ES2167720T3 - Compuestos de 1-fenilpirazol y aplicaciones medicinales de los mismos. - Google Patents

Compuestos de 1-fenilpirazol y aplicaciones medicinales de los mismos.

Info

Publication number
ES2167720T3
ES2167720T3 ES97909603T ES97909603T ES2167720T3 ES 2167720 T3 ES2167720 T3 ES 2167720T3 ES 97909603 T ES97909603 T ES 97909603T ES 97909603 T ES97909603 T ES 97909603T ES 2167720 T3 ES2167720 T3 ES 2167720T3
Authority
ES
Spain
Prior art keywords
compounds
phenylpirazol
same
medicinal applications
hyperuricacidemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97909603T
Other languages
English (en)
Inventor
Seigo Ishibuchi
Hiroshi Morimoto
Atsushi Fukunari
Hiroyoshi Inoue
Yoichi Naka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Pharma Corp
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Application granted granted Critical
Publication of ES2167720T3 publication Critical patent/ES2167720T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE 1 - FENILPIRAZOL REPRESENTADOS POR LA FORMULA (1): EJEMPLIFICADA POR EL ACIDO 5 - AMINO - 1 -(3 - CIANO - 4 ISOBUTOXIFENIL)PIRAZOL 4 - CARBOXILICO, A UN ISOMERO OPTICO DE DICHOS COMPUESTOS Y A UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS. DICHOS COMPUESTOS PRESENTAN ACTIVIDAD INHIBITORIA DE LA XANTINA OXIDASA Y SON UTILES COMO AGENTES TERAPEUTICOS PARA ENFERMEDADES, TALES COMO LA HIPERURICACIDEMIA Y LA GOTA.
ES97909603T 1996-10-25 1997-10-22 Compuestos de 1-fenilpirazol y aplicaciones medicinales de los mismos. Expired - Lifetime ES2167720T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP28447996 1996-10-25
JP5578697 1997-03-11
JP26130597 1997-09-26

Publications (1)

Publication Number Publication Date
ES2167720T3 true ES2167720T3 (es) 2002-05-16

Family

ID=27295710

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97909603T Expired - Lifetime ES2167720T3 (es) 1996-10-25 1997-10-22 Compuestos de 1-fenilpirazol y aplicaciones medicinales de los mismos.

Country Status (17)

Country Link
US (1) US6015829A (es)
EP (1) EP0936217B1 (es)
JP (1) JP3220987B2 (es)
KR (1) KR100345942B1 (es)
CN (1) CN1105708C (es)
AT (1) ATE208379T1 (es)
AU (1) AU731055B2 (es)
CA (1) CA2269721C (es)
DE (1) DE69708142T2 (es)
DK (1) DK0936217T3 (es)
ES (1) ES2167720T3 (es)
HK (1) HK1021982A1 (es)
ID (1) ID21775A (es)
IL (1) IL129409A (es)
PL (1) PL332946A1 (es)
PT (1) PT936217E (es)
WO (1) WO1998018765A1 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569885B1 (en) * 1999-12-23 2003-05-27 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
US7112594B2 (en) 2000-08-09 2006-09-26 Mitsubishi Pharma Corporation Fused bicyclic amide compounds and medicinal use thereof
EP1609479A4 (en) * 2003-03-13 2010-01-20 Mitsubishi Tanabe Pharma Corp Tumorigenesis INHIBITOR
ATE512154T1 (de) * 2004-06-14 2011-06-15 Nippon Chemiphar Co Kondensiertes pyrimidinderivat und xanthinoxidaseinhibitor
US7612108B2 (en) 2004-08-27 2009-11-03 Astellas Pharma Inc. 2-phenylthiophene derivative
JP4894517B2 (ja) * 2004-08-27 2012-03-14 アステラス製薬株式会社 ２−フェニルピリジン誘導体
JP2008545627A (ja) * 2005-05-09 2008-12-18 タツプ・フアーマシユーテイカル・プロダクツ・インコーポレイテツド 腎結石症を治療する方法
CA2617248C (en) * 2005-08-03 2015-09-29 Tap Pharmaceutical Products, Inc. Methods for treating hypertension
BRPI0616939A2 (pt) 2005-10-07 2011-07-05 Astellas Pharma Inc derivado de ácido triarilacarboxìlico
KR20080066938A (ko) 2005-10-07 2008-07-17 깃세이 야쿠힌 고교 가부시키가이샤 질소 함유 복소환 화합물 및 그것을 함유하는 의약 조성물
WO2007097403A1 (ja) * 2006-02-24 2007-08-30 Astellas Pharma Inc. 消化管潰瘍治療又は予防薬
EP2050467B1 (en) * 2006-07-19 2014-09-10 Nippon Medical School Foundation Therapeutic agent for amyotrophic lateral sclerosis
US20090124623A1 (en) * 2006-11-13 2009-05-14 Christopher Lademacher Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors
KR20090103879A (ko) * 2006-11-13 2009-10-01 다케다 파마슈티칼스 노쓰 어메리카, 인코포레이티드 크산틴 옥시도리덕타아제 억제제를 사용하여 신장 기능을 보존하는 방법
US20090042887A1 (en) * 2007-01-19 2009-02-12 Tap Pharmaceutical Products, Inc. Methods for Preventing or Reducing the Number of Gout Flares Using Xanthine Oxidoreductase Inhibitors and Anti-Inflammatory Agents
WO2008126901A1 (ja) * 2007-04-11 2008-10-23 Kissei Pharmaceutical Co., Ltd. 含窒素複素環化合物およびそれを含有する医薬組成物
CN101679251B (zh) * 2007-04-11 2013-10-02 橘生药品工业株式会社 (氮杂)吲哚衍生物及其医药用途
US8227500B2 (en) * 2007-04-11 2012-07-24 Kissei Pharmaceutical Co., Ltd. 5-membered nitrogen containing heterocyclic derivatives and pharmaceutical compositions comprising the same
CN101386605B (zh) * 2008-10-23 2010-09-08 中国科学院上海药物研究所 非布司他新型晶体及其制备方法
US20100311756A1 (en) * 2009-01-22 2010-12-09 Takeda Pharmaceuticals North America, Inc. Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof
EP2754658A1 (en) 2009-02-27 2014-07-16 Teijin Pharma Limited Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst
CN101580495A (zh) * 2009-05-25 2009-11-18 沈阳药科大学 5-取代苯基-3-异噁唑甲酸及其酯类化合物、组合物及其制备方法
TWI423962B (zh) 2009-10-07 2014-01-21 Lg Life Sciences Ltd 有效作為黃嘌呤氧化酶抑制劑之新穎化合物、其製備方法及含該化合物之醫藥組成物
WO2011103439A1 (en) * 2010-02-19 2011-08-25 Takeda Pharmaceuticals North America, Inc. Methods for stabilizing joint damage in subjects using xanthine oxidoreductase inhibitors
PL2610248T3 (pl) 2010-08-27 2016-12-30 Sposób wytwarzania podstawionych fenylem pochodnych heterocyklicznych metodą sprzęgania z użyciem związku palladu
KR101797936B1 (ko) 2010-09-10 2017-11-15 다케다 파마슈티칼스 유에스에이, 인코포레이티드 테오필린과 페북소스타트의 병용 치료 방법
CN102766099B (zh) * 2012-08-07 2015-09-23 沈阳药科大学 具有黄嘌呤氧化酶抑制活性的化合物及其盐、制备方法和用途
CN103848798B (zh) 2012-11-30 2016-01-06 镇江新元素医药科技有限公司 2-芳基硒唑化合物及其药物组合物
ME03055B (me) 2013-03-29 2018-10-20 Teijin Pharma Ltd Derivat pirazola
CN105294584A (zh) * 2015-11-30 2016-02-03 中国医科大学 1-取代苯基-1h-1,2,3-三唑类化合物、制备方法及其用途
CN106279024B (zh) * 2016-07-19 2018-09-14 华南理工大学 一种黄嘌呤氧化还原酶抑制剂及其制备方法与应用
CN106632245B (zh) * 2016-09-30 2019-11-15 华南理工大学 氮取代基苯基吡唑类黄嘌呤氧化还原酶抑制剂及制备与应用
CN108218777A (zh) * 2017-12-13 2018-06-29 华南理工大学 一种硫取代苯基吡唑类xor抑制剂及制备与应用
CN110078668B (zh) * 2019-05-16 2023-03-24 华南理工大学 一种苯基咪唑类xor抑制剂及制备与应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5527916B2 (es) * 1973-02-05 1980-07-24
JPS5527916A (en) * 1978-08-17 1980-02-28 Arekusandorouitsuchi B Nikorai Detecting icing on objects in gas flow and device therefor
US4346094A (en) * 1980-09-22 1982-08-24 Eli Lilly And Company 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels
DE3129429A1 (de) * 1981-07-25 1983-02-10 Basf Ag, 6700 Ludwigshafen 5-amino-1-phenyl-pyrazol-4-carbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
US4495195A (en) * 1982-11-01 1985-01-22 Eli Lilly And Company Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use
DE3420985A1 (de) * 1983-10-15 1985-04-25 Bayer Ag, 5090 Leverkusen Substituierte 5-acylamino-1-phenylpyrazole
ZA847986B (en) * 1983-10-15 1985-06-26 Bayer Ag Substituted 5-acylamino-1-phenylpyrazoles
IL73418A (en) * 1983-11-07 1988-02-29 Lilly Co Eli 5-cyano-1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
IL73419A (en) * 1983-11-07 1988-02-29 Lilly Co Eli 1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
DE3423582A1 (de) * 1984-06-27 1986-01-09 Bayer Ag, 5090 Leverkusen Substituierte 5-acylamino-1-phenylpyrazole
US4666504A (en) * 1984-09-25 1987-05-19 Eli Lilly And Company Pollen formation inhibiting 1-phenyl-4-carboxy-5-pyrazolecarboxamides
US5064851A (en) * 1990-07-24 1991-11-12 Pfizer Inc. 3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
HU218942B (hu) * 1990-11-30 2001-01-29 Teijin Ltd. 2-Fenil-tiazol-származékok, az ezeket tartalmazó gyógyászati készítmények, valamint eljárás a vegyületek előállítására
IL104311A (en) * 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US5436258A (en) * 1992-09-09 1995-07-25 Eli Lilly And Company Prevention of bone resorption
JP3113110B2 (ja) * 1993-01-19 2000-11-27 帝人株式会社 イソキサゾールおよびイソチアゾール誘導体

Also Published As

Publication number Publication date
CA2269721A1 (en) 1998-05-07
AU4723097A (en) 1998-05-22
DE69708142T2 (de) 2002-07-11
US6015829A (en) 2000-01-18
DE69708142D1 (de) 2001-12-13
IL129409A (en) 2002-02-10
ID21775A (id) 1999-07-22
IL129409A0 (en) 2000-02-17
KR100345942B1 (ko) 2002-07-27
EP0936217A4 (en) 2000-01-05
PT936217E (pt) 2002-05-31
CN1105708C (zh) 2003-04-16
DK0936217T3 (da) 2002-03-04
CN1240432A (zh) 2000-01-05
AU731055B2 (en) 2001-03-22
EP0936217A1 (en) 1999-08-18
PL332946A1 (en) 1999-10-25
HK1021982A1 (en) 2000-07-21
ATE208379T1 (de) 2001-11-15
JP3220987B2 (ja) 2001-10-22
WO1998018765A1 (fr) 1998-05-07
KR20000052738A (ko) 2000-08-25
EP0936217B1 (en) 2001-11-07
CA2269721C (en) 2003-04-29

Similar Documents

Publication Publication Date Title
ES2167720T3 (es) Compuestos de 1-fenilpirazol y aplicaciones medicinales de los mismos.
NO953305D0 (no) Antranilsyrederivat
FI935529A (fi) Aminometylensubstituerade icke-aromatiska heterocykliska foereningar
NO882036D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske ketoner.
EA199900853A1 (ru) Замещенные производные бензопирана для лечения воспалительных процессов
NL300407I1 (nl) Difluoroprostaglandinederivaten en hun toepassing
DK0418845T3 (da) Pyrazolderivater, fremgangsmåder til fremstilling deraf og farmaceutisk præparat omfattende samme
PT718293E (pt) Composto ciclodepsipeptidico
DE50011034D1 (de) N-substituierte 4-aminopteridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE316962T1 (de) Pyrimidin-derivate als selective inhibitoren von cox-2
ES2157992T3 (es) Alcoxi-alquil-carbamatos de imidazo(1,2-a)piridinas.
DE69511424D1 (de) Antifungale sordaridinderivate
DK132188D0 (da) Anvendelse af tetrahydrobenz(c,d)indol-6-carboxamider som anxiolytika
ATE92489T1 (de) Imid-derivate, ihre herstellung und verwendung.
CA2219359A1 (en) Hydantoin derivatives as intermediates for pharmaceutical active compounds
DE69330601T2 (de) Serotoninergische ergolin derivate
FI952420A0 (fi) Glukopyranosidibentsotiofeenit
ES2123728T3 (es) Derivados de pirrolo-pirazina de actividad 5-ht3.
ITMI920082A1 (it) Derivati solforati di acidi biliari
DE59406704D1 (de) Verfahren zur Herstellung von gegebenenfalls 2-substituierten 5-Chlorimidazol-4-carbaldehyden
DK0437645T3 (da) Imidazolylpropylguanidinderivat, fremgangsmåde til fremstilling deraf og lægemidler indeholdende denne forbindelse