DE69131488T2 - Kombinationen der Hepatitis-C-Virus (HCV) Antigene zur Verwendung in Immuntests für Anti-HCV-Antikörper - Google Patents

Kombinationen der Hepatitis-C-Virus (HCV) Antigene zur Verwendung in Immuntests für Anti-HCV-Antikörper

Info

Publication number
DE69131488T2
DE69131488T2 DE69131488T DE69131488T DE69131488T2 DE 69131488 T2 DE69131488 T2 DE 69131488T2 DE 69131488 T DE69131488 T DE 69131488T DE 69131488 T DE69131488 T DE 69131488T DE 69131488 T2 DE69131488 T2 DE 69131488T2
Authority
DE
Germany
Prior art keywords
hcv
domain
combinations
antigens
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69131488T
Other languages
English (en)
Other versions
DE69131488D1 (de
Inventor
Michael Houghton
Qui-Lim Choo
George Kuo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24005897&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69131488(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of DE69131488D1 publication Critical patent/DE69131488D1/de
Publication of DE69131488T2 publication Critical patent/DE69131488T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Thermistors And Varistors (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69131488T 1990-04-04 1991-04-03 Kombinationen der Hepatitis-C-Virus (HCV) Antigene zur Verwendung in Immuntests für Anti-HCV-Antikörper Expired - Lifetime DE69131488T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50435290A 1990-04-04 1990-04-04

Publications (2)

Publication Number Publication Date
DE69131488D1 DE69131488D1 (de) 1999-09-02
DE69131488T2 true DE69131488T2 (de) 1999-11-18

Family

ID=24005897

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69131488T Expired - Lifetime DE69131488T2 (de) 1990-04-04 1991-04-03 Kombinationen der Hepatitis-C-Virus (HCV) Antigene zur Verwendung in Immuntests für Anti-HCV-Antikörper
DE69120138T Expired - Lifetime DE69120138T2 (de) 1990-04-04 1991-04-03 Kombinationen Hepatitis-C-Virus(HCV)-Antigene zur Anwendung in Immunoassays für Anti-HCV-Antikörper

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69120138T Expired - Lifetime DE69120138T2 (de) 1990-04-04 1991-04-03 Kombinationen Hepatitis-C-Virus(HCV)-Antigene zur Anwendung in Immunoassays für Anti-HCV-Antikörper

Country Status (25)

Country Link
EP (2) EP0693687B2 (de)
JP (1) JP2733138B2 (de)
KR (1) KR100206150B1 (de)
AT (2) ATE182684T1 (de)
BG (1) BG61291B1 (de)
BR (1) BR9106309A (de)
CY (1) CY1881A (de)
DE (2) DE69131488T2 (de)
DK (2) DK0450931T3 (de)
ES (2) ES2134388T5 (de)
FI (1) FI106317B (de)
GB (1) GB2257784B (de)
GR (2) GR3020964T3 (de)
HU (1) HU217025B (de)
IE (1) IE911105A1 (de)
IL (2) IL97741A0 (de)
LT (1) LT3808B (de)
LV (2) LV10344B (de)
MY (1) MY107499A (de)
NO (1) NO310241B1 (de)
PL (1) PL172133B1 (de)
RO (1) RO109916B1 (de)
RU (1) RU2130969C1 (de)
UA (1) UA41266C2 (de)
WO (1) WO1991015771A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166287B1 (en) 1989-12-18 2007-01-23 Glaxo Wellcome Inc. Viral agent
LU87861A1 (fr) 1989-12-18 1991-10-08 Wellcome Found Agent viral
KR940000755B1 (ko) * 1990-02-16 1994-01-29 유나이티드 바이오메디칼 인코오포레이티드 Hcv에 대한 항체 검출, hcv 감염의 진단 및 백신으로서의 그 예방에 특히 적합한 합성 펩티드
US6194140B1 (en) * 1990-04-04 2001-02-27 Chiron Corporation HCV NS3 protein fragments having helicase activity and improved solubility
DE69132332T2 (de) * 1990-04-06 2000-11-30 Genelabs Tech Inc Hepatitis c-virus-epitope
CA2049679C (en) * 1990-08-24 2005-06-21 Sushil G. Devare Hepatitis c assay utilizing recombinant antigens
US6274148B1 (en) * 1990-11-08 2001-08-14 Chiron Corporation Hepatitis C virus asialoglycoproteins
RO115446B1 (ro) * 1990-11-08 2000-02-28 Chiron Corp Procedeu de obtinere a asialoglicoproteinelor purificate provenind de la virusul hepatitei c
US6007982A (en) * 1990-12-14 1999-12-28 Innogenetics N.V. Synthetic antigens for the detection of antibodies to hepatitis C virus
DK0644202T3 (da) * 1990-12-14 1997-09-15 Innogenetics Nv Syntetiske antigener til påvisning af antistoffer imod hepatitis C virus
US5910404A (en) 1990-12-14 1999-06-08 Innogenetics N.V. Synthetic antigens for the detection of antibodies to hepatitis C virus
DE4041304A1 (de) * 1990-12-21 1992-06-25 Mikrogen Molekularbiol Entw Von strukturproteinen des hepatitis c-virus abgeleitete polypeptide, testkits, die diese polypeptide enthalten und impfstoffe gegen infektionen von hepatitis c-viren
US5574132A (en) * 1991-04-05 1996-11-12 Biochem Immunosystems Inc. Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV)
CA2099883A1 (en) * 1991-11-07 1993-05-08 John A. Kink Epitope mapping of the c33c region of hcv
WO1993010239A2 (en) * 1991-11-21 1993-05-27 Common Services Agency Hepatitis-c virus testing
WO1993015207A2 (en) * 1992-02-04 1993-08-05 Viagene, Inc. Hepatitis therapeutics
GB9203803D0 (en) * 1992-02-21 1992-04-08 Wellcome Found A recombinant polypeptide
UA39944C2 (uk) * 1992-07-07 2001-07-16 Чірон Корпорейшн Спосіб визначення ранньої сероконверсії у ссавця-хазяїна до вірусу гепатиту с і набір для використання в способі
US6153378A (en) * 1992-10-16 2000-11-28 Bionova Corporation Diagnosis of, and vaccination against, a positive stranded RNA virus using an isolated, unprocessed polypeptide encoded by a substantially complete genome of such virus
EP0593291A3 (de) * 1992-10-16 1995-03-15 Evernew Biotech Inc Nichtstrukturales Protein des Hepatitis C-Virus, sowie diagnostisches Verfahren und Testsatz.
JP2778886B2 (ja) * 1992-10-16 1998-07-23 エバーニュー バイオテック インコーポレイティド Ｃ型肝炎ウィルスのコア抗原タンパク質及びそれを用いての診断方法及びキット
WO1994013164A1 (en) 1992-12-10 1994-06-23 Nike International Ltd. Bonding of rubber to plastic in footwear
UA46707C2 (uk) 1993-05-10 2002-06-17 Чірон Корпорейшн Спосіб типування вірусу гепатиту с (варіанти), набір поліпептидів (варіанти), реагент, що включає комбінацію поліпептидів, які містять типоспецифічні епітопи гепатиту с (варіанти)
DE4428705A1 (de) * 1994-08-12 1996-02-15 Boehringer Mannheim Gmbh Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus
JPH0862219A (ja) * 1994-08-19 1996-03-08 Dainabotsuto Kk 還元型抗原に対する抗体アッセイ試薬及びそれを使用した測定方法
JP3665371B2 (ja) * 1994-08-31 2005-06-29 株式会社先端生命科学研究所 Ｃ型肝炎ウイルス感染又はグループ判定のためのエピトープキメラ抗原ペプチド、その製法、及びそれを使用する感染又はグループ判定法
CA2172305A1 (en) * 1995-03-30 1996-10-01 Muneo Aoyama Multiple antigenic peptide comprising at least two hepatitis c virus-associated peptides
WO1996037606A1 (en) * 1995-05-22 1996-11-28 Bionova Corporation Compositions and methods for the diagnosis of, and vaccination against, hepatitis c virus (hcv)
FR2734639B1 (fr) * 1995-05-26 1997-10-03 Parteurop Methode de pronostic de l'evolution d'une infection par le virus de l'hepatite c, et necessaire pour sa mise en oeuvre
FR2737209B1 (fr) 1995-07-25 1997-09-19 Bio Merieux Peptide capable d'etre reconnu par des anticorps reconnaissant l'antigene c33 du virus de l'hepatite c
US6127116A (en) 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
JP3715027B2 (ja) 1996-05-07 2005-11-09 シスメックス株式会社 Ｃ型肝炎ウイルス感染症診断薬
US7338759B1 (en) 1997-03-04 2008-03-04 Washington University HCV variants
US7049428B1 (en) 1998-03-04 2006-05-23 Washington University HCV variants
PT1021719E (pt) * 1997-09-22 2007-03-30 Novartis Vaccines & Diagnostic Método para detecção de anticorpos numa amostra
AU6098900A (en) * 1999-07-15 2001-02-05 Bayer Corporation The use of specific antibody titers to predict hepatic failure in people infected with hepatitis c virus
WO2001030812A2 (en) * 1999-10-27 2001-05-03 Chiron Corporation Activation of hcv-specific t cells
CA2390082C (en) * 1999-11-24 2010-06-29 Chiron Corporation Novel hcv non-structural polypeptide
US6986892B1 (en) 1999-11-24 2006-01-17 Chiron Corporation Immunogenic Hepatitis C virus non-structural polypeptides
ATE368221T1 (de) 2000-06-15 2007-08-15 Novartis Vaccines & Diagnostic Immunoassays für anti-hcv-antikörper
US7491808B2 (en) 2000-06-15 2009-02-17 Novartis Vaccines And Diagnostics, Inc. HCV non-structural protein mutants and uses thereof
US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
AU9215101A (en) 2000-08-17 2002-02-25 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US6858590B2 (en) 2000-08-17 2005-02-22 Tripep Ab Vaccines containing ribavirin and methods of use thereof
FR2839722A1 (fr) 2002-05-17 2003-11-21 Bio Merieux Nouvelles compositions peptidiques et leur utilisation notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l'hepatite c
JP4585314B2 (ja) 2002-09-09 2010-11-24 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Ｈｃｖアッセイ
JP4864891B2 (ja) 2004-06-09 2012-02-01 パサジャン リムーヴァル アンド ダイアグナスティック テクノロジーズ インコーポレイテッド サンプルから標的因子を除去するためのデバイス及び方法
JP2005274584A (ja) * 2005-05-25 2005-10-06 Sysmex Corp Ｃ型肝炎ウイルス感染症診断薬の製造方法
JP4005093B2 (ja) * 2005-05-25 2007-11-07 シスメックス株式会社 Ｃ型肝炎ウイルス感染症診断薬および抗ｈｃｖ抗体検出方法
US7968697B2 (en) 2005-05-25 2011-06-28 Chrontech Pharma Ab Hepatitis C virus non-structural NS3/4A fusion gene
JP5188400B2 (ja) * 2006-03-09 2013-04-24 トランスジーン エス．エー． Ｃ型肝炎ウイルスの非構造融合タンパク質
US20080227111A1 (en) 2007-03-16 2008-09-18 Sysmex Corporation Reagent kit and method for measuring hcv antibody
WO2009022236A2 (en) 2007-08-16 2009-02-19 Tripep Ab Immunogen platform
US20090214593A1 (en) 2007-08-16 2009-08-27 Tripep Ab Immunogen platform
FR2984328B1 (fr) 2011-12-20 2016-12-30 Bio-Rad Innovations Procede de detection d'une infection par le virus de l'hepatite c
WO2016069762A2 (en) * 2014-10-29 2016-05-06 Abbott Laboratories Subject anti-hcv antibody detection assays employing ns3 capture peptides
JP2018124277A (ja) * 2017-02-02 2018-08-09 三洋化成工業株式会社 粒子含有組成物、免疫測定用試薬、免疫測定方法及び粒子の保存方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US456637A (en) 1891-07-28 Fence
US390599A (en) 1888-10-02 Tool for weaver s use
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4870008A (en) * 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
CA1341482C (en) † 1984-10-31 2005-05-10 Paul A. Luciw Process for preparing fragments of aids-associated retroviruses
US4751180A (en) * 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
JPH02500880A (ja) * 1987-11-18 1990-03-29 カイロン　コーポレイション Ｎａｎｂｖの診断用薬およびワクチン
JP2656995B2 (ja) † 1989-03-17 1997-09-24 カイロン コーポレイション Ｎａｎｂｖの診断用薬
LU87861A1 (fr) * 1989-12-18 1991-10-08 Wellcome Found Agent viral
AU638304B2 (en) † 1989-12-22 1993-06-24 Abbott Laboratories Hepatitis c assay

Also Published As

Publication number Publication date
BR9106309A (pt) 1993-04-20
NO923839L (no) 1992-11-19
HU217025B (hu) 1999-11-29
DK0693687T3 (da) 1999-11-29
NO310241B1 (no) 2001-06-11
LT3808B (en) 1996-03-25
ES2134388T3 (es) 1999-10-01
ES2134388T5 (es) 2008-12-01
AU639560B2 (en) 1993-07-29
UA41266C2 (uk) 2001-09-17
MY107499A (en) 1995-12-30
KR100206150B1 (ko) 1999-07-01
DK0450931T3 (da) 1996-07-01
LTIP1747A (en) 1995-07-25
LV10344B (en) 1996-02-20
DK0693687T4 (da) 2008-09-22
BG61291B1 (en) 1997-04-30
ES2088465T3 (es) 1996-08-16
PL172133B1 (pl) 1997-08-29
ATE139343T1 (de) 1996-06-15
IL170719A (en) 2011-04-28
DE69120138T2 (de) 1996-11-14
FI924349A (fi) 1992-09-28
FI924349A0 (fi) 1992-09-28
EP0450931B1 (de) 1996-06-12
IE911105A1 (en) 1991-10-09
EP0693687A1 (de) 1996-01-24
NO923839D0 (no) 1992-10-01
DE69120138D1 (de) 1996-07-18
DE69131488D1 (de) 1999-09-02
ATE182684T1 (de) 1999-08-15
GR3020964T3 (en) 1996-12-31
EP0693687B1 (de) 1999-07-28
RU2130969C1 (ru) 1999-05-27
IL97741A0 (en) 1992-06-21
RO109916B1 (ro) 1995-07-28
EP0693687B2 (de) 2008-06-04
EP0450931A1 (de) 1991-10-09
GR3031361T3 (en) 2000-01-31
AU7651091A (en) 1991-10-30
LV10344A (en) 1994-10-20
CY1881A (en) 1996-04-05
FI106317B (fi) 2001-01-15
GB2257784A (en) 1993-01-20
WO1991015771A1 (en) 1991-10-17
GB2257784B (en) 1995-01-04
HUT62706A (en) 1993-05-28
HU9203146D0 (en) 1992-12-28
GB9220480D0 (en) 1992-11-25
JPH05508219A (ja) 1993-11-18
JP2733138B2 (ja) 1998-03-30

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Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US