ES2164013A1 - Glicosidos de n-acetil-6-o-(2,2-bis(hidroximetil)-3-hidroxipropil)-d-glucosamina, procedimiento de obtencion y uso en el tratamiento de tumores cerebrales. - Google Patents
Glicosidos de n-acetil-6-o-(2,2-bis(hidroximetil)-3-hidroxipropil)-d-glucosamina, procedimiento de obtencion y uso en el tratamiento de tumores cerebrales.Info
- Publication number
- ES2164013A1 ES2164013A1 ES200000982A ES200000982A ES2164013A1 ES 2164013 A1 ES2164013 A1 ES 2164013A1 ES 200000982 A ES200000982 A ES 200000982A ES 200000982 A ES200000982 A ES 200000982A ES 2164013 A1 ES2164013 A1 ES 2164013A1
- Authority
- ES
- Spain
- Prior art keywords
- glycosides
- acetyl
- glucosamine
- hydroxymethyl
- hydroxypropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
Abstract
Glicósidos de N-acetil-6-O-[2,2-bis(hidroximetil)-3- hidroxipropil]-D-glucosamina, procedimiento de obtención y uso en el tratamiento de tumores cerebrales. En ésta patente se describe un procedimiento de obtención de glicósidos derivados del monasacárido N-acetil-D-glucosamina y la investigación sobre su actividad inhibitoria y citotóxica de glioblastomas. Se han preparado glicósidos de fórmula general 1 a partir del monosacáridos N-acetil-D-glucosamina, donde el aglicón R{sup,1} es un resto de naturaleza hidrofóbico, preferentemente una cadena hidrocarbona de 8-16 carbonos, lineal o ramificada. Uso de los glicósidos de N-acetil-6-O- [2,2-bis(hidroximetil)-3-hidroxipropil]-D-glucosamina para inhibición de la proliferación de gliomas humanos en cultivo.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200000982A ES2164013B1 (es) | 2000-04-14 | 2000-04-14 | Glicosidos de n-acetil-6-o-(2,2-bis(hidroximetil)-3-hidroxipropil)-d-glucosamina, procedimiento de obtencion y uso en el tratamiento de tumores cerebrales. |
AU2001246549A AU2001246549A1 (en) | 2000-04-14 | 2001-04-06 | Glycosides of n-acetyl-6-o-(2,2-bis(hydroxymethyl)-3-hydroxypropyl)-d- glucosamine, method for the obtention thereof and their uses in the treatment of brain tumors |
PCT/ES2001/000138 WO2001079243A1 (es) | 2000-04-14 | 2001-04-06 | Glicosidos de n-acetil-6-o-[2,2-bis(hidroximetil)-3-hidroxipropil]-d-glucosamina, procedimiento de obtencion y uso en el tratamiento de tumores cerebrales |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200000982A ES2164013B1 (es) | 2000-04-14 | 2000-04-14 | Glicosidos de n-acetil-6-o-(2,2-bis(hidroximetil)-3-hidroxipropil)-d-glucosamina, procedimiento de obtencion y uso en el tratamiento de tumores cerebrales. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2164013A1 true ES2164013A1 (es) | 2002-02-01 |
ES2164013B1 ES2164013B1 (es) | 2003-06-16 |
Family
ID=8493196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200000982A Expired - Fee Related ES2164013B1 (es) | 2000-04-14 | 2000-04-14 | Glicosidos de n-acetil-6-o-(2,2-bis(hidroximetil)-3-hidroxipropil)-d-glucosamina, procedimiento de obtencion y uso en el tratamiento de tumores cerebrales. |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2001246549A1 (es) |
ES (1) | ES2164013B1 (es) |
WO (1) | WO2001079243A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003094850A2 (en) | 2002-05-09 | 2003-11-20 | Biomira, Inc. | Lipid a and other carbohydrate ligand analogs |
BR112013021779A2 (pt) | 2011-02-24 | 2017-09-19 | Oncothyreon Inc | vacina de glicolipopeptídeo baseada em muc1 com adjuvante. |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4738955A (en) * | 1984-09-05 | 1988-04-19 | Albert Landsberger | Anti-carcinoma therapeutic agent of glycosaminoglycans and cytostatic agents |
WO1995013061A1 (en) * | 1993-11-09 | 1995-05-18 | Immunal Kft. | Pharmaceutical compositions for prevention and treatment of cancerous disease and process for their preparation |
US5708163A (en) * | 1994-03-15 | 1998-01-13 | Sloan-Kettering Institute Of Cancer Research | Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof |
-
2000
- 2000-04-14 ES ES200000982A patent/ES2164013B1/es not_active Expired - Fee Related
-
2001
- 2001-04-06 AU AU2001246549A patent/AU2001246549A1/en not_active Abandoned
- 2001-04-06 WO PCT/ES2001/000138 patent/WO2001079243A1/es active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4738955A (en) * | 1984-09-05 | 1988-04-19 | Albert Landsberger | Anti-carcinoma therapeutic agent of glycosaminoglycans and cytostatic agents |
WO1995013061A1 (en) * | 1993-11-09 | 1995-05-18 | Immunal Kft. | Pharmaceutical compositions for prevention and treatment of cancerous disease and process for their preparation |
US5708163A (en) * | 1994-03-15 | 1998-01-13 | Sloan-Kettering Institute Of Cancer Research | Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2001079243A1 (es) | 2001-10-25 |
AU2001246549A1 (en) | 2001-10-30 |
ES2164013B1 (es) | 2003-06-16 |
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Legal Events
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