BR9916084A - Composto, composição farmacêutica, e, processos para inibir a replicação de um vìrus da herpes, e para tratar um paciente sofrendo de uma infecção por vìrus da herpes - Google Patents

Composto, composição farmacêutica, e, processos para inibir a replicação de um vìrus da herpes, e para tratar um paciente sofrendo de uma infecção por vìrus da herpes

Info

Publication number
BR9916084A
BR9916084A BR9916084-6A BR9916084A BR9916084A BR 9916084 A BR9916084 A BR 9916084A BR 9916084 A BR9916084 A BR 9916084A BR 9916084 A BR9916084 A BR 9916084A
Authority
BR
Brazil
Prior art keywords
carbon atoms
herpes virus
alkyl
virus
heterocycloalkyl
Prior art date
Application number
BR9916084-6A
Other languages
English (en)
Inventor
Jonathan David Bloom
Kevin Joseph Curran
Martin Joseph Digrandi
Russell George Dushin
Stanley Albert Lang
Emily Boucher Norton
Adma Antonia Ross
Bryan Mark O'hara
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of BR9916084A publication Critical patent/BR9916084A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, E, PROCESSOS PARA INIBIR A REPLICAçãO DE UM VìRUS DA HERPES, E PARA TRATAR UM PACIENTE SOFRENDO DE UMA INFECçãO POR VìRUS DA HERPES". Compostos tendo a fórmula (I) em que R~ 1~ - R~ 5~ são independentemente selecionados dentre hidrogênio, alquila de 1 a 6 átomos de carbono, alquenila de 2 a 6 átomos de carbono, alquinila de 2 a 6 átomos de carbono, perhaloalquila de 1 a 6 átomos de carbono, cicloalquila de 3 a 10 átomos de carbono, heterocicloalquila de 3 a 10 membros de carbono, arila, heteroarila, halogênio, -CN, -NO~ 2~, -CO~ 2~R~ 6~, -COR~ 6~, -OR~ 6~, -SR~ 6~, -SOR~ 6~, -SO~ 2~R~ 6~, -CONR~ 7~R~ 8~, -NR~ 6~N (R~ 7~R~ 8~), -N (R~ 7~R~8~) ou W-Y- (CH~ 2~)~ n~ -Z desde que pelo menos um dentre R~ 1~ - R~ 5~ não é hidrogênio; ou R~ 2~ e R~ 3~ ou R~ 3~ e R~ 4~, tomados juntos formam um membro heterocicloalquila de 3 a 7 ou heteroarila de 3 a 7 membros; R~ 6~ e R~ 7~ são independentemente hidrogênio, alquila de 1 a 6 átomos de carbono, perhaloalquila de 1 a 6 átomos de carbono, ou arila; R~ 8~ é hidrogênio, alquila de 1 a 6 átomos de carbono, perhaloalquila de 1 a 6 átomos de carbono, cicloalquila de 3 a 10 átomos de carbono, heterocicloalquila de 3 a 10 membros, arila ou heteroarila, ou R~ 7~ e R~ 8~, tomados juntos, podem formar uma heterocicloalquila de 3 a 7 membros; W é O, NR~ 6~, ou está ausente; Y é -(CO)- ou -(CO~ 2~)-, ou está ausente; Z é alquila de 1 a 4 átomos de carbono, -CN, -CO~ 2~R~ 6~, COR~ 6~, -CONR~ 7~R~ 8~, -OCOR~ 6~, -NR~ 6~COR~ 7~, -OCONR~ 6~, -OR~ 6~, -SR~ 6~, -SOR~ 6~, -SO~ 2~R~ 6~, SR6N (R7R8), -N (R~ 7~R~ 8~) ou fenila; G é arila ou heteroarila bicíclica fundida; X é uma ligação, -NH, alquila de 1 6 átomos de carbono, alquenila de 1 a 6 átomos de carbono, alcoxi de 1 a 6 átomos de carbono, tioalquila de 1 a 6 átomos de carbono, alquilamino de 1 a 6 átomos de carbono, ou (CH) J; J é alquila de 1 a 6 átomos de carbono, cicloalquila de 3 a 7 átomos de carbono, fenila ou benzila; e n é um número inteiro de 1 a 6; utilizável no tratamento de doenças associadas com vírus da herpes incluindo citomegalovírus humano, vírus da herpes simplex, vírus Epstein-Barr, vírus da varicela-zoster, vírus da herpes humano 6 e 7, e vírus da herpes Kaposi.
BR9916084-6A 1998-12-09 1999-12-06 Composto, composição farmacêutica, e, processos para inibir a replicação de um vìrus da herpes, e para tratar um paciente sofrendo de uma infecção por vìrus da herpes BR9916084A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20890298A 1998-12-09 1998-12-09
PCT/US1999/028839 WO2000034260A2 (en) 1998-12-09 1999-12-06 Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group

Publications (1)

Publication Number Publication Date
BR9916084A true BR9916084A (pt) 2001-09-04

Family

ID=22776519

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916084-6A BR9916084A (pt) 1998-12-09 1999-12-06 Composto, composição farmacêutica, e, processos para inibir a replicação de um vìrus da herpes, e para tratar um paciente sofrendo de uma infecção por vìrus da herpes

Country Status (21)

Country Link
EP (1) EP1137645B1 (pt)
JP (1) JP2002531555A (pt)
KR (1) KR20010089551A (pt)
CN (1) CN1165531C (pt)
AR (1) AR035308A1 (pt)
AT (1) ATE267824T1 (pt)
AU (1) AU1934600A (pt)
BR (1) BR9916084A (pt)
CA (1) CA2350833A1 (pt)
CZ (1) CZ20012067A3 (pt)
DE (1) DE69917673T2 (pt)
DK (1) DK1137645T3 (pt)
EA (1) EA004205B1 (pt)
ES (1) ES2221470T3 (pt)
HU (1) HUP0104492A3 (pt)
IL (1) IL143183A0 (pt)
NO (1) NO20012833L (pt)
NZ (1) NZ512135A (pt)
PT (1) PT1137645E (pt)
WO (1) WO2000034260A2 (pt)
ZA (1) ZA200104376B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
WO2001064642A2 (en) 2000-02-29 2001-09-07 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
WO2002016318A1 (en) * 2000-08-21 2002-02-28 Pacific Corporation Novel thiourea derivatives and the pharmaceutical compositions containing the same
JP4360885B2 (ja) 2003-11-28 2009-11-11 富士フイルム株式会社 アルキルチオ基を有する芳香族アミン化合物の製造方法
US20070049592A1 (en) * 2005-08-22 2007-03-01 Geuns-Meyer Stephanie D Bis-aryl urea compounds and methods of use
WO2008057972A1 (en) 2006-11-02 2008-05-15 Millennium Pharmaceuticals, Inc. Methods of synthesizing pharmaceutical salts of a factor xa inhibitor
CN112807294B (zh) * 2019-11-18 2023-09-05 武汉大学 一种酰基硫脲类化合物在制备治疗或预防单纯疱疹病毒i型感染药物中的应用
CN115433093A (zh) * 2022-09-26 2022-12-06 无锡双启科技有限公司 一种3-氯-4-三氟甲基苯胺的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU210683B (en) * 1990-06-18 1995-06-28 Sandoz Ag Process for producing n-benzyl-n1-(phenyl-alkyl)-thiourea derivatives and pharmaceutical compositions containing the same
EP0809492A4 (en) * 1995-02-17 2007-01-24 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
GB9519270D0 (en) * 1995-09-21 1995-11-22 Sandoz Pharma Uk Organic compounds
EP0902782A1 (en) * 1996-04-23 1999-03-24 Vertex Pharmaceuticals Incorporated Urea derivatives as inhibitors of impdh enzyme

Also Published As

Publication number Publication date
DE69917673D1 (de) 2004-07-01
HUP0104492A3 (en) 2002-12-28
WO2000034260A3 (en) 2000-09-08
ZA200104376B (en) 2002-08-28
KR20010089551A (ko) 2001-10-06
EA200100638A1 (ru) 2001-12-24
JP2002531555A (ja) 2002-09-24
ATE267824T1 (de) 2004-06-15
ES2221470T3 (es) 2004-12-16
EP1137645B1 (en) 2004-05-26
CA2350833A1 (en) 2000-06-15
CZ20012067A3 (cs) 2001-10-17
CN1165531C (zh) 2004-09-08
NZ512135A (en) 2003-12-19
PT1137645E (pt) 2004-09-30
EA004205B1 (ru) 2004-02-26
IL143183A0 (en) 2002-04-21
EP1137645A2 (en) 2001-10-04
NO20012833D0 (no) 2001-06-08
NO20012833L (no) 2001-08-02
AR035308A1 (es) 2004-05-12
DK1137645T3 (da) 2004-08-09
WO2000034260A2 (en) 2000-06-15
HUP0104492A2 (hu) 2002-04-29
DE69917673T2 (de) 2005-06-09
CN1329608A (zh) 2002-01-02
AU1934600A (en) 2000-06-26

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Legal Events

Date Code Title Description
TC Change of name
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.