NO20012834L - Acetamid- og substituerte acetamid-holdige tioureainhibitorer for herpesvirus - Google Patents
Acetamid- og substituerte acetamid-holdige tioureainhibitorer for herpesvirusInfo
- Publication number
- NO20012834L NO20012834L NO20012834A NO20012834A NO20012834L NO 20012834 L NO20012834 L NO 20012834L NO 20012834 A NO20012834 A NO 20012834A NO 20012834 A NO20012834 A NO 20012834A NO 20012834 L NO20012834 L NO 20012834L
- Authority
- NO
- Norway
- Prior art keywords
- carbon atoms
- alkyl
- perhaloalkyl
- aryl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Furan Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
Forbindelser med formelen: hvori RrRs uavhengig er valgt fra hydrogen, alkyl med 1 til 6 karbonatomer, alkenyl med 2 til 6 karbonatomer, alkynyl med 2 til 6 karbonatomer, perhalogenalkyl med 1 til 6 karbonatomer. cykloalkyl med 3 til 10 karbonatomer. heterocykloalkyl med 3 til 10 karbonelementer. aryl. heteroaryl. halogen. -CN. -NO* -COzR8. -CORe. -OR6. -SR6. -SOR,. -SOjRa. -CONR7R.. -NR«N(R7FU). -N(R7R«) eller W-Y-(CH2)n-Z forutsatt at minst en av R,-RS ikke er hydrogen; eller R2 og Rs eller R3 og R«, tilsammen danner en 3- til 7-leddet heterocykloalkyl eller 3- til 7-leddet heteroaryl; R« og R7 er uavhengig hydrogen, alkyl med 1 til 6 karbonatomer. perhalogenalkyl med 1 til 6 karbonatomer eller aryl; R» er hydrogen, alkyl med 1 til 6 karbonatomer. perhalogenalkyl med 1 til 6 karbonatomer. cykloalkyl med 3 til 10 karbon- atomer. heterocykloalkyl med 3 til 10 elementer, aryl eller heteroaryl. eller R7 og Rg, danner sammen en 3- til 7-leddet heterocykloalkyl; R,rR12 er uavhengig hydrogen, alkyl med 1 til 4 karbonatomer, perhalogenalkyl med 1 til 4 karbonatomer. halogen, alkoksy med 1 til 4 karbonatomer eller cyano eller R» og R10 eller R,, og R12 kan sammen danne aryl med 5 til 7 karbonatomer; W er O. NR6 eller mangler; Y er -(CO)- eller -(CO2)- eller mangler; Z er alkyl med 1 til 4 karbonatomer, -CN, -CO2R8, COR6, -CONR7R8, -OCOR6, -NR6COR7, -OCONR,,. -OR«, -SRa. -SOR«, -S02R6, SR6N(R7R8), -N(R7R8) eller fenyl; G er alkyl med 1 til 6 karbon- atomer; og X er en binding, -NH. alkyl med 1 til 6 karbonatomer, alkenyl med 1 til 6 karbon- atomer, alkoksy med 1 til 6 karbonatomer, tioalkyl med 1 til 6 karbonatomer, alkylamino med 1 til 6 karbonatomer eller (CH)J; J er alkyl med 1 til 6 karbonatomer, cykloalkyl med 3 til 7 karbonatomer. fenyl eller benzyl; og n er et heltall fra 1 til 6; eller farmasøytiske salter derav, er anvendelige ved behandling av sykdommer i forbindelse med herpesvirus innbefattet human cytomegalovirus, herpes simplex virus, Epstein-Barr virus, varicella-zoster virus, human herpesvirus-6 og -7 og Kapsosi herpesvirus.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20831698A | 1998-12-09 | 1998-12-09 | |
| PCT/US1999/028844 WO2000034237A2 (en) | 1998-12-09 | 1999-12-06 | Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20012834D0 NO20012834D0 (no) | 2001-06-08 |
| NO20012834L true NO20012834L (no) | 2001-08-07 |
Family
ID=22774137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20012834A NO20012834L (no) | 1998-12-09 | 2001-06-08 | Acetamid- og substituerte acetamid-holdige tioureainhibitorer for herpesvirus |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1137633A2 (no) |
| JP (1) | JP2002531544A (no) |
| KR (1) | KR20010087413A (no) |
| CN (1) | CN1333750A (no) |
| AU (1) | AU3111200A (no) |
| BR (1) | BR9916041A (no) |
| CA (1) | CA2350899A1 (no) |
| CZ (1) | CZ20012060A3 (no) |
| EA (1) | EA200100640A1 (no) |
| HU (1) | HUP0104944A3 (no) |
| IL (1) | IL143204A0 (no) |
| NO (1) | NO20012834L (no) |
| PL (1) | PL349131A1 (no) |
| WO (1) | WO2000034237A2 (no) |
| ZA (1) | ZA200104142B (no) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6166028A (en) * | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| DK1259485T3 (da) | 2000-02-29 | 2006-04-10 | Millennium Pharm Inc | Benzamider og beslægtede inhibitorer for faktor Xa |
| RU2005115842A (ru) * | 2002-10-24 | 2006-03-10 | Мерк Патент ГмбХ (DE) | Производные метиленмочевины |
| US7220768B2 (en) * | 2003-02-11 | 2007-05-22 | Wyeth Holdings Corp. | Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus |
| WO2005014825A2 (en) | 2003-08-08 | 2005-02-17 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
| CN100554249C (zh) | 2003-08-29 | 2009-10-28 | 三井化学株式会社 | 农园艺用杀虫剂及其使用方法 |
| US7914771B2 (en) | 2004-03-09 | 2011-03-29 | Arriva Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor |
| EP2074085A2 (en) * | 2006-10-13 | 2009-07-01 | Lica Pharmaceuticals A/S | Anti-infective thiourea compounds |
| ES2382055T3 (es) | 2006-11-02 | 2012-06-04 | Millennium Pharmaceuticals, Inc. | Métodos para sintetizar sales farmacéuticas de un inhibidor del factor Xa |
| CN108619123A (zh) * | 2018-03-13 | 2018-10-09 | 武汉威立得生物医药有限公司 | Tenovin-1在制备防治人类疱疹病毒感染药物中的应用 |
| WO2019193541A1 (en) * | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors |
| CN112807294B (zh) * | 2019-11-18 | 2023-09-05 | 武汉大学 | 一种酰基硫脲类化合物在制备治疗或预防单纯疱疹病毒i型感染药物中的应用 |
| WO2022150962A1 (en) * | 2021-01-12 | 2022-07-21 | Westlake Pharmaceutical (Hangzhou) Co., Ltd. | Protease inhibitors, preparation, and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69811062T2 (de) * | 1997-04-10 | 2003-07-17 | Upjohn Co | Polyaromatische antivirale zusammensetzungen |
-
1999
- 1999-12-06 BR BR9916041-2A patent/BR9916041A/pt not_active Application Discontinuation
- 1999-12-06 IL IL14320499A patent/IL143204A0/xx unknown
- 1999-12-06 JP JP2000586685A patent/JP2002531544A/ja active Pending
- 1999-12-06 CN CN99815640A patent/CN1333750A/zh active Pending
- 1999-12-06 EP EP99965132A patent/EP1137633A2/en not_active Withdrawn
- 1999-12-06 KR KR1020017007052A patent/KR20010087413A/ko not_active Application Discontinuation
- 1999-12-06 CZ CZ20012060A patent/CZ20012060A3/cs unknown
- 1999-12-06 EA EA200100640A patent/EA200100640A1/ru unknown
- 1999-12-06 HU HU0104944A patent/HUP0104944A3/hu unknown
- 1999-12-06 WO PCT/US1999/028844 patent/WO2000034237A2/en not_active Application Discontinuation
- 1999-12-06 PL PL99349131A patent/PL349131A1/xx not_active Application Discontinuation
- 1999-12-06 AU AU31112/00A patent/AU3111200A/en not_active Abandoned
- 1999-12-06 CA CA002350899A patent/CA2350899A1/en not_active Abandoned
-
2001
- 2001-05-21 ZA ZA200104142A patent/ZA200104142B/en unknown
- 2001-06-08 NO NO20012834A patent/NO20012834L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0104944A3 (en) | 2003-03-28 |
| EP1137633A2 (en) | 2001-10-04 |
| ZA200104142B (en) | 2002-10-25 |
| AU3111200A (en) | 2000-06-26 |
| CZ20012060A3 (cs) | 2001-11-14 |
| HUP0104944A2 (hu) | 2002-04-29 |
| EA200100640A1 (ru) | 2001-12-24 |
| CA2350899A1 (en) | 2000-06-15 |
| IL143204A0 (en) | 2002-04-21 |
| BR9916041A (pt) | 2001-12-04 |
| PL349131A1 (en) | 2002-07-01 |
| JP2002531544A (ja) | 2002-09-24 |
| WO2000034237A2 (en) | 2000-06-15 |
| CN1333750A (zh) | 2002-01-30 |
| NO20012834D0 (no) | 2001-06-08 |
| KR20010087413A (ko) | 2001-09-15 |
| WO2000034237A3 (en) | 2000-11-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |