ZA200104144B - Thiourea inhibitors of herpes viruses. - Google Patents

Thiourea inhibitors of herpes viruses.

Info

Publication number
ZA200104144B
ZA200104144B ZA200104144A ZA200104144A ZA200104144B ZA 200104144 B ZA200104144 B ZA 200104144B ZA 200104144 A ZA200104144 A ZA 200104144A ZA 200104144 A ZA200104144 A ZA 200104144A ZA 200104144 B ZA200104144 B ZA 200104144B
Authority
ZA
South Africa
Prior art keywords
herpes viruses
thiourea inhibitors
thiourea
inhibitors
herpes
Prior art date
Application number
ZA200104144A
Other languages
English (en)
Inventor
Jonathan David Bloom
Martin Joseph Digrandi
Stanley Albert Lang
Adma Antonia Ross
Kevin Joseph Curran
Russell George Dushin
Emily Boucher Norton
Bryan Mark O'hara
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ZA200104144B publication Critical patent/ZA200104144B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/16Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/16Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
ZA200104144A 1998-12-09 2001-05-21 Thiourea inhibitors of herpes viruses. ZA200104144B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20856198A 1998-12-09 1998-12-09

Publications (1)

Publication Number Publication Date
ZA200104144B true ZA200104144B (en) 2002-08-21

Family

ID=22775050

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200104144A ZA200104144B (en) 1998-12-09 2001-05-21 Thiourea inhibitors of herpes viruses.

Country Status (26)

Country Link
EP (1) EP1137632B1 (es)
JP (1) JP2002531545A (es)
KR (1) KR20010089559A (es)
CN (1) CN1332725A (es)
AR (1) AR033789A1 (es)
AT (1) ATE272052T1 (es)
AU (1) AU1934500A (es)
BG (1) BG105583A (es)
BR (1) BR9916086A (es)
CA (1) CA2351403A1 (es)
CZ (1) CZ20011957A3 (es)
DE (1) DE69919023T2 (es)
DK (1) DK1137632T3 (es)
EA (1) EA200100634A1 (es)
ES (1) ES2224733T3 (es)
HU (1) HUP0104763A3 (es)
ID (1) ID30287A (es)
IL (1) IL143262A0 (es)
NO (1) NO20012838L (es)
NZ (1) NZ512108A (es)
PL (1) PL348178A1 (es)
PT (1) PT1137632E (es)
SK (1) SK7702001A3 (es)
TR (1) TR200101597T2 (es)
WO (1) WO2000034238A1 (es)
ZA (1) ZA200104144B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
DK1259485T3 (da) 2000-02-29 2006-04-10 Millennium Pharm Inc Benzamider og beslægtede inhibitorer for faktor Xa
DE10217518A1 (de) * 2002-04-19 2003-11-06 Bayer Ag Lactone
DE10222024A1 (de) * 2002-05-17 2003-11-27 Bayer Ag Lactame
DE10257786A1 (de) * 2002-12-11 2004-07-01 Bayer Healthcare Ag Oxazolidinone
WO2008057972A1 (en) 2006-11-02 2008-05-15 Millennium Pharmaceuticals, Inc. Methods of synthesizing pharmaceutical salts of a factor xa inhibitor
CN103717757A (zh) 2011-05-24 2014-04-09 威斯特研究所 用于调节爱泼斯坦-巴尔核抗原1的活性的组合物和方法
EP2914592B1 (en) 2012-11-03 2017-10-11 Boehringer Ingelheim International GmbH Inhibitors of cytomegalovirus
US9284310B2 (en) 2012-11-03 2016-03-15 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
WO2022150962A1 (en) * 2021-01-12 2022-07-21 Westlake Pharmaceutical (Hangzhou) Co., Ltd. Protease inhibitors, preparation, and uses thereof
CN118076593A (zh) * 2021-09-07 2024-05-24 上海齐鲁制药研究中心有限公司 3CLpro蛋白酶抑制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU210683B (en) * 1990-06-18 1995-06-28 Sandoz Ag Process for producing n-benzyl-n1-(phenyl-alkyl)-thiourea derivatives and pharmaceutical compositions containing the same
EP0809492A4 (en) * 1995-02-17 2007-01-24 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
GB9519270D0 (en) * 1995-09-21 1995-11-22 Sandoz Pharma Uk Organic compounds
BR9708735A (pt) * 1996-04-23 1999-08-03 Vertex Pharma Derivados de uréia como inibidores da enzina impdh

Also Published As

Publication number Publication date
NO20012838L (no) 2001-08-08
KR20010089559A (ko) 2001-10-06
EA200100634A1 (ru) 2001-10-22
CA2351403A1 (en) 2000-06-15
JP2002531545A (ja) 2002-09-24
BG105583A (en) 2001-12-29
CN1332725A (zh) 2002-01-23
DK1137632T3 (da) 2004-11-01
BR9916086A (pt) 2001-09-04
EP1137632A1 (en) 2001-10-04
ID30287A (id) 2001-11-15
IL143262A0 (en) 2002-04-21
HUP0104763A2 (hu) 2002-04-29
PT1137632E (pt) 2004-11-30
SK7702001A3 (en) 2002-04-04
DE69919023T2 (de) 2005-07-28
CZ20011957A3 (cs) 2001-10-17
EP1137632B1 (en) 2004-07-28
WO2000034238A1 (en) 2000-06-15
NZ512108A (en) 2003-09-26
AR033789A1 (es) 2004-01-07
TR200101597T2 (tr) 2001-10-22
NO20012838D0 (no) 2001-06-08
ATE272052T1 (de) 2004-08-15
AU1934500A (en) 2000-06-26
PL348178A1 (en) 2002-05-06
DE69919023D1 (de) 2004-09-02
ES2224733T3 (es) 2005-03-01
HUP0104763A3 (en) 2005-04-28

Similar Documents

Publication Publication Date Title
PL342670A1 (en) Derivatives of 2-(purin-9-yl) tetrahydrofurane-3,4-diole
PL342396A1 (en) Derivatives of 2-(purin-9-yl) tetrahydrofurano-3,4-diole
PL364704A1 (en) Enzyme inhibitors
HK1039124A1 (en) Phthalzaine derivatives phosphodiesterase 4 inhibitors.
MXPA00012647A (es) Derivados n-sustituidos de acido 5-oxiiminobarbiturico.
ZA200104144B (en) Thiourea inhibitors of herpes viruses.
NO20012834D0 (no) Acetamid- og substituerte acetamid-holdige tioureainhibitorer for herpesvirus
AU4685799A (en) Telomerase inhibitors
EP1144397A3 (en) Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group
EP1144399A3 (en) Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group
IL143203A0 (en) Thiourea inhibitors of herpes viruses
IL143261A0 (en) Thiourea inhibitors of herpes viruses
HUP0104492A3 (en) Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
GB9809666D0 (en) Modified viruses
GB9816358D0 (en) Enzyme inhibitors
GB9815925D0 (en) HIV Intergrase inhibitors
ZA200200311B (en) 2-amino-benzoxazinones for the treatment of herpes simplex virus.
SI1137645T1 (en) Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
GB2334422B (en) Horseshoe
GB2341470B (en) Delayline
AU2300499A (en) Telomerase inhibitors
GB9803416D0 (en) Inhibitors
SI1068184T1 (en) N-aryloxyethylamine derivatives for the treatment of depression
TW363491U (en) Flat spanner of easy combination
HU9800600D0 (en) Plan against attack of car-drivers