EA200100638A1 - Ингибиторы герпесвирусов на основе альфа-метилбензил-содержащей тиомочевины, включающие фенилендиаминогруппу - Google Patents
Ингибиторы герпесвирусов на основе альфа-метилбензил-содержащей тиомочевины, включающие фенилендиаминогруппуInfo
- Publication number
- EA200100638A1 EA200100638A1 EA200100638A EA200100638A EA200100638A1 EA 200100638 A1 EA200100638 A1 EA 200100638A1 EA 200100638 A EA200100638 A EA 200100638A EA 200100638 A EA200100638 A EA 200100638A EA 200100638 A1 EA200100638 A1 EA 200100638A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- carbon atoms
- alkyl
- sor
- cor
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
Соединения, имеющие формулу (I), где R-Rнезависимо выбраны из водорода, алкила с 1-6 атомами углерода, алкенила с 2-6 атомами углерода, алкинила с 2-6 атомами углерода, пергалогеналкила с 1-6 атомами углерода, циклоалкила с 3-10 атомами углерода, гетероциклоалкила с 3-10 углеродными членами, арила, гетероарила, галогена, -CN, -NO, -COR, -COR, -OR, -SR, -SOR, -SOR, -CONRR, -NRN(RR), -N(RR) или W-Y-(CH)-Z при условии, что, по меньшей мере, один из R-Rне является водородом; или Rи Rлибо Rи R, взятые вместе, образуют (3-7)-членный гетероциклоалкил или (3-7)-членный гетероарил; Rи Rнезависимо представляют водород, алкил с 1-6 атомами углерода, пергалогеналкил с 1-6 атомами углерода или арил; Rпредставляет водород, алкил с 1-6 атомами углерода, пергалогеналкил с 1-6 атомами углерода, циклоалкил с 3-10 атомами углерода, гетероциклоалкил с 3-10 членами, арил или гетероарил, или Rи R, взятые вместе, могут образовывать (3-7)-членный гетероциклоалкил; W представляет O, NRили отсутствует; Y представляет -(CO)- или -(CO)- или отсутствует; Z представляет алкил с 1-4 атомами углерода, -CN, -COR, -COR, -CONRR, -OCOR, -NRCOR, -OCONR, -OR, -SR, -SOR, -SOR, -NRN(RR), -N(RR) или фенил; G представляет арил или конденсированный бициклический гетероарил; Х представляет связь, -NH, алкил с 1-6-атомами углерода, алкенил с 2-6 атомами углерода, алкокси с 1-6 атомами углерода, тиоалкил с 1-6 атомами углерода, алкиламино с 1-6 атомами углерода или (CH)J; J представляет алкил с 1-6 атомами углерода, циклоалкил с 3-7 атомами углерода, фенил или бензил; и n равно целому числу от 1 до 6; полезные при лечении заболеваний, связанных с вирусами герпеса, включая цитомегаловирус человека, вирус простого герпеса, вирус Эпштейн-Барра, вирус ветряной оспы, герпесвирусы-6 и -7 человека и герпесвирус Капози.Отчет о международном поиске был опубликован 2000.09.08.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20890298A | 1998-12-09 | 1998-12-09 | |
PCT/US1999/028839 WO2000034260A2 (en) | 1998-12-09 | 1999-12-06 | Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200100638A1 true EA200100638A1 (ru) | 2001-12-24 |
EA004205B1 EA004205B1 (ru) | 2004-02-26 |
Family
ID=22776519
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200100638A EA004205B1 (ru) | 1998-12-09 | 1999-12-06 | Ингибиторы герпесвирусов на основе альфа-метилбензилсодержащей тиомочевины, включающие фенилендиаминогруппу |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1137645B1 (ru) |
JP (1) | JP2002531555A (ru) |
KR (1) | KR20010089551A (ru) |
CN (1) | CN1165531C (ru) |
AR (1) | AR035308A1 (ru) |
AT (1) | ATE267824T1 (ru) |
AU (1) | AU1934600A (ru) |
BR (1) | BR9916084A (ru) |
CA (1) | CA2350833A1 (ru) |
CZ (1) | CZ20012067A3 (ru) |
DE (1) | DE69917673T2 (ru) |
DK (1) | DK1137645T3 (ru) |
EA (1) | EA004205B1 (ru) |
ES (1) | ES2221470T3 (ru) |
HU (1) | HUP0104492A3 (ru) |
IL (1) | IL143183A0 (ru) |
NO (1) | NO20012833L (ru) |
NZ (1) | NZ512135A (ru) |
PT (1) | PT1137645E (ru) |
WO (1) | WO2000034260A2 (ru) |
ZA (1) | ZA200104376B (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
ES2254385T3 (es) | 2000-02-29 | 2006-06-16 | Millennium Pharmaceuticals, Inc. | Benzamidas e inhibidores relacionados del factor xa. |
DE60133743T2 (de) * | 2000-08-21 | 2009-07-02 | Pacific Corp. | Neue thiourea-derivate und pharmazeutische zusammensetzungen die diese enthalten |
JP4360885B2 (ja) | 2003-11-28 | 2009-11-11 | 富士フイルム株式会社 | アルキルチオ基を有する芳香族アミン化合物の製造方法 |
CA2619366A1 (en) * | 2005-08-22 | 2007-03-01 | Amgen Inc. | Bis-aryl urea compounds for the treatment of protein kinase-mediated diseases |
WO2008057972A1 (en) | 2006-11-02 | 2008-05-15 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing pharmaceutical salts of a factor xa inhibitor |
CN112807294B (zh) * | 2019-11-18 | 2023-09-05 | 武汉大学 | 一种酰基硫脲类化合物在制备治疗或预防单纯疱疹病毒i型感染药物中的应用 |
CN115433093A (zh) * | 2022-09-26 | 2022-12-06 | 无锡双启科技有限公司 | 一种3-氯-4-三氟甲基苯胺的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU210683B (en) * | 1990-06-18 | 1995-06-28 | Sandoz Ag | Process for producing n-benzyl-n1-(phenyl-alkyl)-thiourea derivatives and pharmaceutical compositions containing the same |
EP0809492A4 (en) * | 1995-02-17 | 2007-01-24 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
GB9519270D0 (en) * | 1995-09-21 | 1995-11-22 | Sandoz Pharma Uk | Organic compounds |
CZ298463B6 (cs) * | 1996-04-23 | 2007-10-10 | Vertex Pharmaceuticals Incorporated | Deriváty mocoviny pro použití jako inhibitory IMPDH enzymu a farmaceutické prostredky, které je obsahují |
-
1999
- 1999-12-06 AU AU19346/00A patent/AU1934600A/en not_active Abandoned
- 1999-12-06 HU HU0104492A patent/HUP0104492A3/hu unknown
- 1999-12-06 CZ CZ20012067A patent/CZ20012067A3/cs unknown
- 1999-12-06 IL IL14318399A patent/IL143183A0/xx unknown
- 1999-12-06 KR KR1020017007053A patent/KR20010089551A/ko not_active Application Discontinuation
- 1999-12-06 WO PCT/US1999/028839 patent/WO2000034260A2/en not_active Application Discontinuation
- 1999-12-06 DK DK99963022T patent/DK1137645T3/da active
- 1999-12-06 AT AT99963022T patent/ATE267824T1/de not_active IP Right Cessation
- 1999-12-06 CN CNB998142778A patent/CN1165531C/zh not_active Expired - Fee Related
- 1999-12-06 JP JP2000586707A patent/JP2002531555A/ja active Pending
- 1999-12-06 BR BR9916084-6A patent/BR9916084A/pt not_active IP Right Cessation
- 1999-12-06 DE DE69917673T patent/DE69917673T2/de not_active Expired - Fee Related
- 1999-12-06 EP EP99963022A patent/EP1137645B1/en not_active Expired - Lifetime
- 1999-12-06 EA EA200100638A patent/EA004205B1/ru not_active IP Right Cessation
- 1999-12-06 NZ NZ512135A patent/NZ512135A/en unknown
- 1999-12-06 CA CA002350833A patent/CA2350833A1/en not_active Abandoned
- 1999-12-06 ES ES99963022T patent/ES2221470T3/es not_active Expired - Lifetime
- 1999-12-06 PT PT99963022T patent/PT1137645E/pt unknown
- 1999-12-07 AR ARP990106228A patent/AR035308A1/es not_active Application Discontinuation
-
2001
- 2001-05-28 ZA ZA200104376A patent/ZA200104376B/en unknown
- 2001-06-08 NO NO20012833A patent/NO20012833L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP0104492A3 (en) | 2002-12-28 |
CA2350833A1 (en) | 2000-06-15 |
PT1137645E (pt) | 2004-09-30 |
ATE267824T1 (de) | 2004-06-15 |
DE69917673T2 (de) | 2005-06-09 |
BR9916084A (pt) | 2001-09-04 |
KR20010089551A (ko) | 2001-10-06 |
DE69917673D1 (de) | 2004-07-01 |
HUP0104492A2 (hu) | 2002-04-29 |
NO20012833D0 (no) | 2001-06-08 |
WO2000034260A3 (en) | 2000-09-08 |
JP2002531555A (ja) | 2002-09-24 |
WO2000034260A2 (en) | 2000-06-15 |
NZ512135A (en) | 2003-12-19 |
AR035308A1 (es) | 2004-05-12 |
CN1329608A (zh) | 2002-01-02 |
ZA200104376B (en) | 2002-08-28 |
DK1137645T3 (da) | 2004-08-09 |
EP1137645A2 (en) | 2001-10-04 |
CZ20012067A3 (cs) | 2001-10-17 |
CN1165531C (zh) | 2004-09-08 |
ES2221470T3 (es) | 2004-12-16 |
NO20012833L (no) | 2001-08-02 |
EP1137645B1 (en) | 2004-05-26 |
EA004205B1 (ru) | 2004-02-26 |
AU1934600A (en) | 2000-06-26 |
IL143183A0 (en) | 2002-04-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |