ES2153378T3 - Hidrogeles biodegradables fotopolimerizables como materiales de contacto de tejidos y portadores de descarga controlada. - Google Patents

Hidrogeles biodegradables fotopolimerizables como materiales de contacto de tejidos y portadores de descarga controlada.

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Publication number
ES2153378T3
ES2153378T3 ES93906255T ES93906255T ES2153378T3 ES 2153378 T3 ES2153378 T3 ES 2153378T3 ES 93906255 T ES93906255 T ES 93906255T ES 93906255 T ES93906255 T ES 93906255T ES 2153378 T3 ES2153378 T3 ES 2153378T3
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Spain
Prior art keywords
oligomers
biodegradable
hydrogels
polymerized
photopolimerizable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93906255T
Other languages
English (en)
Inventor
Jeffrey A Hubbell
Chandrashekhar P Pathak
Amarpreet S Sawhney
Neil P Desai
Jennifer L Hill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
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Publication date
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Application granted granted Critical
Publication of ES2153378T3 publication Critical patent/ES2153378T3/es
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Expired - Lifetime legal-status Critical Current

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Abstract

SE DESCRIBEN HIDROGELES DE MACROMEROS POLIMERIZADOS Y ENTRECRUZADOS QUE CONTIENEN OLIGOMEROS HIDROFILICOS QUE TIENEN EXTENSIONES MONOMERICAS Y OLIGOMERICAS BIODEGRADABLES, CUYAS EXTENSIONES BIODEGRADABLES TERMINAN EN TERMINALES LIBRES CON MONOMEROS U OLIGOMEROS DE ACABADO FINALES QUE SE PUEDEN POLIMERIZAR Y ENTRECRUZAR. EL NUCLEO HIDROFILICO MISMO SE PUEDE DEGRADAR, LO QUE COMBINA LAS FUNCIONES DE NUCLEO Y DE LAS EXTENSIONES. LOS MACROMEROS SE POLIMERIZAN UTILIZANDO INICIDADORES DE RADICAL LIBRE BAJO AL INFLUENCIA DE UNA LUZ ULTRAVIOLETA DE LARGA LONGITUD DE ONDA, UNA EXCITACION LUMINOSA VISIBLE O ENERGIA TERMICA. LA BIODEGRADACION TIENE LUGAR EN LOS ENLACES QUE HAY DENTRO DE LOS OLIGOMEROS DE LAS EXTENSIONES Y EL RESULTADO SON UNOS FRAGMENTOS NO TOXICOS Y QUE SE PUEDEN SEPARAR FACILMENTE DEL CUERPO. ENTRE LAS APLICACIONES PREFERENTES DE LOS HIDROGELES CABE INCLUIR LA PREVENCION DE LA FORMACION DE ADHERENCIAS TRAS PRACTICAS QUIRURGICAS, LA LIBERACION CONTROLADA DE FARMACOS Y DE OTRAS ESPECIES BIOACTIVA, LA PROTECCION TEMPORAL O SEPARACION DE LAS SUPERFICIES DE LOS TEJIDOS, LA ADHESION DE TEJIDOS ADHERIBLES ENTRE SI Y LA PREVENCION DEL ACOPLAMIENTO DE CELULAS A LAS SUPERFICIES DE LOS TEJIDOS.
ES93906255T 1992-02-28 1993-03-01 Hidrogeles biodegradables fotopolimerizables como materiales de contacto de tejidos y portadores de descarga controlada. Expired - Lifetime ES2153378T3 (es)

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DE69329594D1 (de) 2000-11-30
US20020091229A1 (en) 2002-07-11
US6602975B2 (en) 2003-08-05
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US5986043A (en) 1999-11-16
US6306922B1 (en) 2001-10-23
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US5567435A (en) 1996-10-22

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