BR112015027561A8 - formulação de rede reticulada por nanopartícula injetável e polimérica, e uso da mesma - Google Patents
formulação de rede reticulada por nanopartícula injetável e polimérica, e uso da mesma Download PDFInfo
- Publication number
- BR112015027561A8 BR112015027561A8 BR112015027561A BR112015027561A BR112015027561A8 BR 112015027561 A8 BR112015027561 A8 BR 112015027561A8 BR 112015027561 A BR112015027561 A BR 112015027561A BR 112015027561 A BR112015027561 A BR 112015027561A BR 112015027561 A8 BR112015027561 A8 BR 112015027561A8
- Authority
- BR
- Brazil
- Prior art keywords
- glucose
- injectable
- insulin
- formulation
- delivery
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
Abstract
resumo géis injetáveis de nano-rede para tratamento de diabates um sistema para fornecimento inteligente de um agente terapêutico, profilático ou diagnóstico, tal como um fornecimento de insulina, mediado por glicose, por meio de uma nano-rede injetável consistindo em nanopartículas de dextrano carregadas opostamente e encapsulando insulina e enzimas específicas de glicose formando uma estrutura em treliça 3d do tipo gel. conforme demonstrado pelos exemplos, o sistema se desassocia eficazmente para liberar insulina em uma condição hiperglicêmica, em que a conversão catalítica de glicose em ácido glicônico e a subsequente degradação da matriz polimérica são facilitadas. essa configuração de formulação provê uma estratégia de fornecimento para o controle tanto da diabetes autorregulada como da diabetes de longa duração. 1/1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361817752P | 2013-04-30 | 2013-04-30 | |
| US201361864069P | 2013-08-09 | 2013-08-09 | |
| PCT/US2014/035927 WO2014179344A1 (en) | 2013-04-30 | 2014-04-29 | Injectable nano-network gels for diabetes treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015027561A2 BR112015027561A2 (pt) | 2017-07-25 |
| BR112015027561A8 true BR112015027561A8 (pt) | 2019-12-24 |
Family
ID=51843897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015027561A BR112015027561A8 (pt) | 2013-04-30 | 2014-04-29 | formulação de rede reticulada por nanopartícula injetável e polimérica, e uso da mesma |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20160067190A1 (pt) |
| EP (1) | EP2991673A4 (pt) |
| JP (1) | JP2016517885A (pt) |
| KR (1) | KR20160024853A (pt) |
| CN (1) | CN105813652A (pt) |
| AU (1) | AU2014260024B2 (pt) |
| BR (1) | BR112015027561A8 (pt) |
| HK (2) | HK1221415A1 (pt) |
| MX (1) | MX2015015079A (pt) |
| RU (1) | RU2015151135A (pt) |
| WO (1) | WO2014179344A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2874562T3 (es) * | 2014-12-19 | 2021-11-05 | Kemin Ind Inc | Suministro intraocular de moléculas bioactivas mediante el uso de iontoforesis |
| CN104740641B (zh) * | 2015-04-08 | 2019-02-01 | 烟台大学 | 一种糖敏感的缓控释微球组合物及其制备方法 |
| CN107530296B (zh) * | 2015-04-21 | 2021-06-22 | 北卡罗来纳州立大学 | 使用缺氧敏感性纳米复合材料的葡萄糖响应性胰岛素递送系统 |
| CA3026561C (en) * | 2016-07-21 | 2021-10-26 | Boston Scientific Scimed, Inc. | Injectable compositions |
| US11351230B2 (en) | 2016-11-07 | 2022-06-07 | North Carolina State University | Patch loaded with dual-sensitive vesicles for enhanced glucose-responsive insulin delivery |
| CA3045882A1 (en) | 2016-12-05 | 2018-06-14 | North Carolina State University | Core-shell microneedle devices and uses thereof |
| CN106668840B (zh) * | 2017-02-10 | 2020-02-14 | 南通大学 | 一种胰岛素控释药物及其制备方法与应用 |
| WO2019055594A1 (en) * | 2017-09-13 | 2019-03-21 | North Carolina State University | BRUSHING ADIPOSE TISSUE INDUCED LOCALLY BY MICRO-NEEDLE STAMPS FOR THE TREATMENT OF OBESITY |
| WO2019104006A1 (en) * | 2017-11-21 | 2019-05-31 | North Carolina State University | Charge-switchable polymeric depot for glucose-triggered insulin delivery with ultrafast response |
| EP3735262A4 (en) * | 2018-01-03 | 2021-09-29 | Penn State Research Foundation | GLUCOSE OXIDASE COMPOSITIONS USED AS AN ANTI-CONVULSIVER IN NEWBORNS |
| CN111195238A (zh) * | 2018-10-31 | 2020-05-26 | 南方医科大学 | 一种用于胰岛素口服递送的聚电解质复合物 |
| US20220204654A1 (en) * | 2019-04-25 | 2022-06-30 | Massachusetts Institute Of Technology | Cyclodextrin supramolecular scaffolds and uses thereof |
| CN116474162A (zh) * | 2023-04-28 | 2023-07-25 | 吉林大学 | 一种用于糖尿病慢性创伤修复的自修复水凝胶的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5359030A (en) * | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| WO1998000170A1 (en) * | 1996-07-01 | 1998-01-08 | Universiteit Utrecht | Hydrolysable hydrogels for controlled release |
| AU2003301064A1 (en) * | 2002-12-17 | 2004-07-14 | Massachusetts Institute Of Technology | Stimuli-responsive systems for controlled drug delivery |
| WO2006088473A2 (en) * | 2004-04-23 | 2006-08-24 | Panduranga Rao Koritala | Microcapsules and nanocapsules for the transmucosal delivery of therapeutic and diagnostic agents |
| EP1595534A1 (en) * | 2004-05-13 | 2005-11-16 | Universiteit Utrecht Holding B.V. | Gel composition comprising charged polymers |
| TWI394580B (zh) * | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
| US20110189299A1 (en) * | 2008-07-01 | 2011-08-04 | Nitto Denko Corporation | Pharmaceutical composition containing surface-coated microparticles |
-
2014
- 2014-04-29 WO PCT/US2014/035927 patent/WO2014179344A1/en active Application Filing
- 2014-04-29 US US14/787,652 patent/US20160067190A1/en not_active Abandoned
- 2014-04-29 RU RU2015151135A patent/RU2015151135A/ru not_active Application Discontinuation
- 2014-04-29 BR BR112015027561A patent/BR112015027561A8/pt not_active Application Discontinuation
- 2014-04-29 AU AU2014260024A patent/AU2014260024B2/en not_active Ceased
- 2014-04-29 JP JP2016511809A patent/JP2016517885A/ja active Pending
- 2014-04-29 KR KR1020157034126A patent/KR20160024853A/ko not_active Application Discontinuation
- 2014-04-29 CN CN201480037463.3A patent/CN105813652A/zh active Pending
- 2014-04-29 MX MX2015015079A patent/MX2015015079A/es unknown
- 2014-04-29 EP EP14792285.0A patent/EP2991673A4/en not_active Withdrawn
-
2016
- 2016-08-12 HK HK16109650.4A patent/HK1221415A1/zh unknown
- 2016-09-08 HK HK16110684.2A patent/HK1222546A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014260024B2 (en) | 2016-09-15 |
| US20160067190A1 (en) | 2016-03-10 |
| EP2991673A1 (en) | 2016-03-09 |
| RU2015151135A (ru) | 2017-06-02 |
| MX2015015079A (es) | 2016-07-05 |
| AU2014260024A1 (en) | 2015-11-19 |
| HK1221415A1 (zh) | 2017-06-02 |
| KR20160024853A (ko) | 2016-03-07 |
| WO2014179344A1 (en) | 2014-11-06 |
| BR112015027561A2 (pt) | 2017-07-25 |
| HK1222546A1 (zh) | 2017-07-07 |
| JP2016517885A (ja) | 2016-06-20 |
| CN105813652A (zh) | 2016-07-27 |
| EP2991673A4 (en) | 2016-12-21 |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
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