ES2125222T3 - Procedimiento de produccion de biopolimeros a base de poliesteres. - Google Patents

Procedimiento de produccion de biopolimeros a base de poliesteres.

Info

Publication number
ES2125222T3
ES2125222T3 ES90911355T ES90911355T ES2125222T3 ES 2125222 T3 ES2125222 T3 ES 2125222T3 ES 90911355 T ES90911355 T ES 90911355T ES 90911355 T ES90911355 T ES 90911355T ES 2125222 T3 ES2125222 T3 ES 2125222T3
Authority
ES
Spain
Prior art keywords
phb
polymers
pha
polymerase
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90911355T
Other languages
English (en)
Inventor
Oliver P Peoples
Anthony J Sinskey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23491962&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2125222(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of ES2125222T3 publication Critical patent/ES2125222T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids

Landscapes

  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

UN METODO PARA CONTROLAR Y MODIFICAR LA SINTESIS DE BIOPOLIMERO MEDIANTE MANIPULACION GENETICA Y ENCIMOLOGIA DE SINTESIS DEL POLIHIDROXIBUTIRATO (PHB) Y POLIESTERES POLIHIDROXIALCANOATOS (PHA) EN EL NIVEL MOLECULAR EN CELULAS PROCARIOTICAS Y ENCARIOTICAS, ESPECIALMENTE PLANTAS. EJEMPLOS DEMUESTRAN EL AISLAMIENTO, CARACTERIZACION, Y EXPRESION DE LOS GENES INVOLUCRADOS EN LA PRODUCCION DE POLIMEROS PHB Y PHA. GENES CODIFICANDO LAS ENCIMAS EN EL PASO SINTETICO PHB Y PHA (BETA-CETOTIDASA-ACETOACETIL -COA REDUCTASA Y POLIERASA PHB O POLIERASA PHA) DE CEPA 1-16-M, "ZOOGLEA RAMIGERA", "ALCALIGENES ENTROPHUS", "NORCARDIA SALMONICOLUR", Y "PSENDOMAS OLEOVARAUS" FUERON IDENTIFICADOS O AISLADOS Y EXPRESADOS EN UN ORGANISMO PRODUCTOR DE NO-PHB, "E. COLI". MODIFICACIONES ESPECIFICAS A LOS POLIMEROS INCLUYEN VARIACION EN LA LONGITUD DE LA CADENA DE LOS POLIMEROS E INCORPORACION DE DIFERENTES MONOMEROS EN LOS POLIMEROS PARA PRODUCIR CO-POLIMEROS CON DIFERENTES PROPIEDADES FISICAS.
ES90911355T 1989-07-10 1990-07-10 Procedimiento de produccion de biopolimeros a base de poliesteres. Expired - Lifetime ES2125222T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37815589A 1989-07-10 1989-07-10

Publications (1)

Publication Number Publication Date
ES2125222T3 true ES2125222T3 (es) 1999-03-01

Family

ID=23491962

Family Applications (2)

Application Number Title Priority Date Filing Date
ES90911355T Expired - Lifetime ES2125222T3 (es) 1989-07-10 1990-07-10 Procedimiento de produccion de biopolimeros a base de poliesteres.
ES97203215T Expired - Lifetime ES2131489T3 (es) 1989-07-10 1990-07-10 Una planta o una celula vegetal recombinante capaz de producir polihidroxibutirato u otro polihidroxialcanoato.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES97203215T Expired - Lifetime ES2131489T3 (es) 1989-07-10 1990-07-10 Una planta o una celula vegetal recombinante capaz de producir polihidroxibutirato u otro polihidroxialcanoato.

Country Status (8)

Country Link
EP (2) EP0482077B1 (es)
JP (8) JPH05500751A (es)
AT (2) ATE227340T1 (es)
CA (1) CA2062816C (es)
DE (3) DE69034017T2 (es)
DK (1) DK0482077T3 (es)
ES (2) ES2125222T3 (es)
WO (1) WO1991000917A1 (es)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480794A (en) * 1987-06-29 1996-01-02 Massachusetts Institute Of Technology And Metabolix, Inc. Overproduction and purification of soluble PHA synthase
GB9108756D0 (en) * 1991-04-24 1991-06-12 Ici Plc Production of polyalkanoate in plants
GB9115245D0 (en) * 1991-07-16 1991-08-28 Ici Plc Production of polyalkanoate
JP3696233B2 (ja) * 1991-07-19 2005-09-14 ミシガン、ステート、ユニバーシティー ポリヒドロキシアルカノエートを生産するトランスジェニック植物
US5610041A (en) * 1991-07-19 1997-03-11 Board Of Trustees Operating Michigan State University Processes for producing polyhydroxybutyrate and related polyhydroxyalkanoates in the plastids of higher plants
US5569595A (en) * 1991-09-27 1996-10-29 Center For Innovative Technology Production of poly-β-hydroxybutyrate in prokaryotic host cells
GB9223332D0 (en) * 1992-11-06 1992-12-23 Ici Plc Production of polyhydroxyalkanoate in plants
AU5676394A (en) * 1992-11-20 1994-06-22 Agracetus, Inc. Transgenic cotton plants producing heterologous bioplastic
WO1995021257A1 (en) * 1994-02-03 1995-08-10 Center For Innovative Technology Improved production of poly-beta-hydroxyalkanoates in transformed prokaryotic hosts
WO1995033065A1 (en) * 1994-06-01 1995-12-07 The Procter & Gamble Company Process for recovering polyhydroxyalkanoates using centrifugal fractionation
CN1079835C (zh) * 1994-06-01 2002-02-27 普罗克特和甘保尔公司 利用空气分级作用回收聚羟基链烷酸酯的方法
US6083729A (en) * 1995-10-26 2000-07-04 Metabolix, Inc. Methods for isolating polyhydroxyalkanoates from plants
US6600029B1 (en) 1995-12-19 2003-07-29 Regents Of The University Of Minnesota Metabolic engineering of polyhydroxyalkanoate monomer synthases
GB9605704D0 (en) * 1996-03-19 1996-05-22 Zeneca Ltd Microorganisms and processes using them
US6060241A (en) * 1996-04-05 2000-05-09 Kieta Holding Sa Compositions and methods relating to drug discovery and detection and treatment of gastrointestinal diseases
US5811272A (en) * 1996-07-26 1998-09-22 Massachusetts Institute Of Technology Method for controlling molecular weight of polyhydroxyalkanoates
JP3062459B2 (ja) * 1996-08-14 2000-07-10 理化学研究所 ポリエステル重合酵素遺伝子及びポリエステルの製造方法
US6117658A (en) * 1997-02-13 2000-09-12 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units
US6391611B1 (en) 1997-04-01 2002-05-21 Japan Science And Technology Corporation Polyester synthase and a gene coding for the same
JPH10276781A (ja) * 1997-04-01 1998-10-20 Rikagaku Kenkyusho ポリエステル重合酵素及び該酵素をコードする遺伝子
EP0881293A1 (en) * 1997-05-28 1998-12-02 Eidgenössische Technische Hochschule Zürich Institut für Biotechnologie Production of medium chain length poly-3-hydroxy alkanoates in Escherichia coli, and monomers derived therefrom
EP1015565B1 (en) 1997-09-19 2006-04-12 Metabolix, Inc. Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids
EP1044278A1 (en) * 1998-01-05 2000-10-18 Monsanto Company Biosynthesis of medium chain length polyhydroxyalkanoates
WO1999034687A1 (en) 1998-01-07 1999-07-15 Metabolix, Inc. Animal nutrition compositions
US6586658B1 (en) 1998-03-06 2003-07-01 Metabolix, Inc. Modification of fatty acid metabolism in plants
US6143952A (en) * 1998-03-31 2000-11-07 Regents Of The University Of Minnesota Modified pseudomonas oleovorans phaC1 nucleic acids encoding bispecific polyhydroxyalkanoate polymerase
US6103956A (en) * 1998-03-31 2000-08-15 Regents Of The University Of Minnesota Polyhydroxyalkanoate synthesis in plants
ATE458822T1 (de) 1998-04-08 2010-03-15 Metabolix Inc Verfahren für die trennung und reinigung von biopolymeren
EP2267133B1 (en) * 1998-05-22 2017-07-12 CJ Research Center LLC Method for making poly(3-hydroxyproprionate)
EP1100928B1 (en) * 1998-07-30 2006-02-01 Metabolix, Inc. Bifunctional enzymes for biopolymer production
AU5247999A (en) * 1998-07-30 2000-02-21 Metabolix, Inc. Production of block copolymers of polyhydroxyalkanoates in biological systems
US6329183B1 (en) 1998-08-04 2001-12-11 Metabolix, Inc. Polyhydroxyalkanoate production from polyols
JP4623829B2 (ja) * 1998-08-18 2011-02-02 メタボリックス，インコーポレイテッド トランスジェニック微生物のポリヒドロキシアルカノエート産生
WO2000052183A1 (en) * 1999-03-05 2000-09-08 Monsanto Technology Llc Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways
WO2001059091A2 (en) 2000-02-11 2001-08-16 Metabolix, Inc. Multi-gene expression constructs containing modified inteins
JP3848048B2 (ja) * 2000-03-30 2006-11-22 キヤノン株式会社 ポリヒドロキシアルカノエート合成酵素及び該酵素をコードする遺伝子
US6803220B2 (en) 2000-03-30 2004-10-12 Canon Kabushiki Kaisha Polyhydroxyalkanoate synthase and gene encoding the same enzyme
US6808910B2 (en) 2000-03-30 2004-10-26 Canon Kabushiki Kaisha Polyhydroxyalkanoate synthase and gene encoding the same enzyme
JP3848047B2 (ja) * 2000-03-30 2006-11-22 キヤノン株式会社 ポリヒドロキシアルカノエート合成酵素及び該酵素をコードする遺伝子
US6875596B2 (en) 2000-03-30 2005-04-05 Canon Kabushiki Kaisha Polyhydroxyalkanoate synthase and gene encoding the same enzyme
US6812013B2 (en) 2000-03-30 2004-11-02 Canon Kabushiki Kaisha Polyhydroxyalkanoate synthase and gene encoding the same
US6803219B2 (en) 2000-03-30 2004-10-12 Canon Kabushiki Kaisha Polyhydroxyalkanoate synthase and gene encoding the same enzyme
JP3848046B2 (ja) * 2000-03-30 2006-11-22 キヤノン株式会社 ポリヒドロキシアルカノエート合成酵素及び該酵素をコードする遺伝子
JP4024676B2 (ja) 2000-11-17 2007-12-19 メタボリックス，インコーポレイテッド 脂肪酸生合成経路からの中間鎖長のポリヒドロキシアルカノエートの産生
US6808907B2 (en) 2001-03-27 2004-10-26 Canon Kabushiki Kaisha Method and apparatus for producing polyhydroxyalkanoate
CA2600882C (en) 2005-03-16 2013-02-26 Metabolix, Inc. Chemically inducible expression of biosynthetic pathways
EP2137315B1 (en) 2007-03-16 2014-09-03 Genomatica, Inc. Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
WO2010030711A2 (en) 2008-09-10 2010-03-18 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
CA2754261A1 (en) 2009-03-05 2010-09-10 Metabolix, Inc. Stable, fertile, high polyhydroxyalkanoate producing plants and methods of producing them
AU2010221135A1 (en) 2009-03-05 2011-09-29 Metabolix, Inc. Propagation of transgenic plants
MY195387A (en) 2009-06-04 2023-01-18 Genomatica Inc Microorganisms for the Production of 1,4-Butanediol and Related Methods
CA2773703A1 (en) 2009-09-15 2011-03-24 Metabolix, Inc. Generation of high polyhydroxybutrate producing oilseeds
EP2495305A1 (en) 2009-10-30 2012-09-05 Daicel Corporation Transgenic microorganism provided with the ability to produce 1,3-butanediol, and usage therefor
US8530210B2 (en) 2009-11-25 2013-09-10 Genomatica, Inc. Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
CA2788596A1 (en) 2010-02-11 2011-08-18 Metabolix, Inc. Process for producing a monomer component from a genetically modified polyhydroxyalkanoate biomass
PL2770836T3 (pl) 2011-10-25 2018-12-31 Marrone Bio Innovations, Inc. Frormulacje, kompozycje i metabolity z Chromobacterium i ich zastsowanie
US11932845B2 (en) 2012-06-04 2024-03-19 Genomatica, Inc. Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
IT201800003441A1 (it) * 2018-03-12 2019-09-12 Bio On Spa Poliidrossialcanoati per l’uso nella prevenzione del cancro colorettale.
CN110699391B (zh) * 2019-11-01 2023-05-30 山东省农业科学院农产品研究所 一种微波辅助碱法预处理牡丹果荚制备生物塑料聚-β-羟丁酸的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989000202A2 (en) * 1987-06-29 1989-01-12 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers

Also Published As

Publication number Publication date
EP0482077A1 (en) 1992-04-29
CA2062816C (en) 2006-09-12
DK0482077T3 (da) 1999-06-28
EP0870837A1 (en) 1998-10-14
ATE172497T1 (de) 1998-11-15
DE69032713D1 (de) 1998-11-26
DE69034017D1 (de) 2002-12-12
JP3964437B2 (ja) 2007-08-22
JP3703983B2 (ja) 2005-10-05
DE870837T1 (de) 1999-09-16
JP3964436B2 (ja) 2007-08-22
JP3967371B2 (ja) 2007-08-29
EP0870837B1 (en) 2002-11-06
DE69034017T2 (de) 2003-07-31
WO1991000917A1 (en) 1991-01-24
ES2131489T1 (es) 1999-08-01
JPH05500751A (ja) 1993-02-18
JPH11332588A (ja) 1999-12-07
ES2131489T3 (es) 2003-05-16
JP2005287517A (ja) 2005-10-20
JP2005278656A (ja) 2005-10-13
JP2001178482A (ja) 2001-07-03
JP2003189858A (ja) 2003-07-08
JP2004329219A (ja) 2004-11-25
JP2007143567A (ja) 2007-06-14
EP0482077B1 (en) 1998-10-21
CA2062816A1 (en) 1991-01-11
DE69032713T2 (de) 1999-04-08
ATE227340T1 (de) 2002-11-15

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