ES2182888T3 - Inhibidores de la sintesis de los acidos grasos como agentes antimicrobianos. - Google Patents
Inhibidores de la sintesis de los acidos grasos como agentes antimicrobianos.Info
- Publication number
- ES2182888T3 ES2182888T3 ES95909239T ES95909239T ES2182888T3 ES 2182888 T3 ES2182888 T3 ES 2182888T3 ES 95909239 T ES95909239 T ES 95909239T ES 95909239 T ES95909239 T ES 95909239T ES 2182888 T3 ES2182888 T3 ES 2182888T3
- Authority
- ES
- Spain
- Prior art keywords
- synthesis
- fatty acids
- cells
- inhibitors
- antimicrobial agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 235000014113 dietary fatty acids Nutrition 0.000 title abstract 5
- 229930195729 fatty acid Natural products 0.000 title abstract 5
- 239000000194 fatty acid Substances 0.000 title abstract 5
- 150000004665 fatty acids Chemical class 0.000 title abstract 5
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 4
- 239000004599 antimicrobial Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000004744 fabric Substances 0.000 abstract 1
- 230000002650 habitual effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
LA SINTESIS DE ACIDOS GRASOS (FAS) VIENE SOBREEXPRESADA POR CIERTOS ORGANISMOS INFECCIOSOS, QUE SON RESISTENTES A LOS ANTIBIOTICOS DISPONIBLES DE FORMA MAS HABITUAL. POR EL CONTRARIO, SE IDENTIFICA UNA ESCASA EXPRESION DE FAS EN LOS TEJIDOS DE PACIENTES. LA INHIBICION DE SINTESIS DE ACIDOS GRASOS ES POR ELLO TOXICA DE FORMA SELECTIVA PARA LAS CELULAS INVASORAS, MIENTRAS QUE LAS CELULAS DEL PACIENTE CON UNA REDUCIDA ACTIVIDAD DE FAS SON RESISTENTES. ESTA INVENCION PROPORCIONA UN METODO PARA TRATAR PACIENTES SEPTICOS, EN LOS QUE LA SINTESIS DE ACIDOS GRASOS POR LAS CELULAS INVASORAS QUEDA INHIBIDA, CON EL RESULTADO DE UNA INTERRUPCION DEL PROCESO DE LA ENFERMEDAD.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/188,421 US5614551A (en) | 1994-01-24 | 1994-01-24 | Inhibitors of fatty acid synthesis as antimicrobial agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2182888T3 true ES2182888T3 (es) | 2003-03-16 |
Family
ID=22693071
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95909239T Expired - Lifetime ES2182888T3 (es) | 1994-01-24 | 1995-01-24 | Inhibidores de la sintesis de los acidos grasos como agentes antimicrobianos. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5614551A (es) |
EP (1) | EP0738107B1 (es) |
JP (1) | JPH09508370A (es) |
KR (1) | KR100395601B1 (es) |
AT (1) | ATE223215T1 (es) |
AU (1) | AU703272B2 (es) |
CA (1) | CA2181031A1 (es) |
DE (1) | DE69528039T2 (es) |
DK (1) | DK0738107T3 (es) |
ES (1) | ES2182888T3 (es) |
MX (1) | MX9602934A (es) |
PT (1) | PT738107E (es) |
WO (1) | WO1995019706A1 (es) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6010881A (en) * | 1996-02-20 | 2000-01-04 | Smithkline Beecham Corporation | RibG |
US5859027A (en) * | 1996-02-26 | 1999-01-12 | Chektec Corporation | Antimicrobial agent |
US5910509A (en) * | 1996-06-20 | 1999-06-08 | Broedel; Sheldon E. | Antimicrobial agent for agriculture |
WO1998003661A2 (en) * | 1996-07-19 | 1998-01-29 | Arch Development Corporation | Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components |
US5750496A (en) * | 1996-08-12 | 1998-05-12 | Utah State University | Method of controlling cryptosporidium infectons using protease inhibitors |
JP2000514308A (ja) * | 1996-08-16 | 2000-10-31 | スミスクライン・ビーチャム・コーポレイション | 新規原核生物ポリヌクレオチド、ポリペプチドおよびそれらの使用 |
US20050112713A1 (en) * | 1996-08-28 | 2005-05-26 | Affinium Pharmaceuticals, Inc. | Methods of using Fab I and compounds modulating Fab I activity |
US6995254B1 (en) | 1996-08-28 | 2006-02-07 | Affinium Pharmaceuticals, Inc. | Polynucleotide encoding the enoyl-acyl carrier protein reductase of Staphylococcus aureus, FAB I |
US5981575A (en) * | 1996-11-15 | 1999-11-09 | Johns Hopkins University, The | Inhibition of fatty acid synthase as a means to reduce adipocyte mass |
US5859028A (en) * | 1997-04-28 | 1999-01-12 | Potomax Limited Partnership | Carotenoid synthesis inhibiting herbicides and fatty acid synthesis inhibiting oxime herbicides as anti-Apicomplexa protozoan parasite agents |
US6171856B1 (en) | 1997-07-30 | 2001-01-09 | Board Of Regents, The University Of Texas System | Methods and compositions relating to no-mediated cytotoxicity |
US6713654B1 (en) | 1997-08-29 | 2004-03-30 | The Johns Hopkins University School Of Medicine | Antimicrobial compounds |
ATE260890T1 (de) * | 1997-08-29 | 2004-03-15 | Univ Johns Hopkins | Antimikrobielle verbindungen |
CO5180550A1 (es) | 1999-04-19 | 2002-07-30 | Smithkline Beecham Corp | Inhibidores de fab i |
CO5370679A1 (es) | 1999-06-01 | 2004-02-27 | Smithkline Beecham Corp | Inhibidores fab 1 |
US7303526B2 (en) * | 1999-08-09 | 2007-12-04 | Cardiokinetix, Inc. | Device for improving cardiac function |
JP2003507467A (ja) * | 1999-08-23 | 2003-02-25 | スミスクライン・ビーチャム・コーポレイション | 脂肪酸シンターゼ阻害剤 |
JP4803935B2 (ja) * | 1999-10-08 | 2011-10-26 | アフィニアム・ファーマシューティカルズ・インコーポレイテッド | Fabi阻害剤 |
US6730684B1 (en) | 1999-10-08 | 2004-05-04 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
US6762201B1 (en) | 1999-10-08 | 2004-07-13 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
WO2001030988A1 (en) * | 1999-10-27 | 2001-05-03 | Smithkline Beecham Corporation | Methods for making and using fatty acid synthesis pathway reagents |
US6951729B1 (en) | 1999-10-27 | 2005-10-04 | Affinium Pharmaceuticals, Inc. | High throughput screening method for biological agents affecting fatty acid biosynthesis |
US6656703B1 (en) * | 1999-12-29 | 2003-12-02 | Millennium Pharamaceuticals, Inc. | High throughput screen for inhibitors of fatty acid biosynthesis in bacteria |
AU2761101A (en) * | 2000-01-07 | 2001-07-24 | Virginia Commonwealth University | A scintillation proximity assay for type ii fatty acid biosynthetic enzymes |
KR20030016228A (ko) * | 2000-02-16 | 2003-02-26 | 존스 홉킨스 유니버시티 스쿨 오브 메디슨 | 신경펩티드 y 농도의 감소에 의해 유도되는 체중 감량 |
US20040157918A1 (en) * | 2001-02-16 | 2004-08-12 | Loftus Thomas M. | Weight loss induced by reduction in neuropeptide y level |
WO2001071045A2 (en) * | 2000-03-23 | 2001-09-27 | Millennium Pharmaceuticals, Inc. | High throughput screening for inhibitors of fatty acid, ergosterol, sphingolipid, or phospholipid synthesis in fungi |
US7048926B2 (en) * | 2000-10-06 | 2006-05-23 | Affinium Pharmaceuticals, Inc. | Methods of agonizing and antagonizing FabK |
EP1560584B1 (en) * | 2001-04-06 | 2009-01-14 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
US7348023B2 (en) * | 2001-11-21 | 2008-03-25 | Kimberly-Clark Worldwide, Inc. | Absorbent articles containing additives |
US6821999B2 (en) * | 2001-11-21 | 2004-11-23 | Kimberly-Clark Worldwide, Inc. | Methods for inhibiting the production of TSST-1 |
US7323186B2 (en) * | 2001-11-21 | 2008-01-29 | Kimberly-Clark Worldwide, Inc. | Non-absorbent articles containing additives |
US6955890B2 (en) * | 2002-02-14 | 2005-10-18 | Pyro Pharmaceuticals, Inc. | Method for the identification and treatment of pathogenic microorganisms infections by inhibiting one or more enzymes in an essential metabolic pathway |
US20060063224A1 (en) * | 2002-05-10 | 2006-03-23 | Schechter Alan M | Method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in an essential metabolic pathway |
CA2767092C (en) | 2002-07-09 | 2013-10-15 | Fasgen, Inc. | Novel compounds, pharmaceutical compositions containing same and methods of use for same |
DK1575951T3 (da) * | 2002-12-06 | 2014-09-15 | Debiopharm Int Sa | Heterocykliske forbindelser, fremgangsmåder til fremstilling deraf og deres anvendelse i terapi |
JP4880448B2 (ja) | 2003-03-17 | 2012-02-22 | アフィナム ファーマシューティカルズ,インコーポレーテッド | 複数の抗生物質を含む組成物、及びそれを用いる方法 |
EP1648928A2 (en) * | 2003-07-11 | 2006-04-26 | Affinium Pharmaceuticals, Inc. | Novel purified polypeptides from staphylococcus aureus |
CN101022792A (zh) * | 2004-05-26 | 2007-08-22 | 法斯根有限责任公司 | 新化合物、包含该化合物的药物组合物及该化合物的应用方法 |
WO2007053131A2 (en) * | 2004-06-04 | 2007-05-10 | Affinium Pharmaceuticals, Inc. | Acrylamide derivatives as antibiotic agents |
US20090156578A1 (en) * | 2005-12-05 | 2009-06-18 | PAULS Henry | 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents |
WO2007092590A2 (en) * | 2006-02-08 | 2007-08-16 | Fasgen, Inc. | Anti-mycobacterial formulation comprising octanesulphonylacetamide (osa), nonanesulphonylacetamide (nsa) and decanesulphonylacetamide (dsa) |
CA2658506C (en) | 2006-07-20 | 2016-01-26 | Affinium Pharmaceuticals, Inc. | Acrylamide derivatives as fab 1 inhibitors |
US8263613B2 (en) | 2007-02-16 | 2012-09-11 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab I inhibitors |
JP5616220B2 (ja) * | 2007-06-01 | 2014-10-29 | ザ トラスティーズ オブ プリンストン ユニバーシティ | 宿主細胞代謝経路の調節によるウイルス感染治療 |
WO2010118324A2 (en) | 2009-04-09 | 2010-10-14 | Nuclea Biotechnologies, LLC | Antibodies against fatty acid synthase |
KR101720885B1 (ko) | 2012-06-19 | 2017-03-28 | 데비오팜 인터네셔날 에스 에이 | (e)-n-메틸-n-((3-메틸벤조푸란-2-일)메틸)-3-(7-옥소-5,6,7,8-테트라히드로-1,8-나프티리딘-3-일)아크릴아미드의전구약물 유도체 |
BR102012033811A8 (pt) * | 2012-12-28 | 2019-12-24 | Uniao Brasileira De Educacao E Assistencia Mantenedora Da Puc Rs | compostos, uso, composição farmacêutica inibidora de redutase em microorganismos, ligante de inha, e, método para obtenção de ligantes de inha |
BR102013006007A2 (pt) * | 2013-03-13 | 2014-11-11 | Ubea | Compostos, uso, composição farmacêutica inibidora de redutase em microorganismos, ligante de inha, e, método para obtenção de ligantes de inha a partir de derivados de acetamida, ureia, fenol e carboxamida |
LT3419628T (lt) | 2016-02-26 | 2021-01-25 | Debiopharm International Sa | Medikamentas diabetinėms pėdų infekcijoms gydyti |
US20210290629A1 (en) * | 2016-07-07 | 2021-09-23 | Forschungzentrum Borstel Leibniz-Zentrum fuer Medizin und Biowissenschaften | Acc inhibitors for use in treating mycobacterial diseases |
EP3266454A1 (en) * | 2016-07-07 | 2018-01-10 | Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften | Acc inhibitors for use in treating mycobacterial diseases |
US20210137934A1 (en) * | 2017-03-16 | 2021-05-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of identifying myc-driven and lipogenesis-dependent neoplasms and methods of treating the same |
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DE252616C (de) * | 1912-01-25 | 1912-10-23 | Gebr Lesser | Ablegerad für Kartoffelerntemaschinen mit einem quer zur Fahrrichtung de Maschine umlaufenden Wurfrad |
US3535309A (en) * | 1967-09-01 | 1970-10-20 | Kitasato Inst | Antibiotics and their production |
US3630846A (en) * | 1967-09-01 | 1971-12-28 | Kitasato Inst And Toyo Jozo Kk | Antibiotic production using streptomyces kitasatoensis |
US3909361A (en) * | 1971-06-29 | 1975-09-30 | Nihon Tokushu Noyaku Seizo Kk | Novel antifungal antibiotic substance, process for production of the same, and agricultural and horticultural fungicidal composition containing said substance |
JPS5619344B2 (es) * | 1972-11-11 | 1981-05-07 | ||
US4602099A (en) * | 1973-04-02 | 1986-07-22 | Merrell Dow Pharmaceuticals Inc. | Antirhinovirus agents |
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US4000164A (en) * | 1973-04-02 | 1976-12-28 | Richardson-Merrell Inc. | Hypolipidemic agents |
US4738984A (en) * | 1973-04-02 | 1988-04-19 | Merrell Dow Pharmaceuticals Inc. | Antirhinovirus agents |
US4032647A (en) * | 1975-06-16 | 1977-06-28 | Richardson-Merrell Inc. | Substituted thenoylacetic acid and esters |
US4011334A (en) * | 1975-10-03 | 1977-03-08 | Richardson-Merrell Inc. | Use of substituted furan and thiophene carboxaldehydes as hypolipidemic agents |
US4328246A (en) * | 1979-08-14 | 1982-05-04 | Joseph Gold | Anti Walker 256 carcinoma agent and combination thereof |
JPS59225115A (ja) * | 1983-06-06 | 1984-12-18 | Ota Seiyaku Kk | 青魚類から得た長鎖高度不飽和脂肪酸を含有する微細カプセル |
JPS6058917A (ja) * | 1983-09-09 | 1985-04-05 | Rikagaku Kenkyusho | 制癌剤 |
FR2552879B1 (fr) * | 1983-10-03 | 1987-08-14 | Pasteur Institut | Procede et reactifs pour la detection d'une anomalie genetique dans une matiere biologique, notamment dans une preparation de leucocytes |
CA1256372A (en) * | 1985-04-11 | 1989-06-27 | Koichiro Miyazima | Process for producing liposome composition |
US5110731A (en) * | 1985-08-26 | 1992-05-05 | Amgen, Inc. | System for biotin synthesis |
US4789630A (en) * | 1985-10-04 | 1988-12-06 | Cetus Corporation | Ionic compounds containing the cationic meriquinone of a benzidine |
GB8607137D0 (en) * | 1986-03-21 | 1986-04-30 | Efamol Ltd | Compositions |
US4968494A (en) * | 1987-03-27 | 1990-11-06 | Merck & Co., Inc. | Methods and compositions for thrombolytic therapy |
US5188830A (en) * | 1987-03-27 | 1993-02-23 | Merck & Co., Inc. | Methods for thrombolytic therapy |
US5185149A (en) * | 1987-03-27 | 1993-02-09 | Merck & Co., Inc. | Methods for thrombolytic therapy |
JPH01132542A (ja) * | 1987-11-19 | 1989-05-25 | Toomen:Kk | ゴッシポールラセミ体の光学分割法 |
US4877782A (en) * | 1988-02-16 | 1989-10-31 | The Upjohn Company | Zinc ceftiofur complexes |
JPH02113850A (ja) * | 1988-10-21 | 1990-04-26 | Nippon Oil & Fats Co Ltd | 発癌抑制用油脂組成物 |
US5190969A (en) * | 1988-12-20 | 1993-03-02 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | 2,3-epoxy derivatives as anti retrovital chemotherapeutic agents |
AU621434B2 (en) * | 1988-12-21 | 1992-03-12 | Merrell Dow Pharmaceuticals Inc. | Antiretroviral furan ketones |
JPH02247125A (ja) * | 1989-03-17 | 1990-10-02 | Koken Kk | 悪性腫瘍細胞増殖抑制剤 |
US5143907A (en) * | 1991-05-10 | 1992-09-01 | Boron Biologicals, Inc. | Phosphite-borane compounds, and method of making and using the same |
US5858784A (en) * | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
WO1993012240A1 (en) * | 1991-12-17 | 1993-06-24 | The Regents Of The University Of California | Gene therapy for cystic fibrosis transmembrane conductance regulator activity (cftr) |
MX9304501A (es) * | 1992-07-24 | 1994-04-29 | Univ Johns Hopkins | Quimioterapia para cancer. |
US5539132A (en) * | 1994-01-24 | 1996-07-23 | Johns Hopkins University | Cerulenin compounds for fatty acid synthesis inhibition |
-
1994
- 1994-01-24 US US08/188,421 patent/US5614551A/en not_active Expired - Lifetime
-
1995
- 1995-01-24 CA CA002181031A patent/CA2181031A1/en not_active Abandoned
- 1995-01-24 PT PT95909239T patent/PT738107E/pt unknown
- 1995-01-24 AT AT95909239T patent/ATE223215T1/de not_active IP Right Cessation
- 1995-01-24 ES ES95909239T patent/ES2182888T3/es not_active Expired - Lifetime
- 1995-01-24 EP EP95909239A patent/EP0738107B1/en not_active Expired - Lifetime
- 1995-01-24 DK DK95909239T patent/DK0738107T3/da active
- 1995-01-24 MX MX9602934A patent/MX9602934A/es not_active IP Right Cessation
- 1995-01-24 KR KR1019960703954A patent/KR100395601B1/ko not_active IP Right Cessation
- 1995-01-24 DE DE69528039T patent/DE69528039T2/de not_active Expired - Fee Related
- 1995-01-24 JP JP7519612A patent/JPH09508370A/ja not_active Ceased
- 1995-01-24 WO PCT/US1995/000544 patent/WO1995019706A1/en active IP Right Grant
- 1995-01-24 AU AU17268/95A patent/AU703272B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU703272B2 (en) | 1999-03-25 |
EP0738107A4 (en) | 1998-09-09 |
AU1726895A (en) | 1995-08-08 |
KR100395601B1 (ko) | 2003-11-17 |
WO1995019706A1 (en) | 1995-07-27 |
EP0738107A1 (en) | 1996-10-23 |
DE69528039D1 (de) | 2002-10-10 |
US5614551A (en) | 1997-03-25 |
EP0738107B1 (en) | 2002-09-04 |
JPH09508370A (ja) | 1997-08-26 |
ATE223215T1 (de) | 2002-09-15 |
CA2181031A1 (en) | 1995-07-27 |
DE69528039T2 (de) | 2003-08-07 |
MX9602934A (es) | 1997-12-31 |
PT738107E (pt) | 2003-01-31 |
DK0738107T3 (da) | 2003-01-06 |
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