BR9916086A - Composto, composição farmacêutica, método para inibir a replicação de um vìrus do herpes, método para tratar um paciente sofrendo de uma infecção por vìrus do herpes - Google Patents
Composto, composição farmacêutica, método para inibir a replicação de um vìrus do herpes, método para tratar um paciente sofrendo de uma infecção por vìrus do herpesInfo
- Publication number
- BR9916086A BR9916086A BR9916086-2A BR9916086A BR9916086A BR 9916086 A BR9916086 A BR 9916086A BR 9916086 A BR9916086 A BR 9916086A BR 9916086 A BR9916086 A BR 9916086A
- Authority
- BR
- Brazil
- Prior art keywords
- carbon atoms
- alkyl
- herpes virus
- hydrogen
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODO PARA INIBIR A REPLICAçãO DE UM VìRUS DO HERPES, MéTODO PARA TRATAR UM PACIENTE SOFRENDO DE UMA INFECçãO POR VìRUS DO HERPES" Compostos de fórmula (I): em que R~ 1~-R~ 5~ são independentemente selecionados dentre hidrogênio, alquila de 1 a 6 átomos de carbono, alquenila de 2 a 6 átomos de carbono, alquinila de 2 a 6 átomos de carbono, perhaloalquila de 1 a 6 átomos de carbono, cicloalquila de 3 a 10 átomos de carbono, heterocicloalquila de 3 a 10 membros de carbono, arila, heteroarila, halogênio,-CN,-NO~ 2~,-CO~ 2~R~ 6~,-COR~ 6~,-OR~ 6~,-SR~ 6~,-SOR~ 6~,-SO~ 2~R~ 6~,-CONR~ 7~R~ 8~,-NR~ 6~N (R~ 7~R~ 8~),-N (R~ 7~R~ 8~) ou W-Y-(CH~ 2~)~ n~-Z desde que pelo menos um dentre R~ 1~-R~ 5~ não seja hidrogênio; ou R~ 2~ e R~ 3~ ou R~ 3~ e R~ 4~, tomados juntos, formam uma heterocicloalquila de 3 a 7 membros ou heteroarila de 3 a 7 membros; R~ 6~ e R~ 7~ são independentemente hidrogênio, alquila de 1 a 6 átomos de carbono, perhaloalquila de 1 a 6 átomos de carbono, ou arila; R~ 8~ é hidrogênio, alquila de 1 a 6 átomos de carbono, perhaloalquila de 1 a 6 átomos de carbono, cicloalquila de 3 a 10 átomos de carbono, heterocicloalquila de 3 a 10 membros, arila ou heteroarila, ou R~ 7~ e R~ 8~, tomados juntos podem formar uma heterocicloalquila de 3 a 7 membros; R~ 9~-R~ 12~ são independentemente hidrogênio, alquila de 1 a 4 átomos de carbono, perhaloalquila de 1 a 4 átomos de carbono, halogênio, alcoxi de 1 a 4 átomos de carbono, ou ciano, ou R~ 9~ e R~ 10~ ou R~ 11~ e R~ 12~ tomados juntos podem formar arila de 5 a 7 átomos de carbono; desde que pelo menos um dentre R9-12 não seja hidrogênio; W é O, NR~ 6~, ou está ausente; Y é -(CO)- ou -(CO~ 2~)-, ou está ausente; Z é alquila de 1 a 4 átomos de carbono,-CN,-CO~ 2~R~ 6~, COR~ 6~,-CONR~ 7~R~ 8~,-OCOR~ 6~,-NR~ 6~COR~ 7~-OCONR~ 6~,-OR~ 6~-SR~ 6~,-SOR~ 6~,-SO~ 2~R~ 6~, SR~ 6~N (R~ 7~R~ 8~),-N (R~ 7~R~ 8~) ou fenila; G é arila ou heteroarila bicíclica fundida, X é uma ligação, -NH, alquila de 1 6 átomos de carbono, alquenila de 1 a 6 átomos de carbono, alcoxi de 1 a 6 átomos de carbono, tioalquila de 1 a 6 átomos de carbono, alquilamino de 1 a 6 átomos de carbono, ou (CH) J; J é alquila de 1 a 6 átomos de carbono, cicloalquila de 3 a 7 átomos de carbono, fenila ou benzila; e n é um número inteiro de 1 a 6; no tratamento de doenças associadas com vírus do herpes incluindo citomegalovírus humano, vírus do herpes simples, vírus Epstein-Barr, vírus da varicela-zoster, vírus do herpes humano 6 e 7, e vírus do herpes de Kaposi.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20856198A | 1998-12-09 | 1998-12-09 | |
| PCT/US1999/028837 WO2000034238A1 (en) | 1998-12-09 | 1999-12-06 | Thiourea inhibitors of herpes viruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9916086A true BR9916086A (pt) | 2001-09-04 |
Family
ID=22775050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9916086-2A BR9916086A (pt) | 1998-12-09 | 1999-12-06 | Composto, composição farmacêutica, método para inibir a replicação de um vìrus do herpes, método para tratar um paciente sofrendo de uma infecção por vìrus do herpes |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1137632B1 (pt) |
| JP (1) | JP2002531545A (pt) |
| KR (1) | KR20010089559A (pt) |
| CN (1) | CN1332725A (pt) |
| AR (1) | AR033789A1 (pt) |
| AT (1) | ATE272052T1 (pt) |
| AU (1) | AU1934500A (pt) |
| BG (1) | BG105583A (pt) |
| BR (1) | BR9916086A (pt) |
| CA (1) | CA2351403A1 (pt) |
| CZ (1) | CZ20011957A3 (pt) |
| DE (1) | DE69919023T2 (pt) |
| DK (1) | DK1137632T3 (pt) |
| EA (1) | EA200100634A1 (pt) |
| ES (1) | ES2224733T3 (pt) |
| HU (1) | HUP0104763A3 (pt) |
| ID (1) | ID30287A (pt) |
| IL (1) | IL143262A0 (pt) |
| NO (1) | NO20012838L (pt) |
| NZ (1) | NZ512108A (pt) |
| PL (1) | PL348178A1 (pt) |
| PT (1) | PT1137632E (pt) |
| SK (1) | SK7702001A3 (pt) |
| TR (1) | TR200101597T2 (pt) |
| WO (1) | WO2000034238A1 (pt) |
| ZA (1) | ZA200104144B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| DK1259485T3 (da) | 2000-02-29 | 2006-04-10 | Millennium Pharm Inc | Benzamider og beslægtede inhibitorer for faktor Xa |
| DE10217518A1 (de) * | 2002-04-19 | 2003-11-06 | Bayer Ag | Lactone |
| DE10222024A1 (de) * | 2002-05-17 | 2003-11-27 | Bayer Ag | Lactame |
| DE10257786A1 (de) * | 2002-12-11 | 2004-07-01 | Bayer Healthcare Ag | Oxazolidinone |
| ES2382055T3 (es) | 2006-11-02 | 2012-06-04 | Millennium Pharmaceuticals, Inc. | Métodos para sintetizar sales farmacéuticas de un inhibidor del factor Xa |
| EP2714941A4 (en) * | 2011-05-24 | 2014-12-03 | Wistar Inst | COMPOSITIONS AND METHODS FOR MODULATING THE EFFECT OF THE EPSTEIN-BARR NUCLEAR ANTIGEN 1 |
| WO2014070979A1 (en) * | 2012-11-03 | 2014-05-08 | Boehringer Ingelheim International Gmbh | Inhibitors of cytomegalovirus |
| EP2914591B1 (en) * | 2012-11-03 | 2017-10-11 | Boehringer Ingelheim International GmbH | Inhibitors of cytomegalovirus |
| WO2022150962A1 (en) * | 2021-01-12 | 2022-07-21 | Westlake Pharmaceutical (Hangzhou) Co., Ltd. | Protease inhibitors, preparation, and uses thereof |
| CN118076593A (zh) * | 2021-09-07 | 2024-05-24 | 上海齐鲁制药研究中心有限公司 | 3CLpro蛋白酶抑制剂 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU210683B (en) * | 1990-06-18 | 1995-06-28 | Sandoz Ag | Process for producing n-benzyl-n1-(phenyl-alkyl)-thiourea derivatives and pharmaceutical compositions containing the same |
| EP0809492A4 (en) * | 1995-02-17 | 2007-01-24 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
| GB9519270D0 (en) * | 1995-09-21 | 1995-11-22 | Sandoz Pharma Uk | Organic compounds |
| CZ298463B6 (cs) * | 1996-04-23 | 2007-10-10 | Vertex Pharmaceuticals Incorporated | Deriváty mocoviny pro použití jako inhibitory IMPDH enzymu a farmaceutické prostredky, které je obsahují |
-
1999
- 1999-12-06 PL PL99348178A patent/PL348178A1/xx not_active Application Discontinuation
- 1999-12-06 EP EP99963021A patent/EP1137632B1/en not_active Expired - Lifetime
- 1999-12-06 WO PCT/US1999/028837 patent/WO2000034238A1/en not_active Application Discontinuation
- 1999-12-06 KR KR1020017007134A patent/KR20010089559A/ko not_active Application Discontinuation
- 1999-12-06 AT AT99963021T patent/ATE272052T1/de not_active IP Right Cessation
- 1999-12-06 EA EA200100634A patent/EA200100634A1/ru unknown
- 1999-12-06 ES ES99963021T patent/ES2224733T3/es not_active Expired - Lifetime
- 1999-12-06 IL IL14326299A patent/IL143262A0/xx unknown
- 1999-12-06 DK DK99963021T patent/DK1137632T3/da active
- 1999-12-06 HU HU0104763A patent/HUP0104763A3/hu unknown
- 1999-12-06 PT PT99963021T patent/PT1137632E/pt unknown
- 1999-12-06 CA CA002351403A patent/CA2351403A1/en not_active Abandoned
- 1999-12-06 AU AU19345/00A patent/AU1934500A/en not_active Abandoned
- 1999-12-06 TR TR2001/01597T patent/TR200101597T2/xx unknown
- 1999-12-06 CZ CZ20011957A patent/CZ20011957A3/cs unknown
- 1999-12-06 BR BR9916086-2A patent/BR9916086A/pt not_active Application Discontinuation
- 1999-12-06 JP JP2000586686A patent/JP2002531545A/ja active Pending
- 1999-12-06 ID IDW00200101228A patent/ID30287A/id unknown
- 1999-12-06 CN CN99815344A patent/CN1332725A/zh active Pending
- 1999-12-06 NZ NZ512108A patent/NZ512108A/en unknown
- 1999-12-06 DE DE69919023T patent/DE69919023T2/de not_active Expired - Fee Related
- 1999-12-06 SK SK770-2001A patent/SK7702001A3/sk unknown
- 1999-12-07 AR ARP990106229A patent/AR033789A1/es not_active Application Discontinuation
-
2001
- 2001-05-21 ZA ZA200104144A patent/ZA200104144B/xx unknown
- 2001-06-08 NO NO20012838A patent/NO20012838L/no not_active Application Discontinuation
- 2001-06-08 BG BG105583A patent/BG105583A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK7702001A3 (en) | 2002-04-04 |
| ZA200104144B (en) | 2002-08-21 |
| NO20012838D0 (no) | 2001-06-08 |
| TR200101597T2 (tr) | 2001-10-22 |
| CA2351403A1 (en) | 2000-06-15 |
| PT1137632E (pt) | 2004-11-30 |
| EP1137632B1 (en) | 2004-07-28 |
| CN1332725A (zh) | 2002-01-23 |
| ATE272052T1 (de) | 2004-08-15 |
| NO20012838L (no) | 2001-08-08 |
| NZ512108A (en) | 2003-09-26 |
| AR033789A1 (es) | 2004-01-07 |
| KR20010089559A (ko) | 2001-10-06 |
| AU1934500A (en) | 2000-06-26 |
| HUP0104763A2 (hu) | 2002-04-29 |
| EP1137632A1 (en) | 2001-10-04 |
| CZ20011957A3 (cs) | 2001-10-17 |
| EA200100634A1 (ru) | 2001-10-22 |
| DE69919023D1 (de) | 2004-09-02 |
| WO2000034238A1 (en) | 2000-06-15 |
| DK1137632T3 (da) | 2004-11-01 |
| BG105583A (en) | 2001-12-29 |
| DE69919023T2 (de) | 2005-07-28 |
| HUP0104763A3 (en) | 2005-04-28 |
| ID30287A (id) | 2001-11-15 |
| ES2224733T3 (es) | 2005-03-01 |
| IL143262A0 (en) | 2002-04-21 |
| PL348178A1 (en) | 2002-05-06 |
| JP2002531545A (ja) | 2002-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TC | Change of name | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI. |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |