一种xenicane型二萜化合物在制备抗氧化神经保护药物中的应用
US20080269339A1 (en) Combined use of egf pathway inhibitors and differentiation promoting compounds