ES2182888T3 - Inhibidores de la sintesis de los acidos grasos como agentes antimicrobianos. - Google Patents

Inhibidores de la sintesis de los acidos grasos como agentes antimicrobianos.

Info

Publication number
ES2182888T3
ES2182888T3 ES95909239T ES95909239T ES2182888T3 ES 2182888 T3 ES2182888 T3 ES 2182888T3 ES 95909239 T ES95909239 T ES 95909239T ES 95909239 T ES95909239 T ES 95909239T ES 2182888 T3 ES2182888 T3 ES 2182888T3
Authority
ES
Spain
Prior art keywords
synthesis
fatty acids
cells
inhibitors
antimicrobial agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95909239T
Other languages
English (en)
Inventor
James D Dick
Francis P Kuhajda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Application granted granted Critical
Publication of ES2182888T3 publication Critical patent/ES2182888T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

LA SINTESIS DE ACIDOS GRASOS (FAS) VIENE SOBREEXPRESADA POR CIERTOS ORGANISMOS INFECCIOSOS, QUE SON RESISTENTES A LOS ANTIBIOTICOS DISPONIBLES DE FORMA MAS HABITUAL. POR EL CONTRARIO, SE IDENTIFICA UNA ESCASA EXPRESION DE FAS EN LOS TEJIDOS DE PACIENTES. LA INHIBICION DE SINTESIS DE ACIDOS GRASOS ES POR ELLO TOXICA DE FORMA SELECTIVA PARA LAS CELULAS INVASORAS, MIENTRAS QUE LAS CELULAS DEL PACIENTE CON UNA REDUCIDA ACTIVIDAD DE FAS SON RESISTENTES. ESTA INVENCION PROPORCIONA UN METODO PARA TRATAR PACIENTES SEPTICOS, EN LOS QUE LA SINTESIS DE ACIDOS GRASOS POR LAS CELULAS INVASORAS QUEDA INHIBIDA, CON EL RESULTADO DE UNA INTERRUPCION DEL PROCESO DE LA ENFERMEDAD.
ES95909239T 1994-01-24 1995-01-24 Inhibidores de la sintesis de los acidos grasos como agentes antimicrobianos. Expired - Lifetime ES2182888T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/188,421 US5614551A (en) 1994-01-24 1994-01-24 Inhibitors of fatty acid synthesis as antimicrobial agents

Publications (1)

Publication Number Publication Date
ES2182888T3 true ES2182888T3 (es) 2003-03-16

Family

ID=22693071

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95909239T Expired - Lifetime ES2182888T3 (es) 1994-01-24 1995-01-24 Inhibidores de la sintesis de los acidos grasos como agentes antimicrobianos.

Country Status (13)

Country Link
US (1) US5614551A (es)
EP (1) EP0738107B1 (es)
JP (1) JPH09508370A (es)
KR (1) KR100395601B1 (es)
AT (1) ATE223215T1 (es)
AU (1) AU703272B2 (es)
CA (1) CA2181031A1 (es)
DE (1) DE69528039T2 (es)
DK (1) DK0738107T3 (es)
ES (1) ES2182888T3 (es)
MX (1) MX9602934A (es)
PT (1) PT738107E (es)
WO (1) WO1995019706A1 (es)

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Also Published As

Publication number Publication date
AU703272B2 (en) 1999-03-25
EP0738107A4 (en) 1998-09-09
AU1726895A (en) 1995-08-08
KR100395601B1 (ko) 2003-11-17
WO1995019706A1 (en) 1995-07-27
EP0738107A1 (en) 1996-10-23
DE69528039D1 (de) 2002-10-10
US5614551A (en) 1997-03-25
EP0738107B1 (en) 2002-09-04
JPH09508370A (ja) 1997-08-26
ATE223215T1 (de) 2002-09-15
CA2181031A1 (en) 1995-07-27
DE69528039T2 (de) 2003-08-07
MX9602934A (es) 1997-12-31
PT738107E (pt) 2003-01-31
DK0738107T3 (da) 2003-01-06

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