DE69528039T2 - Inhibitoren der fettsäuresynthese als antimikrobielle mittel - Google Patents

Inhibitoren der fettsäuresynthese als antimikrobielle mittel

Info

Publication number
DE69528039T2
DE69528039T2 DE69528039T DE69528039T DE69528039T2 DE 69528039 T2 DE69528039 T2 DE 69528039T2 DE 69528039 T DE69528039 T DE 69528039T DE 69528039 T DE69528039 T DE 69528039T DE 69528039 T2 DE69528039 T2 DE 69528039T2
Authority
DE
Germany
Prior art keywords
fatty acid
acid synthesis
inhibitors
fas
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69528039T
Other languages
English (en)
Other versions
DE69528039D1 (de
Inventor
D Dick
P Kuhajda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Application granted granted Critical
Publication of DE69528039D1 publication Critical patent/DE69528039D1/de
Publication of DE69528039T2 publication Critical patent/DE69528039T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69528039T 1994-01-24 1995-01-24 Inhibitoren der fettsäuresynthese als antimikrobielle mittel Expired - Fee Related DE69528039T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/188,421 US5614551A (en) 1994-01-24 1994-01-24 Inhibitors of fatty acid synthesis as antimicrobial agents
PCT/US1995/000544 WO1995019706A1 (en) 1994-01-24 1995-01-24 Inhibitors of fatty acid synthesis as antimicrobial agents

Publications (2)

Publication Number Publication Date
DE69528039D1 DE69528039D1 (de) 2002-10-10
DE69528039T2 true DE69528039T2 (de) 2003-08-07

Family

ID=22693071

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528039T Expired - Fee Related DE69528039T2 (de) 1994-01-24 1995-01-24 Inhibitoren der fettsäuresynthese als antimikrobielle mittel

Country Status (13)

Country Link
US (1) US5614551A (de)
EP (1) EP0738107B1 (de)
JP (1) JPH09508370A (de)
KR (1) KR100395601B1 (de)
AT (1) ATE223215T1 (de)
AU (1) AU703272B2 (de)
CA (1) CA2181031A1 (de)
DE (1) DE69528039T2 (de)
DK (1) DK0738107T3 (de)
ES (1) ES2182888T3 (de)
MX (1) MX9602934A (de)
PT (1) PT738107E (de)
WO (1) WO1995019706A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6010881A (en) * 1996-02-20 2000-01-04 Smithkline Beecham Corporation RibG
US5859027A (en) * 1996-02-26 1999-01-12 Chektec Corporation Antimicrobial agent
US5910509A (en) * 1996-06-20 1999-06-08 Broedel; Sheldon E. Antimicrobial agent for agriculture
WO1998003661A2 (en) * 1996-07-19 1998-01-29 Arch Development Corporation Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components
US5750496A (en) * 1996-08-12 1998-05-12 Utah State University Method of controlling cryptosporidium infectons using protease inhibitors
EP0956289A4 (de) * 1996-08-16 2004-10-13 Smithkline Beecham Corp Prokaryotische polynucleotide, polypeptide und ihre verwendung
US6995254B1 (en) 1996-08-28 2006-02-07 Affinium Pharmaceuticals, Inc. Polynucleotide encoding the enoyl-acyl carrier protein reductase of Staphylococcus aureus, FAB I
US20050112713A1 (en) * 1996-08-28 2005-05-26 Affinium Pharmaceuticals, Inc. Methods of using Fab I and compounds modulating Fab I activity
US5981575A (en) * 1996-11-15 1999-11-09 Johns Hopkins University, The Inhibition of fatty acid synthase as a means to reduce adipocyte mass
US5859028A (en) * 1997-04-28 1999-01-12 Potomax Limited Partnership Carotenoid synthesis inhibiting herbicides and fatty acid synthesis inhibiting oxime herbicides as anti-Apicomplexa protozoan parasite agents
US6171856B1 (en) 1997-07-30 2001-01-09 Board Of Regents, The University Of Texas System Methods and compositions relating to no-mediated cytotoxicity
US6713654B1 (en) 1997-08-29 2004-03-30 The Johns Hopkins University School Of Medicine Antimicrobial compounds
DE69822167T2 (de) * 1997-08-29 2005-02-17 The Johns Hopkins University Antimikrobielle verbindungen
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
CO5370679A1 (es) 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
US7303526B2 (en) * 1999-08-09 2007-12-04 Cardiokinetix, Inc. Device for improving cardiac function
WO2001014362A1 (en) * 1999-08-23 2001-03-01 Smithkline Beecham Corporation Fatty acid synthase inhibitors
PE20010635A1 (es) * 1999-10-08 2001-08-15 Smithkline Beecham Corp Inhibidores de fab i utiles para el tratamiento de infecciones bacterianas
US6730684B1 (en) 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
WO2001030988A1 (en) * 1999-10-27 2001-05-03 Smithkline Beecham Corporation Methods for making and using fatty acid synthesis pathway reagents
US6951729B1 (en) 1999-10-27 2005-10-04 Affinium Pharmaceuticals, Inc. High throughput screening method for biological agents affecting fatty acid biosynthesis
US6656703B1 (en) * 1999-12-29 2003-12-02 Millennium Pharamaceuticals, Inc. High throughput screen for inhibitors of fatty acid biosynthesis in bacteria
WO2001051925A1 (en) * 2000-01-07 2001-07-19 Virginia Commonwealth University A scintillation proximity assay for type ii fatty acid biosynthetic enzymes
US20040157918A1 (en) * 2001-02-16 2004-08-12 Loftus Thomas M. Weight loss induced by reduction in neuropeptide y level
JP2003528051A (ja) * 2000-02-16 2003-09-24 ザ ジョンズ ホプキンス ユニバーシティー スクール オブ メディシン ニューロペプチドｙレベルの減少によって誘導される体重減少
US20020037495A1 (en) * 2000-03-23 2002-03-28 Gutierrez Juan Antonio High throughput screening for inhibitors of fatty acid, ergosterol, sphingolipid, or phospholipid synthesis in fungi
US7048926B2 (en) * 2000-10-06 2006-05-23 Affinium Pharmaceuticals, Inc. Methods of agonizing and antagonizing FabK
ES2320984T3 (es) * 2001-04-06 2009-06-01 Affinium Pharmaceuticals, Inc. Inhibidores de fab i.
US6821999B2 (en) * 2001-11-21 2004-11-23 Kimberly-Clark Worldwide, Inc. Methods for inhibiting the production of TSST-1
US7323186B2 (en) * 2001-11-21 2008-01-29 Kimberly-Clark Worldwide, Inc. Non-absorbent articles containing additives
US7348023B2 (en) * 2001-11-21 2008-03-25 Kimberly-Clark Worldwide, Inc. Absorbent articles containing additives
US6955890B2 (en) * 2002-02-14 2005-10-18 Pyro Pharmaceuticals, Inc. Method for the identification and treatment of pathogenic microorganisms infections by inhibiting one or more enzymes in an essential metabolic pathway
US20060063224A1 (en) * 2002-05-10 2006-03-23 Schechter Alan M Method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in an essential metabolic pathway
EA013371B1 (ru) * 2002-07-09 2010-04-30 Фасджен, Ллс. Новые соединения, содержащие их фармацевтические композиции и способы их применения
ES2518316T3 (es) * 2002-12-06 2014-11-05 Debiopharm International Sa Compuestos heterocíclicos, métodos de fabricación de los mismos y su uso en terapia
CA2519429C (en) 2003-03-17 2013-08-06 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
EP1648928A2 (de) * 2003-07-11 2006-04-26 Affinium Pharmaceuticals, Inc. Neue aufgereinigte polypeptide aus staphylococcus aureus
KR20070095754A (ko) * 2004-05-26 2007-10-01 파스젠, 엘엘씨. 신규 화합물, 그것을 함유하는 약학 조성물, 및 그것을사용하는 방법
ES2515101T3 (es) * 2004-06-04 2014-10-29 Debiopharm International Sa Derivados de acrilamida como agentes antibióticos
KR20080075027A (ko) * 2005-12-05 2008-08-13 아피늄 파마슈티컬스, 인크. Ｆａｂｉ 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물
US20070244199A1 (en) * 2006-02-08 2007-10-18 Fasgen Inc. Anti-mycobacterial formulation
EP2054422B1 (de) * 2006-07-20 2017-06-14 Debiopharm International SA Acrylamidderivate als fab-i-inhibitoren
US8263613B2 (en) 2007-02-16 2012-09-11 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab I inhibitors
EP2581081A3 (de) 2007-06-01 2013-07-31 The Trustees Of Princeton University Behandlung von Virusinfektionen durch Modulation von Hostzellen-Stoffwechselpfaden
WO2010118324A2 (en) 2009-04-09 2010-10-14 Nuclea Biotechnologies, LLC Antibodies against fatty acid synthase
NZ702695A (en) 2012-06-19 2015-10-30 Debiopharm Int Sa Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
BR102012033811A8 (pt) * 2012-12-28 2019-12-24 Uniao Brasileira De Educacao E Assistencia Mantenedora Da Puc Rs compostos, uso, composição farmacêutica inibidora de redutase em microorganismos, ligante de inha, e, método para obtenção de ligantes de inha
BR102013006007A2 (pt) * 2013-03-13 2014-11-11 Ubea Compostos, uso, composição farmacêutica inibidora de redutase em microorganismos, ligante de inha, e, método para obtenção de ligantes de inha a partir de derivados de acetamida, ureia, fenol e carboxamida
US10751351B2 (en) 2016-02-26 2020-08-25 Debiopharm International S.A. Medicament for treatment of diabetic foot infections
EP3266454A1 (de) * 2016-07-07 2018-01-10 Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften Acc-hemmer zur verwendung bei der behandlung von mycobakteriellen erkrankungen
US20210137934A1 (en) * 2017-03-16 2021-05-13 The Board Of Trustees Of The Leland Stanford Junior University Methods of identifying myc-driven and lipogenesis-dependent neoplasms and methods of treating the same

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE252616C (de) * 1912-01-25 1912-10-23 Gebr Lesser Ablegerad für Kartoffelerntemaschinen mit einem quer zur Fahrrichtung de Maschine umlaufenden Wurfrad
US3535309A (en) * 1967-09-01 1970-10-20 Kitasato Inst Antibiotics and their production
US3630846A (en) * 1967-09-01 1971-12-28 Kitasato Inst And Toyo Jozo Kk Antibiotic production using streptomyces kitasatoensis
US3909361A (en) * 1971-06-29 1975-09-30 Nihon Tokushu Noyaku Seizo Kk Novel antifungal antibiotic substance, process for production of the same, and agricultural and horticultural fungicidal composition containing said substance
JPS5619344B2 (de) * 1972-11-11 1981-05-07
US4738984A (en) * 1973-04-02 1988-04-19 Merrell Dow Pharmaceuticals Inc. Antirhinovirus agents
US4602099A (en) * 1973-04-02 1986-07-22 Merrell Dow Pharmaceuticals Inc. Antirhinovirus agents
US4000164A (en) * 1973-04-02 1976-12-28 Richardson-Merrell Inc. Hypolipidemic agents
US4110351A (en) * 1973-04-02 1978-08-29 Richardson-Merrell Inc. Hypolipidemic agents RO- or RS- substituted furoic acids, esters and salts
US4011334A (en) * 1975-10-03 1977-03-08 Richardson-Merrell Inc. Use of substituted furan and thiophene carboxaldehydes as hypolipidemic agents
US4032647A (en) * 1975-06-16 1977-06-28 Richardson-Merrell Inc. Substituted thenoylacetic acid and esters
US4328246A (en) * 1979-08-14 1982-05-04 Joseph Gold Anti Walker 256 carcinoma agent and combination thereof
JPS59225115A (ja) * 1983-06-06 1984-12-18 Ota Seiyaku Kk 青魚類から得た長鎖高度不飽和脂肪酸を含有する微細カプセル
JPS6058917A (ja) * 1983-09-09 1985-04-05 Rikagaku Kenkyusho 制癌剤
FR2552879B1 (fr) * 1983-10-03 1987-08-14 Pasteur Institut Procede et reactifs pour la detection d'une anomalie genetique dans une matiere biologique, notamment dans une preparation de leucocytes
CA1256372A (en) * 1985-04-11 1989-06-27 Koichiro Miyazima Process for producing liposome composition
US5110731A (en) * 1985-08-26 1992-05-05 Amgen, Inc. System for biotin synthesis
US4789630A (en) * 1985-10-04 1988-12-06 Cetus Corporation Ionic compounds containing the cationic meriquinone of a benzidine
GB8607137D0 (en) * 1986-03-21 1986-04-30 Efamol Ltd Compositions
US5185149A (en) * 1987-03-27 1993-02-09 Merck & Co., Inc. Methods for thrombolytic therapy
US5188830A (en) * 1987-03-27 1993-02-23 Merck & Co., Inc. Methods for thrombolytic therapy
US4968494A (en) * 1987-03-27 1990-11-06 Merck & Co., Inc. Methods and compositions for thrombolytic therapy
JPH01132542A (ja) * 1987-11-19 1989-05-25 Toomen:Kk ゴッシポールラセミ体の光学分割法
US4877782A (en) * 1988-02-16 1989-10-31 The Upjohn Company Zinc ceftiofur complexes
JPH02113850A (ja) * 1988-10-21 1990-04-26 Nippon Oil & Fats Co Ltd 発癌抑制用油脂組成物
US5190969A (en) * 1988-12-20 1993-03-02 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services 2,3-epoxy derivatives as anti retrovital chemotherapeutic agents
AU621434B2 (en) * 1988-12-21 1992-03-12 Merrell Dow Pharmaceuticals Inc. Antiretroviral furan ketones
JPH02247125A (ja) * 1989-03-17 1990-10-02 Koken Kk 悪性腫瘍細胞増殖抑制剤
US5143907A (en) * 1991-05-10 1992-09-01 Boron Biologicals, Inc. Phosphite-borane compounds, and method of making and using the same
CA2126101A1 (en) * 1991-12-17 1993-06-24 Robert J. Debs Gene therapy for cystic fibrosis transmembrane conductance regulator activity (cftr)
US5858784A (en) * 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
AU682007B2 (en) * 1992-07-24 1997-09-18 Johns Hopkins University, The Use of inhibitors of fatty acid synthesis for treating cancer
US5539132A (en) * 1994-01-24 1996-07-23 Johns Hopkins University Cerulenin compounds for fatty acid synthesis inhibition

Also Published As

Publication number Publication date
CA2181031A1 (en) 1995-07-27
KR100395601B1 (ko) 2003-11-17
ATE223215T1 (de) 2002-09-15
ES2182888T3 (es) 2003-03-16
MX9602934A (es) 1997-12-31
JPH09508370A (ja) 1997-08-26
DK0738107T3 (da) 2003-01-06
EP0738107B1 (de) 2002-09-04
US5614551A (en) 1997-03-25
EP0738107A1 (de) 1996-10-23
PT738107E (pt) 2003-01-31
AU1726895A (en) 1995-08-08
EP0738107A4 (de) 1998-09-09
DE69528039D1 (de) 2002-10-10
WO1995019706A1 (en) 1995-07-27
AU703272B2 (en) 1999-03-25

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