AR033789A1 - Compuestos de tiourea que contienen diaminopiridina como inhibidores de virus herpes, uso de los mismos para la manufactura de un medicamento y composicion farmaceutica que los contiene - Google Patents
Compuestos de tiourea que contienen diaminopiridina como inhibidores de virus herpes, uso de los mismos para la manufactura de un medicamento y composicion farmaceutica que los contieneInfo
- Publication number
- AR033789A1 AR033789A1 ARP990106229A ARP990106229A AR033789A1 AR 033789 A1 AR033789 A1 AR 033789A1 AR P990106229 A ARP990106229 A AR P990106229A AR P990106229 A ARP990106229 A AR P990106229A AR 033789 A1 AR033789 A1 AR 033789A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- aryl
- virus
- perhaloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Un compuesto de la fórmula (1) donde R1-R5 son independientemente seleccionados de hidrógeno, alquilo de C1-6, alquenilo de C2-6, alquinilo de C2-6, perhaloalquilo de C1-6, cicloalquilo de C3-10, heterocicloalquilo de C3-10, arilo, heteroarilo, halógeno, -CN, -NO2, -CO2R6, -COR6, -OR6, -SR6, -SOR6, -SO2R6, -CONR7R8, -NR6N(R7R8), -N(R7R8) o W-Y-(CH2)n-Z con la condición de que por lo menos uno de R1-R5 no sea hidrógeno; o R2 y R3 o R3 y R4 tomados conjuntamente forman un heterocicloalquilo de 3 a 7 miembros o un heteroarilo de 3 a 7 miembros; R6 y R7 son independientemente hidrógeno, alquilo de C1-6, perhaloalquilo de C1-6 o arilo; R8 es hidrógeno, alquilo de C1-6, perhaloalquilo de C1-6, cicloalquilo de C3-10, heterocicloalquilo de 3 a 10 miembros, arilo o heteroarilo, o R7 y R8 tomados conjuntamente pueden formar un heterocicloalquilo de 3 a 7 miembros; R9-R12 son independientemente hidrógeno, alquilo de C1-4, perhaloalquilo de C1-4, halógeno, alcoxi de C1-4 o ciano, o R9 y R10 o R11 y R12 pueden ser tomados conjuntamente para formar arilo de C5-7, con la condición de que por lo menos uno de R9-R12 no sea hidrógeno; W es O, NR6 o está ausente; Y es -(CO)- ó -(CO2)- o está ausente; Z es alquilo de C1-4, -CN, -CO2R6, COR6, -CONR7R8, -OCOR6, -NR6COR7, -OCONR6, -OR6, -SR6, -SOR6, -SO2R6, SR6N(R7R8), N(R7R8) o fenilo; G es arilo o heteroarilo bicíclico fusionado, X es un enlace, -NH, alquilo de C1-6 , alquenilo de C1-6, alcoxi de C1-6, tioalquilo de C1-6, alquilamino de C1-6, o (CH)J; J es alquilo de C1-6, cicloalquilo de C3-7, fenilo o bencilo; y n es un número de 1 a 6; o una sal farmacéuticamente del mismo, uso del mismo para la manufactura de un medicamento para el tratamiento de enfermedades que están asociadas con el virus herpes incluyendo citomegalovirus humano, virus herpes simplex, virus de Epstein-Barr, virus de varicella-zoster, virus de herpes humano 6 y 7, y virus de herpes de Kaposi y composición farmacéutica que lo contiene.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20856198A | 1998-12-09 | 1998-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR033789A1 true AR033789A1 (es) | 2004-01-07 |
Family
ID=22775050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106229A AR033789A1 (es) | 1998-12-09 | 1999-12-07 | Compuestos de tiourea que contienen diaminopiridina como inhibidores de virus herpes, uso de los mismos para la manufactura de un medicamento y composicion farmaceutica que los contiene |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1137632B1 (es) |
| JP (1) | JP2002531545A (es) |
| KR (1) | KR20010089559A (es) |
| CN (1) | CN1332725A (es) |
| AR (1) | AR033789A1 (es) |
| AT (1) | ATE272052T1 (es) |
| AU (1) | AU1934500A (es) |
| BG (1) | BG105583A (es) |
| BR (1) | BR9916086A (es) |
| CA (1) | CA2351403A1 (es) |
| CZ (1) | CZ20011957A3 (es) |
| DE (1) | DE69919023T2 (es) |
| DK (1) | DK1137632T3 (es) |
| EA (1) | EA200100634A1 (es) |
| ES (1) | ES2224733T3 (es) |
| HU (1) | HUP0104763A3 (es) |
| ID (1) | ID30287A (es) |
| IL (1) | IL143262A0 (es) |
| NO (1) | NO20012838L (es) |
| NZ (1) | NZ512108A (es) |
| PL (1) | PL348178A1 (es) |
| PT (1) | PT1137632E (es) |
| SK (1) | SK7702001A3 (es) |
| TR (1) | TR200101597T2 (es) |
| WO (1) | WO2000034238A1 (es) |
| ZA (1) | ZA200104144B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| ES2254385T3 (es) | 2000-02-29 | 2006-06-16 | Millennium Pharmaceuticals, Inc. | Benzamidas e inhibidores relacionados del factor xa. |
| DE10217518A1 (de) * | 2002-04-19 | 2003-11-06 | Bayer Ag | Lactone |
| DE10222024A1 (de) * | 2002-05-17 | 2003-11-27 | Bayer Ag | Lactame |
| DE10257786A1 (de) * | 2002-12-11 | 2004-07-01 | Bayer Healthcare Ag | Oxazolidinone |
| WO2008057972A1 (en) | 2006-11-02 | 2008-05-15 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing pharmaceutical salts of a factor xa inhibitor |
| WO2012162291A1 (en) * | 2011-05-24 | 2012-11-29 | The Wistar Institute | Compositions and methods for modulating the activity of epstein-barr nuclear antigen 1 |
| US9284310B2 (en) | 2012-11-03 | 2016-03-15 | Boehringer Ingelheim International Gmbh | Inhibitors of cytomegalovirus |
| US9334249B2 (en) | 2012-11-03 | 2016-05-10 | Boehringer Ingelheim International Gmbh | Inhibitors of cytomegalovirus |
| WO2022150962A1 (en) * | 2021-01-12 | 2022-07-21 | Westlake Pharmaceutical (Hangzhou) Co., Ltd. | Protease inhibitors, preparation, and uses thereof |
| WO2023036140A1 (zh) * | 2021-09-07 | 2023-03-16 | 上海齐鲁制药研究中心有限公司 | 3CLpro蛋白酶抑制剂 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU210683B (en) * | 1990-06-18 | 1995-06-28 | Sandoz Ag | Process for producing n-benzyl-n1-(phenyl-alkyl)-thiourea derivatives and pharmaceutical compositions containing the same |
| EP0809492A4 (en) * | 1995-02-17 | 2007-01-24 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
| GB9519270D0 (en) * | 1995-09-21 | 1995-11-22 | Sandoz Pharma Uk | Organic compounds |
| CZ298463B6 (cs) * | 1996-04-23 | 2007-10-10 | Vertex Pharmaceuticals Incorporated | Deriváty mocoviny pro použití jako inhibitory IMPDH enzymu a farmaceutické prostredky, které je obsahují |
-
1999
- 1999-12-06 ES ES99963021T patent/ES2224733T3/es not_active Expired - Lifetime
- 1999-12-06 SK SK770-2001A patent/SK7702001A3/sk unknown
- 1999-12-06 NZ NZ512108A patent/NZ512108A/en unknown
- 1999-12-06 CZ CZ20011957A patent/CZ20011957A3/cs unknown
- 1999-12-06 PL PL99348178A patent/PL348178A1/xx not_active Application Discontinuation
- 1999-12-06 TR TR2001/01597T patent/TR200101597T2/xx unknown
- 1999-12-06 AT AT99963021T patent/ATE272052T1/de not_active IP Right Cessation
- 1999-12-06 IL IL14326299A patent/IL143262A0/xx unknown
- 1999-12-06 DE DE69919023T patent/DE69919023T2/de not_active Expired - Fee Related
- 1999-12-06 BR BR9916086-2A patent/BR9916086A/pt not_active Application Discontinuation
- 1999-12-06 AU AU19345/00A patent/AU1934500A/en not_active Abandoned
- 1999-12-06 DK DK99963021T patent/DK1137632T3/da active
- 1999-12-06 CA CA002351403A patent/CA2351403A1/en not_active Abandoned
- 1999-12-06 PT PT99963021T patent/PT1137632E/pt unknown
- 1999-12-06 JP JP2000586686A patent/JP2002531545A/ja active Pending
- 1999-12-06 ID IDW00200101228A patent/ID30287A/id unknown
- 1999-12-06 KR KR1020017007134A patent/KR20010089559A/ko not_active Application Discontinuation
- 1999-12-06 CN CN99815344A patent/CN1332725A/zh active Pending
- 1999-12-06 HU HU0104763A patent/HUP0104763A3/hu unknown
- 1999-12-06 EP EP99963021A patent/EP1137632B1/en not_active Expired - Lifetime
- 1999-12-06 EA EA200100634A patent/EA200100634A1/ru unknown
- 1999-12-06 WO PCT/US1999/028837 patent/WO2000034238A1/en not_active Application Discontinuation
- 1999-12-07 AR ARP990106229A patent/AR033789A1/es not_active Application Discontinuation
-
2001
- 2001-05-21 ZA ZA200104144A patent/ZA200104144B/xx unknown
- 2001-06-08 BG BG105583A patent/BG105583A/xx unknown
- 2001-06-08 NO NO20012838A patent/NO20012838L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EA200100634A1 (ru) | 2001-10-22 |
| WO2000034238A1 (en) | 2000-06-15 |
| IL143262A0 (en) | 2002-04-21 |
| HUP0104763A2 (hu) | 2002-04-29 |
| EP1137632B1 (en) | 2004-07-28 |
| PL348178A1 (en) | 2002-05-06 |
| BG105583A (en) | 2001-12-29 |
| PT1137632E (pt) | 2004-11-30 |
| NZ512108A (en) | 2003-09-26 |
| NO20012838L (no) | 2001-08-08 |
| CZ20011957A3 (cs) | 2001-10-17 |
| SK7702001A3 (en) | 2002-04-04 |
| JP2002531545A (ja) | 2002-09-24 |
| NO20012838D0 (no) | 2001-06-08 |
| CA2351403A1 (en) | 2000-06-15 |
| ID30287A (id) | 2001-11-15 |
| ATE272052T1 (de) | 2004-08-15 |
| AU1934500A (en) | 2000-06-26 |
| BR9916086A (pt) | 2001-09-04 |
| CN1332725A (zh) | 2002-01-23 |
| DE69919023T2 (de) | 2005-07-28 |
| KR20010089559A (ko) | 2001-10-06 |
| HUP0104763A3 (en) | 2005-04-28 |
| ES2224733T3 (es) | 2005-03-01 |
| TR200101597T2 (tr) | 2001-10-22 |
| DE69919023D1 (de) | 2004-09-02 |
| ZA200104144B (en) | 2002-08-21 |
| EP1137632A1 (en) | 2001-10-04 |
| DK1137632T3 (da) | 2004-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |