PT910412E - Hidrogeis hidrolisaveis para libertacao controlada - Google Patents
Hidrogeis hidrolisaveis para libertacao controladaInfo
- Publication number
- PT910412E PT910412E PT97929571T PT97929571T PT910412E PT 910412 E PT910412 E PT 910412E PT 97929571 T PT97929571 T PT 97929571T PT 97929571 T PT97929571 T PT 97929571T PT 910412 E PT910412 E PT 910412E
- Authority
- PT
- Portugal
- Prior art keywords
- hydrogees
- hydrological
- hydrogel
- hydrolyzable
- physiological conditions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96201821 | 1996-07-01 | ||
US3167196P | 1996-11-22 | 1996-11-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT910412E true PT910412E (pt) | 2003-09-30 |
Family
ID=26142938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97929571T PT910412E (pt) | 1996-07-01 | 1997-07-01 | Hidrogeis hidrolisaveis para libertacao controlada |
Country Status (10)
Country | Link |
---|---|
US (2) | US6497903B1 (pt) |
EP (1) | EP0910412B1 (pt) |
JP (1) | JP4625548B2 (pt) |
AT (1) | ATE238068T1 (pt) |
AU (1) | AU3360197A (pt) |
DE (1) | DE69721265T2 (pt) |
DK (1) | DK0910412T3 (pt) |
ES (1) | ES2198579T3 (pt) |
PT (1) | PT910412E (pt) |
WO (1) | WO1998000170A1 (pt) |
Families Citing this family (69)
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---|---|---|---|---|
US20080131512A1 (en) * | 1996-07-01 | 2008-06-05 | Wilhelmus Everhardus Hennink | Biodegradable hydrogels |
WO1998012243A1 (en) † | 1996-09-23 | 1998-03-26 | Focal, Inc. | Polymerizable biodegradable polymers including carbonate or dioxanone linkages |
DK0901786T3 (da) | 1997-08-11 | 2007-10-08 | Pfizer Prod Inc | Faste farmaceutiske dispersioner med foröget biotilgængelighed |
DK1183016T3 (da) * | 1999-02-19 | 2004-08-09 | Univ Utrecht | Stereokomplekse hydrogeler |
US7425581B2 (en) * | 1999-07-30 | 2008-09-16 | Universiteit Utrecht | Temperature sensitive polymers |
US7008635B1 (en) | 1999-09-10 | 2006-03-07 | Genzyme Corporation | Hydrogels for orthopedic repair |
EP1230855B1 (en) * | 1999-11-19 | 2008-10-01 | Nof Corporation | Sustained-release preparation of aqueous dispersion type and process for producing the same |
US6961765B2 (en) | 2000-04-06 | 2005-11-01 | Bbx Technologies, Inc. | System and method for real time monitoring and control of networked computers |
US6800298B1 (en) * | 2000-05-11 | 2004-10-05 | Clemson University | Biological lubricant composition and method of applying lubricant composition |
US6805879B2 (en) | 2000-06-23 | 2004-10-19 | Biopharm Solutions Inc. | Stable polymer aqueous/aqueous emulsion system and uses thereof |
US20040018228A1 (en) * | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
US7943067B2 (en) * | 2001-08-16 | 2011-05-17 | Polytechnic Institute Of New York University | Nanogels and their production using liposomes as reactors |
DE60132094T3 (de) | 2001-10-26 | 2012-02-02 | Octoplus Polyactive Sciences B.V. | Verfahren zur Herstellung von gereinigten Partikeln |
WO2004085712A2 (en) * | 2003-03-24 | 2004-10-07 | Penn State Research Foundation | Multi-functional polymeric materials and their uses |
ES2396689T3 (es) | 2003-12-11 | 2013-02-25 | Isto Technologies Inc. | Sistema de cartílago particulado |
EP1576952A1 (en) * | 2004-03-18 | 2005-09-21 | OctoPlus Technologies B.V. | Hydrogel microspheres with improved release profile |
EP1595534A1 (en) * | 2004-05-13 | 2005-11-16 | Universiteit Utrecht Holding B.V. | Gel composition comprising charged polymers |
US7968085B2 (en) * | 2004-07-05 | 2011-06-28 | Ascendis Pharma A/S | Hydrogel formulations |
US7235592B2 (en) * | 2004-10-12 | 2007-06-26 | Zimmer Gmbh | PVA hydrogel |
ITTO20040918A1 (it) * | 2004-12-29 | 2005-03-29 | Luigi Ambrosio | Idrogel polimerici superassorbenti biodegradabili e procedimento per la loro preparazione |
JP2008531769A (ja) | 2005-02-23 | 2008-08-14 | ズィマー・テクノロジー・インコーポレーテッド | ブレンドヒドロゲルおよびその製造方法 |
WO2007016622A2 (en) * | 2005-08-02 | 2007-02-08 | Wright Medical Technolody, Inc. | Gel composition for inhibiting cellular adhesion |
US7571295B2 (en) * | 2005-08-04 | 2009-08-04 | Intel Corporation | Memory manager for heterogeneous memory control |
US8480757B2 (en) | 2005-08-26 | 2013-07-09 | Zimmer, Inc. | Implants and methods for repair, replacement and treatment of disease |
CA2621786A1 (en) * | 2005-08-29 | 2007-03-08 | Tuo Jin | Polysaccharide microparticles containing biological agents: there preparation and applications |
EP1764117A1 (en) * | 2005-09-20 | 2007-03-21 | Zimmer GmbH | Implant for the repair of a cartilage defect and method for manufacturing the implant |
WO2007043973A1 (en) * | 2005-10-13 | 2007-04-19 | Dso National Laboratories | Method of enhancing a fluorescent signal |
US20070098799A1 (en) * | 2005-10-28 | 2007-05-03 | Zimmer, Inc. | Mineralized Hydrogels and Methods of Making and Using Hydrogels |
CA2632120C (en) * | 2005-12-07 | 2014-07-08 | Zimmer, Inc. | Methods of bonding or modifying hydrogels using irradiation |
US20070141108A1 (en) * | 2005-12-20 | 2007-06-21 | Zimmer, Inc. | Fiber-reinforced water-swellable articles |
US8017107B2 (en) * | 2005-12-22 | 2011-09-13 | Zimmer, Inc. | Perfluorocyclobutane crosslinked hydrogels |
US8110242B2 (en) * | 2006-03-24 | 2012-02-07 | Zimmer, Inc. | Methods of preparing hydrogel coatings |
EP1891941A1 (en) * | 2006-08-11 | 2008-02-27 | OctoPlus Technologies B.V. | Aqueous gels comprising microspheres |
US20080114096A1 (en) * | 2006-11-09 | 2008-05-15 | Hydromer, Inc. | Lubricious biopolymeric network compositions and methods of making same |
US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
WO2008100142A2 (en) * | 2007-02-12 | 2008-08-21 | Octoplus Sciences B.V. | Vaccine formulation |
EP1985284A1 (en) * | 2007-04-25 | 2008-10-29 | OctoPlus Sciences B.V. | Vaccine formulation |
WO2008128075A1 (en) | 2007-04-12 | 2008-10-23 | Isto Technologies, Inc. | Compositions and methods for tissue repair |
US7731988B2 (en) | 2007-08-03 | 2010-06-08 | Zimmer, Inc. | Multi-polymer hydrogels |
US20090043398A1 (en) * | 2007-08-09 | 2009-02-12 | Zimmer, Inc. | Method of producing gradient articles by centrifugation molding or casting |
US8062739B2 (en) * | 2007-08-31 | 2011-11-22 | Zimmer, Inc. | Hydrogels with gradient |
JP2010540499A (ja) * | 2007-09-26 | 2010-12-24 | ディーエスエム アイピー アセッツ ビー.ブイ. | 架橋ポリマーを含む微粒子 |
US7947784B2 (en) * | 2007-11-16 | 2011-05-24 | Zimmer, Inc. | Reactive compounding of hydrogels |
US8034362B2 (en) | 2008-01-04 | 2011-10-11 | Zimmer, Inc. | Chemical composition of hydrogels for use as articulating surfaces |
US20090202642A1 (en) * | 2008-02-08 | 2009-08-13 | Xiao Huang | Drug Delivery System Comprising Microparticles and Gelation System |
US20110182957A1 (en) * | 2008-06-19 | 2011-07-28 | Nicoll Steven B | Cellulosics for tissue replacement |
US9193948B2 (en) | 2008-11-12 | 2015-11-24 | The Trustees Of The University Of Pennsylvania | Biomaterials for tissue replacement |
WO2010102065A1 (en) | 2009-03-05 | 2010-09-10 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives |
WO2010111132A2 (en) | 2009-03-27 | 2010-09-30 | Bend Research, Inc. | Spray-drying process |
CN102695500A (zh) | 2009-11-09 | 2012-09-26 | 聚光灯技术合伙有限责任公司 | 多糖基水凝胶 |
JP2013509963A (ja) | 2009-11-09 | 2013-03-21 | スポットライト テクノロジー パートナーズ エルエルシー | 断片化ヒドロゲル |
US20120003192A1 (en) * | 2010-07-02 | 2012-01-05 | Zimmer Orthobiologics, Inc. | Hydrogel-forming composition comprising protein and non-protein segments |
US9084944B2 (en) | 2010-09-03 | 2015-07-21 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
US8815294B2 (en) | 2010-09-03 | 2014-08-26 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives and a carrier material |
PT2611529T (pt) | 2010-09-03 | 2019-05-09 | Bend Res Inc | Método de secagem por pulverização |
WO2012040502A1 (en) | 2010-09-24 | 2012-03-29 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
US9084727B2 (en) | 2011-05-10 | 2015-07-21 | Bend Research, Inc. | Methods and compositions for maintaining active agents in intra-articular spaces |
WO2014034884A1 (ja) * | 2012-08-31 | 2014-03-06 | 国立大学法人北陸先端科学技術大学院大学 | 凍結保存可能な細胞足場材料 |
US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
US20160067190A1 (en) * | 2013-04-30 | 2016-03-10 | The Children's Medical Center Corporation | Injectable nano-network gels for diabetes treatment |
AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
EP3340982B1 (en) | 2015-08-26 | 2021-12-15 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
US10712240B2 (en) | 2016-04-19 | 2020-07-14 | Ariana Schanzer | Contaminant monitor system and method |
AU2017290593A1 (en) | 2016-06-27 | 2019-01-03 | Achillion Pharmaceuticals, Inc. | Quinazoline and indole compounds to treat medical disorders |
US10220096B2 (en) * | 2016-10-13 | 2019-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | Injectable and stable hydrogels with dynamic properties modulated by biocompatible catalysts |
EP3581168A1 (en) * | 2018-06-15 | 2019-12-18 | Universiteit Utrecht Holding B.V. | Sustained release composition |
JP2021535112A (ja) | 2018-08-20 | 2021-12-16 | アキリオン ファーマシューティカルズ,インコーポレーテッド | 補体d因子の医学的障害の治療のための医薬化合物 |
EP3866773A4 (en) | 2018-10-16 | 2022-10-26 | Georgia State University Research Foundation, Inc. | CARBON MONOXIDE PRODRUGS FOR THE TREATMENT OF MEDICAL CONDITIONS |
CN110897997B (zh) * | 2019-12-31 | 2023-02-28 | 广州贝奥吉因生物科技股份有限公司 | 一种葡聚糖接枝甲基丙烯酸水凝胶微针及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2370589A (en) * | 1944-02-29 | 1945-02-27 | Pittsburgh Plate Glass Co | Unsaturated carbonate esters |
US4024073A (en) * | 1972-01-08 | 1977-05-17 | Toray Industries, Inc. | Hydrogel and production thereof |
US5356883A (en) * | 1989-08-01 | 1994-10-18 | Research Foundation Of State University Of N.Y. | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use |
US5410016A (en) | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
AU3124793A (en) * | 1991-10-29 | 1993-06-07 | Clover Consolidated, Limited | Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release |
JP3011768B2 (ja) | 1992-02-28 | 2000-02-21 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | 組織接触材料および制御放出キャリアとしての光重合性生分解性親水ゲル |
DE4209160A1 (de) * | 1992-03-20 | 1993-09-30 | Bauer Kurt Heinz Prof Dr | Vernetzte Polysaccharide, Verfahren zu ihrer Herstellung und ihre Verwendung |
DK89592D0 (da) * | 1992-07-07 | 1992-07-07 | Helle Broendsted | Laegemiddelafgivelsesindretning samt fremgangsmaade til fremstilling deraf |
-
1997
- 1997-07-01 DK DK97929571T patent/DK0910412T3/da active
- 1997-07-01 DE DE69721265T patent/DE69721265T2/de not_active Expired - Lifetime
- 1997-07-01 WO PCT/NL1997/000374 patent/WO1998000170A1/en active IP Right Grant
- 1997-07-01 JP JP50401398A patent/JP4625548B2/ja not_active Expired - Fee Related
- 1997-07-01 EP EP97929571A patent/EP0910412B1/en not_active Expired - Lifetime
- 1997-07-01 AU AU33601/97A patent/AU3360197A/en not_active Abandoned
- 1997-07-01 AT AT97929571T patent/ATE238068T1/de not_active IP Right Cessation
- 1997-07-01 PT PT97929571T patent/PT910412E/pt unknown
- 1997-07-01 ES ES97929571T patent/ES2198579T3/es not_active Expired - Lifetime
- 1997-07-01 US US09/214,306 patent/US6497903B1/en not_active Expired - Fee Related
-
2001
- 2001-12-06 US US10/020,627 patent/US7060296B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7060296B2 (en) | 2006-06-13 |
DE69721265D1 (de) | 2003-05-28 |
JP4625548B2 (ja) | 2011-02-02 |
EP0910412A1 (en) | 1999-04-28 |
AU3360197A (en) | 1998-01-21 |
EP0910412B1 (en) | 2003-04-23 |
US20020131952A1 (en) | 2002-09-19 |
US6497903B1 (en) | 2002-12-24 |
DK0910412T3 (da) | 2003-08-11 |
JP2000515853A (ja) | 2000-11-28 |
ES2198579T3 (es) | 2004-02-01 |
ATE238068T1 (de) | 2003-05-15 |
WO1998000170A1 (en) | 1998-01-08 |
DE69721265T2 (de) | 2004-05-06 |
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