ATE208379T1 - 1-phenylpyrozol-verbindungen und ihre medizinische anwendung - Google Patents

1-phenylpyrozol-verbindungen und ihre medizinische anwendung

Info

Publication number
ATE208379T1
ATE208379T1 AT97909603T AT97909603T ATE208379T1 AT E208379 T1 ATE208379 T1 AT E208379T1 AT 97909603 T AT97909603 T AT 97909603T AT 97909603 T AT97909603 T AT 97909603T AT E208379 T1 ATE208379 T1 AT E208379T1
Authority
AT
Austria
Prior art keywords
compounds
phenylpyrozole
medical uses
hyperuricacidemia
isobutoxyphenyl
Prior art date
Application number
AT97909603T
Other languages
English (en)
Inventor
Seigo Yoshitomi Phar Ishibuchi
Yoshitomimachi Oaza-Koiwai
Hiroshi Yoshitomi Pha Morimoto
Yoshitomimchi Oaza-Koiwai
Atsushi Yoshitomi Pha Fukunari
Hiroyoshi Yoshitomi Phar Inoue
Yoichi Yoshitomi Phar Ind Naka
Yoshitomimachi Koiwai
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Application granted granted Critical
Publication of ATE208379T1 publication Critical patent/ATE208379T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
AT97909603T 1996-10-25 1997-10-22 1-phenylpyrozol-verbindungen und ihre medizinische anwendung ATE208379T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP28447996 1996-10-25
JP5578697 1997-03-11
JP26130597 1997-09-26
PCT/JP1997/003840 WO1998018765A1 (fr) 1996-10-25 1997-10-22 Composes de 1-phenylpyrazole et leur application pharmaceutique

Publications (1)

Publication Number Publication Date
ATE208379T1 true ATE208379T1 (de) 2001-11-15

Family

ID=27295710

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97909603T ATE208379T1 (de) 1996-10-25 1997-10-22 1-phenylpyrozol-verbindungen und ihre medizinische anwendung

Country Status (16)

Country Link
US (1) US6015829A (de)
EP (1) EP0936217B1 (de)
JP (1) JP3220987B2 (de)
KR (1) KR100345942B1 (de)
CN (1) CN1105708C (de)
AT (1) ATE208379T1 (de)
AU (1) AU731055B2 (de)
CA (1) CA2269721C (de)
DE (1) DE69708142T2 (de)
DK (1) DK0936217T3 (de)
ES (1) ES2167720T3 (de)
ID (1) ID21775A (de)
IL (1) IL129409A (de)
PL (1) PL332946A1 (de)
PT (1) PT936217E (de)
WO (1) WO1998018765A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569885B1 (en) 1999-12-23 2003-05-27 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
US7112594B2 (en) 2000-08-09 2006-09-26 Mitsubishi Pharma Corporation Fused bicyclic amide compounds and medicinal use thereof
EP1609479A4 (de) * 2003-03-13 2010-01-20 Mitsubishi Tanabe Pharma Corp Tumorigenese-inhibitor
PL1757610T3 (pl) * 2004-06-14 2011-10-31 Nippon Chemiphar Co Skondensowana pochodna pirymidyny oraz inhibitor oksydazy ksantynowej
EP1783124A4 (de) 2004-08-27 2009-07-08 Astellas Pharma Inc 2-phenylthiophenderivat
ES2331579T3 (es) 2004-08-27 2010-01-08 Astellas Pharma Inc. Derivado de 2-fenilpiridina.
WO2006121995A2 (en) * 2005-05-09 2006-11-16 Tap Pharmaceutical Products, Inc. Methods for treating nephrolithiasis
WO2007019153A2 (en) * 2005-08-03 2007-02-15 Tap Pharmaceutical Products, Inc. Methods for treating hypertension
US7947707B2 (en) 2005-10-07 2011-05-24 Kissei Pharmaceutical Co., Ltd. Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same
US7816558B2 (en) 2005-10-07 2010-10-19 Astellas Pharma Inc. Triarylcarboxylic acid derivative
ATE555810T1 (de) * 2006-02-24 2012-05-15 Astellas Pharma Inc Mittel zur behandlung oder prävention von verdauungsgeschwüren
WO2008010315A1 (en) 2006-07-19 2008-01-24 Nippon Medical School Foundation Therapeutic agent for amyotrophic lateral sclerosis
BRPI0718611A2 (pt) * 2006-11-13 2014-02-25 Takeda Pharmaceuticals North America Inc Métodos para preservar a função renal utilizando inibidores da xantina oxidoredutase.
US20090124623A1 (en) * 2006-11-13 2009-05-14 Christopher Lademacher Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors
EP2120956A4 (de) * 2007-01-19 2010-01-20 Takeda Pharmaceuticals North A Verfahren zur verhinderung oder verringerung der anzahl von gichtschüben mit xanthin-oxidoreductase-hemmern und entzündungshemmenden mitteln
EP2133331A4 (de) * 2007-04-11 2011-06-22 Kissei Pharmaceutical Fünfgliedriges heterocyclisches derivat und seine verwendung für medizinische zwecke
BRPI0810524B8 (pt) * 2007-04-11 2021-05-25 Kissei Pharmaceutical derivado de (aza)indol, inibidor de xantina oxidase e composição farmacêutica compreendendo o dito derivado
JP5330990B2 (ja) * 2007-04-11 2013-10-30 キッセイ薬品工業株式会社 含窒素複素環化合物およびそれを含有する医薬組成物
CN101386605B (zh) * 2008-10-23 2010-09-08 中国科学院上海药物研究所 非布司他新型晶体及其制备方法
US20100311756A1 (en) * 2009-01-22 2010-12-09 Takeda Pharmaceuticals North America, Inc. Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof
PL2404908T3 (pl) 2009-02-27 2014-12-31 Teijin Ltd Sposób wytwarzania podstawionej fenylem pochodnej heterocyklicznej przez sprzężenie z użyciem katalizatora metalu przejściowego
CN101580495A (zh) * 2009-05-25 2009-11-18 沈阳药科大学 5-取代苯基-3-异噁唑甲酸及其酯类化合物、组合物及其制备方法
TWI423962B (zh) 2009-10-07 2014-01-21 Lg Life Sciences Ltd 有效作為黃嘌呤氧化酶抑制劑之新穎化合物、其製備方法及含該化合物之醫藥組成物
MX339829B (es) * 2010-02-19 2016-06-13 Takeda Pharmaceuticals Usa Inc Metodo para estabilizar daño de articulacion en sujetos utilizando inhibidores de xantina oxidoreductasa.
SG187843A1 (en) 2010-08-27 2013-03-28 Teijin Pharma Ltd Method for producing phenyl-substituted heterocyclic derivative by means of coupling method using a palladium compound
WO2012033941A1 (en) 2010-09-10 2012-03-15 Takeda Pharmaceuticals North America, Inc. Methods for concomitant treatment of theophylline and febuxostat
CN102766099B (zh) * 2012-08-07 2015-09-23 沈阳药科大学 具有黄嘌呤氧化酶抑制活性的化合物及其盐、制备方法和用途
CN103848798B (zh) 2012-11-30 2016-01-06 镇江新元素医药科技有限公司 2-芳基硒唑化合物及其药物组合物
PT2980085T (pt) 2013-03-29 2018-04-09 Teijin Pharma Ltd Compostos farmaceuticamente activos
CN105294584A (zh) * 2015-11-30 2016-02-03 中国医科大学 1-取代苯基-1h-1,2,3-三唑类化合物、制备方法及其用途
CN106279024B (zh) * 2016-07-19 2018-09-14 华南理工大学 一种黄嘌呤氧化还原酶抑制剂及其制备方法与应用
CN106632245B (zh) * 2016-09-30 2019-11-15 华南理工大学 氮取代基苯基吡唑类黄嘌呤氧化还原酶抑制剂及制备与应用
CN108218777A (zh) * 2017-12-13 2018-06-29 华南理工大学 一种硫取代苯基吡唑类xor抑制剂及制备与应用
CN110078668B (zh) * 2019-05-16 2023-03-24 华南理工大学 一种苯基咪唑类xor抑制剂及制备与应用
CN119431324B (zh) * 2024-10-23 2025-10-31 沈阳药科大学 1-(4/5-氰基-6-取代嘧啶-2-基)-1h-吡唑-4-甲酸类化合物及其制备方法与应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5527916B2 (de) * 1973-02-05 1980-07-24
JPS5527916A (en) * 1978-08-17 1980-02-28 Arekusandorouitsuchi B Nikorai Detecting icing on objects in gas flow and device therefor
US4346094A (en) * 1980-09-22 1982-08-24 Eli Lilly And Company 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels
DE3129429A1 (de) * 1981-07-25 1983-02-10 Basf Ag, 6700 Ludwigshafen 5-amino-1-phenyl-pyrazol-4-carbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
US4495195A (en) * 1982-11-01 1985-01-22 Eli Lilly And Company Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use
DE3420985A1 (de) * 1983-10-15 1985-04-25 Bayer Ag, 5090 Leverkusen Substituierte 5-acylamino-1-phenylpyrazole
JPS6097948A (ja) * 1983-10-15 1985-05-31 バイエル・アクチエンゲゼルシヤフト 置換５‐アシルアミノ‐１‐フエニルピラゾール類
IL73419A (en) * 1983-11-07 1988-02-29 Lilly Co Eli 1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
IL73418A (en) * 1983-11-07 1988-02-29 Lilly Co Eli 5-cyano-1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
DE3423582A1 (de) * 1984-06-27 1986-01-09 Bayer Ag, 5090 Leverkusen Substituierte 5-acylamino-1-phenylpyrazole
US4666504A (en) * 1984-09-25 1987-05-19 Eli Lilly And Company Pollen formation inhibiting 1-phenyl-4-carboxy-5-pyrazolecarboxamides
US5064851A (en) * 1990-07-24 1991-11-12 Pfizer Inc. 3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
DE122008000051I1 (de) * 1990-11-30 2009-02-05 Teijin Ltd 2-arylthiazolderivat sowie dieses enthaltendes arzneimittel
IL104311A (en) * 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US5436258A (en) * 1992-09-09 1995-07-25 Eli Lilly And Company Prevention of bone resorption
JP3113110B2 (ja) * 1993-01-19 2000-11-27 帝人株式会社 イソキサゾールおよびイソチアゾール誘導体

Also Published As

Publication number Publication date
CN1105708C (zh) 2003-04-16
CA2269721C (en) 2003-04-29
EP0936217B1 (de) 2001-11-07
US6015829A (en) 2000-01-18
EP0936217A4 (de) 2000-01-05
AU731055B2 (en) 2001-03-22
EP0936217A1 (de) 1999-08-18
KR20000052738A (ko) 2000-08-25
AU4723097A (en) 1998-05-22
HK1021982A1 (en) 2000-07-21
PL332946A1 (en) 1999-10-25
CA2269721A1 (en) 1998-05-07
IL129409A0 (en) 2000-02-17
ES2167720T3 (es) 2002-05-16
DK0936217T3 (da) 2002-03-04
DE69708142D1 (de) 2001-12-13
WO1998018765A1 (fr) 1998-05-07
JP3220987B2 (ja) 2001-10-22
ID21775A (id) 1999-07-22
PT936217E (pt) 2002-05-31
IL129409A (en) 2002-02-10
KR100345942B1 (ko) 2002-07-27
CN1240432A (zh) 2000-01-05
DE69708142T2 (de) 2002-07-11

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