JP2000515853A - 放出制御用の加水分解可能なヒドロゲル - Google Patents
放出制御用の加水分解可能なヒドロゲルInfo
- Publication number
- JP2000515853A JP2000515853A JP10504013A JP50401398A JP2000515853A JP 2000515853 A JP2000515853 A JP 2000515853A JP 10504013 A JP10504013 A JP 10504013A JP 50401398 A JP50401398 A JP 50401398A JP 2000515853 A JP2000515853 A JP 2000515853A
- Authority
- JP
- Japan
- Prior art keywords
- hydrogel
- hema
- dextran
- hydrogels
- hydrolyzable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.生理的条件下で加水分解可能な複数の結合を含んでなる生分解性ヒドロゲル 。 2.加水分解可能な複数のスペーサーを介して互いに結合した2種の高分子網目 よりなることを特徴とする、請求項1に記載のヒドロゲル。 3.デキストランの架橋体、またはデキストラン誘導体の架橋体を含むことを特 徴とする、請求項1または2に記載のヒドロゲル。 4.複数の架橋性メタクリル酸エステル単位の重合によって形成された高分子を 含むことを特徴とする、請求項1〜3のいずれかに記載のヒドロゲル。 5.乳酸エステル結合、炭酸エステル結合、コハク酸エステル結合及びエチレン グリコール結合よりなる群より選ばれる少なくとも1種の加水分解性結合を含む ことを特徴とする、請求項1〜4のいずれかに記載のヒドロゲル。 6.生理的条件下で加水分解可能な複数の結合を含む巨大分子を、水溶液中で架 橋させることを特徴とする、ヒドロゲルの製造方法。 7.該結合が、乳酸、グリコール酸、コハク酸及びエチレングリコー ルよりなる群より選ばれる少なくとも1種の物質に由来する結合であることを特 徴とする、請求項6に記載の方法。 8.タンパク性薬物の存在下で該巨大分子の架橋を行うことを特徴とする、請求 項6または7に記載の方法
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96201821 | 1996-07-01 | ||
US3167196P | 1996-11-22 | 1996-11-22 | |
US60/031,671 | 1996-11-22 | ||
US96201821.4 | 1996-11-22 | ||
PCT/NL1997/000374 WO1998000170A1 (en) | 1996-07-01 | 1997-07-01 | Hydrolysable hydrogels for controlled release |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000515853A true JP2000515853A (ja) | 2000-11-28 |
JP4625548B2 JP4625548B2 (ja) | 2011-02-02 |
Family
ID=26142938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50401398A Expired - Fee Related JP4625548B2 (ja) | 1996-07-01 | 1997-07-01 | 放出制御用の加水分解可能なヒドロゲル |
Country Status (10)
Country | Link |
---|---|
US (2) | US6497903B1 (ja) |
EP (1) | EP0910412B1 (ja) |
JP (1) | JP4625548B2 (ja) |
AT (1) | ATE238068T1 (ja) |
AU (1) | AU3360197A (ja) |
DE (1) | DE69721265T2 (ja) |
DK (1) | DK0910412T3 (ja) |
ES (1) | ES2198579T3 (ja) |
PT (1) | PT910412E (ja) |
WO (1) | WO1998000170A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002537416A (ja) * | 1999-02-19 | 2002-11-05 | ウニフェルシテイト ユトレヒト | ステレオコンプレックスヒドロゲル |
JP2010540499A (ja) * | 2007-09-26 | 2010-12-24 | ディーエスエム アイピー アセッツ ビー.ブイ. | 架橋ポリマーを含む微粒子 |
JPWO2014034884A1 (ja) * | 2012-08-31 | 2016-08-08 | 国立大学法人北陸先端科学技術大学院大学 | 凍結保存可能な細胞足場材料 |
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US20080131512A1 (en) * | 1996-07-01 | 2008-06-05 | Wilhelmus Everhardus Hennink | Biodegradable hydrogels |
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US7425581B2 (en) * | 1999-07-30 | 2008-09-16 | Universiteit Utrecht | Temperature sensitive polymers |
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DE60040411D1 (de) * | 1999-11-19 | 2008-11-13 | Nof Corp | Gerter freigabe und verfahren zu ihrer herstellung |
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US6800298B1 (en) * | 2000-05-11 | 2004-10-05 | Clemson University | Biological lubricant composition and method of applying lubricant composition |
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US20070141108A1 (en) * | 2005-12-20 | 2007-06-21 | Zimmer, Inc. | Fiber-reinforced water-swellable articles |
US8017107B2 (en) * | 2005-12-22 | 2011-09-13 | Zimmer, Inc. | Perfluorocyclobutane crosslinked hydrogels |
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CN102695500A (zh) | 2009-11-09 | 2012-09-26 | 聚光灯技术合伙有限责任公司 | 多糖基水凝胶 |
US20120003192A1 (en) * | 2010-07-02 | 2012-01-05 | Zimmer Orthobiologics, Inc. | Hydrogel-forming composition comprising protein and non-protein segments |
US8815294B2 (en) | 2010-09-03 | 2014-08-26 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives and a carrier material |
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US9084976B2 (en) | 2010-09-03 | 2015-07-21 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
US9248584B2 (en) | 2010-09-24 | 2016-02-02 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
US9084727B2 (en) | 2011-05-10 | 2015-07-21 | Bend Research, Inc. | Methods and compositions for maintaining active agents in intra-articular spaces |
US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
BR112015027561A8 (pt) * | 2013-04-30 | 2019-12-24 | Massachusetts Inst Technology | formulação de rede reticulada por nanopartícula injetável e polimérica, e uso da mesma |
AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
WO2017035408A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
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-
1997
- 1997-07-01 EP EP97929571A patent/EP0910412B1/en not_active Expired - Lifetime
- 1997-07-01 DE DE69721265T patent/DE69721265T2/de not_active Expired - Lifetime
- 1997-07-01 US US09/214,306 patent/US6497903B1/en not_active Expired - Fee Related
- 1997-07-01 DK DK97929571T patent/DK0910412T3/da active
- 1997-07-01 AU AU33601/97A patent/AU3360197A/en not_active Abandoned
- 1997-07-01 JP JP50401398A patent/JP4625548B2/ja not_active Expired - Fee Related
- 1997-07-01 PT PT97929571T patent/PT910412E/pt unknown
- 1997-07-01 WO PCT/NL1997/000374 patent/WO1998000170A1/en active IP Right Grant
- 1997-07-01 AT AT97929571T patent/ATE238068T1/de not_active IP Right Cessation
- 1997-07-01 ES ES97929571T patent/ES2198579T3/es not_active Expired - Lifetime
-
2001
- 2001-12-06 US US10/020,627 patent/US7060296B2/en not_active Expired - Fee Related
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002537416A (ja) * | 1999-02-19 | 2002-11-05 | ウニフェルシテイト ユトレヒト | ステレオコンプレックスヒドロゲル |
US7776359B1 (en) | 1999-02-19 | 2010-08-17 | Universiteit Utrecht | Stereocomplex hydrogels |
JP4865947B2 (ja) * | 1999-02-19 | 2012-02-01 | ウニフェルシテイト ユトレヒト | ステレオコンプレックスヒドロゲル |
JP2010540499A (ja) * | 2007-09-26 | 2010-12-24 | ディーエスエム アイピー アセッツ ビー.ブイ. | 架橋ポリマーを含む微粒子 |
JPWO2014034884A1 (ja) * | 2012-08-31 | 2016-08-08 | 国立大学法人北陸先端科学技術大学院大学 | 凍結保存可能な細胞足場材料 |
Also Published As
Publication number | Publication date |
---|---|
DE69721265T2 (de) | 2004-05-06 |
JP4625548B2 (ja) | 2011-02-02 |
US7060296B2 (en) | 2006-06-13 |
US20020131952A1 (en) | 2002-09-19 |
US6497903B1 (en) | 2002-12-24 |
DE69721265D1 (de) | 2003-05-28 |
DK0910412T3 (da) | 2003-08-11 |
EP0910412A1 (en) | 1999-04-28 |
WO1998000170A1 (en) | 1998-01-08 |
EP0910412B1 (en) | 2003-04-23 |
ES2198579T3 (es) | 2004-02-01 |
AU3360197A (en) | 1998-01-21 |
PT910412E (pt) | 2003-09-30 |
ATE238068T1 (de) | 2003-05-15 |
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