EA200100640A1 - Ингибиторы вирусов герпеса, представляющие собой ацетамид и замещенные ацетамидосодержащие тиомочевины - Google Patents

Ингибиторы вирусов герпеса, представляющие собой ацетамид и замещенные ацетамидосодержащие тиомочевины

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Publication number
EA200100640A1
EA200100640A1 EA200100640A EA200100640A EA200100640A1 EA 200100640 A1 EA200100640 A1 EA 200100640A1 EA 200100640 A EA200100640 A EA 200100640A EA 200100640 A EA200100640 A EA 200100640A EA 200100640 A1 EA200100640 A1 EA 200100640A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carbon atoms
alkyl
acetamide
perhaloalkyl
sor
Prior art date
Application number
EA200100640A
Other languages
English (en)
Inventor
Джонатан Дэвид Блум
Мартин Джозеф Дигранди
Расселл Джордж Дашин
Стэнли Альберт Лэнг
Брайан Марк О'Хара
Original Assignee
Американ Хоум Продактс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Американ Хоум Продактс Корпорейшн filed Critical Американ Хоум Продактс Корпорейшн
Publication of EA200100640A1 publication Critical patent/EA200100640A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Соединения формулы (I), где R-Rнезависимо выбраны из водорода, алкила с 1-6 углеродными атомами, алкенила с 2-6 углеродными атомами, алкинила с 2-6 углеродными атомами, пергалогеналкила с 1-6 углеродными атомами, циклоалкила с 3-10 углеродными атомами, гетероциклоалкила с 3-10 углеродными членами, арила, гетероарила, галогена, -CN, -NO, -COR, -COR, -OR, -SR, -SOR, -SOR, -CONRR, -NRN(RR), -N(RR) или W-Y-(CH)-Z при условии, что, по крайней мере, один из радикалов R-Rне является водородом; или Rи Rили Rи R, взятые вместе, образуют 3-7-членный гетероциклоалкил или 3-7-членный гетероарил; Rи Rнезависимо представляют водород, алкил с 1-6 углеродными атомами, пергалогеналкил с 1-6 углеродными атомами или арил; Rпредставляет водород, алкил с 1-6 углеродными атомами, пергалогеналкил с 1-6 углеродными атомами, циклоалкил с 3-10 углеродными атомами, гетероциклоалкил с 3-10 членами, арил или гетероарил, или Rи R, взятые вместе, могут образовывать 3-7-членный гетероциклоалкил; R-Rнезависимо представляют водород, алкил с 1-4 углеродными атомами, пергалогеналкил с 1-4 углеродными атомами, галоген, алкокси с 1-4 углеродными атомами или циано, или Rи Rили Rи Rмогут быть взяты вместе с образованием арила с 5-7 углеродными атомами; W представляет O, NRили отсутствует; Y представляет -(CO)- или -(CO)- или отсутствует; Z представляет алкил с 1-4 углеродными атомами, -CN, -COR, -COR, -CONRR, -OCOR, -NRCOR, -OCONR, -OR, -SR, -SOR, -SOR, -SRN(RR), -N(RR) или фенил; G представляет алкил с 1-6 углеродными атомами; X представляет связь, -NH, алкил с 1-6 углеродными атомами, алкенил с 1-6 углеродными атомами, алкокси с 1-6 углеродными атомами, тиоалкил с 1-6 углеродными атомами, алкиламино с 1-6 углеродными атомами или (CH)J; J представляет алкил с 1-6 углеродными атомами, циклоалкил с 3-7 углеродными атомами, фенил или бензил; и n представляет целое число от 1 до 6; или их фармацевтические соли полезны для лечения заболеваний, вызванных вирусами
EA200100640A 1998-12-09 1999-12-06 Ингибиторы вирусов герпеса, представляющие собой ацетамид и замещенные ацетамидосодержащие тиомочевины EA200100640A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20831698A 1998-12-09 1998-12-09
PCT/US1999/028844 WO2000034237A2 (en) 1998-12-09 1999-12-06 Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses

Publications (1)

Publication Number Publication Date
EA200100640A1 true EA200100640A1 (ru) 2001-12-24

Family

ID=22774137

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100640A EA200100640A1 (ru) 1998-12-09 1999-12-06 Ингибиторы вирусов герпеса, представляющие собой ацетамид и замещенные ацетамидосодержащие тиомочевины

Country Status (15)

Country Link
EP (1) EP1137633A2 (ru)
JP (1) JP2002531544A (ru)
KR (1) KR20010087413A (ru)
CN (1) CN1333750A (ru)
AU (1) AU3111200A (ru)
BR (1) BR9916041A (ru)
CA (1) CA2350899A1 (ru)
CZ (1) CZ20012060A3 (ru)
EA (1) EA200100640A1 (ru)
HU (1) HUP0104944A3 (ru)
IL (1) IL143204A0 (ru)
NO (1) NO20012834L (ru)
PL (1) PL349131A1 (ru)
WO (1) WO2000034237A2 (ru)
ZA (1) ZA200104142B (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6166028A (en) * 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
ATE311366T1 (de) 2000-02-29 2005-12-15 Millennium Pharm Inc Benzamide und ähnliche inhibitoren vom faktor xa
JP4690889B2 (ja) * 2002-10-24 2011-06-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング メチレン尿素誘導体
US7220768B2 (en) * 2003-02-11 2007-05-22 Wyeth Holdings Corp. Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus
EP2287326A1 (en) 2003-08-08 2011-02-23 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
KR100878737B1 (ko) 2003-08-29 2009-01-14 미쓰이 가가쿠 가부시키가이샤 농업용 또는 원예용 살충제 및 그의 이용 방법
EP1737499A4 (en) 2004-03-09 2009-07-22 Arriva Pharmaceuticals Inc TREATMENT OF CHRONIC OBSTRUCTIVE LUNG DISEASE BY INHALATION OF LOW DOSES OF A PROTEASE HEMMER
WO2008043840A2 (en) * 2006-10-13 2008-04-17 Lica Pharmaceuticals Anti-infective thiourea compounds
US8524907B2 (en) 2006-11-02 2013-09-03 Millennium Pharmaceuticals, Inc. Methods of synthesizing pharmaceutical salts of a factor Xa inhibitor
CN108619123A (zh) * 2018-03-13 2018-10-09 武汉威立得生物医药有限公司 Tenovin-1在制备防治人类疱疹病毒感染药物中的应用
WO2019193541A1 (en) * 2018-04-06 2019-10-10 Glaxosmithkline Intellectual Property Development Limited Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors
CN112807294B (zh) * 2019-11-18 2023-09-05 武汉大学 一种酰基硫脲类化合物在制备治疗或预防单纯疱疹病毒i型感染药物中的应用
WO2022150962A1 (en) * 2021-01-12 2022-07-21 Westlake Pharmaceutical (Hangzhou) Co., Ltd. Protease inhibitors, preparation, and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69811062T2 (de) * 1997-04-10 2003-07-17 Upjohn Co Polyaromatische antivirale zusammensetzungen

Also Published As

Publication number Publication date
CA2350899A1 (en) 2000-06-15
ZA200104142B (en) 2002-10-25
BR9916041A (pt) 2001-12-04
WO2000034237A3 (en) 2000-11-23
AU3111200A (en) 2000-06-26
EP1137633A2 (en) 2001-10-04
NO20012834D0 (no) 2001-06-08
CZ20012060A3 (cs) 2001-11-14
JP2002531544A (ja) 2002-09-24
WO2000034237A2 (en) 2000-06-15
HUP0104944A3 (en) 2003-03-28
IL143204A0 (en) 2002-04-21
PL349131A1 (en) 2002-07-01
NO20012834L (no) 2001-08-07
CN1333750A (zh) 2002-01-30
KR20010087413A (ko) 2001-09-15
HUP0104944A2 (hu) 2002-04-29

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