ES2239364T3 - Sintesis de peptidos en fase solida. - Google Patents
Sintesis de peptidos en fase solida.Info
- Publication number
- ES2239364T3 ES2239364T3 ES97939974T ES97939974T ES2239364T3 ES 2239364 T3 ES2239364 T3 ES 2239364T3 ES 97939974 T ES97939974 T ES 97939974T ES 97939974 T ES97939974 T ES 97939974T ES 2239364 T3 ES2239364 T3 ES 2239364T3
- Authority
- ES
- Spain
- Prior art keywords
- peptide
- acid
- process according
- sequence
- protected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
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- 238000010521 absorption reaction Methods 0.000 description 1
- PQLVXDKIJBQVDF-UHFFFAOYSA-N acetic acid;hydrate Chemical compound O.CC(O)=O PQLVXDKIJBQVDF-UHFFFAOYSA-N 0.000 description 1
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- 125000000539 amino acid group Chemical group 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
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- 238000004821 distillation Methods 0.000 description 1
- MYRTYDVEIRVNKP-UHFFFAOYSA-N divinylbenzene Substances C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 1
- 229940116441 divinylbenzene Drugs 0.000 description 1
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- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 150000002307 glutamic acids Chemical class 0.000 description 1
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- 125000001165 hydrophobic group Chemical group 0.000 description 1
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 1
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- 239000000543 intermediate Substances 0.000 description 1
- URLZCHNOLZSCCA-UHFFFAOYSA-N leu-enkephalin Chemical compound C=1C=C(O)C=CC=1CC(N)C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=CC=C1 URLZCHNOLZSCCA-UHFFFAOYSA-N 0.000 description 1
- 150000002614 leucines Chemical class 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000012607 strong cation exchange resin Substances 0.000 description 1
- 230000006918 subunit interaction Effects 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Prostheses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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DK97196 | 1996-09-09 | ||
DK97196 | 1996-09-09 |
Publications (1)
Publication Number | Publication Date |
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ES2239364T3 true ES2239364T3 (es) | 2005-09-16 |
Family
ID=8099561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97939974T Expired - Lifetime ES2239364T3 (es) | 1996-09-09 | 1997-09-09 | Sintesis de peptidos en fase solida. |
Country Status (14)
Country | Link |
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US (1) | US7348404B2 (hu) |
EP (1) | EP0929567B1 (hu) |
JP (1) | JP4405594B2 (hu) |
AT (1) | ATE290014T1 (hu) |
AU (1) | AU723268B2 (hu) |
CA (1) | CA2265900C (hu) |
CZ (1) | CZ295838B6 (hu) |
DE (1) | DE69732640T2 (hu) |
DK (1) | DK0929567T3 (hu) |
ES (1) | ES2239364T3 (hu) |
HU (1) | HU230354B1 (hu) |
IL (1) | IL128829A (hu) |
PT (1) | PT929567E (hu) |
WO (1) | WO1998011125A1 (hu) |
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US7550425B2 (en) | 2000-06-16 | 2009-06-23 | Zealand Pharma A/S | Diuretic peptide conjugates |
PT1737889E (pt) | 2004-10-19 | 2010-12-13 | Lonza Ag | Método para síntese de péptidos em fase sólida |
KR101200227B1 (ko) | 2005-05-04 | 2012-11-13 | 질랜드 파마 에이/에스 | 글루카곤 유사 펩티드-2(glp-2) 유사체 |
GB0514071D0 (en) | 2005-07-07 | 2005-08-17 | Zealand Pharma As | N- or C- terminally modified small peptides |
JPWO2007060860A1 (ja) * | 2005-11-22 | 2009-05-07 | 学校法人日本大学 | ピロールイミダゾールポリアミドの固相自動合成 |
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WO2007114454A1 (ja) * | 2006-03-29 | 2007-10-11 | Otsuka Chemical Co., Ltd. | ペプチドのチオエステル化合物の製造方法 |
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---|---|---|---|---|
JPS5116666A (hu) | 1974-07-30 | 1976-02-10 | Shionogi Seiyaku Kk | |
US5021550A (en) * | 1986-10-07 | 1991-06-04 | Thomas Jefferson University | Method for preventing deletion sequences in solid phase synthesis |
JP2807287B2 (ja) | 1989-10-13 | 1998-10-08 | 株式会社医学生物学研究所 | ペプチドおよびその用途 |
CA2170030A1 (en) | 1993-09-14 | 1995-03-23 | Robert A. Lazarus | Pharmaceutical compositions containing ecotin and homologs thereof |
US7176282B1 (en) | 1996-09-09 | 2007-02-13 | Zealand Pharma A/S | Solid-phase peptide synthesis and agent for use in such synthesis |
WO1999046283A1 (en) | 1998-03-09 | 1999-09-16 | Zealand Pharmaceuticals A/S | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
-
1997
- 1997-09-09 CZ CZ1999803A patent/CZ295838B6/cs not_active IP Right Cessation
- 1997-09-09 WO PCT/DK1997/000375 patent/WO1998011125A1/en active IP Right Grant
- 1997-09-09 PT PT97939974T patent/PT929567E/pt unknown
- 1997-09-09 DE DE69732640T patent/DE69732640T2/de not_active Expired - Lifetime
- 1997-09-09 HU HU0102900A patent/HU230354B1/hu not_active IP Right Cessation
- 1997-09-09 DK DK97939974T patent/DK0929567T3/da active
- 1997-09-09 IL IL12882997A patent/IL128829A/xx not_active IP Right Cessation
- 1997-09-09 CA CA002265900A patent/CA2265900C/en not_active Expired - Lifetime
- 1997-09-09 AU AU41993/97A patent/AU723268B2/en not_active Ceased
- 1997-09-09 ES ES97939974T patent/ES2239364T3/es not_active Expired - Lifetime
- 1997-09-09 JP JP51316698A patent/JP4405594B2/ja not_active Expired - Fee Related
- 1997-09-09 AT AT97939974T patent/ATE290014T1/de active
- 1997-09-09 EP EP97939974A patent/EP0929567B1/en not_active Expired - Lifetime
-
2006
- 2006-06-19 US US11/455,388 patent/US7348404B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2265900C (en) | 2007-07-31 |
JP4405594B2 (ja) | 2010-01-27 |
AU4199397A (en) | 1998-04-02 |
DE69732640T2 (de) | 2006-01-12 |
WO1998011125A1 (en) | 1998-03-19 |
EP0929567B1 (en) | 2005-03-02 |
CA2265900A1 (en) | 1998-03-19 |
IL128829A0 (en) | 2000-01-31 |
DK0929567T3 (da) | 2005-06-27 |
DE69732640D1 (de) | 2005-04-07 |
EP0929567A1 (en) | 1999-07-21 |
JP2001500134A (ja) | 2001-01-09 |
AU723268B2 (en) | 2000-08-24 |
CZ295838B6 (cs) | 2005-11-16 |
HU230354B1 (hu) | 2016-02-29 |
CZ80399A3 (cs) | 1999-08-11 |
HUP0102900A2 (hu) | 2002-01-28 |
ATE290014T1 (de) | 2005-03-15 |
IL128829A (en) | 2005-08-31 |
US7348404B2 (en) | 2008-03-25 |
HUP0102900A3 (en) | 2002-02-28 |
US20070004905A1 (en) | 2007-01-04 |
PT929567E (pt) | 2005-07-29 |
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