DE69919023D1 - Thioharnstoff-inhibitoren von herpes-virus - Google Patents
Thioharnstoff-inhibitoren von herpes-virusInfo
- Publication number
- DE69919023D1 DE69919023D1 DE69919023T DE69919023T DE69919023D1 DE 69919023 D1 DE69919023 D1 DE 69919023D1 DE 69919023 T DE69919023 T DE 69919023T DE 69919023 T DE69919023 T DE 69919023T DE 69919023 D1 DE69919023 D1 DE 69919023D1
- Authority
- DE
- Germany
- Prior art keywords
- herpes
- thio
- urban
- virus
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20856198A | 1998-12-09 | 1998-12-09 | |
| US208561 | 1998-12-09 | ||
| PCT/US1999/028837 WO2000034238A1 (en) | 1998-12-09 | 1999-12-06 | Thiourea inhibitors of herpes viruses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69919023D1 true DE69919023D1 (de) | 2004-09-02 |
| DE69919023T2 DE69919023T2 (de) | 2005-07-28 |
Family
ID=22775050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69919023T Expired - Fee Related DE69919023T2 (de) | 1998-12-09 | 1999-12-06 | Thioharnstoff-inhibitoren von herpes-virus |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1137632B1 (de) |
| JP (1) | JP2002531545A (de) |
| KR (1) | KR20010089559A (de) |
| CN (1) | CN1332725A (de) |
| AR (1) | AR033789A1 (de) |
| AT (1) | ATE272052T1 (de) |
| AU (1) | AU1934500A (de) |
| BG (1) | BG105583A (de) |
| BR (1) | BR9916086A (de) |
| CA (1) | CA2351403A1 (de) |
| CZ (1) | CZ20011957A3 (de) |
| DE (1) | DE69919023T2 (de) |
| DK (1) | DK1137632T3 (de) |
| EA (1) | EA200100634A1 (de) |
| ES (1) | ES2224733T3 (de) |
| HU (1) | HUP0104763A3 (de) |
| ID (1) | ID30287A (de) |
| IL (1) | IL143262A0 (de) |
| NO (1) | NO20012838L (de) |
| NZ (1) | NZ512108A (de) |
| PL (1) | PL348178A1 (de) |
| PT (1) | PT1137632E (de) |
| SK (1) | SK7702001A3 (de) |
| TR (1) | TR200101597T2 (de) |
| WO (1) | WO2000034238A1 (de) |
| ZA (1) | ZA200104144B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| EP1259485B1 (de) | 2000-02-29 | 2005-11-30 | Millennium Pharmaceuticals, Inc. | Benzamide und ähnliche inhibitoren vom faktor xa |
| DE10217518A1 (de) * | 2002-04-19 | 2003-11-06 | Bayer Ag | Lactone |
| DE10222024A1 (de) * | 2002-05-17 | 2003-11-27 | Bayer Ag | Lactame |
| DE10257786A1 (de) * | 2002-12-11 | 2004-07-01 | Bayer Healthcare Ag | Oxazolidinone |
| EP2077995B1 (de) | 2006-11-02 | 2012-02-08 | Millennium Pharmaceuticals, Inc. | Verfahren zur synthetisierung pharmazeutischer salze aus einem faktor-xa-hemmer |
| US9309212B2 (en) | 2011-05-24 | 2016-04-12 | The Wistar Institute | Compositions and methods for modulating the activity of Epstein-Barr nuclear antigen 1 |
| US9334249B2 (en) | 2012-11-03 | 2016-05-10 | Boehringer Ingelheim International Gmbh | Inhibitors of cytomegalovirus |
| JP6482466B2 (ja) * | 2012-11-03 | 2019-03-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | サイトメガロウイルスの阻害剤 |
| WO2022150962A1 (en) * | 2021-01-12 | 2022-07-21 | Westlake Pharmaceutical (Hangzhou) Co., Ltd. | Protease inhibitors, preparation, and uses thereof |
| WO2023036140A1 (zh) * | 2021-09-07 | 2023-03-16 | 上海齐鲁制药研究中心有限公司 | 3CLpro蛋白酶抑制剂 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU210683B (en) * | 1990-06-18 | 1995-06-28 | Sandoz Ag | Process for producing n-benzyl-n1-(phenyl-alkyl)-thiourea derivatives and pharmaceutical compositions containing the same |
| WO1996025157A1 (en) * | 1995-02-17 | 1996-08-22 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| GB9519270D0 (en) * | 1995-09-21 | 1995-11-22 | Sandoz Pharma Uk | Organic compounds |
| AU723730B2 (en) * | 1996-04-23 | 2000-09-07 | Vertex Pharmaceuticals Incorporated | Urea derivatives as inhibitors of IMPDH enzyme |
-
1999
- 1999-12-06 EA EA200100634A patent/EA200100634A1/ru unknown
- 1999-12-06 DK DK99963021T patent/DK1137632T3/da active
- 1999-12-06 BR BR9916086-2A patent/BR9916086A/pt not_active Application Discontinuation
- 1999-12-06 NZ NZ512108A patent/NZ512108A/en unknown
- 1999-12-06 AT AT99963021T patent/ATE272052T1/de not_active IP Right Cessation
- 1999-12-06 AU AU19345/00A patent/AU1934500A/en not_active Abandoned
- 1999-12-06 ID IDW00200101228A patent/ID30287A/id unknown
- 1999-12-06 SK SK770-2001A patent/SK7702001A3/sk unknown
- 1999-12-06 CA CA002351403A patent/CA2351403A1/en not_active Abandoned
- 1999-12-06 IL IL14326299A patent/IL143262A0/xx unknown
- 1999-12-06 JP JP2000586686A patent/JP2002531545A/ja active Pending
- 1999-12-06 PT PT99963021T patent/PT1137632E/pt unknown
- 1999-12-06 ES ES99963021T patent/ES2224733T3/es not_active Expired - Lifetime
- 1999-12-06 DE DE69919023T patent/DE69919023T2/de not_active Expired - Fee Related
- 1999-12-06 CN CN99815344A patent/CN1332725A/zh active Pending
- 1999-12-06 TR TR2001/01597T patent/TR200101597T2/xx unknown
- 1999-12-06 PL PL99348178A patent/PL348178A1/xx not_active Application Discontinuation
- 1999-12-06 EP EP99963021A patent/EP1137632B1/de not_active Expired - Lifetime
- 1999-12-06 CZ CZ20011957A patent/CZ20011957A3/cs unknown
- 1999-12-06 HU HU0104763A patent/HUP0104763A3/hu unknown
- 1999-12-06 WO PCT/US1999/028837 patent/WO2000034238A1/en not_active Application Discontinuation
- 1999-12-06 KR KR1020017007134A patent/KR20010089559A/ko not_active Application Discontinuation
- 1999-12-07 AR ARP990106229A patent/AR033789A1/es not_active Application Discontinuation
-
2001
- 2001-05-21 ZA ZA200104144A patent/ZA200104144B/xx unknown
- 2001-06-08 BG BG105583A patent/BG105583A/xx unknown
- 2001-06-08 NO NO20012838A patent/NO20012838L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SK7702001A3 (en) | 2002-04-04 |
| EP1137632B1 (de) | 2004-07-28 |
| IL143262A0 (en) | 2002-04-21 |
| PT1137632E (pt) | 2004-11-30 |
| ZA200104144B (en) | 2002-08-21 |
| JP2002531545A (ja) | 2002-09-24 |
| AR033789A1 (es) | 2004-01-07 |
| NO20012838D0 (no) | 2001-06-08 |
| CN1332725A (zh) | 2002-01-23 |
| WO2000034238A1 (en) | 2000-06-15 |
| KR20010089559A (ko) | 2001-10-06 |
| EP1137632A1 (de) | 2001-10-04 |
| NO20012838L (no) | 2001-08-08 |
| NZ512108A (en) | 2003-09-26 |
| EA200100634A1 (ru) | 2001-10-22 |
| DK1137632T3 (da) | 2004-11-01 |
| CA2351403A1 (en) | 2000-06-15 |
| BG105583A (en) | 2001-12-29 |
| BR9916086A (pt) | 2001-09-04 |
| CZ20011957A3 (cs) | 2001-10-17 |
| HUP0104763A3 (en) | 2005-04-28 |
| ES2224733T3 (es) | 2005-03-01 |
| ID30287A (id) | 2001-11-15 |
| ATE272052T1 (de) | 2004-08-15 |
| TR200101597T2 (tr) | 2001-10-22 |
| DE69919023T2 (de) | 2005-07-28 |
| AU1934500A (en) | 2000-06-26 |
| HUP0104763A2 (hu) | 2002-04-29 |
| PL348178A1 (en) | 2002-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |