ES2156997T3 - Proceso nuevo para la produccion de sal calcica del acido amorfo (r-(r*,r*))-2-(4-fluorofenil)-beta,delta-dihidroxi-5-(1-metiletil)-3-fenil-4-((fenilamino)carbonil)-1h-pirrol-1-heptanoico (2:1). - Google Patents

Proceso nuevo para la produccion de sal calcica del acido amorfo (r-(r*,r*))-2-(4-fluorofenil)-beta,delta-dihidroxi-5-(1-metiletil)-3-fenil-4-((fenilamino)carbonil)-1h-pirrol-1-heptanoico (2:1).

Info

Publication number
ES2156997T3
ES2156997T3 ES96924553T ES96924553T ES2156997T3 ES 2156997 T3 ES2156997 T3 ES 2156997T3 ES 96924553 T ES96924553 T ES 96924553T ES 96924553 T ES96924553 T ES 96924553T ES 2156997 T3 ES2156997 T3 ES 2156997T3
Authority
ES
Spain
Prior art keywords
acid
heptanoico
calcica
fluorophenil
amorfo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96924553T
Other languages
English (en)
Spanish (es)
Inventor
Min Lin
Dieter Schweiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21696097&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2156997(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2156997T3 publication Critical patent/ES2156997T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
ES96924553T 1995-07-17 1996-07-16 Proceso nuevo para la produccion de sal calcica del acido amorfo (r-(r*,r*))-2-(4-fluorofenil)-beta,delta-dihidroxi-5-(1-metiletil)-3-fenil-4-((fenilamino)carbonil)-1h-pirrol-1-heptanoico (2:1). Expired - Lifetime ES2156997T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US145395P 1995-07-17 1995-07-17

Publications (1)

Publication Number Publication Date
ES2156997T3 true ES2156997T3 (es) 2001-08-01

Family

ID=21696097

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96924553T Expired - Lifetime ES2156997T3 (es) 1995-07-17 1996-07-16 Proceso nuevo para la produccion de sal calcica del acido amorfo (r-(r*,r*))-2-(4-fluorofenil)-beta,delta-dihidroxi-5-(1-metiletil)-3-fenil-4-((fenilamino)carbonil)-1h-pirrol-1-heptanoico (2:1).

Country Status (37)

Country Link
US (1) US6274740B1 (d)
EP (1) EP0839132B1 (d)
JP (1) JP4064459B2 (d)
KR (1) KR100400805B1 (d)
CN (1) CN1087289C (d)
AR (1) AR002849A1 (d)
AT (1) ATE199542T1 (d)
AU (1) AU700794B2 (d)
BG (1) BG63631B1 (d)
BR (1) BR9609714A (d)
CA (1) CA2220455C (d)
CO (1) CO4700441A1 (d)
CZ (1) CZ289421B6 (d)
DE (1) DE69611999T2 (d)
DK (1) DK0839132T5 (d)
EA (1) EA000625B1 (d)
EE (1) EE03605B1 (d)
ES (1) ES2156997T3 (d)
GE (1) GEP20002027B (d)
GR (1) GR3035859T3 (d)
HR (1) HRP960312B1 (d)
HU (1) HU220343B (d)
IL (1) IL122161A (d)
IN (1) IN185276B (d)
MX (1) MX9708959A (d)
NO (1) NO309322B1 (d)
NZ (1) NZ313008A (d)
PE (1) PE1698A1 (d)
PL (1) PL191017B1 (d)
PT (1) PT839132E (d)
RO (1) RO120069B1 (d)
SI (1) SI0839132T1 (d)
SK (1) SK283204B6 (d)
UA (1) UA50743C2 (d)
UY (1) UY24286A1 (d)
WO (1) WO1997003960A1 (d)
ZA (1) ZA966043B (d)

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US7411075B1 (en) 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
SI20425A (sl) * 1999-12-10 2001-06-30 LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. Priprava amorfnega atorvastatina
HUP0303555A3 (en) 2000-11-16 2005-08-29 Teva Pharma Hydrolysis of [r(r
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
US7501450B2 (en) * 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
CA2622477A1 (en) 2000-12-27 2002-07-04 Teva Pharmaceutical Industries Ltd. Crystalline forms of atorvastatin
WO2002057228A1 (en) * 2001-01-17 2002-07-25 Biocon India Limited Atorvastatin calcium
WO2002057229A1 (en) 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
SI20814A (sl) * 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) * 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
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MXPA03010266A (es) 2001-06-29 2004-03-10 Warner Lambert Co Formas cristalinas de la sal de calcio del acido [r-(r*, r*)]-2 -(4-fluorofenil)-¦, d-dihidroxi-5 -(1-metiletil)-3 -fenil-4- [(fenilamino) carbonil ]-1h- pirrol-1-heptanoico (2:1) (atorvastatin).
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US7563911B2 (en) 2001-08-31 2009-07-21 Morepen Laboratories Ltd. Process for the preparation of amorphous atorvastin calcium salt (2:1)
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
CZ296967B6 (cs) * 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
CA2479005C (en) * 2002-03-18 2012-05-22 Biocon Limited Amorphous atorvastatin calcium or pravastatin sodium hmg-coa reductase inhibitors of desired particle size
RU2309141C2 (ru) * 2002-03-18 2007-10-27 Байокон Лимитид АМОРФНЫЕ ИНГИБИТОРЫ ГМГ-КоА-РЕДУКТАЗЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
ITMI20020907A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione della forma amorfa del sale di calcio della atorvastatina
AU2002356423A1 (en) * 2002-05-28 2003-12-12 Cadila Healthcare Limited Process for the preparation of amorphous atorvastatin calcium
US7179942B2 (en) 2002-07-05 2007-02-20 Bicon Limited Halo-substituted active methylene compounds
EP1562583A1 (en) * 2002-09-03 2005-08-17 Morepen Laboratories Ltd. Atorvastatin calcium form vi or hydrates thereof
BRPI0409292A (pt) 2003-04-11 2006-04-11 Lek Pharmaceuticals processo para a preparação de sal de cálcio amorfo de atorvastatina
PT1631533E (pt) 2003-04-22 2009-06-04 Biocon Ltd Novo processo para a redução estereosselectiva de betacetoésteres
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
US7557238B2 (en) 2003-09-18 2009-07-07 Biocon Limited Process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
CA2456430A1 (en) * 2004-01-28 2005-07-28 Brantford Chemicals Inc. Improved process for the preparation of amorphous atorvastatin calcium
CZ298382B6 (cs) * 2004-03-10 2007-09-12 Zentiva, A. S. Zpusob prípravy amorfní formy hemivápenaté soli atorvastatinu a její stabilizace
EP1577297A1 (en) * 2004-03-17 2005-09-21 Ranbaxy Laboratories, Ltd. Process for the production of atorvastatin calcium in amorphous form
BRPI0510713A (pt) * 2004-05-05 2007-11-20 Pfizer Prod Inc formas de sal de ácido [r-(r*,r*)]-2-(4-fluorofenil)-beta, delta-diidróxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)ca rbonil]-1h-pirrol-1- heptanóico
ES2586561T3 (es) * 2004-07-16 2016-10-17 Lek Pharmaceuticals D.D. Productos de degradación oxidativa de atorvastatina calcio
JP2008510798A (ja) 2004-08-27 2008-04-10 バイオコン・リミテッド 非晶質アトルバスタチンカルシウムのための方法
WO2006039441A2 (en) * 2004-09-30 2006-04-13 Dr. Reddy's Laboratories Ltd. Amorphous atorvastatin calcium
KR20070054730A (ko) * 2004-10-18 2007-05-29 테바 파마슈티컬 인더스트리즈 리미티드 알콜 및 케톤 및/또는 에스테르의 혼합물인 유기 용매에아토르바스타틴 헤미-칼슘 염을 용해시키고 용매를제거하여 비결정형 아토르바스타틴 헤미-칼슘을 제조하는방법
EP1807055A1 (en) * 2004-10-28 2007-07-18 Warner-Lambert Company LLC Process for forming amorphous atorvastatin
WO2006054308A2 (en) 2004-11-22 2006-05-26 Dexcel Pharma Technologies Ltd. Stable atorvastatin formulations
WO2006059224A1 (en) * 2004-12-02 2006-06-08 Warner-Lambert Company Llc Pharmaceutical compositions of amorphous atorvastatin and process for preparing same
US20080108664A1 (en) * 2005-12-23 2008-05-08 Liu Belle B Solid-state form of AMG 706 and pharmaceutical compositions thereof
EP1810667A1 (en) 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
KR20070116963A (ko) * 2006-03-01 2007-12-11 테바 파마슈티컬 인더스트리즈 리미티드 아토르바스타틴 헤미 칼슘 결정형의 제조 방법
WO2008053312A2 (en) * 2006-11-02 2008-05-08 Cadila Pharmaceuticals Limited Process for preparing amorphous atorvastatin hemi calcium salt and its intermediate
US7834195B2 (en) 2007-01-24 2010-11-16 Apotex Pharmachem Inc. Atorvastatin calcium propylene glycol solvates
EP2185527A2 (en) * 2007-07-11 2010-05-19 Actavis Group PTC EHF Novel polymorph of atorvastatin calcium and use thereof for the preparation of amorphous atorvastatin calcium
US20090124817A1 (en) * 2007-11-09 2009-05-14 The Industry & Academic Cooperation In Chungnam National University Process for Preparing Amorphous Atorvastatin Calcium Nanoparticles
EP2075246A1 (en) 2007-12-27 2009-07-01 M. J. Institute of Research A process for preparation of amorphous form of atorvastatin hemi-calcium salt
WO2010066846A2 (en) * 2008-12-11 2010-06-17 Dsm Ip Assets B.V. Method for the isolation of atorvastatin
EP2373609B1 (en) 2008-12-19 2013-10-16 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
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Also Published As

Publication number Publication date
HRP960312B1 (en) 2001-10-31
JPH11510486A (ja) 1999-09-14
ZA966043B (en) 1997-02-03
IN185276B (d) 2000-12-16
DE69611999T2 (de) 2001-07-26
CZ12298A3 (cs) 1998-12-16
UA50743C2 (uk) 2002-11-15
BG63631B1 (bg) 2002-07-31
CO4700441A1 (es) 1998-12-29
CN1190956A (zh) 1998-08-19
EP0839132B1 (en) 2001-03-07
PL191017B1 (pl) 2006-03-31
DE69611999D1 (de) 2001-04-12
NO980209L (no) 1998-01-16
BG102188A (en) 1998-08-31
NO309322B1 (no) 2001-01-15
SI0839132T1 (d) 2001-06-30
DK0839132T3 (da) 2001-04-09
NZ313008A (en) 2000-01-28
PL324463A1 (en) 1998-05-25
EA199800128A1 (ru) 1998-08-27
HUP9903017A3 (en) 2001-01-29
US6274740B1 (en) 2001-08-14
RO120069B1 (ro) 2005-08-30
MX9708959A (es) 1998-03-31
EE9700369A (et) 1998-06-15
WO1997003960A1 (en) 1997-02-06
IL122161A0 (en) 1998-04-05
PE1698A1 (es) 1998-02-19
GEP20002027B (en) 2000-04-10
SK5898A3 (en) 1998-08-05
ATE199542T1 (de) 2001-03-15
PT839132E (pt) 2001-06-29
DK0839132T5 (da) 2006-03-20
GR3035859T3 (en) 2001-08-31
EP0839132A1 (en) 1998-05-06
SK283204B6 (sk) 2003-03-04
AU6497896A (en) 1997-02-18
IL122161A (en) 1999-07-14
HRP960312A2 (en) 1998-02-28
BR9609714A (pt) 1999-02-23
UY24286A1 (es) 1997-01-17
KR100400805B1 (ko) 2003-12-24
CN1087289C (zh) 2002-07-10
KR19990029045A (ko) 1999-04-15
HK1018054A1 (en) 1999-12-10
JP4064459B2 (ja) 2008-03-19
EE03605B1 (et) 2002-02-15
AR002849A1 (es) 1998-04-29
EA000625B1 (ru) 1999-12-29
AU700794B2 (en) 1999-01-14
CA2220455A1 (en) 1997-02-06
NO980209D0 (no) 1998-01-16
CA2220455C (en) 2002-09-24
CZ289421B6 (cs) 2002-01-16
HU220343B (hu) 2001-12-28

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