ES2134388T3 - Combinaciones de antigenos del virus de la hepatitis c (hcv) para su uso en inmunoensayos para anticuerpos anti-hcv. - Google Patents
Combinaciones de antigenos del virus de la hepatitis c (hcv) para su uso en inmunoensayos para anticuerpos anti-hcv.Info
- Publication number
- ES2134388T3 ES2134388T3 ES95114016T ES95114016T ES2134388T3 ES 2134388 T3 ES2134388 T3 ES 2134388T3 ES 95114016 T ES95114016 T ES 95114016T ES 95114016 T ES95114016 T ES 95114016T ES 2134388 T3 ES2134388 T3 ES 2134388T3
- Authority
- ES
- Spain
- Prior art keywords
- hcv
- domain
- combinations
- antigen
- immuno
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Virology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Thermistors And Varistors (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE PRESENTAN COMBINACIONES DE ANTIGENOS HCV QUE TIENEN UNA GAMA MAS AMPLIA DE REACTIVIDAD INMUNOLOGICA QUE CUALQUIER ANTIGENO HCV SIMPLE. LAS COMBINACIONES CONSTAN DE UN ANTIGENO DEL DOMINANTE C DE LA POLIPROTEINA DEL HCV, Y UN ANTIGENO ADICIONAL DEL HCV DEL DOMINANTE S, OPCIONALMENTE CON UN ANTIGENO ADICIONAL PARA CUALQUIERA DE LOS DOMINANTES NS3, NS4 O NS5, Y TIENEN LA FORMA DE UNA PROTEINA DE FUSION, UNA MEZCLA FISICA SIMPLE, O DE LOS ANTIGENOS INDIVIDUALES COMUNMENTE UNIDOS A UNA MATRIZ SOLIDA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50435290A | 1990-04-04 | 1990-04-04 | |
US504352 | 1990-04-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2134388T3 true ES2134388T3 (es) | 1999-10-01 |
ES2134388T5 ES2134388T5 (es) | 2008-12-01 |
Family
ID=24005897
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95114016T Expired - Lifetime ES2134388T5 (es) | 1990-04-04 | 1991-04-03 | Combinaciones de antigenos del virus de la hepatitis c (hcv) para su uso en inmunoensayos para anticuerpos anti-hcv. |
ES91302910T Expired - Lifetime ES2088465T3 (es) | 1990-04-04 | 1991-04-03 | Combinaciones de antigenos del virus c de la hepatitis (hcv) para uso en inmunoensayos para anticuerpos anti-hcv. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91302910T Expired - Lifetime ES2088465T3 (es) | 1990-04-04 | 1991-04-03 | Combinaciones de antigenos del virus c de la hepatitis (hcv) para uso en inmunoensayos para anticuerpos anti-hcv. |
Country Status (25)
Country | Link |
---|---|
EP (2) | EP0693687B2 (es) |
JP (1) | JP2733138B2 (es) |
KR (1) | KR100206150B1 (es) |
AT (2) | ATE182684T1 (es) |
BG (1) | BG61291B1 (es) |
BR (1) | BR9106309A (es) |
CY (1) | CY1881A (es) |
DE (2) | DE69131488T2 (es) |
DK (2) | DK0450931T3 (es) |
ES (2) | ES2134388T5 (es) |
FI (1) | FI106317B (es) |
GB (1) | GB2257784B (es) |
GR (2) | GR3020964T3 (es) |
HU (1) | HU217025B (es) |
IE (1) | IE911105A1 (es) |
IL (2) | IL97741A0 (es) |
LT (1) | LT3808B (es) |
LV (2) | LV10344B (es) |
MY (1) | MY107499A (es) |
NO (1) | NO310241B1 (es) |
PL (1) | PL172133B1 (es) |
RO (1) | RO109916B1 (es) |
RU (1) | RU2130969C1 (es) |
UA (1) | UA41266C2 (es) |
WO (1) | WO1991015771A1 (es) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7166287B1 (en) | 1989-12-18 | 2007-01-23 | Glaxo Wellcome Inc. | Viral agent |
LU87861A1 (fr) | 1989-12-18 | 1991-10-08 | Wellcome Found | Agent viral |
KR940000755B1 (ko) * | 1990-02-16 | 1994-01-29 | 유나이티드 바이오메디칼 인코오포레이티드 | Hcv에 대한 항체 검출, hcv 감염의 진단 및 백신으로서의 그 예방에 특히 적합한 합성 펩티드 |
US6194140B1 (en) * | 1990-04-04 | 2001-02-27 | Chiron Corporation | HCV NS3 protein fragments having helicase activity and improved solubility |
DE69132332T2 (de) * | 1990-04-06 | 2000-11-30 | Genelabs Tech Inc | Hepatitis c-virus-epitope |
CA2049679C (en) * | 1990-08-24 | 2005-06-21 | Sushil G. Devare | Hepatitis c assay utilizing recombinant antigens |
US6274148B1 (en) * | 1990-11-08 | 2001-08-14 | Chiron Corporation | Hepatitis C virus asialoglycoproteins |
RO115446B1 (ro) * | 1990-11-08 | 2000-02-28 | Chiron Corp | Procedeu de obtinere a asialoglicoproteinelor purificate provenind de la virusul hepatitei c |
US6007982A (en) * | 1990-12-14 | 1999-12-28 | Innogenetics N.V. | Synthetic antigens for the detection of antibodies to hepatitis C virus |
DK0644202T3 (da) * | 1990-12-14 | 1997-09-15 | Innogenetics Nv | Syntetiske antigener til påvisning af antistoffer imod hepatitis C virus |
US5910404A (en) | 1990-12-14 | 1999-06-08 | Innogenetics N.V. | Synthetic antigens for the detection of antibodies to hepatitis C virus |
DE4041304A1 (de) * | 1990-12-21 | 1992-06-25 | Mikrogen Molekularbiol Entw | Von strukturproteinen des hepatitis c-virus abgeleitete polypeptide, testkits, die diese polypeptide enthalten und impfstoffe gegen infektionen von hepatitis c-viren |
US5574132A (en) * | 1991-04-05 | 1996-11-12 | Biochem Immunosystems Inc. | Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV) |
CA2099883A1 (en) * | 1991-11-07 | 1993-05-08 | John A. Kink | Epitope mapping of the c33c region of hcv |
WO1993010239A2 (en) * | 1991-11-21 | 1993-05-27 | Common Services Agency | Hepatitis-c virus testing |
WO1993015207A2 (en) * | 1992-02-04 | 1993-08-05 | Viagene, Inc. | Hepatitis therapeutics |
GB9203803D0 (en) * | 1992-02-21 | 1992-04-08 | Wellcome Found | A recombinant polypeptide |
UA39944C2 (uk) * | 1992-07-07 | 2001-07-16 | Чірон Корпорейшн | Спосіб визначення ранньої сероконверсії у ссавця-хазяїна до вірусу гепатиту с і набір для використання в способі |
US6153378A (en) * | 1992-10-16 | 2000-11-28 | Bionova Corporation | Diagnosis of, and vaccination against, a positive stranded RNA virus using an isolated, unprocessed polypeptide encoded by a substantially complete genome of such virus |
EP0593291A3 (en) * | 1992-10-16 | 1995-03-15 | Evernew Biotech Inc | Non-structural protein of the hepatitis C virus, as well as diagnostic procedure and test kit. |
JP2778886B2 (ja) * | 1992-10-16 | 1998-07-23 | エバーニュー バイオテック インコーポレイティド | C型肝炎ウィルスのコア抗原タンパク質及びそれを用いての診断方法及びキット |
WO1994013164A1 (en) | 1992-12-10 | 1994-06-23 | Nike International Ltd. | Bonding of rubber to plastic in footwear |
UA46707C2 (uk) | 1993-05-10 | 2002-06-17 | Чірон Корпорейшн | Спосіб типування вірусу гепатиту с (варіанти), набір поліпептидів (варіанти), реагент, що включає комбінацію поліпептидів, які містять типоспецифічні епітопи гепатиту с (варіанти) |
DE4428705A1 (de) * | 1994-08-12 | 1996-02-15 | Boehringer Mannheim Gmbh | Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus |
JPH0862219A (ja) * | 1994-08-19 | 1996-03-08 | Dainabotsuto Kk | 還元型抗原に対する抗体アッセイ試薬及びそれを使用した測定方法 |
JP3665371B2 (ja) * | 1994-08-31 | 2005-06-29 | 株式会社先端生命科学研究所 | C型肝炎ウイルス感染又はグループ判定のためのエピトープキメラ抗原ペプチド、その製法、及びそれを使用する感染又はグループ判定法 |
CA2172305A1 (en) * | 1995-03-30 | 1996-10-01 | Muneo Aoyama | Multiple antigenic peptide comprising at least two hepatitis c virus-associated peptides |
WO1996037606A1 (en) * | 1995-05-22 | 1996-11-28 | Bionova Corporation | Compositions and methods for the diagnosis of, and vaccination against, hepatitis c virus (hcv) |
FR2734639B1 (fr) * | 1995-05-26 | 1997-10-03 | Parteurop | Methode de pronostic de l'evolution d'une infection par le virus de l'hepatite c, et necessaire pour sa mise en oeuvre |
FR2737209B1 (fr) | 1995-07-25 | 1997-09-19 | Bio Merieux | Peptide capable d'etre reconnu par des anticorps reconnaissant l'antigene c33 du virus de l'hepatite c |
US6127116A (en) | 1995-08-29 | 2000-10-03 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
JP3715027B2 (ja) | 1996-05-07 | 2005-11-09 | シスメックス株式会社 | C型肝炎ウイルス感染症診断薬 |
US7338759B1 (en) | 1997-03-04 | 2008-03-04 | Washington University | HCV variants |
US7049428B1 (en) | 1998-03-04 | 2006-05-23 | Washington University | HCV variants |
PT1021719E (pt) * | 1997-09-22 | 2007-03-30 | Novartis Vaccines & Diagnostic | Método para detecção de anticorpos numa amostra |
AU6098900A (en) * | 1999-07-15 | 2001-02-05 | Bayer Corporation | The use of specific antibody titers to predict hepatic failure in people infected with hepatitis c virus |
WO2001030812A2 (en) * | 1999-10-27 | 2001-05-03 | Chiron Corporation | Activation of hcv-specific t cells |
CA2390082C (en) * | 1999-11-24 | 2010-06-29 | Chiron Corporation | Novel hcv non-structural polypeptide |
US6986892B1 (en) | 1999-11-24 | 2006-01-17 | Chiron Corporation | Immunogenic Hepatitis C virus non-structural polypeptides |
ATE368221T1 (de) | 2000-06-15 | 2007-08-15 | Novartis Vaccines & Diagnostic | Immunoassays für anti-hcv-antikörper |
US7491808B2 (en) | 2000-06-15 | 2009-02-17 | Novartis Vaccines And Diagnostics, Inc. | HCV non-structural protein mutants and uses thereof |
US6680059B2 (en) | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
AU9215101A (en) | 2000-08-17 | 2002-02-25 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
US6858590B2 (en) | 2000-08-17 | 2005-02-22 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
FR2839722A1 (fr) | 2002-05-17 | 2003-11-21 | Bio Merieux | Nouvelles compositions peptidiques et leur utilisation notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l'hepatite c |
JP4585314B2 (ja) | 2002-09-09 | 2010-11-24 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | Hcvアッセイ |
JP4864891B2 (ja) | 2004-06-09 | 2012-02-01 | パサジャン リムーヴァル アンド ダイアグナスティック テクノロジーズ インコーポレイテッド | サンプルから標的因子を除去するためのデバイス及び方法 |
JP2005274584A (ja) * | 2005-05-25 | 2005-10-06 | Sysmex Corp | C型肝炎ウイルス感染症診断薬の製造方法 |
JP4005093B2 (ja) * | 2005-05-25 | 2007-11-07 | シスメックス株式会社 | C型肝炎ウイルス感染症診断薬および抗hcv抗体検出方法 |
US7968697B2 (en) | 2005-05-25 | 2011-06-28 | Chrontech Pharma Ab | Hepatitis C virus non-structural NS3/4A fusion gene |
JP5188400B2 (ja) * | 2006-03-09 | 2013-04-24 | トランスジーン エス.エー. | C型肝炎ウイルスの非構造融合タンパク質 |
US20080227111A1 (en) | 2007-03-16 | 2008-09-18 | Sysmex Corporation | Reagent kit and method for measuring hcv antibody |
WO2009022236A2 (en) | 2007-08-16 | 2009-02-19 | Tripep Ab | Immunogen platform |
US20090214593A1 (en) | 2007-08-16 | 2009-08-27 | Tripep Ab | Immunogen platform |
FR2984328B1 (fr) | 2011-12-20 | 2016-12-30 | Bio-Rad Innovations | Procede de detection d'une infection par le virus de l'hepatite c |
WO2016069762A2 (en) * | 2014-10-29 | 2016-05-06 | Abbott Laboratories | Subject anti-hcv antibody detection assays employing ns3 capture peptides |
JP2018124277A (ja) * | 2017-02-02 | 2018-08-09 | 三洋化成工業株式会社 | 粒子含有組成物、免疫測定用試薬、免疫測定方法及び粒子の保存方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US456637A (en) | 1891-07-28 | Fence | ||
US390599A (en) | 1888-10-02 | Tool for weaver s use | ||
SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
US4870008A (en) * | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
CA1341482C (en) † | 1984-10-31 | 2005-05-10 | Paul A. Luciw | Process for preparing fragments of aids-associated retroviruses |
US4751180A (en) * | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
JPH02500880A (ja) * | 1987-11-18 | 1990-03-29 | カイロン コーポレイション | Nanbvの診断用薬およびワクチン |
JP2656995B2 (ja) † | 1989-03-17 | 1997-09-24 | カイロン コーポレイション | Nanbvの診断用薬 |
LU87861A1 (fr) * | 1989-12-18 | 1991-10-08 | Wellcome Found | Agent viral |
AU638304B2 (en) † | 1989-12-22 | 1993-06-24 | Abbott Laboratories | Hepatitis c assay |
-
1991
- 1991-03-29 RO RO92-01275A patent/RO109916B1/ro unknown
- 1991-03-29 KR KR1019920702437A patent/KR100206150B1/ko not_active IP Right Cessation
- 1991-03-29 UA UA93004190A patent/UA41266C2/uk unknown
- 1991-03-29 BR BR919106309A patent/BR9106309A/pt not_active IP Right Cessation
- 1991-03-29 PL PL91296329A patent/PL172133B1/pl unknown
- 1991-03-29 RU SU5053084A patent/RU2130969C1/ru active
- 1991-03-29 WO PCT/US1991/002225 patent/WO1991015771A1/en active IP Right Grant
- 1991-03-29 HU HU9203146A patent/HU217025B/hu unknown
- 1991-03-29 JP JP3507636A patent/JP2733138B2/ja not_active Expired - Lifetime
- 1991-04-01 IL IL97741A patent/IL97741A0/xx not_active IP Right Cessation
- 1991-04-01 IL IL170719A patent/IL170719A/en not_active IP Right Cessation
- 1991-04-02 MY MYPI91000551A patent/MY107499A/en unknown
- 1991-04-03 EP EP95114016A patent/EP0693687B2/en not_active Expired - Lifetime
- 1991-04-03 AT AT95114016T patent/ATE182684T1/de not_active IP Right Cessation
- 1991-04-03 IE IE110591A patent/IE911105A1/en unknown
- 1991-04-03 DK DK91302910.4T patent/DK0450931T3/da active
- 1991-04-03 DK DK95114016T patent/DK0693687T4/da active
- 1991-04-03 AT AT91302910T patent/ATE139343T1/de not_active IP Right Cessation
- 1991-04-03 DE DE69131488T patent/DE69131488T2/de not_active Expired - Lifetime
- 1991-04-03 ES ES95114016T patent/ES2134388T5/es not_active Expired - Lifetime
- 1991-04-03 ES ES91302910T patent/ES2088465T3/es not_active Expired - Lifetime
- 1991-04-03 EP EP91302910A patent/EP0450931B1/en not_active Expired - Lifetime
- 1991-04-03 DE DE69120138T patent/DE69120138T2/de not_active Expired - Lifetime
-
1992
- 1992-09-28 GB GB9220480A patent/GB2257784B/en not_active Expired - Lifetime
- 1992-09-28 FI FI924349A patent/FI106317B/fi active
- 1992-10-01 NO NO19923839A patent/NO310241B1/no not_active IP Right Cessation
- 1992-10-02 BG BG96943A patent/BG61291B1/bg unknown
-
1993
- 1993-05-31 LV LVP-93-438.1A patent/LV10344B/en unknown
- 1993-05-31 LV LV930038D patent/LV10344A/en unknown
- 1993-12-30 LT LTIP1747A patent/LT3808B/lt not_active IP Right Cessation
-
1996
- 1996-04-05 CY CY188196A patent/CY1881A/xx unknown
- 1996-09-05 GR GR960402319T patent/GR3020964T3/el unknown
-
1999
- 1999-09-29 GR GR990402455T patent/GR3031361T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2134388T3 (es) | Combinaciones de antigenos del virus de la hepatitis c (hcv) para su uso en inmunoensayos para anticuerpos anti-hcv. | |
NO934542D0 (no) | Hepatitt C virus (HCV) polypeptider | |
BRPI0111682B8 (pt) | suporte sólido de imunoensaio, kit de teste de imunodiagnóstico, métodos de produção de um suporte sólido de imunoensaio, e de detecção de infecção pelo vírus da hepatite c (hcv) em uma amostra biológica, e, uso de um suporte sólido de imunoensaio | |
ES2171414T3 (es) | Inmunoensayos para anticuerpos anti-hcv utilizando antigenos con epitopos conformacionales. | |
FI942369A (fi) | Hepatitis-C-virustesti | |
DK1002092T3 (da) | Mimotoper af hypervariabel region 1 af E2-glycoproteinet fra HCV og anvendelser deraf | |
PT97247A (pt) | Processo de preparacao de combinacoes de antigenios do virus da hepapite c (hcv) para uso em imunoensaios para anticorpos anti-hcv | |
DK0599913T3 (da) | Monoklonale antistoffer mod formodet hepatitis C-virus NS5-proteiner og anvendelsesmetoder af samme | |
TH11517EX (th) | การใช้แอนติเจนชนิดต่างๆของไวรัสตับอักเสบซี (hcv) ร่วมกัน เพื่อใช้ในการวิเคราะห์ทางอิมมูนสำหรับแอนติ - hcv แอนติบอดี |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 693687 Country of ref document: ES |