PT936217E - Compostos de 1-fenilpirazole e sua utilizacao em medicina - Google Patents

Compostos de 1-fenilpirazole e sua utilizacao em medicina

Info

Publication number
PT936217E
PT936217E PT97909603T PT97909603T PT936217E PT 936217 E PT936217 E PT 936217E PT 97909603 T PT97909603 T PT 97909603T PT 97909603 T PT97909603 T PT 97909603T PT 936217 E PT936217 E PT 936217E
Authority
PT
Portugal
Prior art keywords
compounds
phenylpirazole
medicine
hyperuricacidemia
isobutoxyphenyl
Prior art date
Application number
PT97909603T
Other languages
English (en)
Inventor
Seigo Ishibuchi
Hiroshi Morimoto
Atsushi Fukunari
Hiroyoshi Inoue
Yoichi Naka
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Publication of PT936217E publication Critical patent/PT936217E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
PT97909603T 1996-10-25 1997-10-22 Compostos de 1-fenilpirazole e sua utilizacao em medicina PT936217E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP28447996 1996-10-25
JP5578697 1997-03-11
JP26130597 1997-09-26

Publications (1)

Publication Number Publication Date
PT936217E true PT936217E (pt) 2002-05-31

Family

ID=27295710

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97909603T PT936217E (pt) 1996-10-25 1997-10-22 Compostos de 1-fenilpirazole e sua utilizacao em medicina

Country Status (17)

Country Link
US (1) US6015829A (pt)
EP (1) EP0936217B1 (pt)
JP (1) JP3220987B2 (pt)
KR (1) KR100345942B1 (pt)
CN (1) CN1105708C (pt)
AT (1) ATE208379T1 (pt)
AU (1) AU731055B2 (pt)
CA (1) CA2269721C (pt)
DE (1) DE69708142T2 (pt)
DK (1) DK0936217T3 (pt)
ES (1) ES2167720T3 (pt)
HK (1) HK1021982A1 (pt)
ID (1) ID21775A (pt)
IL (1) IL129409A (pt)
PL (1) PL332946A1 (pt)
PT (1) PT936217E (pt)
WO (1) WO1998018765A1 (pt)

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JP4532408B2 (ja) * 2003-03-13 2010-08-25 田辺三菱製薬株式会社 腫瘍形成抑制剤
EP1757610B1 (en) * 2004-06-14 2011-06-08 Nippon Chemiphar Co., Ltd. Condensed pyrimidine derivative and xanthine oxidase inhibitor
EP1783124A4 (en) * 2004-08-27 2009-07-08 Astellas Pharma Inc 2-PHENYLTHIOPHENDERIVAT
JP4894517B2 (ja) * 2004-08-27 2012-03-14 アステラス製薬株式会社 ２−フェニルピリジン誘導体
CA2607953A1 (en) * 2005-05-09 2006-11-16 Tap Pharmaceutical Products, Inc. Methods for treating nephrolithiasis
WO2007019153A2 (en) * 2005-08-03 2007-02-15 Tap Pharmaceutical Products, Inc. Methods for treating hypertension
EP1932833B1 (en) * 2005-10-07 2012-08-01 Kissei Pharmaceutical Co., Ltd. Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same
KR20080051157A (ko) 2005-10-07 2008-06-10 아스텔라스세이야쿠 가부시키가이샤 트리아릴카르복시산 유도체
US8067446B2 (en) * 2006-02-24 2011-11-29 Astellas Pharma Inc. Methods for treating an ulcer of the small intestine and stomach
US8318792B2 (en) * 2006-07-19 2012-11-27 Nippon Medical School Foundation Therapeutic agent for amyotrophic lateral sclerosis
US20090124623A1 (en) * 2006-11-13 2009-05-14 Christopher Lademacher Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors
EP2101761A4 (en) * 2006-11-13 2010-01-27 Takeda Pharmaceuticals North A METHODS FOR PRESERVING RENAL FUNCTION USING XANTHINE OXYDOREDUCTASE INHIBITORS
US20090042887A1 (en) * 2007-01-19 2009-02-12 Tap Pharmaceutical Products, Inc. Methods for Preventing or Reducing the Number of Gout Flares Using Xanthine Oxidoreductase Inhibitors and Anti-Inflammatory Agents
KR101502957B1 (ko) 2007-04-11 2015-03-16 깃세이 야쿠힌 고교 가부시키가이샤 (아자)인돌 유도체 및 그 의약 용도
WO2008126901A1 (ja) * 2007-04-11 2008-10-23 Kissei Pharmaceutical Co., Ltd. 含窒素複素環化合物およびそれを含有する医薬組成物
RU2515968C2 (ru) * 2007-04-11 2014-05-20 Киссеи Фармасьютикал Ко., Лтд. 5-членное гетероциклическое соединение и его применение для лекарственных целей
CN101386605B (zh) * 2008-10-23 2010-09-08 中国科学院上海药物研究所 非布司他新型晶体及其制备方法
US20100311756A1 (en) * 2009-01-22 2010-12-09 Takeda Pharmaceuticals North America, Inc. Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof
CA2752485C (en) 2009-02-27 2017-01-03 Teijin Pharma Limited Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst
CN101580495A (zh) * 2009-05-25 2009-11-18 沈阳药科大学 5-取代苯基-3-异噁唑甲酸及其酯类化合物、组合物及其制备方法
TWI423962B (zh) 2009-10-07 2014-01-21 Lg Life Sciences Ltd 有效作為黃嘌呤氧化酶抑制劑之新穎化合物、其製備方法及含該化合物之醫藥組成物
WO2011103439A1 (en) * 2010-02-19 2011-08-25 Takeda Pharmaceuticals North America, Inc. Methods for stabilizing joint damage in subjects using xanthine oxidoreductase inhibitors
AU2011294204B2 (en) 2010-08-27 2015-07-23 Teijin Limited Method for producing phenyl-substituted heterocyclic derivative by means of coupling method using a palladium compound
ES2532210T3 (es) 2010-09-10 2015-03-25 Takeda Pharmaceuticals U.S.A., Inc. Métodos para el tratamiento concomitante de teofilina y febuxostat
CN102766099B (zh) * 2012-08-07 2015-09-23 沈阳药科大学 具有黄嘌呤氧化酶抑制活性的化合物及其盐、制备方法和用途
CN103848798B (zh) 2012-11-30 2016-01-06 镇江新元素医药科技有限公司 2-芳基硒唑化合物及其药物组合物
RS57154B1 (sr) 2013-03-29 2018-07-31 Teijin Pharma Ltd Derivat pirazola
CN105294584A (zh) * 2015-11-30 2016-02-03 中国医科大学 1-取代苯基-1h-1,2,3-三唑类化合物、制备方法及其用途
CN106279024B (zh) * 2016-07-19 2018-09-14 华南理工大学 一种黄嘌呤氧化还原酶抑制剂及其制备方法与应用
CN106632245B (zh) * 2016-09-30 2019-11-15 华南理工大学 氮取代基苯基吡唑类黄嘌呤氧化还原酶抑制剂及制备与应用
CN108218777A (zh) * 2017-12-13 2018-06-29 华南理工大学 一种硫取代苯基吡唑类xor抑制剂及制备与应用
CN110078668B (zh) * 2019-05-16 2023-03-24 华南理工大学 一种苯基咪唑类xor抑制剂及制备与应用

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JPS5527916B2 (pt) * 1973-02-05 1980-07-24
JPS5527916A (en) * 1978-08-17 1980-02-28 Arekusandorouitsuchi B Nikorai Detecting icing on objects in gas flow and device therefor
US4346094A (en) * 1980-09-22 1982-08-24 Eli Lilly And Company 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels
DE3129429A1 (de) * 1981-07-25 1983-02-10 Basf Ag, 6700 Ludwigshafen 5-amino-1-phenyl-pyrazol-4-carbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
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DE3420985A1 (de) * 1983-10-15 1985-04-25 Bayer Ag, 5090 Leverkusen Substituierte 5-acylamino-1-phenylpyrazole
IL73419A (en) * 1983-11-07 1988-02-29 Lilly Co Eli 1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
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DE3423582A1 (de) * 1984-06-27 1986-01-09 Bayer Ag, 5090 Leverkusen Substituierte 5-acylamino-1-phenylpyrazole
US4666504A (en) * 1984-09-25 1987-05-19 Eli Lilly And Company Pollen formation inhibiting 1-phenyl-4-carboxy-5-pyrazolecarboxamides
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AU645867B2 (en) * 1990-11-30 1994-01-27 Teijin Pharma Limited 2-arylthiazole derivative and pharmaceutical composition containing the same
IL104311A (en) * 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US5436258A (en) * 1992-09-09 1995-07-25 Eli Lilly And Company Prevention of bone resorption
JP3113110B2 (ja) * 1993-01-19 2000-11-27 帝人株式会社 イソキサゾールおよびイソチアゾール誘導体

Also Published As

Publication number Publication date
ID21775A (id) 1999-07-22
DK0936217T3 (da) 2002-03-04
DE69708142T2 (de) 2002-07-11
AU4723097A (en) 1998-05-22
PL332946A1 (en) 1999-10-25
WO1998018765A1 (fr) 1998-05-07
JP3220987B2 (ja) 2001-10-22
ES2167720T3 (es) 2002-05-16
CN1105708C (zh) 2003-04-16
IL129409A0 (en) 2000-02-17
HK1021982A1 (en) 2000-07-21
AU731055B2 (en) 2001-03-22
EP0936217B1 (en) 2001-11-07
CA2269721A1 (en) 1998-05-07
EP0936217A1 (en) 1999-08-18
CA2269721C (en) 2003-04-29
CN1240432A (zh) 2000-01-05
DE69708142D1 (de) 2001-12-13
EP0936217A4 (en) 2000-01-05
US6015829A (en) 2000-01-18
KR100345942B1 (ko) 2002-07-27
IL129409A (en) 2002-02-10
KR20000052738A (ko) 2000-08-25
ATE208379T1 (de) 2001-11-15

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