ES2243370T3 - Composiciones poliaromaticas para el tratamiento de infecciones por virus herpes. - Google Patents

Composiciones poliaromaticas para el tratamiento de infecciones por virus herpes.

Info

Publication number
ES2243370T3
ES2243370T3 ES01117751T ES01117751T ES2243370T3 ES 2243370 T3 ES2243370 T3 ES 2243370T3 ES 01117751 T ES01117751 T ES 01117751T ES 01117751 T ES01117751 T ES 01117751T ES 2243370 T3 ES2243370 T3 ES 2243370T3
Authority
ES
Spain
Prior art keywords
phenylene
bis
methoxy
compound
herpes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01117751T
Other languages
English (en)
Spanish (es)
Inventor
Michael R. Barbachyn
Fred L. Homa
Antonio Monge
Esteban Santiago
Juan J. Martinez-Irujo
Maria Font
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Application granted granted Critical
Publication of ES2243370T3 publication Critical patent/ES2243370T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/20—Quaternary compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
ES01117751T 1997-04-10 1998-04-01 Composiciones poliaromaticas para el tratamiento de infecciones por virus herpes. Expired - Lifetime ES2243370T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4323297P 1997-04-10 1997-04-10
US43232P 1997-04-10

Publications (1)

Publication Number Publication Date
ES2243370T3 true ES2243370T3 (es) 2005-12-01

Family

ID=21926169

Family Applications (2)

Application Number Title Priority Date Filing Date
ES01117751T Expired - Lifetime ES2243370T3 (es) 1997-04-10 1998-04-01 Composiciones poliaromaticas para el tratamiento de infecciones por virus herpes.
ES98913241T Expired - Lifetime ES2191292T3 (es) 1997-04-10 1998-04-01 Compuestos antivirales poliaromaticos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES98913241T Expired - Lifetime ES2191292T3 (es) 1997-04-10 1998-04-01 Compuestos antivirales poliaromaticos.

Country Status (9)

Country Link
US (2) US5958983A (enExample)
EP (1) EP0973735B1 (enExample)
JP (1) JP2001519808A (enExample)
AT (2) ATE298741T1 (enExample)
AU (1) AU6783698A (enExample)
DE (2) DE69811062T2 (enExample)
DK (1) DK0973735T3 (enExample)
ES (2) ES2243370T3 (enExample)
WO (1) WO1998045259A2 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
WO2000034261A2 (en) * 1998-12-09 2000-06-15 American Home Products Corporation Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group
WO2000034269A1 (en) * 1998-12-09 2000-06-15 American Home Products Corporation Thiourea inhibitors of herpes viruses
CA2350767A1 (en) * 1998-12-09 2000-06-15 Stanley Albert Lang Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group
US6201013B1 (en) 1998-12-09 2001-03-13 American Home Products Corporation Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group
US6166028A (en) 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
IL143261A0 (en) * 1998-12-09 2002-04-21 American Home Prod Thiourea inhibitors of herpes viruses
US6197803B1 (en) 1998-12-09 2001-03-06 American Home Products Corporation Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group
US6335350B1 (en) 1998-12-09 2002-01-01 American Home Products Corporation Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
US6262090B1 (en) 1998-12-09 2001-07-17 American Home Products Corporation Aminopyridine-containing thiourea inhibitors of herpes viruses
EA200100640A1 (ru) * 1998-12-09 2001-12-24 Американ Хоум Продактс Корпорейшн Ингибиторы вирусов герпеса, представляющие собой ацетамид и замещенные ацетамидосодержащие тиомочевины
EP1158985B1 (en) 1999-01-13 2011-12-28 Bayer HealthCare LLC OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
US7351834B1 (en) 1999-01-13 2008-04-01 Bayer Pharmaceuticals Corporation ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1140840B1 (en) 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
JP2003508512A (ja) * 1999-09-08 2003-03-04 ギルフォード ファーマシュウティカルズ インコーポレイテッド 非ペプチド性サイクロフィリン結合化合物とその用途
US7371763B2 (en) 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
CA2475818C (en) 2002-02-11 2011-07-19 Bayer Pharmaceuticals Corporation Aryl ureas as kinase inhibitors
ES2425739T3 (es) 2002-02-11 2013-10-17 Bayer Healthcare Llc Sorafenib-tosilato para el tratamiento de enfermedades caracterizadas por angiogénesis anormal
AU2003209119A1 (en) 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
DE10217518A1 (de) * 2002-04-19 2003-11-06 Bayer Ag Lactone
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
ES2383298T3 (es) 2003-04-30 2012-06-20 Novartis Ag Derivados del amino-propanol como moduladores del receptor esfingosina-1-fosfato
DE602004011340T2 (de) 2003-05-20 2008-11-06 Bayer Healthcare Llc Diaryl-harnstoffe mit kinasehemmender wirkung
WO2005007621A2 (en) * 2003-05-30 2005-01-27 Rigel Pharmaceuticals, Inc. Ubiquitin ligase inhibitors
US7718671B2 (en) * 2003-07-10 2010-05-18 Achillion Pharmaceuticals, Inc. Substituted arylthiourea derivatives useful as inhibitors of viral replication
NZ544920A (en) 2003-07-23 2009-11-27 Bayer Healthcare Llc 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide and metabolites for the treatment and prevention of diseases and conditions
CN1849117B (zh) * 2003-09-11 2010-05-26 泰博特克药品有限公司 Hiv病毒的侵入抑制剂
JP5327744B2 (ja) * 2009-03-13 2013-10-30 国立大学法人 鹿児島大学 ジフェニルメタン誘導体を有効成分とする抗ウイルス剤
WO2020006494A1 (en) 2018-06-29 2020-01-02 Fred Hutchinson Cancer Research Center Cell-stored barcoded deep mutational scanning libraries and uses of the same
TWI838401B (zh) 2018-09-12 2024-04-11 瑞士商諾華公司 抗病毒性吡啶并吡𠯤二酮化合物
TWI867053B (zh) 2019-09-26 2024-12-21 瑞士商諾華公司 抗病毒吡唑并吡啶酮化合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56108759A (en) * 1980-01-29 1981-08-28 Mitsui Toatsu Chem Inc Novel bisphenol compound and its preparation
NL8120075A (nl) * 1981-03-30 1983-02-01 Ciba Geigy Fenoxyfenylisothiourea, fenoxyfenylthiourea als tussenprodukten, de bereiding en toepassing ervan bij de bestrijding van schadelijke organismen.
DE3626309A1 (de) * 1986-08-02 1988-02-18 Stockhausen Chem Fab Gmbh Antivirusmittel
JPH02237922A (ja) * 1989-01-24 1990-09-20 Green Cross Corp:The 抗ウィルス剤
NZ240313A (en) * 1990-10-22 1994-04-27 Res Corp Technologies Inc Anti-retrovirus compositions containing aryl and heteroaryl derivatives
ATE116637T1 (de) * 1991-02-05 1995-01-15 Merrell Dow Pharma Sulfonische stilbenderivate zur behandlung von viruserkrankungen.
US5569643A (en) * 1991-03-07 1996-10-29 Nippon Oil Co., Ltd. Grease composition for constant velocity joint
YU63392A (sh) * 1991-06-19 1994-11-15 Schering Corporation Bis(oksi) jedinjenja i postupak za njihovo dobijanje
EP0571083B1 (en) * 1992-05-18 1997-06-18 Kao Corporation Developer additive, toner and developer composition
JP3603315B2 (ja) * 1993-02-19 2004-12-22 日本製紙株式会社 近赤外線吸収剤およびそれを含有した熱線遮蔽材
JP3509082B2 (ja) * 1994-06-23 2004-03-22 日本製紙株式会社 感熱記録体
US5629124A (en) * 1995-01-31 1997-05-13 Mitsubishi Chemical Corporation Charge controlling agent for electrostatic image development, and toner and charge-imparting material employing it

Also Published As

Publication number Publication date
ATE298741T1 (de) 2005-07-15
DE69811062D1 (de) 2003-03-06
EP0973735B1 (en) 2003-01-29
JP2001519808A (ja) 2001-10-23
ES2191292T3 (es) 2003-09-01
DE69811062T2 (de) 2003-07-17
AU6783698A (en) 1998-10-30
DK0973735T3 (da) 2003-06-23
ATE231839T1 (de) 2003-02-15
US5958983A (en) 1999-09-28
DE69830751T2 (de) 2006-05-18
EP0973735A2 (en) 2000-01-26
WO1998045259A3 (en) 1999-02-25
DE69830751D1 (de) 2005-08-04
WO1998045259A2 (en) 1998-10-15
US6147116A (en) 2000-11-14

Similar Documents

Publication Publication Date Title
ES2243370T3 (es) Composiciones poliaromaticas para el tratamiento de infecciones por virus herpes.
ES2607901T3 (es) Profármacos hidrosolubles cargados positivamente de 1H-imidazo[4,5-c]quinolin-4-aminas y compuestos relacionados con ratas de penetración de piel muy altas
ES2445442T3 (es) Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
ES2266313T3 (es) Derivados de triazolodiamina sustituidos como inhibidores de la quinasa.
ES2315566T3 (es) Tiazolidin-4-onas para inhibir proteinas hyak3.
ES2657687T3 (es) Derivados de pirrolopirimidina para uso en el tratamiento de infecciones virales
ES2387780T3 (es) Preparación de azabencimidazoles 1,6-disustituidos como inhibidores de quinasas
ES2260036T3 (es) Derivados de urea como inhibidores del receptor ccr-3.
CN101677554A (zh) 化合物
ES2336425T3 (es) Derivados de tiazoles utiles como agentes antiinflamatorios.
SA99200059A (ar) مركبات إميدازول جديدة مستبدلة
CN102351931A (zh) 嘧啶核苷衍生物、合成方法及其在制备抗肿瘤、抗病毒药物中的应用
RU2003101319A (ru) Фармацевтическая композиция, обладающая улучшенным противоопухолевым действием и/или сниженными побочными эффектами, содержащая противоопухолевый агент и производное гидроксамовой кислоты
JP2002537396A (ja) 抗ウィルス活性を有する［１，８］ナフチリジン誘導体
ES2347136T3 (es) Derivados de bencenosulfonamidas farmaceuticamente activos en calidad de inhibidores de proteinas jun-quinasas.
CN115873065B (zh) 半胱氨酸蛋白酶抑制剂及其用途
ES2782357T3 (es) Inhibidores de IRE 1 alfa
ES2201666T3 (es) Nuevas sulfonamidas sustituidas por naftilo y anilida.
US6177437B1 (en) Inhibitors of Herpes Simplex virus uracil-DNA glycosylase
ES2323137T3 (es) Composicion antiparasitaria que contiene una sal de amina organica de closantel.
ES2315650T3 (es) Uso farmaceutico de 1-azabiciclo-2,2,2 octanos y un metodo para ensayar compuetos con respecto a la capacidad de activar wt p53 inactivo.
ES2322263T3 (es) Mitroxiderivados de enalapril y compuestos relacionados con inhibidores de ace, para el tratamiento de enfermedades cardiovasculares.
ES2218216T3 (es) Analogos de nucleosidos de dioxolano para el tratamiento o la prevencion de infecciones viricas.
ES2355421T3 (es) Agente preventivo o terapéutico para enfermedades asociadas con el virus herpes.
EP1148048B1 (en) Polyaromatic compounds for treating herpes viral infections