HUP0104944A2 - Acetamidot és szubsztituált acetamidot tartalmazó tiokarbamidok, mint herpeszvírus inhibitorok és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Acetamidot és szubsztituált acetamidot tartalmazó tiokarbamidok, mint herpeszvírus inhibitorok és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0104944A2 HUP0104944A2 HU0104944A HUP0104944A HUP0104944A2 HU P0104944 A2 HUP0104944 A2 HU P0104944A2 HU 0104944 A HU0104944 A HU 0104944A HU P0104944 A HUP0104944 A HU P0104944A HU P0104944 A2 HUP0104944 A2 HU P0104944A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- carbon atoms
- acetamide
- hydrogen atom
- herpes viruses
- Prior art date
Links
- 241001529453 unidentified herpesvirus Species 0.000 title abstract 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 title 3
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 title 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 150000003869 acetamides Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Furan Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Quinoline Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Az (1) ltal nos képletű vegyületek - a képletben R1-R5 jelentése egymstól függetlenül hidrogénatom, 1-6 szénatomos alkilcsoport, 2-6szénatomos alkenilcsoport, 2-6 szénatomos alkinilcsoport, 1-6szénatomos perhalogénalkilcsoport, 3-10 szénatomos cikloalkilcsoport,3-10 gyűrű-szénatomot tartalmazó heterocikloalkilcsoport, arilcsoport,heteroarilcsoport, halogénatom, -CN, -NO2, -CO2R6, -COR6, -OR6, -SR6,-SOR6, -SO2R6, -CONR7R8, -NR6N(R7R8), -N(R7R8) vagy W-Y-(CH2)n-Z ltalnos képletű csoport, azzal a megk"téssel, hogy az R1-R5szubsztituensek legal bb egyike hidrogénatomtól eltérő; vagy R2 és R3vagy R3 és R4 együtt 3-7 tagú heterocikloalkilcsoportot vagy 3-7 tagúheteroarilcsoportot alkotnak; R9-R12 jelentése egym stól függetlenülhidrogénatom, 1-4 szénatomos alkilcsoport, 1-4 szénatomosperhalogénalkilcsoport, halogénatom, 1-4 szénatomos alkoxicsoport vagycianocsoport, vagy R9 és R10 vagy R11 és R12 együtt 5-7 szénatomosarilcsoportot alkotnak; G jelentése 1-6 szénatomos alkilcsoport és Xjelentése kémiai k"tés, -NH, 1-6 szénatomos alkilcsoport, 1-6szénatomos alkenilcsoport, 1-6 szénatomos alkoxicsoport, 1-6szénatomos tioalkilcsoport, 1-6 szénatomos alkilaminocsoport vagy(CH)J és gyógy szatilag elfogadható sóik herpeszvírusok szaporod s t gtló aktivit ssal rendelkeznek, fenti aktivit suk k"vetkeztében gyógyszati készítmények hatóanyagaként alkalmazhatók. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20831698A | 1998-12-09 | 1998-12-09 | |
| PCT/US1999/028844 WO2000034237A2 (en) | 1998-12-09 | 1999-12-06 | Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0104944A2 true HUP0104944A2 (hu) | 2002-04-29 |
| HUP0104944A3 HUP0104944A3 (en) | 2003-03-28 |
Family
ID=22774137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104944A HUP0104944A3 (en) | 1998-12-09 | 1999-12-06 | Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1137633A2 (hu) |
| JP (1) | JP2002531544A (hu) |
| KR (1) | KR20010087413A (hu) |
| CN (1) | CN1333750A (hu) |
| AU (1) | AU3111200A (hu) |
| BR (1) | BR9916041A (hu) |
| CA (1) | CA2350899A1 (hu) |
| CZ (1) | CZ20012060A3 (hu) |
| EA (1) | EA200100640A1 (hu) |
| HU (1) | HUP0104944A3 (hu) |
| IL (1) | IL143204A0 (hu) |
| NO (1) | NO20012834L (hu) |
| PL (1) | PL349131A1 (hu) |
| WO (1) | WO2000034237A2 (hu) |
| ZA (1) | ZA200104142B (hu) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6166028A (en) * | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| DK1259485T3 (da) | 2000-02-29 | 2006-04-10 | Millennium Pharm Inc | Benzamider og beslægtede inhibitorer for faktor Xa |
| CN1705645A (zh) * | 2002-10-24 | 2005-12-07 | 默克专利有限公司 | 作为raf－激酶抑制剂的亚甲基脲衍生物 |
| US7220768B2 (en) * | 2003-02-11 | 2007-05-22 | Wyeth Holdings Corp. | Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus |
| CA2534352A1 (en) | 2003-08-08 | 2005-02-17 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
| CA2904555C (en) | 2003-08-29 | 2017-03-07 | Mitsui Chemicals, Inc. | Agricultural/horticultural insecticide and method for using the same |
| CA2559062A1 (en) | 2004-03-09 | 2005-09-22 | Arriva Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor |
| US20100093864A1 (en) * | 2006-10-13 | 2010-04-15 | Lica Pharmaceuticals | Anti-infective thiourea compounds |
| WO2008057972A1 (en) | 2006-11-02 | 2008-05-15 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing pharmaceutical salts of a factor xa inhibitor |
| CN108619123A (zh) * | 2018-03-13 | 2018-10-09 | 武汉威立得生物医药有限公司 | Tenovin-1在制备防治人类疱疹病毒感染药物中的应用 |
| WO2019193541A1 (en) * | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors |
| CN112807294B (zh) * | 2019-11-18 | 2023-09-05 | 武汉大学 | 一种酰基硫脲类化合物在制备治疗或预防单纯疱疹病毒i型感染药物中的应用 |
| WO2022150962A1 (en) * | 2021-01-12 | 2022-07-21 | Westlake Pharmaceutical (Hangzhou) Co., Ltd. | Protease inhibitors, preparation, and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001519808A (ja) * | 1997-04-10 | 2001-10-23 | ファルマシア・アンド・アップジョン・カンパニー | ポリ芳香族抗菌組成物 |
-
1999
- 1999-12-06 KR KR1020017007052A patent/KR20010087413A/ko not_active Application Discontinuation
- 1999-12-06 WO PCT/US1999/028844 patent/WO2000034237A2/en not_active Application Discontinuation
- 1999-12-06 EA EA200100640A patent/EA200100640A1/ru unknown
- 1999-12-06 IL IL14320499A patent/IL143204A0/xx unknown
- 1999-12-06 AU AU31112/00A patent/AU3111200A/en not_active Abandoned
- 1999-12-06 CA CA002350899A patent/CA2350899A1/en not_active Abandoned
- 1999-12-06 HU HU0104944A patent/HUP0104944A3/hu unknown
- 1999-12-06 CN CN99815640A patent/CN1333750A/zh active Pending
- 1999-12-06 CZ CZ20012060A patent/CZ20012060A3/cs unknown
- 1999-12-06 JP JP2000586685A patent/JP2002531544A/ja active Pending
- 1999-12-06 PL PL99349131A patent/PL349131A1/xx not_active Application Discontinuation
- 1999-12-06 EP EP99965132A patent/EP1137633A2/en not_active Withdrawn
- 1999-12-06 BR BR9916041-2A patent/BR9916041A/pt not_active Application Discontinuation
-
2001
- 2001-05-21 ZA ZA200104142A patent/ZA200104142B/en unknown
- 2001-06-08 NO NO20012834A patent/NO20012834L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU3111200A (en) | 2000-06-26 |
| CA2350899A1 (en) | 2000-06-15 |
| ZA200104142B (en) | 2002-10-25 |
| NO20012834D0 (no) | 2001-06-08 |
| WO2000034237A2 (en) | 2000-06-15 |
| BR9916041A (pt) | 2001-12-04 |
| EA200100640A1 (ru) | 2001-12-24 |
| IL143204A0 (en) | 2002-04-21 |
| KR20010087413A (ko) | 2001-09-15 |
| WO2000034237A3 (en) | 2000-11-23 |
| PL349131A1 (en) | 2002-07-01 |
| CZ20012060A3 (cs) | 2001-11-14 |
| CN1333750A (zh) | 2002-01-30 |
| EP1137633A2 (en) | 2001-10-04 |
| JP2002531544A (ja) | 2002-09-24 |
| HUP0104944A3 (en) | 2003-03-28 |
| NO20012834L (no) | 2001-08-07 |
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