BR9916084A - Composto, composição farmacêutica, e, processos para inibir a replicação de um vìrus da herpes, e para tratar um paciente sofrendo de uma infecção por vìrus da herpes - Google Patents
Composto, composição farmacêutica, e, processos para inibir a replicação de um vìrus da herpes, e para tratar um paciente sofrendo de uma infecção por vìrus da herpesInfo
- Publication number
- BR9916084A BR9916084A BR9916084-6A BR9916084A BR9916084A BR 9916084 A BR9916084 A BR 9916084A BR 9916084 A BR9916084 A BR 9916084A BR 9916084 A BR9916084 A BR 9916084A
- Authority
- BR
- Brazil
- Prior art keywords
- carbon atoms
- herpes virus
- alkyl
- virus
- heterocycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, E, PROCESSOS PARA INIBIR A REPLICAçãO DE UM VìRUS DA HERPES, E PARA TRATAR UM PACIENTE SOFRENDO DE UMA INFECçãO POR VìRUS DA HERPES". Compostos tendo a fórmula (I) em que R~ 1~ - R~ 5~ são independentemente selecionados dentre hidrogênio, alquila de 1 a 6 átomos de carbono, alquenila de 2 a 6 átomos de carbono, alquinila de 2 a 6 átomos de carbono, perhaloalquila de 1 a 6 átomos de carbono, cicloalquila de 3 a 10 átomos de carbono, heterocicloalquila de 3 a 10 membros de carbono, arila, heteroarila, halogênio, -CN, -NO~ 2~, -CO~ 2~R~ 6~, -COR~ 6~, -OR~ 6~, -SR~ 6~, -SOR~ 6~, -SO~ 2~R~ 6~, -CONR~ 7~R~ 8~, -NR~ 6~N (R~ 7~R~ 8~), -N (R~ 7~R~8~) ou W-Y- (CH~ 2~)~ n~ -Z desde que pelo menos um dentre R~ 1~ - R~ 5~ não é hidrogênio; ou R~ 2~ e R~ 3~ ou R~ 3~ e R~ 4~, tomados juntos formam um membro heterocicloalquila de 3 a 7 ou heteroarila de 3 a 7 membros; R~ 6~ e R~ 7~ são independentemente hidrogênio, alquila de 1 a 6 átomos de carbono, perhaloalquila de 1 a 6 átomos de carbono, ou arila; R~ 8~ é hidrogênio, alquila de 1 a 6 átomos de carbono, perhaloalquila de 1 a 6 átomos de carbono, cicloalquila de 3 a 10 átomos de carbono, heterocicloalquila de 3 a 10 membros, arila ou heteroarila, ou R~ 7~ e R~ 8~, tomados juntos, podem formar uma heterocicloalquila de 3 a 7 membros; W é O, NR~ 6~, ou está ausente; Y é -(CO)- ou -(CO~ 2~)-, ou está ausente; Z é alquila de 1 a 4 átomos de carbono, -CN, -CO~ 2~R~ 6~, COR~ 6~, -CONR~ 7~R~ 8~, -OCOR~ 6~, -NR~ 6~COR~ 7~, -OCONR~ 6~, -OR~ 6~, -SR~ 6~, -SOR~ 6~, -SO~ 2~R~ 6~, SR6N (R7R8), -N (R~ 7~R~ 8~) ou fenila; G é arila ou heteroarila bicíclica fundida; X é uma ligação, -NH, alquila de 1 6 átomos de carbono, alquenila de 1 a 6 átomos de carbono, alcoxi de 1 a 6 átomos de carbono, tioalquila de 1 a 6 átomos de carbono, alquilamino de 1 a 6 átomos de carbono, ou (CH) J; J é alquila de 1 a 6 átomos de carbono, cicloalquila de 3 a 7 átomos de carbono, fenila ou benzila; e n é um número inteiro de 1 a 6; utilizável no tratamento de doenças associadas com vírus da herpes incluindo citomegalovírus humano, vírus da herpes simplex, vírus Epstein-Barr, vírus da varicela-zoster, vírus da herpes humano 6 e 7, e vírus da herpes Kaposi.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20890298A | 1998-12-09 | 1998-12-09 | |
PCT/US1999/028839 WO2000034260A2 (en) | 1998-12-09 | 1999-12-06 | Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9916084A true BR9916084A (pt) | 2001-09-04 |
Family
ID=22776519
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9916084-6A BR9916084A (pt) | 1998-12-09 | 1999-12-06 | Composto, composição farmacêutica, e, processos para inibir a replicação de um vìrus da herpes, e para tratar um paciente sofrendo de uma infecção por vìrus da herpes |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1137645B1 (pt) |
JP (1) | JP2002531555A (pt) |
KR (1) | KR20010089551A (pt) |
CN (1) | CN1165531C (pt) |
AR (1) | AR035308A1 (pt) |
AT (1) | ATE267824T1 (pt) |
AU (1) | AU1934600A (pt) |
BR (1) | BR9916084A (pt) |
CA (1) | CA2350833A1 (pt) |
CZ (1) | CZ20012067A3 (pt) |
DE (1) | DE69917673T2 (pt) |
DK (1) | DK1137645T3 (pt) |
EA (1) | EA004205B1 (pt) |
ES (1) | ES2221470T3 (pt) |
HU (1) | HUP0104492A3 (pt) |
IL (1) | IL143183A0 (pt) |
NO (1) | NO20012833L (pt) |
NZ (1) | NZ512135A (pt) |
PT (1) | PT1137645E (pt) |
WO (1) | WO2000034260A2 (pt) |
ZA (1) | ZA200104376B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
DK1259485T3 (da) | 2000-02-29 | 2006-04-10 | Millennium Pharm Inc | Benzamider og beslægtede inhibitorer for faktor Xa |
WO2002016318A1 (en) * | 2000-08-21 | 2002-02-28 | Pacific Corporation | Novel thiourea derivatives and the pharmaceutical compositions containing the same |
JP4360885B2 (ja) | 2003-11-28 | 2009-11-11 | 富士フイルム株式会社 | アルキルチオ基を有する芳香族アミン化合物の製造方法 |
WO2007024754A1 (en) * | 2005-08-22 | 2007-03-01 | Amgen Inc. | Bis-aryl urea compounds for the treatment of protein kinase-mediated diseaes |
ES2382055T3 (es) | 2006-11-02 | 2012-06-04 | Millennium Pharmaceuticals, Inc. | Métodos para sintetizar sales farmacéuticas de un inhibidor del factor Xa |
CN112807294B (zh) * | 2019-11-18 | 2023-09-05 | 武汉大学 | 一种酰基硫脲类化合物在制备治疗或预防单纯疱疹病毒i型感染药物中的应用 |
CN115433093A (zh) * | 2022-09-26 | 2022-12-06 | 无锡双启科技有限公司 | 一种3-氯-4-三氟甲基苯胺的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU210683B (en) * | 1990-06-18 | 1995-06-28 | Sandoz Ag | Process for producing n-benzyl-n1-(phenyl-alkyl)-thiourea derivatives and pharmaceutical compositions containing the same |
EP0809492A4 (en) * | 1995-02-17 | 2007-01-24 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
GB9519270D0 (en) * | 1995-09-21 | 1995-11-22 | Sandoz Pharma Uk | Organic compounds |
CZ298463B6 (cs) * | 1996-04-23 | 2007-10-10 | Vertex Pharmaceuticals Incorporated | Deriváty mocoviny pro použití jako inhibitory IMPDH enzymu a farmaceutické prostredky, které je obsahují |
-
1999
- 1999-12-06 DE DE69917673T patent/DE69917673T2/de not_active Expired - Fee Related
- 1999-12-06 HU HU0104492A patent/HUP0104492A3/hu unknown
- 1999-12-06 AU AU19346/00A patent/AU1934600A/en not_active Abandoned
- 1999-12-06 IL IL14318399A patent/IL143183A0/xx unknown
- 1999-12-06 CZ CZ20012067A patent/CZ20012067A3/cs unknown
- 1999-12-06 EP EP99963022A patent/EP1137645B1/en not_active Expired - Lifetime
- 1999-12-06 KR KR1020017007053A patent/KR20010089551A/ko not_active Application Discontinuation
- 1999-12-06 NZ NZ512135A patent/NZ512135A/en unknown
- 1999-12-06 CA CA002350833A patent/CA2350833A1/en not_active Abandoned
- 1999-12-06 BR BR9916084-6A patent/BR9916084A/pt not_active IP Right Cessation
- 1999-12-06 ES ES99963022T patent/ES2221470T3/es not_active Expired - Lifetime
- 1999-12-06 WO PCT/US1999/028839 patent/WO2000034260A2/en not_active Application Discontinuation
- 1999-12-06 AT AT99963022T patent/ATE267824T1/de not_active IP Right Cessation
- 1999-12-06 CN CNB998142778A patent/CN1165531C/zh not_active Expired - Fee Related
- 1999-12-06 PT PT99963022T patent/PT1137645E/pt unknown
- 1999-12-06 EA EA200100638A patent/EA004205B1/ru not_active IP Right Cessation
- 1999-12-06 DK DK99963022T patent/DK1137645T3/da active
- 1999-12-06 JP JP2000586707A patent/JP2002531555A/ja active Pending
- 1999-12-07 AR ARP990106228A patent/AR035308A1/es not_active Application Discontinuation
-
2001
- 2001-05-28 ZA ZA200104376A patent/ZA200104376B/en unknown
- 2001-06-08 NO NO20012833A patent/NO20012833L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20010089551A (ko) | 2001-10-06 |
JP2002531555A (ja) | 2002-09-24 |
NO20012833L (no) | 2001-08-02 |
CN1329608A (zh) | 2002-01-02 |
NZ512135A (en) | 2003-12-19 |
DK1137645T3 (da) | 2004-08-09 |
WO2000034260A2 (en) | 2000-06-15 |
CA2350833A1 (en) | 2000-06-15 |
IL143183A0 (en) | 2002-04-21 |
WO2000034260A3 (en) | 2000-09-08 |
DE69917673T2 (de) | 2005-06-09 |
EA004205B1 (ru) | 2004-02-26 |
NO20012833D0 (no) | 2001-06-08 |
CN1165531C (zh) | 2004-09-08 |
ZA200104376B (en) | 2002-08-28 |
AR035308A1 (es) | 2004-05-12 |
CZ20012067A3 (cs) | 2001-10-17 |
ES2221470T3 (es) | 2004-12-16 |
DE69917673D1 (de) | 2004-07-01 |
AU1934600A (en) | 2000-06-26 |
EA200100638A1 (ru) | 2001-12-24 |
ATE267824T1 (de) | 2004-06-15 |
EP1137645A2 (en) | 2001-10-04 |
HUP0104492A2 (hu) | 2002-04-29 |
HUP0104492A3 (en) | 2002-12-28 |
PT1137645E (pt) | 2004-09-30 |
EP1137645B1 (en) | 2004-05-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9916041A (pt) | Composto, composição farmacêutica, e, métodospara inibir a replicação de um vìrus do herpes epara tratar um paciente sofrendo de uma infecçãopor vìrus do herpes | |
AU644095B2 (en) | Antiviral compounds | |
BR9916086A (pt) | Composto, composição farmacêutica, método para inibir a replicação de um vìrus do herpes, método para tratar um paciente sofrendo de uma infecção por vìrus do herpes | |
BR9905109A (pt) | "compostos farmaceuticamente ativos" | |
MY117892A (en) | Therapeutic compounds | |
BR9916084A (pt) | Composto, composição farmacêutica, e, processos para inibir a replicação de um vìrus da herpes, e para tratar um paciente sofrendo de uma infecção por vìrus da herpes | |
BR9916046A (pt) | Composto, composição farmacêutica, e, processos para inibir a replicação de um vìrus herpes e para tratamento de um paciente que sofra de uma infecção do vìrus herpes | |
BR9916042A (pt) | Composto, composição farmacêutica, e, processospara inibir a replicação de um vìrus herpes, e detratamento de um paciente que sofra de umainfecção do vìrus herpes | |
MX9805441A (es) | Compuestos terapeuticos. | |
DE69005994T2 (de) | 1,8-Benzonaphthyridinderivate, ihre Herstellung und diese enthaltende Zusammensetzungen. | |
BR9915993A (pt) | Composto, composição farmacêutica, processo para inibir a replicação de um vìrus herpes, e, processo para tratar um paciente sofrendo de uma infecção de vìrus herpes | |
GB2122197B (en) | Antiviral guanine derivatives | |
ES2149247T3 (es) | Nuevos compuestos de n-bencil-piperazina, su procedimiento de preparacion y las composiciones farmaceuticas que los incluyen. | |
NO893279L (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-amino-4-morfolino-6-propyl-1,3,5-triaziner. | |
DE69511247D1 (de) | Therapeutische benzonitrile | |
ATE210445T1 (de) | Verwendung von 2-aminopurinderivaten zur behandlung und prophylaxe der menschlichen herpesvirus 7 infektionen | |
ATE320260T1 (de) | Schwefelhaltige phosphonoformat-derivate und deren verwendung. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
TC | Change of name | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008. |